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단미음료제(單味飮料劑)를 통한 소갈(消渴)의 치료(治療)에 관한 고찰(考察)
박춘하,위통순,김용성,이경환,Park Choon-Ha,Wei Tung-Sheun,Kim Yong-Sung,Lee Kyung-Hwan 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
In Oriental medicine, So-gal(消渴) is similar to Diabetes Mellitus in the symptoms. In the medical treatment of So-gal(消渴), one kind of herb medicine is recorded in ancent medicine literatures. That herb medicine is a juice of vegetable drunken with herb medicine of So-gal(消渴). Milk(牛乳汁), human milk(人乳汁), gam-ja-jup(甘蔗汁), wo-jul-jup(藕節汁), li-jup(梨汁), sang-gang-jup(生薑汁) etc. is that. In that juices, Milk(牛乳汁), human milk(人乳汁), gam-ja-jup(甘蔗汁), wo-jul-jup(藕節汁), li-jup(梨汁) have sweety tastes, and cold nature. So they cure So-gal(消渴) come from dry and hot nature. Sang-gang-jup(生薑汁) is different with others in the taste and nature that sweety and hot taste and hot nature. Sang-gang-jup(生薑汁) cure the sequela of So-gal(消渴) by his hot nature. We think In Diabetes Mellitus, that juice can be used by drink for the treatment of diet because of simility between So-gal(消渴) and DM.
배추의 배축절편으로부터 캘러스와 뿌리 발생을 통한 안정적 형질전환
조미애,김춘해,민성란,고석민,유장렬,최필선,Cho, Mi-Ae,Kim, Choon-Ae,Min, Sung-Ran,Ko, Suck-Min,Liu, Jang-Ryol,Choi, Pil-Son 한국식물생명공학회 2007 식물생명공학회지 Vol.34 No.2
'정상' 배추의 배축절편을 선발마커로서 paromomycin 저항 성유전자를 갖고 있는 pPTN290으로 각각 형질전환된 EHA101, LBA4404, GV3101균주와 공동배양한 후 갤러스유도배지에서 형질전환캘러스를 얻은 후, 뿌리유도배지에서 부정근을 그리고 신초유도배지에서 신초를 각각 순차적으로 유도하였다. 형질전환캘러스를 얻은 후, 뿌리유도배지에서 부정근을 그리고 신초유도배지에서 신초를 가각 순차적으로 유도하였다. 형질전환캘러스 형성은 Agrobacterium균주에 따라 차이가 있었으며, 특히 EHA101균주에 공동배양된 배축절편으로부터 최대 6.1%까지 얻어졌다. 또한 각각의 형질전환캘러스 클론으로부터 형질전환 부정근과 신초 발생은 EHA101균주에서 60.7%와 38.2%, LBA4404에서 8.3%와 0%, GV3101에서 20.5%와 85.7%까지 각각 얻을 수 있었다. 형질전환식물체는 특별한 형태적 이상 없이 온실에서 정상적으로 자라 $T_{2}$종자를 얻을 수 있었다. GUS방법으로 7개의 후대 유식물체를 분석한 결과 gus유전자가 안정적으로 발현하고 있음을 확인하였고, 배추 genome에 single 또는 multiple copy로 전달되고 있음을 추측할 수 있었다. Hypocotyl explants of Chinese cabbage (cvs. "Jeong Sang") produced transgenic calli on callus induction medium (MS salt, B5 vitamin, 5 mg/L acetosyringone, 1 mg/L 2,4-D, 3% sucrose, 400 mg/L cefotaxime, 100 mg/L paromomycin, pH 5.8) after cocultivation with strains of Agrobacterium tumefaciens (EHA101, LBA4404, GV3101) harboring the pPTN290 containing paromomycin-resistance gene as a selectable marker, and then they transferred to root induction medium (1/2MS salt, MS vitamins, 2% sucrose, 100 mg/L paromomycin, 100 mg/L cefotaxime, pH 5.8) and shoot induction medium (MS salt, B5 vitamin, 4 mg/L $AgNO_3$, 4 mg/L 6-benzyladenine, 3 mg/L alpha-naphthaleneacetic acid, 100 mg/L paromomycin, 100 mg/L cefotaxime, 3% sucrose, pH 5.8) in order. There was a significant difference in the frequency of transgenic calli depending on Agrobacterium strains. In particular, the highest frequency (6.1%) of transgenic calli was obtained from the hypocotyls cocultivated with EHA101 strains. Also, the frequency (%) of transgenic root and plants from each transgenic callus clone were obtained with 60.7% and 38.2% in EHA101, with 8.3% and 0% in LBA4404, with 20.5% and 85.7% in GV3101 strains, respectively. They were grown to maturity in a greenhouse and normally produced $T_2$ seeds. GUS histochemical assay for progeny ($T_2$) revealed that the transgenes was expressed in the plant genome, and progeny analysis from 7 independent transgenic events demonstrated that the transformants transmitted the transgene as a single or multiple functional locus.
동씨침(董氏鍼)의 경항통(頸項痛) 치료(治療)에 관한 임상적(臨床的) 고찰(考察)
이채우,조태성,박인범,김상우,안창범,송춘호,윤현민,장경전,Lee, Chae-woo,Cho, Tai-Sung,Park, In-beohm,Kim, Sang-woo,Ahn, Chang-beohm,Song, Choon-ho,Youn, Hyoun-min,Jang, Kyung-jeon 대한침구의학회 2003 대한침구의학회지 Vol.20 No.2
Objective : The purpose of this study was to evidence the effect of Dong-Shi Acupuncture by improving degree of forty four patients who have received a Dong-Shi Acupuncture therapy at Dong Eui oriental hospital OPD and chiefly complained for neck pain and related symptoms. Materials and Methods: Forty four patients were diagnosed with physical inspection and radiography, and investigated into the effect of treatment sharing before treatment and after 2 weeks and 4 weeks treatment by Dr. Kim's method. Results and Conclusions: The conclusion of this study was that improving degree of forty four patients who have received a Dong-Shi acupuncture therapy for all items and excellence of the Dong-Shi Acupuncture was evidenced.
( Sung Woo Park ),( Ae Rin Baek ),( Do Jin Kim ),( An Soo Jang ),( Soo Taek Uh ),( Yong Hoon Kim ),( Choon Sik Park ),( Yoon Pyo Kang ),( Sung Won Kwon ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Idiopathic pulmonary fibrosis (IPF) is characterized chronic progressive lung fibrosis with poor prognosis. Many part of pathogenesis of IPF is still not known. Metabolomics is the study of molecules created by cellular metabolic pathways. we hypothesize that exploring the metabolic pathways of lung tissues from IPF could revealing a clear pathogenesis of IPF Methods: Lung tissues obtained from 12 patients with IPF and from 12 normal subjects and performed global metabolomic profiling using gas chromatography coupled to mass spectrometry. Results: Through unsupervised principal component analysis (PCA), the variation and outlier of samples were monitored and the clustering patterns between IPF and control groups were confirmed. Based on this, we performed a supervised method, partial least squares discriminant analysis (PLS-DA), to establish the predictive and discriminative models. To interpret the data more reliably, the metabolites selected by PLS-DA and univariate statistical analyses due to the value of area under the receiver operator characteristic curve (AUROC) more than 0.9, were proved to have high prediction performance between the groups. The expression patterns of the identified metabolites indicated an anaerobic glycolysis, depletion of ATP, impairment of glutathione biosynthesis, and increase of ornithine-proline metabolism as distinctive metabolic phenotypes of IPF. Conclusions: Our enhanced metabolomics approach verified the existing hypotheses of pathogenesis in IPF at the metabolite level and suggested noteworthy signals of pathogenic metabolites related to IPF.
( Sung Woo Park ),( Ae Rin Baek ),( Do Jin Kim ),( An Soo Jang ),( Soo Taek Uh ),( Y Ong Hoon Kim ),( Choon Sik Park ),( Yoon Pyo Kang ),( Sung Won Kwon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Idiopathic pulmonary fi brosis (IPF) is characterized chronic progressive lung fi brosis with poor prognosis. Many part of pathogenesis of IPF is still not known. Metabolomics is the study of molecules created by cellular metabolic pathways. we hypothesize that exploring the metabolic pathways of lung tissues from IPF could revealing a clear pathogenesis of IPF Methods: Lung tissues obtained from 12 patients with IPF and from 12 normal subjectsand performed global metabolomic profi ling using gas chromatography coupled to mass spectrometry. Results: Through unsupervised principal component analysis (PCA), the variation and outlier of samples were monitored and the clustering patterns between IPF and control groups were confi rmed. Based on this, we performed a supervised method, partial least squares discriminant analysis (PLS-DA), to establish the predictive and discriminative models. To interpret the data more reliably, the metabolites selected by PLS-DA and univariate statistical analyses due to the value of area under the receiver operator characteristic curve (AUROC) more than 0.9, were proved to have high prediction performance between the groups. The expression patterns of the identifi ed metabolites indicated an anaerobic glycolysis, depletion of ATP, impairment of glutathione biosynthesis, and increase of ornithine-proline metabolism as distinctive metabolic phenotypes of IPF. Conclusions: Our enhanced metabolomics approach verifi ed the existing hypotheses of pathogenesis in IPF at the metabolite level and suggested noteworthy signals of pathogenic metabolites related to IPF.
( Sang Hee An ),( Sun Young Lee ),( Sang Pyo Lee ),( Jeong Hwan Kim ),( In Kyung Sung ),( Hyung Seok Park ),( Chan Sup Shim ),( Choon Jo Jin ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The serum titer of anti- Helicobacter pylori immunoglobulin G (IgG) antibody starts to increase again when reinfection occurs after a successful eradication. The aim of this study was to evaluate whether the serum pepsinogen (PG) assay is effective for the diagnosis of gastric atrophy after reinfection. Methods: This study included consecutive Korean adults who had a remote H. pylorieradication therapy, but showed positive serum anti- H. pylori IgG antibody test on the day of upper gastrointestinal endoscopy and serum PG test at our center. Advanced chronic atrophic gastritis on endoscopy was defi ned as either closed- or open-type atrophy. Serologic atrophy was defi ned as PG I/II ratio <3.0 and PG I level < 70 ng/ml. Results: Of the 131 subjects who fulfi lled the study inclusion criteria, 50 showed high bacterial loads (serum anti- H. pylori antibody titer =150 AU/ml) and 28 showed low bacterial loads (<50 AU/ml). The high bacterial load group showed highest PG levels and lowest PG I/II ratio (Table 1). Although serologic atrophy was more frequent in thehigh bacterial load group (p=0.034), this group showed the highest serum PG I levels (p=0.001). Conclusions: The severity of gastric atrophy cannot be assessed by serum PG assay after reinfection, as suggested by our fi nding that PG I/II ratio is inversely related to the PG I level. Higher bacterial load induces a larger increase in PG II level than PG I level due to severe infi ammatory reaction upon reinfection. Therefore, a decreased PG I/II ratio is no longer valuable for detecting serologic atrophy in the reinfected subjects after a successful H. pylori eradication.