推論과 證明指導에 관한 考察

김종구,임석훈,설영수 경북대학교 과학교육연구소 1997 科學敎育硏究誌 Vol.21 No.-

This study is to discuss the educational problem about whether an exact proof is useful in the secondary school mathematics education formally in the development of mathematical thought and whether we should teach students an exact proof up to an extent.

만성주정중독자의 시각유발전위반응

설석구,김종길 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.4

Visual evoked potentials(VEP) were recorded on 24 male chronic alcoholics and 20 normal male controls. Alcoholic patients met the criteria of the DSM-Ⅲ-R for alcoholism, with a mean age 45 years and drinking history for an average of 21 years. Control-subjects were ate matched male volunteers tree of medical problems. The results were as follows : 1) Mean latency and mean amplitude of P100 were 98.35±3.33ms, 8.61±2.54μV in control group and 102±6.76ms, 5.22±2.28μV in alcohol group. The statistical analyses of above results using two-tailed t-test indicate that mean latency of P100(p<0.01)was significantly prolonged and mean amplitude of P100(p<0.01) was significantly decreased in alcoholic group compared to control group. 2) Of the 24 patients, 6(25%) had abnormal VEP. There were 5 patients with abnormally prolonged latency(above mean latency of control group+2.5SD) of P100 and 1 with abnormally prolonged interocular latency difference(above mean ILD of control group+2.5SD) only. Of the 5 patients with abnormally prolonged latency of P100, 3 had both of the abnormalities. These findings provide the possibility for pathological involvement of the visual pathway in chronic alcoholics. And so the authors suggest that VEP may be useful in detection of the early stage of alcohol induced brain damage.

치과주조용 저카라트 금합금의 시효경화

김형일,김종렬,안호경,장명익,설효정,김교한 대한치과기재학회 1997 대한치과재료학회지 Vol.24 No.2

The age-hardening behavior of a commercial dental casting low-carat gold alloy was investigated by means of differential thermal analysis, hardness test, optical microscopic observation and X-ray diffraction study. The following results were obtained. 1. By the isothermal aging of this alloy at 300∼400℃, the hardness increased markedly at the initial stage and continued to increased gradually for the time, and then decreased dractically after longer aging time. 2. The hardening was attributed to the formation of the metastable AuCu I' ordered phase from the α matrix. 3. The overaging with softening was attributed to the precipitation of the fine lamellar structure which was composed of the Ag-rich α1 and AuCu I ordered phases.

加味鷄血藤湯이 Glutamate receptor와 Free radical 및 뇌손상 보호에 미치는 영향

안종석,김동희,김윤식,이용구,박종오,남궁욱,설인찬 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3

This study was investigated to prove the effect of GMGHT on the gultamate receptor, free radical and brain damage in rats sujected to Brain Ischemia The results were as follows ; 1. GMGHT showed significant inhibitory effect of GMGHT on LDH release induced by NMDA, AMPA, and kinate. 2. GMGHT showed significant inhibitory effect of GMGHT on LDH release induced by BSO and Fe^2+. 3. GMGHT decreased coma duration time in a infatal dose of KCN and showed 30% of survival rate in a fatal dose. 4. GMGHT decreased ischemic area and edema incited by the MCA blood flow block. 5. GMGHT showed improvement of forelimb test after MCA occulusion in neurological exemination. 6. GMGHT showed no significant change after MCA occulusion in pathological observation as normal group. These results indicate that GMGHT can be used in the brain damage sujected to Brain Ischemia. Further study will be needed about the functional mechanism and etc.

사람의 비후성 반흔에서 면역조직화학기법에 의한 형질전환인자 알파와 표피성장인자 발현의 차이에 관한 면역조직화학적 연구

박영란,김현곤,김종중,문정석,송준섭,설경수,정윤영 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background and Objectives: Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are polypeptides which interact with the epidermal growth factor receptor (EGFR) to produce their biological effects. The aim of the present investigation was to elucidate the immunolocalization of TGF-α and EGF in normal human skin, hypertrophic scar with skin graft on soft tissue defect, and postburn hypertrophic scar without graft. Methods: The data presented in this paper focused attention on differences of expression between two kinds of hypertrophic scars in relation to skin graft using immunohistochemistry. Formalin-fixed and paraffin-embedded tissues from 3 normal skin tissues, 3 hypertrophic scars after skin graft and 8 postburn hypertrophic scars without graft were immunolabelled with antibodies directed against TGF-α and EGF. Results: In normal epidermis of skin, strong TGF-α immunoreactivity (IR) was observed in all epidermal layers except the stratum (S.) basale, whereas EGF was immunopositive in a few cells over all epidermal layers. The staining for TGF-α was found in cell membrane, and EGF was seen either diffuse cytoplasmic or peripheral part of cells in normal epidermis. In hypertrophic scar after six months postoperation, TGF-α IR was observed in the upper part of S. spinosum and S. corneum, whereas EGF was diffusely expressed in the S. spinosum, also its intensity was slightly increased compared to normal skin. In hypertrophic scar without skin graft, very strong expression of EGF was detected in the S. spinosum and S. corneum, and intensity of EGF was increased when compared to normal skin and postoperative hypertrophic scar. EGF and TGF-α coexisted in the cells of S. spinosum in normal skin as well as hypertrophic scars. Double-labeled cells were increased in postburn hypertrophic scar compared to normal skin and postoperative hypertrophic scar. In addition, intensity of EGF and TGF-α double IR was the strongest in postburn hypertrophic scar. Conclusion: These results indicate that EGF may have a more complex regulatory role not only in the early stages of wound healing but also in hypertrophic scar.

한랭작업 근로자들의 건강위해에 관한 연구

박호추,정설미,문덕환,이종태,김대환,김정호,최재일,황용식,이용희,이채언 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

In order to evaluate the status of cold exposure and its health hazards of workers at cold storage workplaces and to provide basic data for effective health care, the author measured core temperature and also observed clinical symptoms and signs, past and present history, and general health examination data on 99 cold exposed workers for exposure group and 96 non-exposed workers for control group working at 2 food refrigerating companies in Pusan area from January 6, 1998 to February 24, 1998. The results were as follows: 1. There was statistically significant difference in water intake between the exposure and control group and increased urine volume, urine frequency in exposure group without statistically significant difference. 2. Past and present illness in exposure group were hypertension (18.2%), hepatopathy (8.1%), gastro-intestinal disease(7.1%), arthritis (4.0%), intervertebral disc herniation(4.0%), and so on, and hypertension, arthritis was statistically significant difference compared to control group. 3. Symptoms in exposure group were fatigue(89.9%), headache (64.6%). drowsy(63.6%), neck stiffness(59.6%), excessive food intake(59.6%). general weakness(58.6%), hunger(58.6%), numbness(54.5%), and so on, and there was statistically significant difference between the exposure and control group except fatigue, drowsy. 4. As results of clinical test abnormality rate of the systolic, diastolic blood pressure and electrocardiogram were significantly higher in exposed group than control. 5. Core temperature in exposure group was statistically significantly lower than control group and the highest statistically significant inverse correlation with the working hours and working frequency of daily mean cold storage. As above results, the author suggested that the further studies should be conducted to evaluate the health status of workers about chronic health effects in cold workplaces and to establish effective health care methods for them.

소아에서의 Nd : YAG Laser를 이용한 치은착색제거술 YAG Laser in children

모경희,박헌동,박종휘,김효석,정현구,설재헌,이병채 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1

Melanin is normally found in the skin of all people, and normal pigmentation of the intraoral tissues is a relative frequent finding. Gingival hyperpigmentation may cause esthetic problems and embarrassment, especially in patients with a gummy smile. Melanin pigmentation is related to etiologic factor such as hormon, systemic factor, drug, smoking and gingival inflamation. Depigmentation procedure can be Performed by gingival epithelium removing procedure, gingivectomy, free gingival graft, laser therapy, dry ice, Vitamin C and phenol-alcohol method. We could obtain favorable esthetic results by procedures such as Nd: YAG laser. The Nd:YAG laser was set at 4 watt, 50mJ, 80 pulse per second. The procedures were performed with contact mode in all pigmented areas by using a handpiece with a 320㎛ diameter fiber optic. Ablation of the gingival hyperpigmented gingiva appeared healthy, pink, and firm. No recurrence of hyperpigmentation had been found in 6 months of follow-up.

Methanol extract of Dioscoreae Rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis

Kim, Min-Jong,Kim, Ha-Na,Kang, Kyung-Sun,Baek, Nam-In,Kim, Dae-Keun,Kim, Young-Seol,Kim, Sung-Hoon,Jean, Byung-Hun WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Dioscoreae Rhizoma (MDR), the root of Dioscorea tokoro MAKINO, has been used for the treatment of arthritis, muscular pain and urinary diseases in oriental medicine. The present work evaluates a methanol extract of Dioscoreae Rhizoma (MDR). MDR did not Show any cytotoxic effect an mouse lang fibroblast cells (mLFCs) or human fibroblast-like synovial cells (hFLSCs). However, it significantly reduced the proliferation of hFLSCs stimulated by interleukin-lbeta (IL-lβ) and tumor necrosis factor-alpha (TNF-α). MDR significantly inhibited the production of TNF-α and IL-β as well as down-regulating the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in IL-1β- and TNF-α-stimulated hFLSCs. MDR also effectively reduced the level of reactive oxygen species (ROS) in these cells. Taken together, these findings provide evidence that MDR may be a candidate for the treatment of rheumatoid arthritis (RA).

A case of sarcoidosis on forehead with penile involvement

( Jong Uk Kim ),( Seung Hee Jang ),( Sang Woo Ahn ),( Seong Min Hong ),( Woo Jung Jin ),( So Hee Park ),( Jung Eun Seol ),( Hyojin Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

Alitretinoin compliance in patients with chronic hand eczema

( Jong Uk Kim ),( Gyeong Je Cho ),( Woo Jung Jin ),( So Hee Park ),( Seung Hyun Moon ),( Jung Eun Seol ),( Hyojin Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Alitretinoin is the first drug approved as a treatment option for chronic hand eczema (CHE) unresponsive to topical steroids. Adherence to alitretinoin for 12 weeks or more is known to be effective. But, poor compliance is the most common obstacle to treatment. Objectives: This study was conducted to evaluate the compliance rate of alitretinoin treatment and explore common reasons of poor-compliance in patients with CHE Methods: We reviewed medical record of CHE patients treated with alitretinoin. Poor-compliance group was defined as subjects with alitretinoin medication for less than 12 weeks, while good-compliance group was defined as those with medication for more than 12 weeks. Results: A total of 137 subjects were enrolled and 87 of them were poor-compliance group. The percentage of subjects with clinical improvement was significantly higher in good-compliance group (88.0%) compared with poor-compliance group (43.7%). In poor-compliance group, reasons of alitretinoin cessation were insufficient response (40.8%), high cost (34.7%) and adverse events (24.5%) in which headache was the most common followed by GI problem and flushing. The rate of insufficient response was higher in male, whereas old age (>60) and female was favorable factor in occurrence of adverse reaction in poor-compliance group. Conclusion: It is probable that alitretinoin with sufficient period might increase the rate of improvement in CHE. Thus, it is important to control the factors affecting compliance in CHE treatment.