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( Hyeong Seop Kim ),( Ye Rin Choi ),( Mi Gun Hong ),( Min Jea Shin ),( Sang Jun Yoon ),( Na Young Lee ),( Hyun Ji Ye ),( Sang Hak Han ),( Dong Joon Kim ),( Gi Soo Youn ),( Ki Tae Suk ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Liver fibrosis constitutes a serious problem worldwide due to its rapidly leads to cirrhosis, and even cancer. However, there is no clear medical treatment other than treating the cause. Urushiol has been known to have anti-inflammatory and anti-oxidative effects on various disease. We investigated the effect of urushiol on liver fibrosis induced by thioacetamide (TAA). Methods: Thirty C57BL/6 mice were randomly divided into 3 groups and urushiol was dissolved in vehicle (DMSO) for in vivo experiments: (1) control group; (2) TAA (normal saline as solvent, 300 mg/kg/day, 3 times/week, i.p.) + vehicle (gavage). (3) TAA (300 mg/kg/day, 3 times/week, i.p.) + urushiol (0.128 mg/ mL/day, 28 times, gavage). These groups were analyzed by immunohistochemical staining, reverse transcription polymerase chain reaction, and microarray. Results: The TAA + Urushiol group improved the deposition of fibrillar collagen (Sirius Red (%) 1.55 ± 0.25 vs. TAA, P<0.0001), Fibrosis stage reduced (1.64 ± 0.20 vs. TAA, P<0.0001) and Inflammation activity decreased concurrently (1.17 ± 0.16 vs. TAA, P<0.0001). The analysis of mRNA expression showed that Col1a1 (2.30-fold change vs. TAA, P<0.0001) and TIMP-1 (1.48-fold change vs. TAA, P<0.05), IL-6 (3.03- fold change vs. TAA, P<0.0001), JAK2 (0.89-fold change vs. TAA, P<0.05), STAT3 (3.26-fold change vs. TAA, P<0.0001) downregulated significantly. As shown microarray analysis, downregulation of Col1a1 (1.12-fold change vs. TAA, P<0.05), Chka, lipid metabolic process gene (2.21-fold change vs. TAA, P<0.001), Pnpla3, patatin-like phospholipase domain containing 3 (1.57-fold change, P<0.001) Contrast, Orm2, regulation of immune system process gene (2.28-fold change vs. TAA, P<0.001) Saa1, serum amyloid A (2.25-fold changes vs. TAA, P<0.05), Saa2 (3.09-fold change, P<0.001) Conclusions: Our results indicated that urushiol has therapeutic effect on liver fibrosis. Although it is needed more clinical research, urushiol can be a potential agent for the treatment of liver fibrosis.
Free-flap reconstruction in recurrent head and neck cancer: A retrospective review of 124 cases
Kim, Hyeong Seop,Chung, Chul Hoon,Chang, Yong Joon Korean Cleft Palate-Craniofacial Association 2020 Archives of Craniofacial Surgery Vol.21 No.1
Background: Free-flap reconstruction for recurrent head and neck cancer may be challenging depending on the previous treatments, those are, chemotherapy, radiotherapy, and surgery, including neck dissection or free tissue transfer. Specifically, the previous treatment could compromise the neck vessels, thereby making free-flap reconstruction more difficult. This study aimed to investigate the correlation between previous treatments and vascular compromise of the free flap. Methods: In this retrospective study, 124 free-flap reconstructions in 116 patients for recurrent head and neck cancer between 1993 and 2017 were investigated. The demographic characteristics, previous treatments, flap choices, infections, recipient vessels, and vascular crises were evaluated. Results: Of the 124 reconstruction cases, 10 had vascular crises. There were six revisions, totaling six flap failures. The success rate of free-flap reconstruction for recurrent cancer was 95.2%, which significantly differed from that for primary cancer (98.8%, p= 0.006). Moreover, in the recurrent cancer group, no correlation was found between previous treatments and vascular crises (p> 0.05). Increased rates of contralateral or uncommon anastomoses were found following neck dissection (p< 0.05). Conclusion: Previous neck dissection or radiotherapy could lead to scarring and tissue damage, which could in turn make microvascular reconstruction more challenging; however, the effect was not definite in this study. Approximately 60% of patients with previous neck dissection had compromised ipsilateral recipient vessels, which resulted in contralateral or uncommon anastomoses. In this study, free-flap reconstruction seems to be quite safe and preferable in patients with recurrent head and neck cancer based on the overall survival rate.
Kim, Hyeong Seop,Lee, Na Kyung,Yoo, Dongkyeom,Lee, Jeongmin,Choi, Soo Jin,Oh, Wonil,Chang, Jong Wook,Na, Duk L. Elsevier 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Due to their widely known therapeutic benefits, mesenchymal stem cells have been proposed as a novel treatment option for a wide range of diseases including Alzheimer's disease. To maximize these benefits, critical factors such as delivery route, cell viability, and cell migration must be accounted for. Out of the various delivery routes to the brain, the intracerebroventricular (ICV) route stands out due to the widespread distribution that can occur via cerebrospinal fluid flow. The major objective of this present study was to observe how altering cell concentration influences the migration and viability of human umbilical cord blood derived-mesenchymal stem cells (hUCB-MSCs), delivered via ICV injection, in the brains of wild-type (WT) mice. C3H/C57 WT mice were divided into three groups and were injected with 1 × 10<SUP>5</SUP> hUCB-MSCs suspended in varying volumes: high (3 μl), middle (5 μl), and low (7 μl) concentrations, respectively. Lowering the concentration increased the migratory capabilities and elevated the viability of hUCB-MSCs. These results suggest that cell concentration can affect the physiological state of hUCB-MSCs, and thus the extent of therapeutic efficacy that can be achieved.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cell concentration must be considered for stem cell therapy. </LI> <LI> More widespread distribution in the brain is achieved with ICV injections of lower cell concentrations. </LI> <LI> A higher number of engrafted cells was observed with ICV injections of higher cell concentrations. </LI> <LI> Lowering concentration increased viability and enhanced migration. </LI> </UL> </P>
Hyeong Seop Kim,Heesuk Shin,Chul Ho Yoon,Eun Shin Lee,Min-Kyun Oh,Se-Woong Chun,Seung-Kyu Lim,Hoi Sik Min,Hayoung Byun 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.1
Objective To retrospectively review the characteristics of preschool children with speech and language disorders to determine their clinical features and compares the average degrees of language delay based on hospital visit purposes, language developmental delay causes, and maternal language. Methods One thousand one hundred two children (832 males, 270 females) with the chief complaint of language or speech problems who underwent language assessment for the first time were included. Their medical records, including demographic data, language environments, and family history of language problems and other developmental problems, were collected. Furthermore, the results of language and developmental assessments and hearing tests were collected. Results Among the children enrolled in this study, 24% had parental problems and 9% were nurtured by their grandparents. The average degree of language delay did not differ regarding purposes of hospital visits. The average degree of language delay was greatest in children with autism spectrum disorders and least in children with mixed receptive–expressive language disorders. In children with mothers who do not speak Korean as their native language, social quotients in the social maturity scale were less than 70. Conclusion Language environment is an essential factor that may cause speech and language disorders. Moreover, maternal language seems to affect the social quotient of the social maturity scale.
Klebsiella pneumoniae necrotizing fasciitis on the upper lip in a patient with uncontrolled diabetes
Kim, Hyeong Seop,Chang, Yong Joon,Chung, Chul Hoon Korean Cleft Palate-Craniofacial Association 2020 Archives of Craniofacial Surgery Vol.21 No.2
A 60-year-old woman with a history of diabetes mellitus and chronic renal failure was admitted to the hospital with severe pain in the upper lip, which began 4 days prior to admission, accompanied by a bullous lesion and suspected cellulitis in the upper lip. Immediately after admission, as the patient's general condition worsened, tests revealed a non-ST elevated myocardial infarction, septic embolism of the lung, as well as septic shock. Her upper lip suddenly presented a gangrenous and necrotic change, which the tissue and blood culture confirmed to be a Klebsiella pneumoniae infection. After a quick response, the patient's general condition improved. Subsequently, serial debridement was performed to effectively clear away the purulent discharge. While under general anesthesia, the process confirmed full-layer necrosis of the upper lip including the orbicularis oris muscle. Almost half of the entire upper lip sustained a full-layer skin and soft tissue defect, with scar contracture. Six months later, to correct the drooling and lip sealing following the defects, a scar release and an Abbe flap coverage were performed considering both functional and aesthetic aspects. The follow-up revealed a favorable corrective result of the upper lip drooling, and the patient was satisfied from a functional perspective.
『상한론(傷寒論)』 '明'에 대한 고찰 : 변병진단체계(辨病診斷體系)에 입각해 치료한 양명병(陽明病) 증례 2례에 근거하여
김형섭 ( Hyeong-seop Kim ),조성환 ( Seong-hwan Cho ),이성준 ( Sung-jun Lee ) 대한상한금궤의학회 2018 대한상한금궤의학회지 Vol.10 No.1
Objectives : This study is to propose a new hypothesis about the interpretation of 'Ming (明)' in Shanghanlun and the direction of future research about Yangmingbing(陽明病). Methods : We analyzed the original form of the chinese characters 'Ming(明)' and tried to understand their contexts in Shanghanlun. At the same time, we analyzed 2 clinical cases diagnosed and treated as Yangmingbing according to newly hypothesized definition. Results : From etymology, ‘Ming(明)' means becoming distinct. Patients in 2 cases suffered from cold hypersensitivity of hands and feet, overactive bladder syndrome and dizziness, all of which became distinct and problematic. For this reason, we diagnosed patients with Yangmingbing(陽明病) and administered herbal medicine then they improved. Conclusions : The disease names in Shanghanlun have clinical message by the name itself. From etymology, at least in 15 characters provision of Shanghanlun, Yanmingbing means the disease made by becoming conscious about symptoms. Future research about Yangmingbing (陽明病) should start from here.
Current trends of major arterial diseases in Korea
Mi-Hyeong Kim,Sanghyun Ahn,Jang-Yong Kim,Kang-Woong Jun,Sang-Seop Yun,Yong Sung Won 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.90 No.4
Purpose: This study aims to figure out the changes of the prevalence and management of carotid arterial occlusive diseases (CAOD), abdominal aortic diseases (AAA), and arterial diseases of the lower extremities (LAOD) in Korea over the past 5 years. Methods: Data were extracted from the Health Insurance Review and Assessment Service during the period from 2008 to 2012. Results: The number of patients with CAOD increased by about 30% every year. From the year 2008, the number of open surgeries (OS) and endovascular treatments (ET) increased by more than 20% during each of the first 2 years and by 10% every year for 3 years thereafter for CAOD. ET was preferred to OS and occupied 77%–79% of the total number of procedures. The number of patients with AAA increased by 11%–17% every year. ET for AAA occupied 52% of the total number of procedures in 2008 and gradually increased to 70% in 2012. The number of patients who were diagnosed with LAOD fluctuated over the five years. The total number of procedures to treat LAOD increased each year by 20%–25%. ET for LAOD constantly increased by 18%–24% each year and occupied 80%–95% of the total number of procedures. Conclusion: It is evident that the incidence of vascular diseases will be increasing as our society ages, not to mention its care costs. The need for long-range plans and guidelines are urgent.