Reliability of the Pinch Strength with Digitalized Pinch Dynamometer

Shin, Heesuk,Moon, Seung Won,Kim, Gab-Soon,Park, Jung Dong,Kim, Jin Hoan,Jung, Mi Jin,Yoon, Chul Ho,Lee, Eun Shin,Oh, Min-Kyun Korean Academy of Rehabilitation Medicine 2012 Annals of Rehabilitation Medicine Vol.36 No.3

<P><B>Objective</B></P><P>To examine the intra-rater, inter-rater, and inter-instrumental reliability of the digitalized pinch muscle strength dynamometer.</P><P><B>Method</B></P><P>Thirty normal subjects were examined for pinch strength, using both the Preston pinch gauge and the digitalized pinch dynamometer. The participants performed all pinch strength tests in the seated position as recommended by the American Society of Hand Therapists (ASHT). Three successive measurements were taken for each hand. The mean of the three trials was used for data analysis. The pinch strength tests performed used a repeated measure design and measurements were taken by each rater.</P><P><B>Results</B></P><P>The relationship between the Preston pinch gauge and the digitalized pinch dynamometer in pinch strength was reliable (the ICC were 0.821 and 0.785 in rater 1 and rater 2 respectively). The relationship between the first session and second session in pinch strength using the digitalized pinch dynamometer was reliable (the ICC were 0.872 and 0.886 in rater A and rater B respectively). The relationship between rater A and rater B in pinch strength using the digitalized pinch dynamometer was reliable (the ICC was 0.754).</P><P><B>Conclusion</B></P><P>The pinch strength measurement using the digitalized pinch dynamometer is reliable within the rater and between raters. Thus, the Preston pinch gauge and the digitalized dynamometer measure grip strength equivalently, and can be used interchangeably.</P>

가토의 좌골신경손상후 비복근육의 자기공명영상 신호변화에 관한 연구

신희석,김재형,김인호 大韓再活醫學會 1997 Annals of Rehabilitation Medicine Vol.21 No.5

HIV Peptide-Mediated Binding Behaviors of Nanoparticles on a Lipid Membrane

Phan, Minh Dinh,Kim, Heesuk,Lee, Songyi,Yu, Chung-Jong,Moon, Bongjin,Shin, Kwanwoo American Chemical Society 2017 Langmuir Vol.33 No.10

<P>The bioinspired design of ligands for nano-particle coating with remarkable precision in controlling anisotropic connectivity and with universal binding efficiency to the membrane has made a great impact on nanoparticle self assembly. We utilize the HIV-1-derived trans-activator of transcription peptide (TAT), a member of the cell-penetrating peptides, as a soft shell coating on gold nanoparticles (GNPs) and characterize TAT pepide-mediated binding behaviors of GNPs on the lipid membrane. Whereas the peptides enable GNPs to firmly attach to the membrane, the binding structures are driven by two electrostatic forces: the interparticle peptide repulsion and the peptide membrane attraction. Although transmission electron microscopy images showed that the densities of membrane-embedded GNPs were almost equal, X-ray reflectivity revealed a significant difference in binding structures of GNPs along the surface normal upon the increase of charge densities (phi) of the membrane. In particular, GNPs were densely suspended at phi = 70% while they adopted an additional well-defined layer underneath the membrane at phi = 100%, in addition to a translocation of the initially bound particles into the membrane. The observed behaviors of GNPs manifest a 3D to 2D transformation of the self-assembled structures from the diffused state to the closely packed state with the increase in the charge density of the membrane. The present study also provides insights on the binding mechanisms of the cell-penetrating peptide-coated nanoparticles to the lipid membranes, which is a common theme of delivery systems in pharmaceutical research.</P>

The Clinical Features of Preschool Children With Speech and Language Disorder and the Role of Maternal Language

Hyeong Seop Kim,Heesuk Shin,Chul Ho Yoon,Eun Shin Lee,Min-Kyun Oh,Se-Woong Chun,Seung-Kyu Lim,Hoi Sik Min,Hayoung Byun 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.1

Objective To retrospectively review the characteristics of preschool children with speech and language disorders to determine their clinical features and compares the average degrees of language delay based on hospital visit purposes, language developmental delay causes, and maternal language. Methods One thousand one hundred two children (832 males, 270 females) with the chief complaint of language or speech problems who underwent language assessment for the first time were included. Their medical records, including demographic data, language environments, and family history of language problems and other developmental problems, were collected. Furthermore, the results of language and developmental assessments and hearing tests were collected. Results Among the children enrolled in this study, 24% had parental problems and 9% were nurtured by their grandparents. The average degree of language delay did not differ regarding purposes of hospital visits. The average degree of language delay was greatest in children with autism spectrum disorders and least in children with mixed receptive–expressive language disorders. In children with mothers who do not speak Korean as their native language, social quotients in the social maturity scale were less than 70. Conclusion Language environment is an essential factor that may cause speech and language disorders. Moreover, maternal language seems to affect the social quotient of the social maturity scale.

Phase separation of phospholipid multilayers incorporated with cell penetrating peptides

Jing, Huaiyu,Kim, Heesuk,Choi, Dongjin,Lee, Dong Ryeol,Lee, Jeong Soo,Yu, Chung-Jong,Shin, Kwanwoo American Vacuum Society 2011 Biointerphases Vol.6 No.2

Correction: The Clinical Features of Preschool Children With Speech and Language Disorder and the Role of Maternal Language

Hyeong Seop Kim,Heesuk Shin,Chul Ho Yoon,Eun Shin Lee,Min-Kyun Oh,Se-Woong Chun,Seung-Kyu Lim,Hoi Sik Min,Hayoung Byun 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.3

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Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination

Ham, Su Jin,Lee, Daewon,Yoo, Heesuk,Jun, Kyoungho,Shin, Heejin,Chung, Jongkyeong National Academy of Sciences 2020 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.117 No.8

<P><B>Significance</B></P><P>VDAC1 transports ions and small molecules at the mitochondrial outer membrane. In this study, we discover that Parkin, a frequently mutated Parkinson disease protein, ubiquitinates VDAC1 in two different manners, poly- and monoubiquitination. Interestingly, VDAC1 defective in polyubiquitination hinders Parkin-mediated mitophagy, but VDAC1 defective in monoubiquitination induces apoptosis. When VDAC1 deficient with monoubiquitination is expressed in mammalian cells and fruit fly, we observe increased mitochondrial calcium influx and apoptosis and typical in vivo phenotypes related to Parkinson disease, such as defective locomotive activity and loss of dopaminergic neurons. These results suggest that the dual regulation of mitophagy and apoptosis by Parkin via VDAC1 poly- and monoubiquitination is highly critical in protecting cells from the pathogenesis of Parkinson disease.</P><P>VDAC1 is a critical substrate of Parkin responsible for the regulation of mitophagy and apoptosis. Here, we demonstrate that VDAC1 can be either mono- or polyubiquitinated by Parkin in a PINK1-dependent manner. VDAC1 deficient with polyubiquitination (VDAC1 Poly-KR) hampers mitophagy, but VDAC1 deficient with monoubiquitination (VDAC1 K274R) promotes apoptosis by augmenting the mitochondrial calcium uptake through the mitochondrial calcium uniporter (MCU) channel. The transgenic flies expressing <I>Drosophila</I> Porin K273R, corresponding to human VDAC1 K274R, show Parkinson disease (PD)-related phenotypes including locomotive dysfunction and degenerated dopaminergic neurons, which are relieved by suppressing MCU and mitochondrial calcium uptake. To further confirm the relevance of our findings in PD, we identify a missense mutation of Parkin discovered in PD patients, T415N, which lacks the ability to induce VDAC1 monoubiquitination but still maintains polyubiquitination. Interestingly, <I>Drosophila</I> Parkin T433N, corresponding to human Parkin T415N, fails to rescue the PD-related phenotypes of <I>Parkin</I>-null flies. Taken together, our results suggest that VDAC1 monoubiquitination plays important roles in the pathologies of PD by controlling apoptosis.</P>

A Multi-Dimensional Smart Community Discovery Scheme for IoT-Enriched Smart Homes

Kim, Taehun,Lim, Junsung,Son, Heesuk,Shin, Byoungheon,Lee, Dongman,Hyun, Soon J. Association for Computing Machinery 2018 ACM transactions on Internet technology Vol.18 No.1

<P>The proliferation of the Internet into every household has provided more opportunities for residents to become closer to each other than before. However, solid structural barrier is raised and social relationships within such neighborhoods are weak compared to those in traditional towns. Accordingly, activating communities and ultimately enhancing a sense of community through constructive participation and communal sharing of labor among residents has currently emerged as a challenging issue in a contemporary housing complex. In an effort to activate those communities, a notion of smart community is presented in which multiple smart homes are equipped with Internet of Things and interconnected with each other. Beyond the unadorned smart community composed by physical proximity, it is essential to discover a human-centric community that achieves communal benefits and enables residents to maximize individual economic gain by leveraging collective intelligence. In this article, we present a multi-dimensional smart community discovery scheme that enables householders to find human-centric community considering multi-dimensional factors in terms of physical, social, and economical aspects. We conduct experiments with 30 real households by applying a community-based energy saving scenario. Experiment results show that the proposed scheme performs better when compared to the physical proximity-based one in energy consumption and user satisfaction.</P>

Colloidal Spherical Quantum Wells with Near-Unity Photoluminescence Quantum Yield and Suppressed Blinking

Jeong, Byeong Guk,Park, Young-Shin,Chang, Jun Hyuk,Cho, Ikjun,Kim, Jai Kyeong,Kim, Heesuk,Char, Kookheon,Cho, Jinhan,Klimov, Victor I.,Park, Philip,Lee, Doh C.,Bae, Wan Ki American Chemical Society 2016 ACS NANO Vol.10 No.10

<P>Thick inorganic shells endow colloidal nanocrystals (NCs) with enhanced photochemical stability and suppression of photoluminescence intermittency (also known as blinking). However, the progress of using thick-shell 100 90 heterostructure NCs in applications has been limited due to the low photoluminescence quantum yield (PL QY <= 60%) at room temperature. Here, we demonstrate thick-shell NCs with CdS/CdSe/CdS seed/spherical quantum well/shell (SQW) geometry that exhibit near-unity PL QY at room temperature and suppression of blinking. In SQW NCs, the lattice mismatch is diminished between the emissive CdSe layer and the surrounding CdS layers as a result of coherent strain, which suppresses the formation of misfit defects and consequently permits, similar to 100% PL QY for SQW NCs with a thick CdS shell (>5 nm). High PL QY of thick-shell SQW NCs is preserved even in concentrated dispersion and in film under thermal stress, which makes them promising candidates for applications in solid-state concentrators.</P>

Change of Femoral Anteversion Angle in Children With Intoeing Gait Measured by Three-Dimensional Computed Tomography Reconstruction: 3-Year Follow-Up Study

Park Yeongchae,Byun Hayoung,Kim Mi-Ji,Shin Heesuk 대한재활의학회 2023 Annals of Rehabilitation Medicine Vol.47 No.3

Objective: To investigate long-term changes in femoral anteversion angle (FAA) in children with intoeing gait and to identify factors that affect FAA changes.Methods: We retrospectively analyzed three-dimensional computed tomography data from 2006 to 2022 of children with intoeing gait with ≥3 years of follow-up without active treatment. The study examined the mean changes in FAA, the effects of sex, age, and initial FAA on FAA change, and mean FAAs by age. Changes in FAA severity up to eight years of age were also observed and analyzed by sex.Results: A total of 126 lower limbs of 63 children (30 males, 33 females) with intoeing gait were included, with a mean age of 5.11±1.05 years and a mean follow-up period of 43.59±7.74 months. The initial FAA was 41.42°±8.29° and the follow-up FAA was 33.25°±9.19°, indicating a significant decrease (p<0.001). Significant correlations were observed between age and changes in FAA, as well as between initial FAA and changes in FAA (r=0.248, p=0.005; r=-0.333, p<0.001). At age 8 years, only 22 limbs were classified as having mild FAA severity.Conclusion: During the follow-up period, children with intoeing gait had a significant decreased in FAA. No significant difference in FAA change was found between sex, but younger children and those with greater initial FAA were more likely to have decreased FAA. However, most children retained moderate to severe severity of increased FAA. Further studies are required to validate these findings.