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『상한론(傷寒論)』 처방에서 감초(甘草) 용량의 안전성 및 임상 사용에 대한 문헌 고찰
김형섭,이숭인,Kim, Hyeong-Seop,Lee, Soong-In 대한상한금궤의학회 2016 대한상한금궤의학회지 Vol.8 No.1
Objectives : The purpose of this paper is to find out the safe dose and clinical use for administration of Glycyrrhizae Radix in Shanghanlun(傷寒論). Methods : Web-databases(OASIS, NDSL, Pubmed, Google) were searched with keywords including 'Licorice', 'Pseudoaldosteronism', 'Glycyrrhizin', 'Testosterone' on 14/10/2016. The searched about 40 papers and books were reveiwed. Results : Glycyrrhizin(GL) and 3-monoglucuronyl glycyrrhetinic acid(3MGA) in Glycyrrhizae Radix are found to be the main compounds vulnerable for inducing pseudoaldosteronism. The dose range of Glycyrrhizae Radix in Shanghanlun prescriptions is from 0.25 g to 12 g as a daily administration, and this dose satisfies the guidelines of WHO, European Union, ABC etc. And risk factors contributing for personal sensitivities are old age(>60), female sex, liver dysfunction, hypokalemia, prolonged gastrointestinal transit time, anorexia nervosa, decreased 11-${\ss}$-hydroxysteroid dehydrogenase-2 activity and hypertension. Conclusions : As a result, dose of Glycyrrhizae Radix in Shanghanlun(傷寒論) is safe. However, the personal sensitivity and unexpected drug interactions are independent from doses of GL, so doctors should monitor those risk factors and symptoms of pseudoaldosteronism when administering Glycyrrhizae Radix.
폴리에틸렌, 폴리프로필렌, 폴리스티렌 이성분 혼합물의 유변학적 성질 및 다이 팽윤
김형섭,김상용,전붕수,Kim, Hyeong-Seop,Kim, Sang-Yong,Jeon, Bung-Su 한국섬유공학회 1994 한국섬유공학회지 Vol.31 No.10
A study has been made on the die-swell and rheological properties of bicemponent polymer blends of low density polyethylene(PE), polypropylene(PP) and polystyrene(PS); PE/PP, PE/PS, and PP/PS. In the case of PE/PP blends the continuous phase transferred from PE to PP at the PE content of 60wt%. Meanwhile the PE/PS and PP/PS blends the continuous phase transferred from PE to PS and from PP to PS at the PS content of 60wt%. respectively. The die-swelling ratio. normal stress difference(N1) and dynamic shear viscosity of PE/PP blends appear, to show same tendency by chaneine the blend-ratios. For the cases of both PE/PS and PP/PS blends, where PE and PP are in the continuous phase, the die-swelling ratios increase as the N1 increases but decrease as the dynamic shear viscosity increases. But N1 of the PS has been found not to contribute to the die-swelling ratios when PS is in the continuous phase.
한국인의 상악 유치악 치열 및 무치악 치조제에 관한 삼차원적 연구
김형섭,신상완,Kim Hyeong-Seop,Shin Sang-Wan 대한치과보철학회 2005 대한치과보철학회지 Vol.43 No.2
Statement of problem. In Korea, the preliminary impression trays for dental and edentulous maxillae are manufactured on the base of the statistical value of Westerners. There had been less study on the dental and edentulous arches of Koreans. Purpose. The purpose of this study was to evaluate an average dental cast, preliminary impression trays, three-dimensional relation of dental and edentulous maxilla of Koreans Material and methods. The subjects for this study were 173 dental casts of maxilla (dental: 52, edentulous : 146) with ages $18\{\sim}60$ years old. Each of the master casts was measured 69 measuring points on the dental cast or maxilla, and 46 measuring points on the edentulous cast of maxilla with three-dimensional digital measuring machine. Each measuring points were analysed and were overlapped, that three dimensional dental graphic manufactured by CAD/CAM system. Results. 1. A standard of distribution to alveolar bone were width between left and right buccal border lines of the standard 3/4 line. The mean value of dental and edentulous casts were 67.27mm, 63.49mm respectively. 2. Morphological classification of dental casts were divided into three groups or V-shape, O-shape, U-shape, that proportion of distribution were 17%, 16%, 67%, respectively. Dimensional classification of the dental casts were divided into five groups of less than 63mm, 63 up to 65mm, 65 up to 67mm. 67 up to 69mm, more than 69mm, respectively. 3. Morphological classification of edentulous casts were divided into three groups or V-shape, O-shape, U-shape, that proportion of distribution were 18%, 17%, 65%, respectively Dimensional classification of the edentulous casts were divided into five groups of less than 57mm, 57 up to 61mm, 61 up to 65mm, 65 up to 69mm, more than 69mm, respectively. 4. Mean dental and edentulous cast of maxilla were overlapped, the proportion of bone resorption to alveolar bone is higher than that of palatal bone, its difference were higher anterior 2/4 area than posterior 3/4 area. Conclusion. It obtains information of preliminary impression trays for dental and edentulous maxilla of Koreans.
『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 따른 대시호탕(大柴胡湯) 투여와 압출치료를 병행하여 호전된 성인 여드름 증례보고
김형섭,Kim, Hyeong-Seop 대한상한금궤의학회 2017 대한상한금궤의학회지 Vol.9 No.1
Objectives : The purpose of this case report is to report the effect of Daesiho-tang on adult acne by Shanghanlun provisions with extrusion therapy. Methods : According to diagnostic system based on Shanghanlun provisions, the patient was diagnosed with Taeyang-byung Gyeolhyung and treated by Daesiho-tang with extrusion therapy. The result of administrations were evaluated by Korean Acne Grading System(KAGS), Korean Skindex-29, and change of clinical symptoms. Results : After administration of Daesiho-tang for 150 days with weelky extrusion therapy, KAGS improved from grade 4 to grade 1, Skindex-29 improved from 67.93 to 15.51, and patient was very satisfied with the treatment. No serius treatment-related adverse events were reported. Limitations : This case is only one case that the level of evidence is weak. Two interventions were used together and the duration of photo was uneven. Conclusions : The patient almost recovered from acne treated by Daesiho-tang according to diagnostic system based on Shanghanlun provisions with extrusion therapy. This is the first case report that suggests '熱結在裏' on the number 136 provision of Shanghanlun means fever that is always present in chronic skin lesions.
『상한론(傷寒論)』 '明'에 대한 고찰 : 변병진단체계(辨病診斷體系)에 입각해 치료한 양명병(陽明病) 증례 2례에 근거하여
김형섭 ( Hyeong-seop Kim ),조성환 ( Seong-hwan Cho ),이성준 ( Sung-jun Lee ) 대한상한금궤의학회 2018 대한상한금궤의학회지 Vol.10 No.1
Objectives : This study is to propose a new hypothesis about the interpretation of 'Ming (明)' in Shanghanlun and the direction of future research about Yangmingbing(陽明病). Methods : We analyzed the original form of the chinese characters 'Ming(明)' and tried to understand their contexts in Shanghanlun. At the same time, we analyzed 2 clinical cases diagnosed and treated as Yangmingbing according to newly hypothesized definition. Results : From etymology, ‘Ming(明)' means becoming distinct. Patients in 2 cases suffered from cold hypersensitivity of hands and feet, overactive bladder syndrome and dizziness, all of which became distinct and problematic. For this reason, we diagnosed patients with Yangmingbing(陽明病) and administered herbal medicine then they improved. Conclusions : The disease names in Shanghanlun have clinical message by the name itself. From etymology, at least in 15 characters provision of Shanghanlun, Yanmingbing means the disease made by becoming conscious about symptoms. Future research about Yangmingbing (陽明病) should start from here.