http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이건범,정회민,편영식,주상윤 한국공작기계학회 1998 한국생산제조학회지 Vol.7 No.1
In order to increase the modeling power and productivity of CAD/CAM systems, demands for customization of CAD/CAM system increased. Customization of a CAM system involves making it easier to learn and use, adding new modeling features not supported in a general purpose CAM system, and providing parametric inputting mechanisms. A customization from a commercial CAM system (OMEGA) has implemented for two dimensional free curve CNC glass scribing machine of medium size company in Cheonan. A CAD technician who has no CAM experience can operate this customized CAM system satisfactorily.
Nedumaran, Balachandar,Hong, Sungpyo,Xie, Yuan-Bin,Kim, Yong-Hoon,Seo, Woo-Young,Lee, Min-Woo,Lee, Chul Ho,Koo, Seung-Hoi,Choi, Hueng-Sik American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.40
<P>DAX-1 (dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome, gene 1) is an atypical member of the nuclear receptor family and acts as a corepressor of a number of nuclear receptors. HNF4alpha (hepatocyte nuclear factor 4alpha) is a liver-enriched transcription factor that controls the expression of a variety of genes involved in cholesterol, fatty acid, and glucose metabolism. Here we show that DAX-1 inhibits transcriptional activity of HNF4alpha and modulates hepatic gluconeogenic gene expression. Hepatic DAX-1 expression is increased by insulin and SIK1 (salt-inducible kinase 1), whereas it is decreased in high fat diet-fed and diabetic mice. Coimmunoprecipitation assay from mouse liver samples depicts that endogenous DAX-1 interacts with HNF4alpha in vivo. In vivo chromatin immunoprecipitation assay affirms that the recruitment of DAX-1 on the phosphoenolpyruvate carboxykinase (PEPCK) gene promoter is inversely correlated with the recruitment of PGC-1alpha and HNF4alpha under fasting and refeeding, showing that DAX-1 could compete with the coactivator PGC-1alpha for binding to HNF4alpha. Adenovirus-mediated expression of DAX-1 decreased both HNF4alpha- and forskolin-mediated gluconeogenic gene expressions. In addition, knockdown of DAX-1 partially reverses the insulin-mediated inhibition of gluconeogenic gene expression in primary hepatocytes. Finally, DAX-1 inhibits PEPCK and glucose-6-phosphatase gene expression and significantly lowers fasting blood glucose level in high fat diet-fed mice, suggesting that DAX-1 can modulate hepatic gluconeogenesis in vivo. Overall, this study demonstrates that DAX-1 acts as a corepressor of HNF4alpha to negatively regulate hepatic gluconeogenic gene expression in liver.</P>
Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH
Lee, Min-Woo,Chanda, Dipanjan,Yang, Jianqi,Oh, Hyunhee,Kim, Su Sung,Yoon, Young-Sil,Hong, Sungpyo,Park, Keun-Gyu,Lee, In-Kyu,Choi, Cheol Soo,Hanson, Richard W.,Choi, Hueng-Sik,Koo, Seung-Hoi Elsevier 2010 Cell metabolism Vol.11 No.4
<P><B>Summary</B></P><P>Endoplasmic reticulum (ER)-bound transcription factor families are shown to be involved in the control of various metabolic pathways. Here, we report a critical function of ER-bound transcription factor, CREBH, in the regulation of hepatic gluconeogenesis. Expression of CREBH is markedly induced by fasting or in the insulin-resistant state in rodents in a dexamethasone- and PGC-1α-dependent manner, which results in the accumulation of active nuclear form of CREBH (CREBH-N). Overexpression of constitutively active CREBH activates transcription of <I>PEPCK-C</I> or <I>G6Pase</I> by binding to its enhancer site that is distinct from the well-characterized CREB/CRTC2 regulatory sequences in vivo. Of interest, knockdown of CREBH in liver significantly reduces blood glucose levels without altering expression of genes involved in the ER stress signaling cascades in mice. These data suggest a crucial role for CREBH in the regulation of hepatic glucose metabolism in mammals.</P> <P><B>Highlights</B></P><P>► PGC-1α/GR activates CREBH expression under fasting or insulin-resistant conditions ► CREBH enhances hepatic gluconeogenesis via a CRTC2-dependent manner ► Depletion of CREBH in the liver ameliorates fasting hyperglycemia in diabetic mice</P>
Application of the Fixed-bed Gasification System for Energy recovery of Municipal Solid Waste
( Young-sik Yoon ),( Jae-hoi Gu ),( Su-nam Park ),( Young-su Park ),( Ki-hyun Kim ),( Ji-hong Min ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 3RINCs초록집 Vol.2015 No.-
Recently, the Korean government have interested in the Recovery of Physico-Chemical energy from the waste because rapidly changing of petroleum price and supply to nation of primary energy. At home, above a certain level of MSW (municipal solid waste) is discharged. In this study, the gasification experiments were performed to evaluate for recovery applicability of energy from MSW using the pilot-scale gasifier. MSW was necessary to pre-treatment because It was not only containing non-combustibles and moisture but also heterogeneous. MSW was performed the pre-treatment to crushing and sorting. In the results of experiments, best cold gas efficiency presented by TEST 2, 64.8 percentage at 0.27 equivalent ratio (O<sub>2-mass</sub>/C<sub>-mass</sub>). In this paper, recovery value of energy was estimated by the using gasification system from MSW as TOE at the city of N. In view of the effects on the environmental, this results of analysis were proposed net efficiency of clean-up system as after gasifier combination.
Lee, Ji-Min,Han, Hye-Sook,Jung, Yoon Seok,Harris, Robert A.,Koo, Seung-Hoi,Choi, Hueng-Sik American Society for Biochemistry and Molecular Bi 2018 The Journal of biological chemistry Vol.293 No.34
<P>Under fasting conditions, activation of several hepatic genes sets the stage for gluconeogenesis in the liver. cAMP response element-binding protein (CREB), CREB-regulated transcription coactivator 2 (CRTC2), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) are essential for this transcriptional induction of gluconeogenic genes. PGC-1insight that may help inform potential therapeutic approaches targeting PGC-l alpha-mediated regulation of hepatic glucose metabolism. induction is mediated by activation of a CREB/CRTC2 signaling complex, and recent findings have revealed that small heterodimer partner-interacting leucine zipper protein (SMILE), a member of the CREB/ATF family of basic region-leucine zipper (bZIP) transcription factors, is an insulin-inducible corepressor that decreases PGC-1 alpha expression and abrogates its stimulatory effect on hepatic gluconeogenesis. However, the molecular mechanism whereby SMILE suppresses PGC-1a expression is unknown. Here, we investigated SMII.E's effects on the CREB/CRTC2 signaling pathway and glucose metabolism. We found that SMILE significantly inhibits CREB/ CRTC2-induced PGC-1 alpha expression by interacting with and disrupting the CREB/CRTC2 complex. Consequently, SMILE decreased PGC-1 alpha-induced hepatic gluconeogenic gene expression. Furthermore, SMILE inhibited CREB/CRTC2-induced phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) gene expression by directly repressing the expression of these genes and by indirectly inhibiting the expression of PGC-1 alpha via CREB/CRTC2 repression. Indeed, enhanced gluconeogenesis and circulating blood glucose levels in mice injected with an adenovirus construct containing a constitutively active CRTC2 variant (CRTC2-S171A) were significantly reduced by WT SMILE, but not by leucine zipper-mutated SMILE. These results reveal that SMILE represses CREB/CRTC2-induced PGC-1 alpha expression, an insight that may help inform potential therapeutic approaches targeting PGC-1 alpha-mediated regulation of hepatic glucose metabolism.</P>
자기공명영상이 정상인 대퇴골두무혈성괴사 위험군의 혈관조영술, 골주사, 골수압 및 조직학적 소견
구경회 ( Kyung Hoi Koo ),조세현 ( Se Hyun Cho ),송해룡 ( Hae Ryong Song ),민영식 ( Young Sik Min ),김재수 ( Jae Soo Kim ),김지연 ( Ji Youn Kim ) 대한고관절학회 1994 Hip and Pelvis Vol.6 No.1
Twenty-eight hips(22 Patients), at high-risk of osteonecrosis(ON) of the femoral head, with negative magnetie resonance(MR) images, underwent superselective angiography of the medial femoral circumflex artery. Six patients(seven hips) suffered groin pain since one to 12 weeks prior to this study. Superselective angiography showed the interruption of the superior retinacular aiteries(SRAs) in 13 hips(12 patients), including six of seven symptomatic hips. bone scan was performed on eight out of 13 angiographically positive hips. Decrease of radionuclide uptake(cold lesions) was observed in all of the eight femoral heads. Thufeen femoral heads with interruption of SRAs, underwent intraosseous pressure(IOP) measurement and core biopsy. IOPs were elevated in 11 femoral heads. Histologic study showed evidence of early necrosis in ten femoral heads. But the remaining three were negative for ON. This study indicates that there exists a considerable number of highrisk femoral heads, even with negative MR images, which has positive findings on angiography, scintigraphy(cold lesions), and IOP measurement, which reflects the interruption of SRAs, decreased perfusion, and marrow edema, and that among those patients, a large portion shows positive findings for early necrosis on histologic study.