인슐린 비의존형 당뇨병 환자에서 혈장 Endothelin-1농도의 변화

신양수,조희충,김원식,국기용,김용화,정종훈,문철웅,배학연,양성훈 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

Endothelin(ET) is a 21-residue peptide originally isolated from the cultured porcine endothelial cells. There are at least three genes for endothelin:endothelin-1(ET-1), endothelin-2(ET-2), and endothelin-3(ET-3). Endothelins are present in various human biological fluids including plasma, urine, breast milk, and saliva and have been found elevated plasma ET concentrations in patients with diabetes mellitus, Patients undergoing maintenance hemodialysis due to chronic renal failure, patients with acute myocardial infarction, and patients with subarachnoid hemorrhage. Endothelial cell damage is suspected to occur in diabetic patients and may be one important cause of angiopathy, a major complication in diabetes mellitus. The elevation of ET in diabetic patients may be a marker of, and further exacerbate, their vascular disease. We measured the levels of ET-1 in plasma of 50 patients with non-insulin dependent diabetes mellitus(NIDDM) and 25 normal subjects by radioimmunoassay. The plasma ET-1 concentration (mean±S.D.) in NIDDM was 6.461 A2.510 f㏖/ ㎖, and was significantly higher than in normal subjects (4.567±1.155f㏖/㎖) (P<0.05). The plasma ET-1 concentration (mean±S.D.) in diabetic retinopathy group( 7.15±2.454 f㏖/ml) was significantly elevated than those in otherwise uncomplicated groups (5.348±2.390 f㏖/㎖)(P<0.01). The correlation between any clinical parameters and plasma ET-1 levels in NIDDM was not significant, In conclusion, this study suggest that the elevated levels of ET-1 in diabetic patients may be play a important role in the pathogenesis of diabetic complications.

소수성 촉매를 이용한 수소동위원소 교환 반응 측정을 위한 순환 반응기

최희주,이한수,안도희,강희석,김광락 한국공업화학회 2002 응용화학 Vol.6 No.2

The catalytic rate constants of hydrophobic catalysts developed for the removal of tritium mainly generated in the pressurized heavy water reactors should be measured. A recycle reactor was designed and built for characterzing the long-term behavior of the catalyst performance at the various temperatures and gas velocities.The catalytic rate constants were measured at the apparent gas velocity of 0.5 m/s and the temperature of 60℃. The initial catalytic constant was 8.44×10^-4mol/g.sec. This value is much greater than that considered in the design of Wolsong Tritium Removal Facility.

New Zealand White 토끼의 생식세포 및 체세포 분열에 의한 염색체 분석

신선희,김희수,최영현,이원호 부산대학교 유전공학연구소 2001 분자생물학 연구보 Vol.17 No.-

토끼(New Zealand White rabbit)의 감수분열 및 유사분령상을 통해 그 염색체적 특징을 조사하였다. 감수분열 염색체의 표본 작성은 공기건조법을 다소 변형하여 사용하였고, 유사분열 중기상의 핵형분석에는 G-분염법을 이용하여 다음과 같은 결과를 얻었다. 1. 제1감수분열의 접합기와 태사기의 염색소립과 sex vesicles 및 동원체가 뚜렷하게 구별되었다. 태사기의 중기에서부터 후기 과정이 진행되는 동안에 2가염색체에서 측면으로 돌출한 머리카락 모양의 돌기들이 관찰되어졌고, 이 돌기들은 염색체가 lampbrush 염색체 구조의 모양이 되도록 해주었다. 이동기의 염색체들은 키아즈마의 수와 위치에 따라 분류가 가능하였다. 제1 감수분열 전기의 후반부 과정과 중기Ⅰ 시기에는 2가염색체로 된 21개의 상염색체와 1개의 말단결합으로 연결된 X-Y 염색체를 관찰할 수 있었다. 2. New Zealand White rabbit의 생식세포에서 관찰된 2가 염색체의 형태는 1CH, 1TAl 및 2TA 2가염색체 유형이 대부분을 이루었다. New Zealand White rabbit에서의 평균 키아즈마 빈도는 약 30.2로 나타났으며, 키아즈마 빈도가 복사기, 이동기 및 중기Ⅰ로 분열이 진행됨에 따라 다소 감소하는 경향이 있었다. 3. New Zealand White rabbit의 핵형분석에 의하면 염색체 수는 44개(2n=44)로서, 8쌍의 중부염색체, 9쌍의 차중부염색체, 4쌍의 단부염색체로 된 21쌍의 상염색체와 중부염색체인 1개의 X 염색체 및 단부염색체인 1개의 Y 염색체로 구성되어 있음을 알 수 있었다. Chromosomal characteristics of New Zealand White rabbit was studied at meiosis and mitosis. The meiotic chromosomal preparations were made with the modified air-drying method and karyotype analysis was performed with the G-banding technique, using isolated mitotic metaphase chromosomes of the New Zealand White rabbit. Chromosomes, sex vesicles and centromeres could be could be classified in the zygotene and the pachytene of the meiosis Ⅰ. The hair-like processes projecting laterally from the axes of bivalent chromosomes at the mid-late pachytene were basis of the numbers and the locations of chiasma in the diakinesis. Twenty-one autosomal bivalents and a single unequal terminally associated X-Y bivalent were observed during the late prophase and the metaphase of the meiosis Ⅰ. Most of the bivalent types observed in the New Zealand White rabbit spermatocytes were 1CH, 1TAl, and 2TA bivalents. The mean chiasma frequency (CE) of the male New Zealand White rabbit was 30.2, and it was found that the CF value tended to decrease through the diakinesis and the metaphase Ⅰ. The karyotype of the New Zealand White rabbit was a male chromosome number of 44(2n=44), comprising 8 pairs of metacentric, 9 pairs of submetacentric, 4 pairs of acrocentric autosomes, metacentric X chromosome and acrocentric Y chromosome.

크래시된 이미지와 딥 클러스터링을 통한 크래시 분류 개선

김요한 ( Yo-han Kim ),이상준 ( Sang-jun Lee ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2

소프트웨어 크래시 분류를 개선하기 위해 호출 스택 정보를 기반한 많은 연구들이 있다. 본 연구에서는 크래시 직전 이미지를 수집하여, 기존 호출 스택 기반의 분류에서 발생하는 문제를 개선하고자 한다. 또한 이미지 자체의 직관성으로 개발자뿐만 아니라 개발 지식이 없는 실무자도 크래시 정보를 활용할 수 있고, 문제 해결을 위한 재현 루트 파악, 위변조 여부와 같은 추가 정보를 확인할 수 있을 것으로 기대한다. 비지도 학습 기반인 딥러닝 클러스터링 N2D 알고리즘을 통하여 이미지를 자동 분류하고 순위화하는 시스템을 구축하여, 특정 소프트웨어에 특화되지 않고 다양한 소프트웨어의 크래시 이미지 자동 분류에 기여할 수 있을 것으로 기대한다.

Isolation and Phylogeny of SINE-R Retroposons Derived from Human Endogenous Retrovirus HERV-K Family in Schizophrenia

Kim, Heui-Soo,Crow, Timothy J. The Korean Society for Integrative Biology 2002 Korean journal of biological sciences Vol.6 No.1

SINE-R retroposons have been derived from human endogenous retrovirus HERV-K family and found to be hominoid specific. Both SINE-R retroposons and HERV_K family are potentially capable of affecting the expression of closely located genes. Using the genomic DNA from patients with schizophrenia, we identified 26 SINE-R retroposons and analyzed them with the sequences derived from the hominoid primates. The SINE-R retroposons from schizophrenia showed 89.7-96.6% sequence similarities with the sequence of the schizo-cDNA clone that derived from postmortem tissue from the frontal cortex of an individual suffering from schizophrenial. Phylogenetic analysis using the neighbor-joining method revealed that the new SINE-R retroposons in schizophrenia have proliferated independently during hominid evolution. Such retroposons have great relevance to genomic change connected to human diseases. The data suggest that new SINE-R retroposons identified in schizophrenia deserve further investigation as potential leads on the understanding of neuropsychiatric diseases.

Safety Analysis of Plant Concrete Structure by Time Domain Reflectory

Heui-Soo Han(한희수),Yong-Gil Kim(김용길),Nam-Soo Kim(김남수) 한국생산제조학회 2007 한국공작기계학회 춘계학술대회논문집 Vol.2007 No.-

Most civil structure performance assessment, e.g., damage, failure, and non-destructive inspection approaches, are difficult to execute on hard-to-reach elements of a structure. These routine methods are also time-consuming, with uncertainties involved and not cost-effective because of technologies limits. In civil engineering field, the monitoring of element of a long-type structure by Time Domain Refectory (TDR) or Fiber Optic Sensor (FOS) is aimed at early detecting of the safety of structure through the analysis of obtained deformation data at numerous points along the axis of the element. This study presents reasonable relationships to estimate the concrete safety and deformation based on TDR data to analyze concrete temperature variance. To measure the temperature variance in civil structure, TDR composed of two copper lines is installed in concrete specimen, From the laboratory test, TDR system could make the correct information about temperature variance of concrete curing. Therefore it is concluded, at first the mechanism of correct concrete curing could be acquired by TDR system, secondly from curing data, construction process in field could be controlled properly, it would be much more effective to apply at health monitoring system in civil structure compared to conventional sensor or FOS systems.

Alzheimer’s disease related genes during primate evolution

Kim, Dong Hee,Gim, Jeong-An,Kim, Kwang Hee,Han, Chang Woo,Jang, Se Bok,Kim, Heui-Soo 한국유전학회 2017 Genes & Genomics Vol.39 No.11

<P>During primate evolution, the neuronal and cognition-related genes have evolved rapidly. These genes seem to induce neurological illnesses such as Alzheimer's disease (AD). In this study, we analyzed genes APOE, TOMM40, and PICALM known as the risk factors of AD. We performed bioinformatics analyses in relation to evolution, phylogeny, and protein structure for those genes in humans, Neanderthals, chimpanzees, bonobos, gorillas, orangutans, crab-eating monkeys, and rhesus monkeys. Cholesterol-related genes showed relatively rapid evolution toward a lower risk of AD. Neanderthals showed relatively higher polymorphism in genes APOE, TOMM40, and PICALM than humans did. Phylogeny indicated different topologies in the trichotomy of humans, chimpanzees, and gorillas in terms of genes APOE, TOMM40, and PICALM. These results provide to hominin-specific patterns in three genes, and give clues to the modern human-specific traits of AD and shed light on further functional research helping to understand AD.</P>

Phylogenetic Analysis of HERV-K LTR Family in Human Chromosome Xq26 and New World Monkeys

Heui Soo Kim,Joo Young Choi,Won Ho Lee,Kyung Lib Jang,Won Hyuck Park,Doo Ho Moon,Osamu Takenaka,Byung Hwa Hyun 한국생명과학회 2000 Journal of Life Science Vol.10 No.1

Dynamic Modeling of the Stator Core of the Electrical Machine Using Anisotropic Characteristics

Heui-Won Kim(김희원),Soo-Mok Lee(이수목),Kwan-Young Kim(김관영) 한국소음진동공학회 2002 한국소음진동공학회 학술대회논문집 Vol.2002 No.11(영문초록)

Molecular Cloning of Monkey Cytohesin-1 cDNA

Heui Soo Kim 한국유전학회 2005 Genes & Genomics Vol.27 No.3