뇌졸중 후 불안의 유병률 및 예측인자

김규온(Gyu On Kim),강희주(Hee Ju Kang),김주완(Ju Wan Kim),배경열(Kyung Yeol Bae),김성완(Sung Wan Kim),김준태(Joon Tae Kim),박만석(Man Seok Park),조기현(Ki Hyun Cho),김재민(Jae Min Kim) 대한노인정신의학회 2018 노인정신의학 Vol.22 No.2

Objective:This study aimed to investigate the prevalence and predictors of poststroke anxiety (PSA) at acute and chronic stage. Methods:PSA was defined as 7 or higher score on Hospital Anxiety and Depression Scale-anxiety subscale within 2 weeks (n=286) and at 1 year (n=222) after the index stroke. Following variables were examined at baseline: sociodemographic characteristics (age, sex, education years, marital status, living alone, and unemployment), risk factor of vascular disease, stroke location on brain imaging, severity of stroke (National Institute of Health Stroke Scale), physical impairment (Barthel Index), etc. These variables were compared by PSA initially using t-test or χ2 test. Those variables shown significant associations (p<0.05) entered simultaneously to logistic regression analysis for evaluating independent predictive factors. Results:PSA was observed in 27 patients (9.4%) at acute stage, and in 35 patients (15.8%) at chronic stage. Acute PSA was associated with younger age and higher Hamilton Depression Rating Scale (HAM-D) score, and chronic PSA was associated with hypertension and higher HAM-D score. Conclusion:PSA was prevalent and was associated with those variables on poor prognosis of stroke outcome. Therefore, early screening of PSA and referral to proper treatment may reduce stroke burden.

Pulmonary Colonization Resistance to Pathogens via Noncanonical Wnt and Interleukin-17A by Intranasal pep27 Mutant Immunization

Kim, Gyu-Lee,Lee, Seungyeop,Kim, Se-Jin,Lee, Si-on,Pyo, Suhkneung,Rhee, Dong-Kwon Oxford University Press 2018 The Journal of Infectious Diseases Vol.217 No.12

Screening for Resistance of Tomato Genetic Resources to Bacterial wilt caused by Ralstonia solanacearum

On-Sook Hur,Sang Gyu Kim,Ho-Cheol Ko,Su Ran Ahn,Jung-Sook Sung,Na-Young Ro,Sukyeung Lee,Yu-mi Choi,Do yoon Hyun,Kyoung-Yul Ryu,Hyung-Jin Baek 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

This study aimed to evaluate 105 tomato accessions conserved in National Agrobiodiversity Center regarding their resistance to Ralstonia solanacearum, a soil-borne vascular bacterium that causes lethal wilt diseases of a wide range of crops worldwide. All the accessions are Solanum lycopericum var. lycopersicum including cultivar or breeding lines. At the four leaf stage, the seedlings were inoculated by drenching the soil with the bacterial suspension concentrated of 108 CFU/ml. Plant roots were wounded before inoculation by cutting with the knife. Seven accessions including IT 32899 were rated as resistant, while other 98 accessions were rated as susceptible. IT 32899 scored 0.1 of disease rate and 0.7 of disease index. The selected accessions will be used as a material to reveal the mechanism of wilt tolerance and to identify the host gene involved in defense response.

First Report of Fusarium Wilt Caused by Fusarium proliferatum on Safflower

Kim, Sang Gyu,Ko, Ho-Cheol,Hur, On-Sook,Luitel, Binod Prasad,Rhee, Ju-Hee,Yoon, Mun-Sup,Baek, Hyung-Jin,Ryu, Kyoung-Yul,Sung, Jung Sook The Korean Society of Plant Pathology 2016 식물병연구 Vol.22 No.2

Wilt disease appeared the first in greenhouse-grown safflower (Carthamus tinctorius) in Jeonju, Korea. With the advancement of the disease, the infected plants were withered and died. In order to investigate the causal organism of this symptom disease, fungus was isolated from the infected plants and cultured on potato dextrose agar medium. The fungus showed the white or orange colony color with aerial mycelium. Macroconidia were from falcate to straight, usually 3-5 septate with $38.0-66.7{\times}2.9-4.4{\mu}m$. The fungus was inoculated to a new safflower plant and caused the same wilt. With morphological characters and pathogenicity results, sequence analyses (internal transcribed spacer ribosomal DNA and translation elongation factor $1{\alpha}$) suggested that, the isolated fungus is Fusarium proliferatum. This is the first report of Fusarium wilt disease caused by F. proliferatum on safflower in Korea.

Effect of Korean Red Ginseng extracts on drug-drug interactions

Kim, Se-Jin,Choi, Seungmok,Kim, Minsoo,Park, Changmin,Kim, Gyu-Lee,Lee, Si-On,Kang, Wonku,Rhee, Dong-Kwon The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3

Background: Ginseng has been the subject of many experimental and clinical studies to uncover the diverse biological activities of its constituent compounds. It is a traditional medicine that has been used for its immunostimulatory, antithrombotic, antioxidative, anti-inflammatory, and anticancer effects. Ginseng may interact with concomitant medications and alter metabolism and/or drug transport, which may alter the known efficacy and safety of a drug; thus, the role of ginseng may be controversial when taken with other medications. Methods: We extensively assessed the effects of Korean Red Ginseng (KRG) in rats on the expression of enzymes responsible for drug metabolism [cytochrome p450 (CYP)] and transporters [multiple drug resistance (MDR) and organic anion transporter (OAT)] in vitro and on the pharmacokinetics of two probe drugs, midazolam and fexofenadine, after a 2-wk repeated administration of KRG at different doses. Results: The results showed that 30 mg/kg KRG significantly increased the expression level of CYP3A11 protein in the liver and 100 mg/kg KRG increased both the mRNA and protein expression of OAT1 in the kidney. Additionally, KRG significantly increased the mRNA and protein expression of OAT1, OAT3, and MDR1 in the liver. Although there were no significant changes in the metabolism of midazolam to its major metabolite, 1'-hydroxymidazolam, KRG significantly decreased the systemic exposure of fexofenadine in a dose-dependent manner. Conclusion: Because KRG is used as a health supplement, there is a risk of KRG overdose; thus, a clinical trial of high doses would be useful. The use of KRG in combination with P-glycoprotein substrate drugs should also be carefully monitored.

Evaluation of Resistance to Ralstonia solanacearum in Tomato Genetic Resources at Seedling Stage

Kim, Sang Gyu,Hur, On-Sook,Ro, Na-Young,Ko, Ho-Cheol,Rhee, Ju-Hee,Sung, Jung Sook,Ryu, Kyoung-Yul,Lee, Sok-Young,Baek, Hyung Jin The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.1

Bacterial wilt of tomatoes caused by Ralstonia solanacearum is a devastating disease that limits the production of tomato in Korea. The best way to control this disease is using genetically resistant tomato plant. The resistance degree to R. solanacearum was evaluated for 285 tomato accessions conserved in the National Agrobiodiversity Center of Rural Development Administration. These accessions of tomato were originated from 23 countries. Disease severity of tomato accessions was investigated from 7 days to 14 days at an interval of 7 days after inoculation of R. solanacearum under greenhouse conditions. A total of 279 accessions of tomato germplasm were susceptible to R. solanacearum, resulting in wilt and death in 70 to 90% of these plants. Two tomato accessions were moderately resistant to R. solanacearum. Only four accessions showed high resistance against R. solanacearum. No distinct symptom of bacterial wilt appeared on the resistant tomato germplasms for up to 14 days after inoculation of R. solanacearum. Microscopy of resistant tomato stems infected with R. solanacearum revealed limited bacterial spread with thickening of pit membrane and gum production. Therefore, these four resistant tomato germplasms could be used in tomato breeding program against bacterial wilt.

Standardization of the Discrimination and Stigma Scale-Korean Version (DISC 12-K) in Patients with Depressive Disorders

Kim Gyu-On,Yoo Tae-Young,Kim Nam-Jun,Lee Hee-Joon,Jhon Min,Kim Ju-Wan,Kang Hee-Ju,Kim Sung-Wan,Kim Jae-Min 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.7

Objective The Discrimination and Stigma Scale (DISC 12), which assesses behavioral and experienced stigma, has not been translated into Korean. We developed and standardized the Korean version of the DISC 12 (DISC 12-K) in patients with depressive disorders.Methods The study included 230 patients with depressive disorders who were assessed on the four subscales of the DISC 12-K: Unfair Treatment, Stopping Self, Overcoming Stigma, and Positive Treatment. Additionally, stigma was assessed using the Internalized Stigma of Mental Illness scale, depressive symptoms using the Hamilton Depression Rating Scale and Beck Depression Inventory, level of functioning using the Social and Occupational Functioning Assessment Scale, self-esteem using the Rosenberg Self-Esteem Scale, and quality of life was assessed using the EuroQol-5D. The reliability of DISC 12 was assessed by internal consistency using Cronbach’s alpha coefficient and estimating the intercorrelation of items and corrected item-total correlations; interrater reliability and test–retest reliability were assessed using intraclass correlation coefficients at the item and subscale levels; and the concurrent validity of the DISC 12-K relative to the other assessment scales was assessed using Spearman’s correlation coefficient.Results All of the DISC 12-K subscales had high reliability. The validity was good for the Unfair Treatment and Stopping Self subscales, but only fair for the Overcoming Stigma and Positive Treatment subscales.Conclusion The Unfair Treatment and Stopping Self subscales of the new DISC 12-K are reliable and valid measures of stigma in patients with depressive disorders. Future studies are needed to test the validity of this scale in other mental disorders.

An Empirical Study on the Intention to Reuse Computational Science and Engineering Platforms: A Case Study of EDISON

( Noori On ),( Gi-myeong Ryu ),( Myoung-ju Koh ),( Jongsuk Ruth Lee ),( Nam-gyu Kim ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.8

The computational science and engineering field, which combines basic science and computing technology, has emerged as a third scientific methodology, following theories and experiments. This study aimed to identify factors and relationships that affect the continued use of the computational science and engineering (CSE) platform for its successful operation, utilization, and diffusion. To that end, the quality factors of the platform were derived by combining the information system success model and the technology acceptance model. These factors affected user satisfaction and intention to reuse through users’ perceived usefulness and perceived ease of use of the platform. An empirical analysis was conducted through a questionnaire survey of 373 users of the EDISON platform, a representative CSE platform in Korea. The results revealed that all quality factors have a positive influence on perceived usefulness and perceived ease of use. Specifically, information quality has a significant influence on perceived ease of use, and system quality has a significant influence on perceived usefulness. Perceived ease of use has a greater impact on user satisfaction than perceived usefulness, and satisfaction affects intention to reuse. The results can contribute to the development of CSE platforms and the development strategy to expand the number of users.

외기온도 및 시험체 크기를 고려한 콘크리트의 간이-단열온도 상승시험에 관한 실험적 연구

온정권 ( On Jeong-kwon ),김영선 ( Kim Young-sun ),문형재 ( Moon Hyoung-jae ),남정수 ( Nam Jeong-soo ),김규용 ( Kim Gyu-yong ) 한국건축시공학회 2021 한국건축시공학회지 Vol.21 No.6

최근 초고층 아파트 및 주상복합 건축물의 증가로 두께 3m이상의 메가급 매스콘크리트 부재의 설계가 다수 수행되고 있다. 초고층 주상복합 건축물은 기초부재 뿐만 아니라 특수한 구조형태로 전이 보 및 슬라브 등과 같은 매스콘크리트 시공이 증가하고 있어 매스콘크리트의 온도균열저감에 관한 연구가 수행되고 있다. 매스콘크리트의 온도균열을 검토하기 위해서는 콘크리트 열특성 검토가 중요하나 현장에서 단열온도상승 시험기를 활용하기는 어렵기 때문에 간이-단열온도상승시험을 주로 활용한다. 본 연구에서는 간이-단열온도상승시험에 의한 콘크리트 열특성 결과의 정밀도를 향상시키기 위해 열손실을 보정하기 위한 방안과 열손실 보정에 미치는 다양한 요인을 검토하여 제시하였다. Recently, due to the increase in high-rise apartment and residential-commercial complex buildings, a number of mega-class mass concrete members with a thickness of 3m or more have been designed. As the construction of mass concrete such as transfer beam and slab is increasing not only in foundation members but also in special structures, research on reducing temperature cracks in mass concrete is being conducted. To review temperature cracks in mass concrete, it is important to review the thermal properties of concrete, but it is difficult to use an adiabatic temperature rise tester in the field, so the semi-adiabatic temperature rise test is mainly used. In this study, to improve the accuracy of the results of concrete heat characteristics gained by the semi-adiabatic temperature rise test, various factors affecting heat loss compensation and methods were reviewed and presented.

First Report of Fusarium Wilt Caused by Fusarium proliferatum on Safflower

Sang Gyu Kim,Ho-Cheol Ko,On-Sook Hur,Binod Prasad Luitel,Ju-Hee Rhee,Mun-Sup Yoon,Hyung-Jin Baek,Kyoung-Yul Ryu,Jung Sook Sung 한국식물병리학회 2016 식물병연구 Vol.22 No.2

Wilt disease appeared the first in greenhouse-grown safflower (Carthamus tinctorius) in Jeonju, Korea. With the advancement of the disease, the infected plants were withered and died. In order to investigate the causal organism of this symptom disease, fungus was isolated from the infected plants and cultured on potato dextrose agar medium. The fungus showed the white or orange colony color with aerial mycelium. Macroconidia were from falcate to straight, usually 3–5 septate with 38.0–66.7× 2.9–4.4 μm. The fungus was inoculated to a new safflower plant and caused the same wilt. With morphological characters and pathogenicity results, sequence analyses (internal transcribed spacer ribosomal DNA and translation elongation factor 1α) suggested that, the isolated fungus is Fusarium proliferatum. This is the first report of Fusarium wilt disease caused by F. proliferatum on safflower in Korea.