FET형 반도체센서 및 시스템 개발

손병기,조진호,최평,박이순,서화일,권대혁,고광락 경북대학교 센서기술연구소 1996 연차보고서 Vol.1996 No.-

기존의 센서들의 난점을 극복할 수 있는 새로운 형태의 FET형 전해질(electrolyte :H^+, K^+, Ca^2+, Na^+)센서소자 및 분석 시스템의 개발을 중점적으로 추진하였으며, FET형 포도당센서 및 압력센서의 개별 FET형 센서에 관한 연구도 병행하였다. FET형 전해질센서를 이용한 휴대용 전해질 측정기와 desktop형 4채널 전해질 분석기를 제작하였다. 또한 이 시스템을 소형화하기 위한 주문형 아날로그-디지탈 변환기 내장형 CMOS 프로세서를 설계하고 검증하였다. The main object of this research is to develope a new FET type electrolyte(H^+, K^+, Ca^2+, Na^+) sensors and analysis system which can overcome the problems of the conventional sensors. Parallel researches on FET type sensors such as glucose and pressure humidity are also in progress. A portable electrolyte meter and desktop 4-channel electrolyte analysis system is fabricated. A customized CMOS processor with built-in analog-to-digital converter is designed and verified.

편측안면경련에 대한 미세혈관 감압술

최창락,나형균,이경진,조경근,박성찬,박해관,조정기 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.4

FET형 마이크로센서 개발

손병기,박이순,서화일,고광락 경북대학교 센서기술연구소 1997 연차보고서 Vol.1997 No.-

FET형 마이크로센서 개발

손병기,박이순,서화일,권대혁,고광락 경북대학교 센서기술연구소 1996 연차보고서 Vol.1996 No.-

丹蔘의 抗癌效果와 活性物質 分離에 關한 硏究

成樂其,金聖勳,李權益 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2

“怪病必瘀 久病必瘀”라 하여 癌 등의 難治病에는 瘀血證이 자주 나타나, 直接的인 抗腫류作用외에도 惡性腫瘍으로 인한 疑血과 織溶系統을 調節하는 作用이 있는 活血化瘀法은 현재 임상세선 活用 價値가 높다. 이에 本 論文에서는 活血祛瘀劑 및 安神劑로 活用되고 있는 丹蔘을 이용 抗癌 및 抗轉移 效果를 糾明하고 活性 物質을 採索함으로써 癌 治療에 도움이 되고자 한다. in vitro에서 B16-Fo와 A549 癌細胞 등의 패癌株에 對한 細胞毒性, 複合細胞外基質과 單味細胞外基質에 對한 細胞附着 沮止作用, 血小板疑集 促進劑중의 하나인 ADP에 對한 血小板凝集抑制作用, 有效 分劃으로부터 分離된 有效物質의 構造同定, 多樣한 사람 癌株에 對한 ED(50)값 및 自然殺害作用을 檢討하고, in vivo에서는 丹蔘의 有效 分劃을 S-180이 移植된 ICR 생쥐에 經口 投與한 後, 體重變化와 T/C%를 尾靜脈에 B16-Fo를 注入 후 C157BL/6의 pulmonary colonization assay, 臟器무게, WBC 및 platelet 數 等을 測定하였다. 丹蔘 分劃중 ethly ether층이 抗癌 및 抗轉移效果에 있어 가장 有意性있는 效果가 認定되었고, 이 층에서 分離된 tanshione IIA는 丹蔘의 主要 抗癌活性物質로 이를 이용한 數種 癌株의 細胞毒性 實驗에서 ED(50)이 모두 1.5㎍/㎖ 以下로 나타나 有效한 抗腫瘍 效果을 보였으며, 10㎍/㎖부터 HL-60에 대해 DNA fragmentation을 나타냈다. In order to confirm the antitumor effect of Salviae miltiorrhizae Radix(SMR) and isolate its active compound, the experiment was done. In vitro cytotoxicity against several cancer cell lines, inhibition of cell adhesion to extracellular matrix, inhibition of platelet aggregation by ADP were studied, in vivo T/C % of S-180 bearing ICR treated with ethyl ether(EE) layer of SMR, pulmonary colonization assay, changes of organ weight, WBC, number of platelet were evaluated experimentally and the results were obtained as follows: 1. The concentration inhibiting cell growth below 55% was 10~3g/ml of water layer and EE layer of SMR(ESR) against B16-Fo and 10-3g/ml of EE layer of SMR against A549. 2. Active compound isolated from Salviae miltiorrhizae Radix was identified as tanshion II A. 3. ED50 of tanshion II A was 0.8177 ㎍/㎖, 0.3431 ㎍/㎖, 1.3284 ㎍/㎖ and 0.8912 ㎍/㎖ against cancer cell lines as HCT15, XF498, SK-MEL-2, SK-OV-3, A549. 4. Tanshion II A induced DNA fragmentation of HL-60 from the concentration of 10 ㎍/㎖. 5. Solvent fractions of SMR showed the inhibitory effect on cell adhesion of A549 and B16-F0 most effectively specific to collagen Ⅳ. 6. Methanol and Ehtyl Ether extract of SMR inhibited platelet aggregation of ADP up to 35.6%, 46.1% at the concentration of 50 ㎍/㎖, 42.1%, 48.4% at the concentration of 100 ㎍/㎖ in the dose-dependent fashion. 7. T/c % ESR treated group was 143% based on the data that MST of ESR treated group was 22.6 days, while MST of control group was 15.7 days. 8. In pulmonary colonization assay ESR significantly inhibited pulmonary colonization of B16-Fo as compared with control group. 9. Gaining weight of lungs and spleen was significantly inhibited in ESR treated group, While the weight of kidney and liver was not signicantly changed as compared with control group. 10. ESR significantly decreased leukocytosis by B16-Fo to nomal range and significantly increased number of platelet as compared with control group. Above results indicate that Salviae miltiorrhizae Radix had antitumor effect and antitumor compound was indentified as tanshion ⅡA.

建築物을 土地情報시스템에 登錄하는 方法의 硏究

박운용,이동락,백기석 東亞大學校建設技術硏究所 2004 硏究論文集 Vol.28 No.1

In this study. we investigated 3 methods for precise registration of buildings into LIS. They are : 1. using digital topographic maps. 2. using registered building maps. 3. cadastral surveyings on sites. The first method was found that it hardly met required precision. and the second one was also lack of precision because of unmatched actual buildings with registered ones and many unregistered buildings. The last method produced the most precise results. although it required laborious cadastral surveyings on sites. Considering the importance of building registration as it shows the ownerships of properties. the third method was thought to be desirable.

강섬유 보강 폴리머 콘크리트의 재료특성 및 인성에 관한 실험적 연구

연규석,이윤수,김기락 강원대학교 부설 석재복합신소재 제품연구센터 1999 석재연 논문집 Vol.4 No.-

본 연구는 강섬유의 종횡비(ℓ/d) 및 혼입율(vol. %)을 변화시켜 폴리머 콘크리트에 강섬유를 혼입하여 강섬유 보강 폴리머 콘크리트를 제조하였으며, 이에 대한 재료특성 및 인성을 실험적으로 구명한 것이다. 그 결과 강섬유 폴리며 콘크리트의 강도특성 및 인성은 종횡비가 약 50인 조건에서 혼입율이 증가할 수록 우수한 특성을 보였고, 작업성은 종횡비 및 혼입율이 증가할 수록 저하하였으며, 경화수축 및 충격저항성은 종횡비 및 혼입율이 증가함에 따라 현저히 개선되는 경향을 나타냈다. Steel fiber reinforced polymer concrete (SFRPC) with different aspect ration (ℓ/d) and addition rate (vol. %) were prepared and tested for material characteristics and toughness. The strength and toughness indexes of SFRPC tended to linearly increase as steel fiber content increased when the aspect ratio was 50. Hardening shrinkage and impact resistance of SFRPC also improved dramatically as steel fiber content increased while workability dropped as aspect ratio and steel fiber addition rate increased.

진동에 의한 혈관 내 폐 보조장치의 산소전달 특성

김기범,권대규,이삼철,김성종,정인수,오인혁,김기주,변윤섭,정경락 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

본 연구는 급성호흡부전환자를 치료하기 위하여 사용되고 있는 혈관 내 폐 보조장치의 기체전달을 향상시키기 위하여 중공사막에 진동기법을 사용하여 기체전달을 향상시키고자 시도하였다. 그리고 혈관 내 폐 보조장치를 정맥에 삽입하기 전, 혈관 내 폐 보조장치의 설계조건을 실험적 모델을 통하여 기체전달을 예측할 수 있는 예측식을 만들고자 하였다. 실험결과, 본 연구에서는 진동기법이 기체전달을 향상시키는데 효과적임을 확인할 수 있었다. 뿐만 아니라, 충진율과 가징 주파수의 함수관계를 이용하여 기체전달을 예측 할 수 있었다. 실험에 의하여 얻어진 결과는 예측식에 의하여 얻어진 결과와 유사한 결과를 얻었다. 그러므로 본 연구에서는 충진율과 가진 주파수의 함수를 이용하여 VIVLAD의 기체전달을 예측할 수 있었다. In this paper, we tried to improve gas exchange of the vibrating intravascular lung assist device(VIVLAD) using vibrating method in the hollow fiber membrane, for the patients suffering from acute respiratory distress syndrome(ARDS). And we tried to formularize prediction equations to make a prediction about gas transfer for designing intravenous artificial lung assist device, and designed modules under various conditions were studied through an experimental modeling before inserted the artificial lung assist device into as venous. As a result, we are convinced that vibration method is very useful for the has transfer increasing. Also, we can estimate the gas transfer as a function of the packing density and excited frequencies. The gas transfer obtained from the experiment was similar to that from the prediction equation, confirming the usefulness prediction equation. Therefore, we can estimate the gas transfer of the VIVLAD as a function of the packing density and excited frequencies.

로케트 工學에 관한 硏究 : 第1報 : 亞音速 亂流流動에서 飛行翼模型의 剝離現象 Ⅰst Report : Separation of Airfoils in Subsonic Turbulent Flow

朴煥奎,金鍾一,金鎭興,李茂錫,朴吉文,鄭洛奎,李行男,李東起 조선대학교 동력자원연구소 1984 動力資源硏究所誌 Vol.6 No.2

Separation, pressure and velocity distributions were studied fully developed two dimensinonal, incompressible flow over a flat airfoil in subsonic wind tunnel. Velocity and turbulence were measured with a two channel constant temperature hot wire anemometer and pressure with a pitot tube and pressure tranducer system. The experimental results were obtained as follow: (1) Turbulent intensity of shear layer just outside the separation point is considered to affect the size of separation bubble. (2) Static pressure coefficient is separated into three regions according to its value change. (3) Separation point is varied with the change of attack angle. (4) Velocity distributions and boundary layers normal to airfoil surface are changed as variation of attack angle of airfoil.

Polyol Synthesis of Ruthenium Selenide Catalysts for Oxygen Reduction Reaction

Ki Rak Lee,우성일 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11

Ruthenium catalysts modified by selenium have been introduced as alternative materials to Pt in Direct methanol fuel cells (DMFCs). RuSe nano-particles were synthesized on the Vulcan XC72R carbon supports via polyol method. The prepared catalysts were electrochemically and physically characterized by cyclic voltammetry (CV,) linear sweep voltammetry, methanol tolerance test, X-ray diffraction (XRD), Transmission electron microscopy (TEM), Energydispersive Spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS). Increasing the Se concentration up to 20 at % increased the electro-catalytic activity for the oxygen reduction. By increasing Se amount, Ru metallic form on the surface was increased. The Ru80Se20/C catalysts showed the highest oxygen reduction reaction (ORR) activity and outstanding methanol tolerant property in half cell tests as well as single cell test.