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加減茵蔯蒿湯 水鍼液이 膽道結紮로 유도된 肝損傷에 미치는 영향
成樂箕,金元信,田炳薰,李建穆 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-
연구배경 : 肝癌 및 肝硬變은 韓國人의 疾病으로 인한 중요한 喪亡原因의 하나이며, 특히 우리나라 B型肝炎의 流行地域으로 急慢性 肝炎이나 肝經辨證, 肝癌의 發病率이 높다. 그리하여 肝硬變症을 寢具治療法중 水鍼을 이용하여 肝의 募穴인 期門穴에 投與하면 治療效果가 있는지에 대하여, 그리고 藥量에 따라 治療效果가 달라지는 지에 대하여 알아보기 위하여 본 연구를 시행하였다. 방법 : 加減茵蔯蒿湯 水鍼液을 膽道를 結紮한 白鼠에 26guage의 1ml 주사기를 이용하여 투여하였다. 經穴은 人體의 期門에 相應하는 左石部位와 腹部內의 任意의 部位를 設定하여 매일 1회 7주간 수침하였다. 결과 : 體重과 Total Bilirubin은 實驗群 A, C에서 有意性 있는 增加와 減少를 보였고, WBC·ALT·AST·ALT 및 Cholesterole은 全實驗群에서 有意性 있는 減少를, Albumin은 全實驗群에서 有意性 있는 增加를 각각 나타내었으며, 組織學的 觀察도 全實驗群에서 有意性을 나타내었다. 또한 Hydroxyproline도 實驗群 A, B에서 有意性있는 減少를 보였다. 결론 : 加減茵蔯蒿湯 水鍼液을 膽道를 結紮한 白鼠의 期門穴에 投與한 缺課 有意한 효과를 보였으나 水鍼量에 따라 有意性의 차이가 있어 敵意한 水鍼量을 투여하는 것이 治療시 重要하다고 思料되며, 또한 水鍼에 대한 安全性 問題에 대하여서도 더욱 硏究할 필요가 있다. In order to study the effects of the water extract of Gagaminjinhotang in the Meridian points Liv 14 on the liver damage indued by bile duct ligation during 7 weeks after the operation of bile duct ligation, blood was taken from the heart and body weight, WBC, RBC, hemoglobin, hematocrit, total bilirubin, ALT, AST, ALP, cholesterol, albumin and hydroxyproline were in each experimental apparatus. The results of this study were as follows; 1. Body weight of EXA, C were significantly increased by the water extract of Gagaminjinhotang. 2. WBC of EXA,B,C were significantly decreased by the water extract of Gagaminjinhotang. 3. RBC, hemoglobin and hematocrit of EXA,B,C were not significantly influenced by the water extract of Gagaminjinhotang. 4. Total bilirubin of EXA,C and direct bilirubin of EXA,B,C were significantly decreased by the water extract of Gagaminjinhotang. 5. ALT, AST,ALP of EXA,B,C were significantly decreased by the water extract of Gagaminjinhotang. 6. Cholesterol of EXA,B,C, were significantly decreased by the water extract of Gagaminjinhotang. 7. Albumin of EXA,B,C, were significantly increased by the water extract Gagaminjinhotang. 8. Hydroxyproline of EXA,B were significantly decreased by the water extract Gagaminjinhtang. 9. On the histological observation, the results of the experimental groups showed significant hepatoprotective effects compared with control group from 3 weeks after the administration of the water extract of Gagaminjinhotang. According to the above result, it is suggested that the water extract Gagaminjinhotang was significantly effective in WBC, bilirubin, ALT, AST, ALP, cholesterol, albumin and hydroxyproline level and then it seems to be applicable to the fibrosis or cirrhosis of liver.
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成樂其,金聖勳,李權益 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2
“怪病必瘀 久病必瘀”라 하여 癌 등의 難治病에는 瘀血證이 자주 나타나, 直接的인 抗腫류作用외에도 惡性腫瘍으로 인한 疑血과 織溶系統을 調節하는 作用이 있는 活血化瘀法은 현재 임상세선 活用 價値가 높다. 이에 本 論文에서는 活血祛瘀劑 및 安神劑로 活用되고 있는 丹蔘을 이용 抗癌 및 抗轉移 效果를 糾明하고 活性 物質을 採索함으로써 癌 治療에 도움이 되고자 한다. in vitro에서 B16-Fo와 A549 癌細胞 등의 패癌株에 對한 細胞毒性, 複合細胞外基質과 單味細胞外基質에 對한 細胞附着 沮止作用, 血小板疑集 促進劑중의 하나인 ADP에 對한 血小板凝集抑制作用, 有效 分劃으로부터 分離된 有效物質의 構造同定, 多樣한 사람 癌株에 對한 ED(50)값 및 自然殺害作用을 檢討하고, in vivo에서는 丹蔘의 有效 分劃을 S-180이 移植된 ICR 생쥐에 經口 投與한 後, 體重變化와 T/C%를 尾靜脈에 B16-Fo를 注入 후 C157BL/6의 pulmonary colonization assay, 臟器무게, WBC 및 platelet 數 等을 測定하였다. 丹蔘 分劃중 ethly ether층이 抗癌 및 抗轉移效果에 있어 가장 有意性있는 效果가 認定되었고, 이 층에서 分離된 tanshione IIA는 丹蔘의 主要 抗癌活性物質로 이를 이용한 數種 癌株의 細胞毒性 實驗에서 ED(50)이 모두 1.5㎍/㎖ 以下로 나타나 有效한 抗腫瘍 效果을 보였으며, 10㎍/㎖부터 HL-60에 대해 DNA fragmentation을 나타냈다. In order to confirm the antitumor effect of Salviae miltiorrhizae Radix(SMR) and isolate its active compound, the experiment was done. In vitro cytotoxicity against several cancer cell lines, inhibition of cell adhesion to extracellular matrix, inhibition of platelet aggregation by ADP were studied, in vivo T/C % of S-180 bearing ICR treated with ethyl ether(EE) layer of SMR, pulmonary colonization assay, changes of organ weight, WBC, number of platelet were evaluated experimentally and the results were obtained as follows: 1. The concentration inhibiting cell growth below 55% was 10~3g/ml of water layer and EE layer of SMR(ESR) against B16-Fo and 10-3g/ml of EE layer of SMR against A549. 2. Active compound isolated from Salviae miltiorrhizae Radix was identified as tanshion II A. 3. ED50 of tanshion II A was 0.8177 ㎍/㎖, 0.3431 ㎍/㎖, 1.3284 ㎍/㎖ and 0.8912 ㎍/㎖ against cancer cell lines as HCT15, XF498, SK-MEL-2, SK-OV-3, A549. 4. Tanshion II A induced DNA fragmentation of HL-60 from the concentration of 10 ㎍/㎖. 5. Solvent fractions of SMR showed the inhibitory effect on cell adhesion of A549 and B16-F0 most effectively specific to collagen Ⅳ. 6. Methanol and Ehtyl Ether extract of SMR inhibited platelet aggregation of ADP up to 35.6%, 46.1% at the concentration of 50 ㎍/㎖, 42.1%, 48.4% at the concentration of 100 ㎍/㎖ in the dose-dependent fashion. 7. T/c % ESR treated group was 143% based on the data that MST of ESR treated group was 22.6 days, while MST of control group was 15.7 days. 8. In pulmonary colonization assay ESR significantly inhibited pulmonary colonization of B16-Fo as compared with control group. 9. Gaining weight of lungs and spleen was significantly inhibited in ESR treated group, While the weight of kidney and liver was not signicantly changed as compared with control group. 10. ESR significantly decreased leukocytosis by B16-Fo to nomal range and significantly increased number of platelet as compared with control group. Above results indicate that Salviae miltiorrhizae Radix had antitumor effect and antitumor compound was indentified as tanshion ⅡA.
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중완(中脘)에 시술(施術)한 홍화약침(紅花藥鍼)이 항암(抗癌) 및 면역기능(免疫機能)에 미치는 영향(影響)
오치석,이현,임윤경,성락기,Oh, Chi-suk,Lee, Hyun,Yim, Yun-kyoung,Seong, Nak-ki 대한침구의학회 2004 대한침구의학회지 Vol.21 No.5
Objectives : The purpose of this experiment is to study on the anti-cancer, anti-metastasis and immune response improvement effects of Herbal-acupuncture with Carthami Flos infusion solution(CTT-HAS). Methods : We injected Carthami Flos infusion solution into Chung-wan(CV12) of C57BL/6 mouse which is corresponding to human Chung-wan(CV12). We observed its effect on the number of $CD25^{+}/CD4^{+}$, $CD8^{+}/CD3e^{+}$, $CD69^{+}/B220^{+}$, $NK^{+}/CD3e^{+}$ cells in mouse PBMCs, the number of the pulmonary colony, and the effect on MST and ILS of C57BL/6 mice implanted intravenously with B16-F10 melanoma. Results Conclusions : 1. The spleen cells proliferation of the sample groups treated with CTT-HAS extract has increased significantly compared with that of the control group. 2. The percentage of the $CD25^{+}/CD4^{+}$, $CD8^{+}/CD3e^{+}$, $CD69^{+}/B220^{+}$, $NK^{+}/CD3e^{+}$ cells in C57BL/6 mouse PBMCs of the sample groups treated with CTT herbal-acupuncture has increased compared with that of the control group. 3. The lung colony number of the sample groups CTT Herbal-acupuncture has decreased significantly compared with that of the control group. 4. MST and ILS of the sample groups CTT herbal-acupuncture have increased significantly compared with those of the control group.
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