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To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.
Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam
Vu Van Khien,Duong Minh Thang,Tran Manh Hai,Nguyen Quang Duat,Pham Hong Khanh,Dang Thuy Ha,Tran Thanh Binh,Ho Dang Quy Dung,Tran Thi Huyen Trang,Yoshio Yamaoka 거트앤리버 소화기연관학회협의회 2019 Gut and Liver Vol.13 No.5
Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. The search terms included the following: H. pylori infection, antibiotic (including clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug) resistance in Vietnam. The data were summarized in an extraction table and analyzed manually. Finally, Excel 2007 software was used to create charts. Ten studies (three studies in English and seven in Vietnamese) were included in this review. A total of 308, 412, 523, 408, 399, and 268 H. pylori strains were included in this review to evaluate the prevalence of H. pylori primary resistance to amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance, respectively. Overall, the primary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 15.0%, 34.1%, 69.4%, 27.9%, 17.9% and 48.8%, respectively. Secondary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 9.5%, 74.9%, 61.5%, 45.7%, 23.5% and 62.3%, respectively. In Vietnam, primary and secondary resistance to H. pylori is increasing over time and affects the effectiveness of H. pylori eradication.
Khanh B. Vu,Thanh Khoa Phung,Thao T.T. Tran,Clement Mugemana,Ha N. Giang,Truong Le Phuc Nhi 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.97 No.-
Polystyrene was synthesized and applied as a template for fabricating hollow silica nanoparticles. Organic solvent and water were used as a solvent and an anti-solvent, respectively, to produce thepolystyrene nanoparticles via. nanoprecipitation technique. The influence of precipitation method (oneshotor drop), solvent for dissolution of polystyrene, and concentration of polystyrene or CTAB linker onthe diameter of polystyrene nanoparticles was investigated. The hollow silica nanoparticles werefabricated using the as-made polystyrene nanoparticles as a template with the help of CTAB linker. Polystyrene was recovered by the extraction of polystyrene@SiO2 composite with the tetrahydrofuransolvent, and the recovered polystyrene was re-used to make the polystyrene nanoparticles as a templatefor fabricating hollow silica nanoparticles. Our study can be applied for other types of polymericmaterials as long as those polymeric materials form nanoparticles via. nanoprecipitation technique. Incomparison with the polystyrene hard template prepared by emulsion polymerization, the size ofpolystyrene nanoparticles produced by the nanoprecipitation technique can be well-tuned by changingthe polystyrene and linker concentrations.
Fast pyrolysis of pitch pine biomass in a bubbling fluidized-bed reactor for bio-oil production
Quoc Khanh Tran,Manh Linh Le,Hoang Vu Ly,우희철,김진수,김승수 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-
The kinetic parameters for the pyrolysis of biomass of the pitch pine (Rigida pine P. Mill) were examinedby thermogravimetric analysis in the temperature range 25 C to 700 C, in which the maindecomposition was occurred from 250 C to 400 C. Pyrolysis of pitch pine has been investigated in abubblingfluidized bed reactor. In this system, silica sand and nitrogen were used as thefluidizing bedmaterial andfluidizing medium, respectively. The experimental was systemically performed on differenttemperature,fluidized velocity, and particle size of biomass. The optimum temperature condition atwhich the bio-oil yields reached the highest value (65.5%) was 500 C. In addition, the higher heatingvalues of bio-oils from pitch pine biomass were reached in the range 22 MJ/kg to 24 MJ/kg. Moreover, thisbio-oil had high content of useful chemicals including such as levoglucosan, furfural, and guaiacol. Thelarge amount of C5–C11 (gasoline fraction) produced make the pyrolyzed oil originating from pitch pinetrees a promising biofuel candidate.
Spectrum of Lysosomal Storage Disease Targeted for Newborn Screening in Vietnam
Dung, Vu Chi,Ngoc, Can Thi Bich,Khanh, Nguyen Ngoc,Mai, Do Thi Thanh,Thao, Bui Phuong,Mai, Tran Thi Chi,Ha, Nguyen Thu,Huong, Nguyen Thi Mai,Nam, Nguyen Hoang,Hai, Le Thanh,Tomatsu, Shunji,Yoo, Han-Wo Association for Research of MPS and Rare Diseases 2017 Journal of mucopolysaccharidosis and rare disease Vol.3 No.1
Bio-oil production from fast pyrolysis of furniture processing residue
Hoang Vu Ly,Quoc Khanh Tran,천병희,오창호,김진수,김승수 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.2
The pyrolysis characteristic of furniture processing residue (FPR), which was analyzed by thermogravimetric analysis (TGA) under nitrogen atmosphere, mainly decomposed between 230 oC and 500 oC. The FPR was submitted to fast pyrolysis in a bubbling fluidized-bed reactor (BFR) for converting into bio-oil, bio-char. The product distribution and characteristics of bio-oil depend on the operating conditions (temperature, fluidizing flow rate, particle size of sample). The bio-oil yield showed the highest value (50.68 wt%) at the pyrolysis temperature of 450 oC with a biomass particle size of 1.0mm and a fluidization velocity of 2.0×Umf. The bio-oil had high selectivity for dioctyl phthalate, levoglucosan, and phenolic derivatives. The carbon number proportions in bio-oils of FPR were 32.74wt% for C5- C11 fraction, 47.60 wt% for C12-C18 fraction and 19.38 wt% of C25-C38 fraction, respectively. The gas product included CO, CO2, H2, and hydrocarbons (C1-C4), and the selectivity of CO2 was the highest. The high heating value (HHV) of gas products was between 4.60 and 12.90 MJ/m3. The bio-char shows high HHV (23.87 MJ/kg) and high C content (62.47wt%) that can be applied as a solid fuel.