축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

Impaired fasting glucose, single-nucleotide polymorphisms, and risk for colorectal cancer in Koreans

Keum Ji Jung,Miyong To Kim,Sun Ha Jee 한국역학회 2016 Epidemiology and Health Vol.38 No.-

OBJECTIVES: Numerous studies have demonstrated that fasting serum glucose (FSG) levels and certain single-nucleotide polymorphisms (SNPs) are related to an increased risk of colorectal cancer (CRC); however, their combined effects are still unclear. METHODS: Of a total of 144,527 men and women free of cancer at baseline, 317 developed CRC during 5.3 years of follow-up. A case-cohort study (n=1,691) was used, consisting of participants with a DNA sample available. Three well-known SNPs (rs3802842, rs6983267, rs10795668) were genotyped. Hazard ratios (HR) and 95% confidence intervals (CI) of CRC, colon and rectal cancer were calculated, with the Cox proportional hazard models. RESULTS: The crude incidence rates per 100,000 person-years were 41.1 overall, 48.4 for men, and 29.3 for women. Among participants with dysglycemia, SNPs rs3802842 and rs6983267 were both associated with an increased risk of CRC (HR, 3.2; 95% CI, 1.9 to 5.5 and HR, 1.8; 95% CI, 1.1 to 3.1, respectively) and rectal cancer (HR, 3.4; 95% CI, 1.8 to 6.6 and HR, 3.3; 95% CI, 1.6 to 7.1, respectively). The interaction effect of dysglycemia and SNPs was positive, that is, resulted in an elevated risk of CRC, but was not statistically significant. CONCLUSIONS: This study demonstrates that both high FSG and certain SNPs are major risk factors for CRC and rectal cancer but that they did not interact synergistically. The difference in effect size of the SNPs according to CRC subtype (i.e., colon or rectal cancer) and presence of dysglycemia merits further research.

Metabolic Risk Score and Vascular Mortality Among Korean Adults : The Korean Metabolic Syndrome Mortality Study

Jung, Keum Ji,Jee, Yon Ho,Jee, Sun Ha SAGE Publications 2017 Asia-Pacific journal of public health Vol.29 No.2

<P>Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors. However, rather than using a dichotomous scale, a continuous metabolic syndrome (cMetS) score has been proposed to evaluate MetS because current MetS criteria do not function well in identifying those at high risk of cardiovascular mortality. The objective of this study was to examine the association between cMetS score and vascular mortality among Korean population. We included 441 411 individuals who visited health promotion centers and were given a medical examination from 1994 to 2004. MetS status, sum of MetS components, and cMetS score were calculated. The individuals with MetS had a higher hazard ratio (HR) for mortality from atherosclerotic vascular disease (HR = 1.54, 95% CI = 1.42-1.67), ischemic heart disease (HR = 1.74, 95% CI = 1.51-2.01), and total stroke (HR = 1.44, 95% CI = 1.28-1.62) when compared with those without MetS. Graded, strong associations between cMetS score and vascular mortality, particularly from ischemic heart disease and ischemic stroke, were observed. Subjects with a cMetS score = 30 were at about 64 times greater risk for vascular mortality than those with a cMetS score below 0. cMetS score can be used to predict the risk of vascular death and provides a useful guideline to identify individuals at high risk for metabolic syndrome among Koreans.</P>

The effect of smoking on lung cancer: ethnic differences and the smoking paradox

Keum Ji Jung,Christina Jeon,Sun Ha Jee 한국역학회 2016 Epidemiology and Health Vol.38 No.-

The objectives of this review were to determine whether the smoking paradox still exists and to summarize possible explanations for the smoking paradox. Based on published data, we compared the risk of cigarette smoking for lung cancer in Western and Asian countries. We extracted data from the relevant studies about annual tobacco consumption, lung cancer mortality rates according to smoking status from each country, and possible explanations for the smoking paradox. A significantly greater risk of lung cancer death was found among current smokers in Asian countries than among nonsmokers, with relative risks (RRs) of 4.0 to 4.6 for Koreans, 3.7 to 5.1 for Japanese, and 2.4 to 6.5 for Chinese. Although a significantly greater risk of lung cancer was present among current smokers in Asian countries, the RRs in Asian countries were much lower than those reported in Western countries (range, 9.4 to 23.2). Possible explanations for the smoking paradox included epidemiologic characteristics, such as the smoking amount, age at smoking initiation, and the use of filtered or mild tobacco. The smoking paradox definitely exists, but may be explained by major epidemiologic characteristics. Therefore, the smoking paradox should not be interpreted as indicating that tobacco is safer or less harmful for Asians.

Genetically determined alcohol consumption and cancer risk in Korea

Keum Ji Jung,Ji Woo Baek,Sang Yop Shin,Sun Ha Jee 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: The purpose of this study was to determine the causal relationship between the genetically determined amount of alcohol consumption and the occurrence of major cancers. METHODS: The data used in this study were from 129,324 people selected from the Korean Cancer Prevention Study-II, the participants of which visited 18 health examination centers between 2004 and 2013. Cancer incidence was confirmed as of 2020 using data from the National Cancer Center. A genome-wide association study (GWAS) on alcohol consumption was performed using PLINK 2.0, and sex, age, chip type, and principal components were adjusted. RESULTS: From the GWAS, a genetic risk score for alcohol consumption was calculated and genetically determined alcohol consumption (GDAC) was estimated. GDAC was divided into quintile groups and showed significant causal relationships with rectal cancer and liver cancer, but not with other cancers. For liver cancer, an association was shown in the hepatitis B surface antigen (HBsAg)-negative group, and a particularly strong association was found in the over-60-year-old HBsAg-negative group, in which, compared to the GDAC Q1 group, the Q4 group had a 2.35 times higher risk (95% confidence interval [CI], 1.05 to 5.23), and the Q5 group had a 2.40 times higher risk (95% CI, 1.09 to 5.30). CONCLUSIONS: The results of this study provided evidence that the amount of alcohol consumed is causally related to the occurrence of rectal cancer and liver cancer in HBsAg-negative individuals. Additional studies should be continued for other cancer types through long-term follow-up.

Traditional and Genetic Risk Score and Stroke Risk Prediction in Korea

Jung, Keum Ji,Hwang, Semi,Lee, Sunmi,Kim, Hyeon Chang,Jee, Sun Ha The Korean Society of Cardiology 2018 Korean Circulation Journal Vol.48 No.8

<P><B>Background and Objectives</B></P><P>Whether using both traditional risk factors and genetic variants for stroke as opposed to using either of the 2 alone improves the prediction of stroke risk remains unclear. The purpose of this study was to compare the predictability of stroke risk between models using traditional risk score (TRS) and genetic risk score (GRS).</P><P><B>Methods</B></P><P>We used a case-cohort study from the Korean Cancer Prevention Study-II (KCPS-II) Biobank (n=156,701). We genotyped 72 single nucleotide polymorphisms (SNPs) identified in genome-wide association study (GWAS) on the KCPS-II sub-cohort members and stroke cases. We calculated GRS by summing the number of risk alleles. Prediction models with or without GRS were evaluated in terms of the area under the receiver operating characteristic curve (AUROC).</P><P><B>Results</B></P><P>Sixteen out of 72 SNPs identified in GWAS showed significant associations with stroke, with an odds ratio greater than 2.0. For participants aged <40 years, AUROCs for incident stroke were 0.58, 0.65, and 0.67 in models using modifiable TRS only, GRS only, and TRS plus GRS, respectively, showing that GRS only model had better prediction than TRS only. For participants aged ≥40 years, however, TRS only model had better prediction than GRS only model. Favorable levels of traditional risk were associated with significantly lower stroke risks within each genetic risk category.</P><P><B>Conclusions</B></P><P>TRS and GRS were both independently associated with stroke risk. Using genetic variants in addition to traditional risk factors may be the most accurate way of predicting stroke risk, particularly in relatively younger individuals.</P>

Duration of ovarian hormone exposure and atherosclerotic cardiovascular disease in Korean women: the Korean Heart Study

Jung, Keum Ji,Kim, Mee-Ran,Yun, Young Duk,Kim, Hyeon Chang,Jee, Sun Ha by The North American Menopause Society. 2016 Menopause Vol.23 No.1

<P>Objective: Although reproductive and hormonal factors, such as menarche and menopause, have been reported as independent risk factors for atherosclerotic cardiovascular disease (ASCVD), few studies have examined these factors in East Asian populations. In the Korean Heart Study, ASCVD risk related to duration of ovarian hormone exposure was examined in a cohort of 66,104 Korean women. Methods: Study members were recruited from participants of routine health examinations at health promotion centers across South Korea in 1996-2004. Ovarian hormone exposure was defined as duration between menarche and menopause. Incidence rates for ASCVD, stroke, and ischemic heart disease were examined in relation to ovarian hormone exposure. Results: The mean duration of ovarian hormone exposure at study baseline was 33.7 years, and risk for ASCVD was negatively associated with duration. Women with shorter ovarian hormone exposure (<30 y) had a higher risk of developing ASCVD (hazard ratio [HR], 1.30; 95% CI, 1.01-1.68) than women with longer ovarian hormone exposure (35-35 y). In similar comparison groups, women with ovarian hormone exposure shorter than 30 years were at increased risk for developing total stroke (HR, 1.18; 95% CI, 1.00-1.38), thrombotic stroke (HR, 1.30; 95% CI, 1.05-1.61), ischemic heart disease (HR, 1.40; 95% CI, 1.19-1.63), and acute myocardial infarction (HR, 1.73; 95% CI, 1.08-2.47). Conclusions: Our study provides further confirmation of increased cardiovascular risk with shorter reproductive years. Therefore, women with reduced lifetime ovarian hormone exposure should focus on minimizing ASCVD risk by lifestyle modifications such as smoking avoidance or increased physical activities.</P>

Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics

Bae, Jung-woo,Choi, Chang-ik,Kim, Mi-jeong,Oh, Da-hee,Keum, Seul-ki,Park, Jung-in,Kim, Bo-hye,Bang, Hye-kyoung,Oh, Sung-gon,Kang, Byung-sung,Park, Hyun-joo,Kim, Hae-deun,Ha, Ji-hey,Shin, Hee-jung,Kim, Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.10

암 발생예측 모형과 유전위험점수에 관한 고찰

정금지 ( Keum Ji Jung ),김소리울 ( Soriul Kim ),윤미욱 ( Miwuk Yun ),전티나 ( Christina Jeon ),지선하 ( Sun Ha Jee ) 한국보건정보통계학회(구 한국보건통계학회) 2014 보건정보통계학회지 Vol.39 No.1

Objectives: In genome-wide association studies (GWASs), single-nucleotide polymorphisms (SNPs) that have been identified as cancer-associated loci are common, but they confer only small increases in risk. The question was whether combining multiple disease-related SNPs and the modest effects within Genetic Risk Score (GRS) may be useful in identifying subgroups that are at high risk of cancer. Methods: In this paper, we first reviewed articles that examined the predictability of GRS on cancer prediction models. Our data sources included a PubMed search of the literature published until February 2014. Secondly, we have calculated the GRS using the data example data with five SNPs related colorectal cancer (CRC) obtained from the Korean cancer prevention study II. Two approaches were used to calculate the GRS: a simple risk alleles count method (counted GRS) and a weighted method based on the genotype frequencies for each SNP and the effect sizes (allelic odds ratio or beta coefficient) from our study (weighted GRS). Results: Of 31 studies initially identified, 16 (135,110 participants) met the inclusion criteria. Among 16 articles, 7 studies were related to prostate cancer, 6 studies to breast cancer, and 3 studies to colon cancer and lung cancer. Fifteen studies except for one study concluded that in general, a genetic score may be helpful or useful in identifying the high risk group and particularly to determining the high risk individual among patients within a ‘‘gray zone’’ of cancer risk. The weighted GRS with age and sex (AUC=0.9333) had higher predictability on the CRC risk than the model with GRS alone (AUC=0.816). Conclusions: Although adding GRS improves prediction model performance, the clinical utility of these genetic risk models is limited. Nonetheless, the modelling suggests public health potential since it is possible to stratify the population into cancer risk categories, thereby informing targeted prevention and management.

고등어 및 해조류의 염소산염 및 과염소산염 정량 분석 방법 조사

이정훈 ( Jung-hoon Lee ),안희연 ( Hui-yeon Ahn ),유지우 ( Ji-woo Yu ),송민호 ( Min-ho Song ),신지원 ( Ji-won Shin ),박건우 ( Geon-woo Park ),금영수 ( Young-soo Keum ),이지호 ( Ji-ho Lee ) 한국환경농학회 2023 한국환경농학회 학술대회집 Vol.2023 No.0

Monitoring food contaminants is important to ensure human health. Consumer’s needs for hygiene have increased and led to a consumption of chlorine-based disinfectants and sanitizers. Chlorate and perchlorate, which can be found in washed food, are considered potential contaminants that may have adverse effects on the human body. Therefore, there is an urgent need for analytical methods to assess the toxicity of chlorate and perchlorate. In this study, we aimed to establish and validate analytical methods for the quantification of chlorate and perchlorate in seaweed (as a representative of marine products) and mackerel (as a representative of fish products) to evaluate their contamination levels. Given the substantial worldwide consumption of seafood, it is crucial to ensure the safety of seafood through proper washing processes. It is anticipated that residues of chlorate and perchlorate may be present during these processes. To solve this concern, seaweed and mackerel were selected as target samples based on domestic food intake patterns. The analytical methods were developed based on the QuPPe method (Quick polar pesticide extraction method developed by Anastassiades) with some modifications to the extraction procedure due to the diverse matrix effects. Additionally, for seaweed, which has low moisture content, a final analysis method with an additional rehydration step was established. Quantitative analysis of chlorates and perchlorates was conducted using HPLC-MS/MS, and the establishment and validation of the analytical methods were performed through recovery test.