Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

해녀에서 발생한 성게육아종 1례

전영승,김상태,서기석 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Some aquatic animals can cause important skin diseases in humans. Sea urchin granuloma is a rare skin disorder showing chronic granulomatous lesion caused by injury with sea-urchin spines. Sometimes patients were injured in fishing activities and among them, correspond to divers involved in sea-urchin harvesting. We report a case of sea-urchin granuloma in 67-year-old female, who presented with multiple erythematous pin-head to rice-grain sized papules on the both elbow and knee.

Methyl Aminolevulinate(MAL)와 Light Emitting Diodes(LEDs)를 이용하여 국소 광역동 요법으로 치료한 여드름 1례

전영승,서기석,김상태 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Ance is a common multifactorial skin disease of the pilosebaceous unit. Conventional treatments of acne include a variety of topical agents (cleansing, antibiotics agents, benzoyl peroxide, retinoids) and oral medications (antibiotics, retinoids, hormones). But there are some disadvantages in terms of adverse effects and patient inconvenience with such treatments. Therefore new effective well-tolerable treatments needed. Photodynamic therapy (PDT) is a non-invasive therapeutic modality which is developing increasing use in dermatology. Photodynamic therapy (PDT) using with the new highly selective photosensitizer methyl aminolevulinate (MAL)(MetvixⓇ, Galderma, U.K.) is a promising treatment modality for acne. We report herein a case of acne treated by PDT using with MAL, with satisfactory outcome in clinical aspects.

고온 초전도체 Y₁Ba₂Cu₃O_7-δ(CdO)_x의 핵사중극 상호작용 연구

전인,김복수,노태호,김영훈,서용문,송승기,박영민 명지대학교 자연과학연구소 2000 자연과학논문집 Vol.19 No.-

CdO가 첨가된 고온 초전도체 Y1Ba2CU3O7-δ(CdO)x(x=0.00,0.09,0.22,0.34,0.42,0.49)를 고상 반응법으로 제작하여 상온에서 Cu 핵사중극 공명 실험을 하였다. 구리-산소 평면에 있는 63Cu(2)의 핵사중극 공명 진동수는 31.13∼31.39 MHz이고, 65Cu(2)의 공명 진동수는 28.82∼29.06 MHz이었다. 이러한 공명 진동수는 χ가 증가할수록 높은 진동수 방향으로 이동하였다. 63Cu(2)과 65Cu(2)의 NQR 공명 진동수의 비는 모든 시료가 1.08로 63Cu과 65Cu의 핵 사중극 모멘트의 비와 같았다. 구리-산소 사슬에 있는 63Cu(1)의 공명 진동수는 22.15~22.36 MHz에서 관측되었는데, χ에 따른 공명 진동수의 이동 경향은 63Cu(2)과 65Cu(2)의 경우와 비슷하였다. 선폭은 63Cu(2)과 65Cu(2)그리고 63Cu(1)의 경우 모두 약 200∼300 kHz고, 전반적으로 χ가 증가할 수록 감소하였다. 스핀-에코 방법으로 구한 스핀-스핀 이완 시간 T2는 χ가 증가함에 따라 약간씩 증가하였다. We have studied Cu-NQR in CdO-mixed high-Tc superconductor Y1Ba2Cu3O7-δ(CdO)x(x=0.00, 0.09, 0.22, 0.34, 0.42, 0.49) at room temperature prepared by solid state reaction method. In the Cu-O plane, 63Cu(2)-NQR frequencies were measured to be in the range of 31.13-31.39 MHz and those of 65Cu(2) were in the range of 28.82-29.06 MHz. The position of spectrum-peaks shifted to the higher frequency with increasing χ. The ratio of 63Cu(2) and 65Cu(2)-NQR frequencies have the value of 1.08 which is equal to the ratio of 63Cu(2) and 65Cu(2) nuclear quadrupole moment for all samples. The resonance frequencies of 63Cu(1) in the Cu-O chain have been observed in the range of 22.15-22.36 MHz and the tendency of resonance frequency behaviour with χ were nearly the same for both 63Cu(2) and 65Cu(2). The line-widths of 63Cu(2), 65Cu(2) and 63Cu(1) were observed to the value of 200∼300 kHz and they decreased with increasing χ. The spin-spin relaxation time T2 obtained by spin-echo method increased slightly with increasing χ.

HPV에 감염된 자궁경부 상피세포의 Keratin 아형 변화에 관한 연구

기근홍,이영미,장원재,임용,임성철,김창원,전호종 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

The human papillomavirus (HPV) are wide spread in the world, causing proliferation of epidermal and mucosal surface. Certain papillomaviral types are oncogenic in vivo and in vitro. HPV DNA has been detected in most of cervical lesions such as condyloma acuminata, dysplasias, and invasive carcinomas. The materials for this study consisted of 5 dysplasias. 5 squamous cell carcinomas, and 5 exocervix for control, that resected for definite treatment of uterine disease at Chosen University Hospital from January, 1991 to December, 1993. All cases were performed of in situ hybridization for HPV DNA type 6/11, 16, and 18. And also immununohistochemical stain for panel of monoclonal cytokeratin (CK) antibodies were done. The result obtained is as fallows : 1. HPV DNA type 6/11 are detected in all dysplasias. HPV DNA type 16 and 18 are detected in squamous cell carcinomas. 2. Stratifed squamous epithelium of exocervix are positive staining for CK 1, CK 5/6, CK 8, CK 13, CK 14, and CK 19. HPV DNA type 6/11 infected cells are positive for CK 1, CK 13, CK 14, CK 17, CK 18, and CK 19. HPV DNA type 16/18 infected cells are positive for CK 1, CK 5/6, CK 10, CK 13, CK 14, CK 17, CK 18, and CK 19. In conclusion, HPV infection of uterine cervix is associated with change of normal cytokeratin expression pattern. Dysplastic cells are changed of CK 5/6, CK 8, CK 17 and CK18. Squamous cell carcinoma cells are changed of CK 8, CK 17, and CK 18.

고온 초전도체 Y₁-x Ndx Ba₂Cu₃O7-y의 임계 전류밀도에 관한 연구

박영민,전인,송승기 명지대학교자연과학연구소 1991 자연과학논문집 Vol.9 No.-

고온 초전도체 Y₁-??Nd??Ba₂Cu₃O??-??(x=0.0,0.2,0.4,0.6,0.8,1.0)를 고상 반응법을 이용하여 제작하여 제작하였다. X-ray 회절실험 결과로 부터 격자상수를 구했다. x가 증가함에 따라 a,b,c값이 증가하였고 x=0.6과 x=1.0에서 anomaly 현상을 보였다. SEM 사진을 통한grain size는 x= 0.0,1.0에서 2∼3μm, x=0.6,0.8에서 4/μm, x=0.2,0.4에서 5μm 정도로 나타났다. 온도 변화에 따른 비저항 측정으로 구한 초전도 전이온도는 모든 시료에 대해 85∼92K 사이에 존재하였고 x가 증가함에 따라 감소하였다. 수송 임계전류밀도는 20-92 A/㎠사이에서 측정 되었으며 시료내의 Nd 치환량이 증가하면 J?는 증가하였고 x=0.4에서 anomaly 현상이 나타났다. 자기장을 가해준 상태엣 측정한 수송 임계전류밀도는 자기 장이 증가함에 따라 x=0.0 시료에서 급격히 감소하였고 Nd가 많이 치환된 시료에서는 감소율이 작았다. High-T??superconductor Y₁-??Nd??Ba₂Cu₃O??-??(0.0, 0.2, 0.4, 0.6, 0.8, 1.0)has been prepared by the solid state reaction method. Lattice constants are calculated from the result of X-ray diffraction pattern. The lattice constant a, b, and c are increased as increasing x except for x=0.6 and 1.0 samples. SEM photograph showed that the grain size is 2∼3μm for x=0.0 and 1.0 samples, 4μm for x=0.6, 0.8 and 5μm for x=0.2, 0.4 samples. The superconducting transition temperature determined by the temperature dependence of resistivity are detected between 85K and 95K decreased as increasing x. Transport current density was observed between 20 and 92 A/㎠ and J?? increased as increasing Nd concentration in the sample except for the x=0.4 sample. Transport current density of x=0.0 sample decreased abruptly with increasing applied magnetic field and the smaple of large Nd concentration has the slowly decreasing transport current density with inereasing magnetic field.

남매에서 발생한 심한 용혈성 빈혈과 간경변증을 동반한 Wilson 병 2례

노영일,박동호,서우철,문경래,박상기,박영봉,이미숙,전호종 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

We experienced two case of Wilson's disease in female and male sibling. The first case was a 10 year-old female who showed jaundice. pancytopenia and cirrhotic change in liver biopsy. She died 10 days after diagnosis. The second case of 7 year-old male showed specific symptoms and revealed increased AST/ALT, low serun copper level and increased 24 hour urinary copper excretion level He is being treated with D-penicillamine and follow up examinations.

V₂O-B₂O₃-PbO 유리의 전자 상자성 공명연구

노태호,전인,박영민,강재필,김성재,박현진,송승기 명지대학교 자연과학연구소 1996 자연과학논문집 Vol.14 No.-

V₂O??-B₂O₃-PbO 유리의 VO??에 관한 전자 상자성 (EPR) 스펙트럼으 연구하였으며, vanadium이온의 스핀해밀토니안 상수들을 구하였다. 유리시료안의 V₂O??양을 증가시킴에 따라 g??과 g??값은 증가하였으나 A??과 A??값은 감소하였다. 이는 V₂O??수가 증가하면 동일 평면상의 vanadium과 oxygen배위간 결합의 공유성이 증가함을 의미한다. 유리내의 vanadium 4가이온은 정방형 일그러진 8면체를 한 vanadyl착물로 존재한다. Electron Paranmagnetic Resonance(EPR) SPECTRA OF (VO)?? in V₂O??-B₂O₃-PbO glasses have been studied and spin hamiltonian paramenters of vanadium ion have been calculated. It is found that the value of g??and g?? increases while the value of A?? and A?? decreases with an increase of V₂O?? content in the glass samples, showing that the covalency in the in-plane vanadium -oxygen ligand bonds increase with increasing the concentration of V₂O??. The tetravalent vanadium ions exist as vanadyl complexes with tetragonally distorted octahedral sites in the glasses.

칼슘과 아연으로 치환된 Y0.8 Pr0.₂ Ba₂ Cu₃ O7_δ 의 전기 및 자기적 성질에 관한 연구

김성재,전인,박영민,강재필,노태호,박현진,최숙자,송승기 명지대학교 자연과학연구소 1996 자연과학논문집 Vol.14 No.-

전이온도가 72K인 고온초전도체 Y?P?B?Cu?O?에서 초전도성을 감소시키는 Pr원소자리에 Ca과 Zn를 적당히 치환시켜 자기적 성질을 연구하였다. 초전도 전이온도(Tc)는 Ca이 치환된 시료의 경우 80~85k의 범위에서 측정되었으며, Zn가 치환된 경우에는 35~49K의 값을 보였다. 비저항의 온도 변화로부터 결정된 전기적 전이온도는 온도에 대한 자기모우먼트으 변화에서 구한 자기적 전이온도와 비슷한 값을 보였다. 자기이력곡선으로부터 Bean의 모델을 이용하여 Hcl(저임계자기장), Hc?(고임계자기장), 반자성정도, 임계전류밀도를 측정하였다. 이러한 성질들은 시료 내에 Ca의 치환량이 많아질수록 증가하였으며, Zn가 많아질수록 급격히 감소하였다. 특히 임계전류밀도는 x=0.0인 시료는 1.60x10?A/㎠이었으며 Ca이 치환된 시료는 1.30~1.98x10? A/㎠, Zn가 첨가된 시료는 3.5x10?~1.3x10?A/㎠의 값으로 계산되었다. 이것은 시료 내에서 Ca은 초전도성을 증가시키고, Zn는 초전도성을 감소시키는 것을 의미한다. We have studied magnetic properties as a appropriate substitute of Ca and Zn element for Prelement which reduces superconducting properties in the high-temperature superconductor Y?Pr?Ba?Cu?O? of transition temperature 72K. When Ca is put into, the critical temperature(Tc)showed the value of measurement at the range of 80~85K while for Zn the Tc had the range of 35~49K. The electric critical temperature determined by the temperature dependence of resistivity had a similar data to the magnetic field), Hc?(high critical magnetic field), diamagnetic ratio and critical current density have observed by Bean's model from the magnetic hysterisis curve. These properties were increased with adding Ca and abruptly decreased with adding Zn in the samples. Especially, the critical current density of x=0.0 sample was calculated at 1.60x10?A/㎠ and those of the other Ca-added samples at the range of 1.30~1.98xA/㎠and those of Zn-added samples at the range of 3.50x10?~1.30x10?A/㎠. These mean that Ca increases supercondecting properties in the sample and Zn element decreases them.

77K와 상온에서 CO(NH₂)₂의 ¹⁴N Pulsed NQR 연구

강재필,박영민,전인,김성재,최숙자,박현진,송승기,서용문 명지대학교 자연과학연구소 1996 자연과학논문집 Vol.13 No.-

77K와 상온에서 CO(NH₂)₂분말 시료의 ??N Pulsed NQR실험을 하여 위와 아래 공명 진동수, 핵 사중극 결합상수, 비대칭 인자, 스핀-스핀 완화시간, 결정 격자 진동에서의 평균 비틀림 진동수, 진동자의 관성 모먼트 등을 구하였다. 공명 진동수의 온도 의존성은 전형적인 Bayer이론의 격자 진동에 의한 주파수 변화를 보였다. Bayer-Kushida이론의 고온근사식을 실험값에 적용하여 OK에서 공명 진동수 ν??와 ν??를 구했으며, 77K와 상온에서의 스핀-스핀 완화시간 T₂를 관측했다. 상온에서 T₂의 감소는 결정 내의 reorientation motion과 관련이 있을 것으로 보인다. Upper and lower resonance frequencies, nuclear quadrupole coupling constants, asymmetry parameters, spin-spin relaxation time, average torsional frequency in the crystal lattice motion and moment of inertia in the oscillator are found for CO(NH₂)₂powder sample by using ??N Pulsed NQR(Nuclear Quadrupole Resonance) technique at 77K and room temperature. Temperature dependence of resonance frequencies showed frequency variation in agreement with the typical Bayer's theory in lattice motion. Resonance frequencies ν?? and ν?? at OK were obtained by fitting the high temperature approximation of Bayer-Kushida theory to the experimental data and spin-spin relaxation time (T₂) was observed at 77K and room temperature. Decrease of T₂at room temperature was explained by the effect of reorientational motion in the crystal lattice.