디지털 신호처리에 적합한 Golay 복호 알고리듬

강인식(In-Sk Kang),이현(Hyun Lee),송영준(Yuong-Joon Song) 한국정보기술학회 2010 Proceedings of KIIT Conference Vol.2010 No.-

Kasami 복호기는 가장 잘 알려진 Golay 부호의 복호기 중 하나로 Kasami 복호기의 오류 포착 기법을 이용하여 Golay 부호를 간편하게 복호 할 수 있다. 본 논문에서는 소프트웨어 기반의 디지털 신호 처리 시스템에서 효과적으로 사용될 수 있도록 Kasami 복호기를 설계하였다. 또한 시뮬레이션을 통하여 기존 복호기와 동일한 성능을 가지는 것을 확인하였다. Kasami decoder is one of commonly used Golay decoders. This decoder based on error trapping method is very simple in principle. In this paper, we designed effective Golay code decoder used in digital signal processing. Designed decoder and previous decoder have same performance in simulation.

Contributions of primary organic matter sources to macroinvertebrate production in an intertidal salt marsh (Scirpus triqueter) ecosystem

Kang, CK,Choy, EJ,Paik, SK,Park, HJ,Lee, KS,An, S Inter-Research 2007 Marine ecology progress series Vol.334 No.-

Interaction between udenafil and tamsulosin in rats: non-competitive inhibition of tamsulosin metabolism by udenafil via hepatic CYP3A1/2 : PK interaction between udenafil and tamsulosin

Kang, HE,Bae, SK,Yoo, M,Lee, DC,Kim, YG,Lee, MG Wiley (Blackwell Publishing) 2009 British journal of pharmacology Vol.156 No.6

<P>BACKGROUND AND PURPOSE: Orthostatic hypotension has been observed when PDE 5 (cGMP-specific phosphodiesterase type 5) inhibitors are co-administered with alpha-adrenoceptor antagonists. Here we assessed the pharmacokinetic and haemodynamic interactions between udenafil and tamsulosin in rats, as both drugs are metabolized via rat hepatic cytochrome P450 3A1/2. EXPERIMENTAL APPROACH: Interactions between the two drugs were evaluated in rats after simultaneous 1 or 15 min i.v. infusion or after p.o. administration of udenafil (30 mg x kg(-1)) and/or tamsulosin (1 mg x kg(-1)). In vitro metabolism of tamsulosin with udenafil was measured to obtain the inhibition constant (K(i)) and [I]/K(i) ratio of udenafil. KEY RESULTS: The total area under the plasma concentration-time curve from time zero to time infinity (AUC)s (or AUC(0-4 h)) of tamsulosin were significantly greater after 15 min of i.v. infusion or after oral administration with udenafil, compared with tamsulosin alone. The hepatic first-pass metabolism of tamsulosin was inhibited by udenafil, and the inhibition in vitro was in a non-competitive mode. The arterial systolic blood pressure was significantly lower at 5, 10 and 60 min after oral co-administration of the drugs. CONCLUSIONS AND IMPLICATIONS: The significantly greater AUC of tamsulosin after i.v. and p.o. administration of both drugs may be attributable to non-competitive inhibition of cytochrome P450 3A1/2-mediated hepatic tamsulosin metabolism by udenafil. The inhibition was also observed in human liver S9 fractions, suggesting that a reassessment of the oral dosage of tamsulosin is necessary when udenafil and tamsulosin are co-administered to patients with benign prostatic hyperplasia.</P>

제대기저부 탈장의 산전진단 2 례

강재성,이은주,김서경,김용욱,이도근,박석진 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.1

고려의대 산부인과학교실에서는 산전진찰중 초음파검사에 의해서 제대기저부 탈장으로 진단된 2례를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. The omphalocele (exomphalos) is a defect of the abdominal wall at the umbilicus with herniation of abdminal contents. Even though the mortality is high, recently increased neonatal survival is reported, due to various surgical advancement and associated with a better understanding of preoperative and postoperative cares. 2 cases of omphalocele prenatally diagnosed by ultrasonography are reported with a brief review of the literatures.

Randomized phase II study of axitinib versus placebo plus best supportive care in second-line treatment of advanced hepatocellular carcinoma

Kang, Y.-K.,Yau, T.,Park, J.-W.,Lim, H. Y.,Lee, T.-Y.,Obi, S.,Chan, S. L.,Qin, SK.,Kim, R. D.,Casey, M.,Chen, C.,Bhattacharyya, H.,Williams, J. A.,Valota, O.,Chakrabarti, D.,Kudo, M. Oxford University Press 2015 Annals of oncology Vol.26 No.12

<P>Axitinib plus best supportive care failed to meet the primary end point of overall survival in second-line treatment of advanced hepatocellular carcinoma in a randomized phase II study. However, the axitinib arm showed substantially improved progression-free survival, time to tumour progression, and clinical benefit rate compared with the placebo arm, with acceptable safety profile. Background: The efficacy and safety of axitinib, a potent and selective vascular endothelial growth factor receptors 1-3 inhibitor, combined with best supportive care (BSC) was evaluated in a global, randomized, placebo-controlled phase II trial in patients with locally advanced or metastatic hepatocellular carcinoma (HCC). Patients and methods: Patients with HCC and Child-Pugh Class A who progressed on or were intolerant to one prior antiangiogenic therapy were stratified by tumour invasion (presence/absence of extrahepatic spread and/or vascular invasion) and region (Asian/non-Asian) and randomized (2:1) to axitinib/BSC (starting dose 5 mg twice-daily) or placebo/BSC. The primary end point was overall survival (OS). Results: The estimated hazard ratio for OS was 0.907 [95% confidence interval (CI) 0.646-1.274; one-sided stratified P = 0.287] for axitinib/BSC (n = 134) versus placebo/BSC (n = 68), with the median (95% CI) of 12.7 (10.2-14.9) versus 9.7 (5.9-11.8) months, respectively. Results of prespecified subgroup analyses in Asian versus non-Asian patients or presence versus absence of tumour invasion were consistent with the overall population. Improvements favouring axitinib/BSC (P < 0.01) were observed in secondary efficacy end point analyses [progression-free survival (PFS), time to tumour progression (TTP), and clinical benefit rate (CBR)], and were retained among Asian patients in the prespecified subgroup analyses. Overall response rate did not differ significantly between treatments and patient-reported outcomes favoured placebo/BSC. Most common all-causality adverse events with axitinib/BSC were diarrhoea (54%), hypertension (54%), and decreased appetite (47%). Baseline serum analyses identified potential new prognostic (interleukin-6, E-selectin, interleukin-8, angiopoietin-2, migration inhibitory factor, and c-MET) or predictive (E-selectin and stromal-derived factor-1) factors for survival. Conclusions: Axitinib/BSC did not improve OS over placebo/BSC in the overall population or in stratification subgroups. However, axitinib/BSC resulted in significantly longer PFS and TTP and higher CBR, with acceptable toxicity in patients with advanced HCC. Trial Registration: ClinicalTrials.gov, NCT01210495.</P>

Platelet Activation Factor (PAF) 가 정자의 활동성과 시험관 실험에서 생쥐의 수정에 미치는 영향

강길전,최송기,유병대,원철 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.4

본 연구는 PAF가 정자의 활덩성에 미치는 영향과 생쥐를 모델로 하여 수정전 정자를 PAF로 처리시수정에 미치는 영향을 알아보고자 시도되었으며 그 결과 다음과 같은 결론을 얻게 되었다. 1. PAF는 10^-8 M에서는 부유정자의 수를 유의하게 증가시켰으며, 10^-6 M에서는 부유 정자수를 유의하게 저하시켰다. 2. PAF노출시간이 부유정자에 미치는 영향에서는 30분, 60분 비교시 유의한 증가는 없었으며, 대조군에서는 유의한 증가를 보였다. 3. PAF로 생쥐 정자처리 후 수정률과 분사분열률에 미치는 영향에서, 각 대조군 및 각 PAF농도연구군에서 유의한 차이를 보이지 않았다. 이상의 결과로 미루어 보아 PAF는 정자의 활동성 및 정자의 수정능 획득에 작용함을 알 수 있었으며, 체외수정 기법에 응용하여 체외수정과 배아이식 성공을 높이는 데 기여할 수 있으리라 사료되었다. An synthetic activating factor (PAF) has been demonstrate to play an important role in reproduction. This report examined the effect of PAF on human sperm motility by the time and murine fertilization and fragmented rate in vitro when murine sperm swum up in the PAF diluted Hams F-10 media. PAF and stimulatory effect swimming up sperm count at the moderate concentration and toxic effect at high concentration, but no effect of PAF on the murine fertilization and fragmented rate at any concentration. These results demonstrate that synthetic PAF could enhance sperm motility and give suggestion that PAF may play an role in human IVF program.

산과 경막외마취의 임상적 의의

강상대,이계현,채진호,손성권,정성욱,이리라,박후철,왕중서 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.6

저자들은 1996년 1월 1일부터 1996년 12월 31일까지 분만키 위해 내원한 산모 중 정상 분만 2,931예 중에 100예, 경막외마취를 시행한 252예 중에 각각 100예씩 무작위 추출하여 비교 관찰하여 다음과 같은 결론을 얻었다. 1. 경막외마취 시행군에서 초산모가 58예, 경산모가 37예였고(제왕절개술 5예), 정상분만 100예 중에 초산모 가 26예, 경산모가 72예였으며(제왕절개술 2예) 평균 연 령은 연구군이 27.78세, 대조군은 27.27세였으며 산모의 평균 몸무게 및 신장은 연구군에서 66.69 kg, 160.08 cm 였고 대조군에서 65.72 kg, 160.69 cm였으며 산모의 직 업은 연구군에서 주부가 86명, 기타 직업을 가진 산모가 14명, 대조군에서 주부가 83명, 기타 직업을 가진 산모 가 17명이였으며 임신 주수는 시행군이 평균 40.07주, 대조군이 평균 39.78주로 산모의 연령, 몸무게 및 신장, 직업, 임신 주수는 두 군 사이에 유의한 차이점은 없었 다(P>0.05). 2. 분만 제1기의 기간은 초산모에서 연구군이 평균 273.4분, 대조군이 261.2분이었고 경산모에서 연구군이 평균 198.6분, 대조군이 175.7분으로 두 군 사이에 초산 모, 경산모 모두 유의한 차이점은 없었다(P>0.05). 3. 분만 제2기의 기간은 초산모에서 연구군이 63.8분, 대조군이 43.3분이었으며 경산모에서 연구군이 30.6분, 대조군이 11.2분으로 초산모, 경산모 모두 분만 제2기의 기간이 지연되는 경향을 보였다(P<0.05). 4. 출혈량은 연구군이 평균 390 cc, 대조군이 391 cc 로 두 군 사이에 유의한 차이점은 없었다(P>0.05). 5. 1분 Apgar 평점은 9∼10점이 연구군 85예, 대조군 98예였고, 5분 Apgar 평점은 9∼10점이 연구군 97예, 대 조군 99예로 두 군 사이에 유의한 차이는 없었다(P> 0.05). 6. Meconium staining이 없는 경우는 연구군에서 79예, 대조군에서 88예였고, mild한 경우가 각각 10예, 4예였 고, moderate한 경우가 각각 4예, 3예였으며, severe한 경 우가 각각 7예, 5예로 두 군 사이에 유의한 차이점은 없 었다(P>0.05). 7. 경막외마취를 원하는 이유로 통증 때문이 88예, 경 험에 의해서 원하는 경우가 3예, 주위 권유가 9예로 통 증 때문이 제일 많았다. 8. 경막외마취의 효과로는 아주 좋았다는 36예, 좋다 는 56예 그저 그렇다는 8예였으며 VAS(Visual Analogue Scale) 통증 점수는 3.78±4.87(Mean±SD)이었다. Authors have analyzed the clinical significance of epidural anesthesia applied on labor progress on 100 cases of normal delivery groups given epidural anesthesia from January 1, 1996 to December 31, 1996 at obstetrical service in Masan Fatima Hospital. The results of these studies were as followings. 1. There was no significant difference in mean age, body weight, height, occupation and gestational age between epidural anesthesia group and control group (P>0.05). 2. The effect of epidural anesthesia on the first stage of labor revealed no significant difference in both group (P>0.05). 3. Prolongation of second stage of labor was noticed in nullipara and multipara of epidural anesthetic group compared to control group (P<0.05). 4. The mean blood loss of epidural anesthetic group was 390cc and control group was 391cc. There was no significant difference in blood loss (P>0.05). 5. There was no significant difference in 1 minute and 5 minutes Apgar score between study and control group (P>0.05). 6. The reasons for selecting epidural anesthesia were pain (88 case), experience (3 case), adivise (9 case). 7. The efficacy of pain control by epidural anesthesia was excellent (36%), good (56%), poor (8%). Mean VAS (Visual Analogue Scale) score was 3.78 (±4.87, Standard Deviation).

재발한 청신경초종에 대한 전S자상정맥동 경추체 접근법:적응증 및 수술 결과

강재훈,황승균,곽호신,김동규,정희원 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.31 No.5

자궁외 전위를 일으킨 Lippes Loop의 3예

이상근(SK Lee),류지선(GS Yoo),강영기(YK Kang),임헌정(HJ lm) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.5

Three cases of extrauterine displacement of Lippes loop are presented with brief discussion about its incidence, possible mechanism and prevention through the references, which would be, we believe, helpful to minimize such a rare but complication of Intrauterine Contraceptive Devices further.

쌍태아간 수혈증후군 1 례

박신근,신경재,안철영,김태국,전영식,박경원,강영제 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.6

본 병원 산부인과에서는 반복 양수천자로 임신을 지속시킨 쌍태아간 수혈증후군 1례를 경험 하였기에 문헌고찰과 함께 보고하는 바이다. TWIN-TWIN Transfusion Syndrome(TTTS) is a serious complication of monochorionic gestaions and is associated with high rates of perinatal morbidity and mortality resulting from shunting of blood from one twin(donor) to the other(recipient) through placental vascular anastomoses. We experienced a case of TTTS at 27 wks in which amniocentesis was attempted serially for therapeutic purpose. Therefore, we present this case with a brief review of the literatures.