POSITIVELY EXPANSIVE ENDOMORPHISMS ON SUBSHIFTS OF FINITE TYPE

Kim, Young-One,Lee, Jung-Seob Korean Mathematical Society 1997 대한수학회논문집 Vol.12 No.2

It is shown that if S is a positively expansive endomorphism on a one-sided mixing SFT (X,T), then (X,S) is conjugate to a one-sided mixing SFT, and the Parry measures of (X,T) and (X,S) are identical.

Application of Vendor-Neutral Iterative Reconstruction Technique to Pediatric Abdominal Computed Tomography

Woo Hyeon Lim,Young Hun Choi,Ji Eun Park,Yeon Jin Cho,이승현,Jung-Eun Cheon,Woo Sun Kim,In-One Kim,Jong Hyo Kim 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.9

ObjectiveTo compare image qualities between vendor-neutral and vendor-specific hybrid iterative reconstruction (IR) techniques for abdominopelvic computed tomography (CT) in young patients. Materials and MethodsIn phantom study, we used an anthropomorphic pediatric phantom, age-equivalent to 5-year-old, and reconstructed CT data using traditional filtered back projection (FBP), vendor-specific and vendor-neutral IR techniques (ClariCT; ClariPI) in various radiation doses. Noise, low-contrast detectability and subjective spatial resolution were compared between FBP, vendor-specific (i.e., iDose1 to 5; Philips Healthcare), and vendor-neutral (i.e., ClariCT1 to 5) IR techniques in phantom. In 43 patients (median, 14 years; age range 1–19 years), noise, contrast-to-noise ratio (CNR), and qualitative image quality scores of abdominopelvic CT were compared between FBP, iDose level 4 (iDose4), and ClariCT level 2 (ClariCT2), which showed most similar image quality to clinically used vendor-specific IR images (i.e., iDose4) in phantom study. Noise, CNR, and qualitative imaging scores were compared using one-way repeated measure analysis of variance. ResultsIn phantom study, ClariCT2 showed noise level similar to iDose4 (14.68–7.66 Hounsfield unit [HU] vs. 14.78–6.99 HU at CT dose index volume range of 0.8–3.8 mGy). Subjective low-contrast detectability and spatial resolution were similar between ClariCT2 and iDose4. In clinical study, ClariCT2 was equivalent to iDose4 for noise (14.26–17.33 vs. 16.01–18.90) and CNR (3.55–5.24 vs. 3.20–4.60) (p > 0.05). For qualitative imaging scores, the overall image quality ([reader 1, reader 2]; 2.74 vs. 2.07, 3.02 vs. 2.28) and noise (2.88 vs. 2.23, 2.93 vs. 2.33) of ClariCT2 were superior to those of FBP (p < 0.05), and not different from those of iDose4 (2.74 vs. 2.72, 3.02 vs. 2.98; 2.88 vs. 2.77, 2.93 vs. 2.86) (p > 0.05). ConclusionVendor-neutral IR technique shows image quality similar to that of clinically used vendor-specific hybrid IR technique for abdominopelvic CT in young patients.

간아세포종 환아의 임상적 특성과 예후

김민영,김대연,안효섭,김종재,김인원,정성은,이성철,박귀원,김우기,Kim, Min-Young,Kim, Dae-Yeon,Ahn, Hyo-Seep,Kim, Chong-Jai,Kim, In-One,Jung, Sung-Eun,Lee, Seong-Cheol,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 1997 소아외과 Vol.3 No.2

Hepatoblastoma is a rare pediatric malignancy which frequently presents at an advanced un resectable stage. With the neoadjuvant chemotherapy, improved resectability and survival have been reported. Twenty children with biopsy proven hepatoblastoma were treated during the period between January 1987 and June 1995. Median age at diagnosis was 13 months(2 months to 7 year and 10 months), and 13 were male. Histologic profile was 13 epithelial(5 fetal, 4 mixed, 1 embryonal, 3 undetermined), and 5 mixed mesenchymal and epithelial and 2 of undetermined type. Chemotherapy effectively reduced the tumor volume($p$=0.008), and was able to convert 7 out of 9 initially unresectable cases(78%) to resectable ones. Twelve radical and 2 palliative operations were done with or without adjuvant chemotherapy. The Median follow up period was 33 months and the median survival was 26 months. The group with curative resection had a 61.1% 5 year survival rate, but none of palliative resection group survived more than 13 months($p$=0.0001). In univariate analysis for prognostic factors revealed, large tumor size at diagnosis and abscence of thrombocytopenia were associated with poor survival, but these differences were not statistically significant. Histological pure fetal type did not mean a better prognosis. Even with a recent neoadjuvant chemotherapy, the strategy should be focused on the radical resection as early as possible.

가사노동의 에너지 대사에 관한 연구 : 작업대 높이를 중심으로 On the basis of the height of Work Surface

김미현,김영숙,신경원,이미선 효성여자대학교 가정대학 학도호국단 1986 家政大論集 Vol.5 No.-

본 연구의 목적은 동일 작업대에서 가사노동시 작업자의 신장과 에너지 대사와의 관계를 분석하는데 있다. 실험은 가사에 경험이 있는 자로서 신장별로 A(152㎝), B(159㎝), C(172㎝)를 피실험자로 하여 Respilyzer를 이용한 간접열량 측정법을 이용하였다. 실험 결과를 요약하면 다음과 같다. 1. 각 작업의 R. M. R. 평균은 설겆이 작업 0.64, 고구마 채썰기 0.77, 고구마 볶기는 0.42였다. 2. 개수대 작업에서 신장별에 따라 R. M. R.은 피실험자 C. A. B.의 순으로 키가 큰 사람이 (C) 1.16으로 에너지소모가 가장 많았다. 3. 준비대 작업에서 신장별에 따라 R. M. R.은 피실험자 A. B. C의 순으로 나타났으나 그 차이가 타작업에 비해 근소하였다. 이상의 결과를 볼 때 현재 시판되고 있는 작업대 높이에서 주부가 가사노동할 경우 표준신장에 가까운 사람에 비해 신장에 차이가 있는 사람은 개수대, 준비대에서의 작업시 에너지소모가 많다는 것을 알 수 있다. 생활수준의 향상과 더불어 신장도 증가하는 일로에 있으나 가사노동하는 주부의 체위는 다양하다. 이러한 점을 고려할 때 기업체에서는 시판 작업대 제작시 높이를 평균 키에 맞추어 단일화시킬 것이 아니라 작업자의 체위를 고려하여 적어도 상, 중, 하의 높이의 형으로라도 되어질 것이 요구된다고 하겠다. The purpose of present research is to analyze the relation of the height of homeworker and the Energy- Metabolism when welted on Sink Center, Mix Center andRange . Experiment was used indirection - calorimetry with Respilyzer and subjects wereclassified into A(152cm), B(158.6cm) and C(172cm) according to height. The results of this study were as follows ; 1. The average of R. M. R. in each homeworking was 0.64 in dishwashing (Sink Center), 0.77 in sweet potato slicing (Mix Center) and 0.42 in sweet potato Panbroiling (Range). 2. In dishwashing, R. H. R. according to height was the highest in the subject Cin order of C.A. B. 3. In sweet potato slicing, R. M. R. according to height was the hightest in thesubject A in order of A. C. B. 4. In sweet potato pan-broiling, R. M. R. according to height was high in orderof the subject A. B. C but the difference of R. M. R. among A. B. C was a few ascompared with dishwashing and sweet potato slicing.

P024 Increased expression of TRPV3, PAR2 and NK1R in burn scars with post burn pruritus

( Yong Se Cho ),( Yong Won Choi ),( Jee Hee Son ),( Yun Sun Byun ),( Bo Young Chung ),( Hee Jin Cho ),( Chun Wook Park ),( Hye One Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Post burn pruritus is a common distressing sequela of burn wounds. Empirical antipruritic treatment often fails, as the mechanism has not been fully elucidated. Objectives: The aim of this study was to evaluate the manifestation of transient receptor potential vanilloid 3 (TRPV3), transient receptor potential ankyrin 1 (TRPA1) and other related receptors in post burn pruritus. Methods: Sixty-five burn patients with (n=40) or without (n=25) pruritus were investigated, including skin biopsy and clinical assessments such as VAS (Visual analogue scale) for pruritus, PSAS (Patient scar assessment scale), and OSAS (Observer scar assessment scale). Keratinocytes and fibroblasts from skin biopsy samples were separated and real time PCR, western blotting, intracellular Ca2+ measurements were performed. Results: Real time-PCR showed that mRNA of TRPV3 was significantly increased in keratinocytes from pruritic burn scars than in keratinocytes from non-pruritic burn scars. With TRPV3 activation, intracellular Ca2+ concentrations were more significantly increased in keratinocytes from pruritic burn scars than in those from non-pruritic ones. Additionally, mRNA and protein levels of protease-activated receptor 2 (PAR2) and neurokinin-1 receptor (NK1R) were also significantly increased in pruritic burn scars. Conclusion: We confirmed that TRPV3, PAR2, and NK1R were highly expressed in pruritic burn scars. These results may help determine a novel mechanism for post burn pruritus.

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 1. Definition, Methodology and First-line Management

송우정,Mira Choi,Dong Hun Lee,Jae-Woo Kwon,Gun-Woo Kim,Myung Hwa Kim,Mi-Ae Kim,Min-Hye Kim,Byung-Keun Kim,Sujeong Kim,Joung Soo Kim,Jung Eun Kim,Ju Young Kim,Joo Hee Kim,Hyun Jung Kim,Hye One Kim,Hyo-Bin 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.4

Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for >6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals and societies in many countries, including Korea. CSU frequently persists for several years and requires high-intensity treatment; therefore, patients experience deteriorations in quality of life and medication-associated complications. During the last decade, there have been major advances in the pharmacological treatment of CSU and there is an outstanding need for evidence-based guidelines that reflect clinical practice in Korea. The guidelines reported here represent a joint initiative of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Dermatological Association, and aim to provide evidence-based guidance for the management of CSU in Korean adults and children. In Part 1, disease definition, guideline scope and development methodology as well as evidence-based recommendations on the use of antihistamines and corticosteroids are summarized.

HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice

Kim, Young-Eun,Lee, Minji,Gu, Hyejung,Kim, Jeongwoo,Jeong, Seongju,Yeo, Sujin,Lee, You Jeong,Im, Sin-Hyeog,Sung, Young-Chul,Kim, Hak Jae,Weissman, Irving L.,Ahn, G-One The Company of Biologists Ltd 2018 Disease models & mechanisms Vol.11 No.7

<P><B>ABSTRACT</B></P><P>Inflammatory bowel disease (IBD) is a chronic inflammatory disease, in which the intestinal epithelium loses its barrier function. Given the existence of the oxygen gradient in the intestinal epithelium and that inflammation further contributes to the tissue hypoxia, we investigated the role of hypoxia-inducible factor (HIF), a transcription factor activated under hypoxic conditions in myeloid cells, in the progression of IBD. To do this, we utilized myeloid-specific knockout (KO) mice targeting HIF pathways, created by a Cre-loxP system with human MRP8 (hMRP8), an intracellular calcium-binding protein, as the myeloid promoter. By feeding 5% dextran sodium sulfate (DSS) to hMRP8 von Hippel Lindau (<I>Vhl</I>) KO mice, in which HIF-1α and HIF-2α are constitutively activated in myeloid cells, we found that these mice were highly susceptible to DSS-induced colitis, demonstrating greater body weight loss, increased mortality, faster onset of rectal bleeding, shortened colon length, and increased CD11b- or Gr-1-positive myeloid cells in the colon compared with wild-type (WT) mice. These parameters were restored to, if not better than, the WT levels when we examined hMRP8 <I>Hif-1a</I> KO mice upon 5% DSS feeding. hMRP8 <I>Hif-2a</I> KO mice, on the other hand, exhibited a similar degree of DSS-induced colitis to that of WT mice. Lastly, when DSS was given together with azoxymethane to induce tumorigenesis in the colon, we found that hMRP8 <I>Hif-1a</I> KO mice exhibited comparable levels of colorectal tumors to those of WT mice, indicating that HIF-1α in myeloid cells is dispensable for tumorigenesis. Collectively, our results suggest that HIF-1α activation in myeloid cells critically regulates IBD progression.</P>

Gene Promoter Hypermethylation in Tumors and Plasma of Breast Cancer Patients

Young Kyung Bae,Young Ran Shim,Joon Hyuk Choi,Mi Jin Kim,Edward Gabrielson,Soo Jung Lee,Tae Yoon Hwang,Sei One Shin 대한암학회 2005 Cancer Research and Treatment Vol.37 No.4

Purpose: To measure the hypermethylation of four genes in primary tumors and paired plasma samples to determine the feasibility of gene promoter hypermethylation markers for detecting breast cancer in the plasma.Materials and Methods: DNA was extracted from the tumor tissues and peripheral blood plasma of 34 patients with invasive breast cancer, and the samples examined for aberrant hypermethylation in cyclin D2, retinoic acid receptor β (RAR β), twist and high in normal-1 (HIN-1) genes using methylation-specific PCR (MSP), and the results correlated with the clinicopathological parameters.Results: Promoter hypermethylation was detected at high frequency in the primary tumors for cyclin D2 (53%), RAR β (56%), twist (41%) and HIN-1 (77%). Thirty-threeof the 34 (97%) primary tumors displayed promoter hypermethylation in at least one of the genes examined. The corresponding plasma samples showed hyperme thylation of the same genes, although at lower frequencies (6% for cyclin D2, 16% for RAR β, 36% for twist, and 54% for HIN-1). Overall, 22 of the 33 (67%) primary tumors with hypermethylation of at least one of the four genes also had abnormally hypermethylated DNA in their matched plasma samples. No significant relationship was recognized between any of the clinical or pathological parameters (tumor size, axillary lymph node metastasis, stage, or Ki-67 labeling index) with the frequency of hypermethylated DNA in the primary tumor or plasma.Conclusion: The detection of aberrant promoter hypermethylation of cancer-related genes in the plasma may be a useful tool for the detection of breast cancer.

?티스속 근경과 탈지된 크로톤 종자의 혼합 추출물(CP-2)이 수종 암세포에 대한 세포독성의 효과

김춘원,서경원,조영호,홍은경,한영복,문정조,경홍기,김정한,김종배 中央醫學社 1993 中央醫學 Vol.58 No.3

In order to develop anti-cancer drug with strong anti-cancer activity without side effects, we extracted by various steps from the mixture of Coptis chinensis (CO) and Croton tiglium L (CR), and evaluated it by measuring the cytotoxicity against various tumor cell-lines including normal spleen and thymus cells. Five murine cell lines including leukemia L-1210 and 9 human tumor cell lines including leukemia HL-60 derived from various organs such as stomach, liver, lung, colon and breast cancers were used. The cytotoxicity were measured by the well-known colorimetric [3-(4,5dimethylthiazol-2-yl)2,5 -diphenyltetrazolium bromice] (MTT) assay. The extract (CP-2) from the mixture of CO and CR were very effective to all tumor cell lines with different degrees but showed no significant effects on normal spleen and thymus cells. Specially stomach SNU-1, lymphoma Raji and colon SNU-C2A compared with others showed very strong cytotoxicity; 60? 80 %, 55 ?96 % and 40~80 %, within the range of 10 ~45 ?g/ ml, 10 ~90 ?g/ml and 55 ~96 ?g/ml of the extract (CP-2) respectively. The range of ID50 values were from 4.4 ?g/ml in lymphoma Raji to 350 ?g/mi in liver HEP-3B, which were relatively low compared with other natural crude extracts reported elsewhere.

A NOTE ON THE ZEROS OF JENSEN POLYNOMIALS

Kim, Young-One,Lee, Jungseob Korean Mathematical Society 2022 대한수학회지 Vol.59 No.4

Sufficient conditions for the Jensen polynomials of the derivatives of a real entire function to be hyperbolic are obtained. The conditions are given in terms of the growth rate and zero distribution of the function. As a consequence some recent results on Jensen polynomials, relevant to the Riemann hypothesis, are extended and improved.