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      • KCI등재

        Comparison of the Effect of Vitamin K2 and Risedronate on Trabecular Bone in Glucocorticoid-Treated Rats: A Bone Histomorphometry Study

        Jun Iwamoto,Hideo Matsumoto,Tsuyoshi Tadeda,Yoshihiro Sato,James K. Yeh 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.2

        Purpose: To compare the effect of vitamin K2 and risedronate on trabecular bone in glucocorticoid (GC)-treated rats. Materials and Methods: Forty-eight Sprague-Dawley female rats, 3 months of age, were randomized by the stratified weight method into 5 groups according to the following treatment schedule: age-matched control, GC administration, and GC administration with concomitant administration of vitamin K2, risedronate, or vitamin K2 + risedronate. GC (methylprednisolone sodium succinate, 5.0 mg/kg) and risedronate (10 μg/kg) were administered subcutaneously three and five times a week, respectively. Vitamin K2 (menatetrenone, 30 mg/kg) was administered orally three times a week. At the end of the 8-week experiment, bone histomorphometric analysis was performed on trabecular bone of the tibial proximal metaphysis. Results: GC administration decreased trabecular bone mass compared with age-matched controls because of decreased bone formation (mineralizing surface, mineral apposition rate, and bone formation rate) and increased bone erosion. Vitamin K2 attenuated GC-induced trabecular bone loss by preventing GC-induced decrease in bone formation (mineralizing surface) and subsequently reducing GC-induced increase in bone erosion. Risedronate prevented GC-induced trabecular bone loss by preventing GC-induced increase in bone erosion although it also suppressed bone formation (mineralizing surface, mineral apposition rate, and bone formation rate). Vitamin K2 mildly attenuated suppression of bone formation (mineralizing surface) and bone erosion caused by risedronate without affecting trabecular bone mass when administered in combination. Conclusion: The present study showed differential effect of vitamin K2 and risedronate on trabecular bone in GC-treated rats. Purpose: To compare the effect of vitamin K2 and risedronate on trabecular bone in glucocorticoid (GC)-treated rats. Materials and Methods: Forty-eight Sprague-Dawley female rats, 3 months of age, were randomized by the stratified weight method into 5 groups according to the following treatment schedule: age-matched control, GC administration, and GC administration with concomitant administration of vitamin K2, risedronate, or vitamin K2 + risedronate. GC (methylprednisolone sodium succinate, 5.0 mg/kg) and risedronate (10 μg/kg) were administered subcutaneously three and five times a week, respectively. Vitamin K2 (menatetrenone, 30 mg/kg) was administered orally three times a week. At the end of the 8-week experiment, bone histomorphometric analysis was performed on trabecular bone of the tibial proximal metaphysis. Results: GC administration decreased trabecular bone mass compared with age-matched controls because of decreased bone formation (mineralizing surface, mineral apposition rate, and bone formation rate) and increased bone erosion. Vitamin K2 attenuated GC-induced trabecular bone loss by preventing GC-induced decrease in bone formation (mineralizing surface) and subsequently reducing GC-induced increase in bone erosion. Risedronate prevented GC-induced trabecular bone loss by preventing GC-induced increase in bone erosion although it also suppressed bone formation (mineralizing surface, mineral apposition rate, and bone formation rate). Vitamin K2 mildly attenuated suppression of bone formation (mineralizing surface) and bone erosion caused by risedronate without affecting trabecular bone mass when administered in combination. Conclusion: The present study showed differential effect of vitamin K2 and risedronate on trabecular bone in GC-treated rats.

      • KCI등재

        Magnetic and Transport Properties of a New Caged Compound PrOs2Zn20

        K. Wakiya,N. Nagasawa,K. T. Matsumoto,T. Onimaru,K. Umeo,T. Takabatake 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12

        The magnetic and transport properties of a Pr-encaged compound PrOs2Zn20 have been studiedby the electrical resistivity (T), magnetic susceptibility ρ(T), and specific heat C(T) measurementsdown to 2 K. The (T) and the C(T) show distinct anomalies at Ts = 87 K, which resemble theanomalies in the isostructural and isoelectronic compound PrRu2Zn20 with the structural phasetransition at Ts = 138 K. Above 50 K, the ρ(T) follows the Curie-Weiss law with the effectivemagnetic moment of 3.64 µB/f.u., which indicates the trivalent state of the Pr ion. The saturatedbehavior of ρ(T) below 5 K indicates the Van-Vleck paramagnetic state. Hence, the Pr3+ ion fallsin a nonmagnetic ground state under the crystalline electric field.

      • A NOVEL ZVS-PWM QUASI-RESONANT INVERTER WITH ACTIVE VOLTAGE-CLAMPED CAPACITOR FOR HIGH-FREQUENCY INDUCTION-HEATED APPLIANCE

        K.Izaki,I.hirota,H.Yamashita,H.Omon,K.Matsumoto,K.Nishida,J.M.Sun,M.Nakaoka 전력전자학회 1998 ICPE(ISPE)논문집 Vol.- No.-

        This paper describes an advanced prototype of voltage-fed zero voltage soft-switching PWM resonant inverter with an active voltage clamped capacitor, which is put into practice for high-frequency high-power induction-heated appliances This application-specific quasi-resonant inverter using the latest generation IGBTs for soft-switching can regulate its output power under a principle of a fixed frequency ZVS-PWM strategy. Its operating principle and unique features are presented as compared with a conventional quasi-resonant ZVS inverter for induction-heated cooker, together with its power regulation characteristics on the basis of its simulation and experimental results. The steady-state performances of this inverter developed for mutli-bumer type induction-heated food cooking appliance are evaluated and discussed from a practical point of view.<br/>

      • A Two-Phase High Step Down Coupled-Inductor Converter for Next Generation Low Voltage CPU

        K. Matsumoto,K. Nishijima,T. Sato,T. Nabeshima 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5

        In this paper, a novel two-phase high step down coupled-inductor converter for next generation low voltage CPU is proposed. This converter has a very high step down characteristic as Vo/Vi = D/4. The switching loss and noise of all switching elements are sufficiently reduced because the drain-source voltages at switching periods are reduced to a quarter of the input source voltage. Low withstand voltage MOSFETs with low on resistance and low Qg(total gate charge) characteristics are possible to use for the all switching elements because the maximum voltage stresses of the main switches and the synchronous rectifier switches are reduced to a half and a quarter of the input source voltage respectively. Further, the branch currents flowed through the paralleled converters are automatically and mostly balanced without the current detection and balance control. The above fine characteristics are simply achieved with three additional capacitors.

      • SINGLE-PHASE CURRENT SOURCE INVERTER WITH PULSE AREA MODULATION SCHEME FOR SOLAR POWER CONDITIONER

        K.Hirachi,K.Matsumoto,M.Ishitobi,M.Ishibashi,M.Nakaoka 전력전자학회 1998 ICPE(ISPE)논문집 Vol.- No.-

        In general, a singte-phase current-fed PWM inverter using IGBTs has some unique advantages for small scale distributed utility-interactive power supply system as compared with voltage-fed PWM inverter. In particular, this is more suitable and acceptable for a non-isolated type utility-interactive power conditioner, which is going to be widely used for residential solar photovoltaic (PV) power generation system in Japan However, this current-fed PWM inverter has a significant disadvantage. The output current of this inverter includes large harmonic contents when the inductance of smoothing reactor in its DC side is not large enough to eliminate its current ripple components of this inverter In order to overcome this problem, a new conceptual pulse area modulation scheme for this inverter is introduced in difference with conventional PWM strategy. This paper presents a new effective control implementation of this PV power conditioner which is able to reduce the harmonic component in the output current produced by the single-phase current-fed PWM inverter even when the npple current in the smoothing DC reactor is relatively large. The operating principle of the proposed control strategy introdued for this inverter system is described, and its simulation results are evaluated and discussed herein.<br/>

      • KCI등재

        Electronic Structure of the SrTiO3(001) Surfaces: Effects of the Oxygen Vacancy and Hydrogen Adsorption

        K. Fukutania,S. Ogura,K. Fukada,M. Matsumoto 한국진공학회 2014 Applied Science and Convergence Technology Vol.23 No.5

        The influence of electron irradiation and hydrogen adsorption on the electronic structure of the SrTiO3 (001) surface was investigated by ultraviolet photoemission spectroscopy (UPS). Upon electron irradiation of the surface, UPS revealed an electronic state within the band gap (in-gap state: IGS) with the surface kept at 1×1. This is considered to originate from oxygen vacancies at the topmost surface formed by electron-stimulated desorption of oxygen. Electron irradiation also caused a downward shift of the valence band maximum indicating downward band-bending and formation of a conductive layer on the surface. With oxygen dosage on the electron-irradiated surface, on the other hand, the IGS intensity was decreased along with upward band-bending, which points to disappearance of the conductive layer. The results indicate that electron irradiation and oxygen dosage allow us to control the surface electronic structure between semiconducting (nearly-vacancy free: NVF) and metallic (oxygen de cient: OD) regimes by changing the density of the oxygen vacancy. When the NVF surface was exposed to atomic hydrogen, in-gap states were induced along with downward band bending. The hydrogen saturation coverage was evaluated to be 3.1±0.8×1014 cm−2 with nuclear reaction analysis. From the IGS intensity and H coverage, we argue that H is positively charged as H~0:3+ on the NVF surface. On the OD surface, on the other hand, the IGS intensity due to oxygen vacancies was found to decrease to half the initial value with molecular hydrogen dosage. H is expected to be negatively charged as H− on the OD surface by occupying the oxygen vacancy site.

      • KCI우수등재

        Electronic Structure of the SrTiO₃(001) Surfaces

        K. Takeyasua,K. Fukada,S. Ogura,M. Matsumoto,K. Fukutani 한국진공학회(ASCT) 2014 Applied Science and Convergence Technology Vol.23 No.5

        The influence of electron irradiation and hydrogen adsorption on the electronic structure of the SrTiO3 (001) surface was investigated by ultraviolet photoemission spectroscopy (UPS). Upon electron irradiation of the surface, UPS revealed an electronic state within the band gap (in-gap state: IGS) with the surface kept at 1×1. This is considered to originate from oxygen vacancies at the topmost surface formed by electron-stimulated desorption of oxygen. Electron irradiation also caused a downward shift of the valence band maximum indicating downward band-bending and formation of a conductive layer on the surface. With oxygen dosage on the electron-irradiated surface, on the other hand, the IGS intensity was decreased along with upward band-bending, which points to disappearance of the conductive layer. The results indicate that electron irradiation and oxygen dosage allow us to control the surface electronic structure between semiconducting (nearly-vacancy free: NVF) and metallic (oxygen de cient: OD) regimes by changing the density of the oxygen vacancy. When the NVF surface was exposed to atomic hydrogen, in-gap states were induced along with downward band bending. The hydrogen saturation coverage was evaluated to be 3.1±0.8×10<SUP>14</SUP> cm<SUP>?2</SUP> with nuclear reaction analysis. From the IGS intensity and H coverage, we argue that H is positively charged as H<SUP>~0:3+</SUP> on the NVF surface. On the OD surface, on the other hand, the IGS intensity due to oxygen vacancies was found to decrease to half the initial value with molecular hydrogen dosage. H is expected to be negatively charged as H? on the OD surface by occupying the oxygen vacancy site.

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