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이하연 ( Ha Youn Lee ),김영훈 ( Young Hoon Kim ),엄선영 ( Sun Young Um ),정욱순 ( Uk Sun Jung ),장문식 ( Moon Sik Chang ),이남호 ( Nam Ho Lee ) 대한화장품학회 2014 대한화장품학회지 Vol.40 No.4
본 연구에서는 노무라입깃해파리(Nemopilema nomurai) 가수분해 추출물의 미백활성에 대하여 검색하였다. 가수분해 시료(NHE, N. nomurai Hydrolized Extract)는 노무라입깃해파리를 상업용 단백질분해효소(Protamex, Alcalase, Flavourzyme, Neutrase)를 이용하여 55 ℃에서 pH 5-8 조건으로 처리하는 과정을 거쳐 얻었다. 미백활성은 B16-F1 멜라노마 세포에서 멜라닌 색소 합성 저해능 평가를 통하여 확인하였다. 실험결과, Neutrase로 처리된 시료(N-NHE)에서 100 μg/mL의 농도에서 멜라닌 생성이 가장 효율적으로 89.9%감소되는 것을 관찰하였다. 이 시료는 또한 tyrosinase와 TRP-1 (tyrosinase related protein-1) 단백질의 발현을 억제하였다. 이상의 연구 결과는 노무라입깃해파리 가수분해 추출물의 화장품 미백 소재로의 개발 가능성을 보여주고 있다. This study was aimed to investigate skin whitening effects of Nomura’s jellyfish (Nemopilema nomurai) hydrolyzed extracts (NHE). The extracts were prepared through the hydrolysis of N. nomurai using commercial proteolytic enzymes such as Protamex, Alcalase, Flavourzyme and Neutrase with optimum pHs (pH 5-8) at 55 ℃. Their whitening activities were examined from the inhibition of melanin synthesis using B16-F1 cell lines. Among the examined samples, Neutrase-treated extract (N-NHE) showed the most significant inhibition effect on melanin synthesis by 89.9% at a concentration of 100 μg/mL. This sample decreased the expression of tyrosinase and TRP-1 (tyrosinase related protein-1) proteins as well. These results suggested the potential application of NHE as whitening ingredients in cosmetic preparation.
3차원 저마루구조물(LCS) 주변에서 불규칙파동장의 변동특성
이광호(Kwang-Ho Lee),이준형(Jun Hyeong Lee),정욱진(Uk Jin Jung),김도삼(Do-Sam Kim) 한국해안해양공학회 2020 한국해안해양공학회 논문집 Vol.32 No.2
최근 동해안을 비롯한 많은 해안에서 심각한 해안침식과 인접한 해안도로 유실 등과 같은 연안재해가 발생되고 있는 것은 널리 알려진 사실이다. 이에 대한 대안으로 유럽을 비롯한 해외에서는 저마루구조물(LCS, Low-Crested Structure)에 의한 연안재해 저감법이 활발하게 연구되고 있다. 본 연구에서는 선행연구를 바탕으로 투과성의 LCS 및 그의 주변 파동장에 olaFlow 모델을 적용하여 불규칙파동장 하의 3차원 수치해석을 수행한다. 이로부터 Hrms, 해빈류 및 평균난류운동에너지를 수치적으로 검토하며, 해빈류의 패턴과 평균난류운동에너지의 공간분포에 관해서는 불규칙파동장 하 잠제의 경우와 비교하였다. 이로부터 해빈류의 양상이 잠제의 경우와는 상반되게 나타나는 등의 중요한 결과를 얻을 수 있었다. On the many coasts of South Korea, including the eastern side, it has been recently increasing the coastal disaster such as the severe coastal erosion and road damage swept away by the wave. As one of the alternatives to prevent the coastal disaster, it has been widely studied the coastal disaster reduction method by the Low-Crested Structure (LCS) in the many countries including several European countries. In this study, the ola- FLow model is used to simulate the permeable LCS and wave field of the LCS through the three-dimensional irregular waves numerical analysis on the basis of the previous research. From the numerical analysis, it is evaluated the Hrms, nearshore current and time-averaged turbulent kinetic energy. In addition, the pattern of nearshore current and spatial distribution of time-averaged turbulent kinetic energy are compared with the case of submerged breakwater under the irregular wave fields. As one of significant results, it is confirmed that the pattern of nearshore current is different with the case of submerged breakwater.
임준환 ( Jun Hwan Yim ),장문식 ( Moon Sik Jang ),정욱순 ( Uk Sun Jung ),문미연 ( Mi Yeon Moon ),이하연 ( Ha Youn Lee ),김영훈 ( Young Hoon Kim ),이기용 ( Gi Yong Lee ),이남호 ( Nam Ho Lee ) 대한화장품학회 2014 대한화장품학회지 Vol.40 No.3
본 연구에서는 주름개선 화장품 원료를 개발하기 위하여 돌외 잎 70% 에탄올 추출물을 제조하여 섬유아세포 HDFn에 대하여 콜라겐 합성능을 측정하였다. 그 결과 돌외 추출물이 세포 독성 없이 농도 의존적으로 콜라겐 합성을 촉진함을 확인하였다. 돌외 추출물로부터 용매 분획 및 크로마토그래피 분리과정을 거쳐 2개의 활성 성분을 분리하였다. NMR 데이터 및 문헌치로 확인한 결과 이들은 플라보노이드 배당체인 Ombuine 3-O-rutinoside(1) 및 Quercetin 3-O-rutinoside(2)로 규명되었다. 섬유아세포의 type I procollagen 생합성에 미치는 영향을 분석한 결과 상기 화합물은 농도 의존적으로 콜라겐 합성을 촉진함을 알 수 있었다. 본 실험 결과는 화합물 1과 2를 함유한 돌외 추출물의 주름개선 화장품 소재로서의 개발 가능성을 보여주고 있다. In order to discover ingredients for wrinkle-care cosmetics, we prepared 70% ethanol extract from Gynostemma pentaphyllum and examined its activity on collagen synthesis using fibroblast HDFn cells. The G. pentaphyllum extract induced the production of type I procollagen in a dose-dependent manner without showing cell toxicity. The active constituents were isolated from the extract by solvent fractionation and chromatographic purification procedures. NMR data and literature studies led to determine the two isolated compounds as the flavonoid glycosides such as ombuine 3-O-rutinoside (1) and quercetin 3-O-rutinoside (2). The activity screening tests showed that the isolates 1 and 2 induced the production of type I procollagen in a dose-dependent manner. These results suggested that G. pentaphyllum extract containing the flavonoids 1 and 2 could be useful as an active ingredient for wrinkle-care cosmetics.
이정욱(Jung-Uk Lee),윤수환(Su-Hwan Yun),곽민호(Min-ho Kwak),이동호(Dong-ho Lee),권혁빈(Hyeok-bin Kwon),고태환(Tae-Hwan Ko) 한국철도학회 2011 한국철도학회 학술발표대회논문집 Vol.2011 No.5
When a train passes a conventional tunnel at high speed, an environmental noise issue arises by pressure variation and micro-pressure waves at the exit of the tunnel. It is known that this issue can be reduced by using dummy tunnel duct on the tunnel entrance. We studied the variances of micro-pressure waves at the exit of tunnel and pressure variation within the tunnel, by altering surface area and length of the dummy tunnel duct. For analyze this train-tunnel relation problem, axi-simmetric steady compressible flow solver was used. Changing the length of the dummy tunnel duct can adjust pressure variation, changing the surface area of the dummy tunnel duct can adjust volume and pressure variation of the micro-pressure wave. Thus, optimized surface area and length of the dummy tunnel duct can simultaneously reduce environmental noise pollution by micro-pressure wave and issues by the pressure variation.
함안군북지구(咸安郡北地區)의 지질(地質)과 동광상(銅鑛床)
문정욱,김명환,이지헌,최충정,Moon, Chung Uk,Kim, Myung Whan,Lee, Ji Hern,Choi, Chung Jung 대한자원환경지질학회 1970 자원환경지질 Vol.3 No.2
The district investigated covers the central and southern portions of the Uiryong Quadrangle amounting to $40km^2$ in area and is bounded approximately by geographical coordinates of $128^{\circ}$ 28' $40^{{\prime}{\prime}}{\sim}128^{\circ}$ 24' 25"E in longitude and $35^{\circ}10{\prime}{\sim}35^{\circ}14^{\prime}06^{{\prime}{\prime}}N$ in latitude. The purpose of this investigation was to provide basic information in drawing up a comprehensive development plan of the copper ore deposits known to exist in the HamanKumbuk district with special emphasis given to the ascertainment of geological and paragenetic characteristics. The area consists chiefly of shale, sandy shale and chert, all belong to Kyongsang System of Cretaceous age. Intruded into these rocks are andesite, granodiorite, basic dikes, and acidic dikes. The mineralization which took place in the area, consists of mostly fissure-filling vein deposits, numbering several tens, with varying magnitudes. The fissures and shear zones created in rocks, such as chert and granodiorite, hosted the deposition of mineralizing vapors and/or hydrothermal solutions along their openings. The strike lengths of these veins vary from 50 to 600 meters in extension and 0.1 to 3 meters in width. Although the degree of fluctuation in width is great, it averages 0.3m. The stuctural patterns, which apparently affected the deposition of veins, are fissure patterns, trend NS to $N30^{\circ}W$, and steep-pitching tension fractures as well as normal fault pattern. Ore minerals associated with vein matters are primarily chalcopyrite and small amounts of scheelite, cobaltiferous arsenopyrite, and gold and silver intimately associated with sulphide minerals. Associated with these ore mineral are pyrite, pyrrhotite, magnetite, specularite and arsenopyrite. Gangue minerals noted are quartz, calcite, chlorite, tourmaline and hornblende. In terms of the compositions of associated minerals, the vein deposits in the district could be grouped under the following four categories: 1. Pyrrhoitite, Arsenopyrite, Gold and Silver Bearing Copper Vein (Type I) 2. Calcite-Scheelite-Copper Vein (Type II) 3. Magnetite-Pyrite-Copper Vein (Type III) 4. Tourmaline Copper Vein (Type IV) Of the four types, the first and the fourth are presently yielding relatively higher grades: of copper ores and concentrates. The estimated ore reserves total some 222,000 metric tons with the following breakdown in terms of metal contents: Name of Mines Au(g/t) Ag(g/t) Cu(%) Reserves(M/T) Kunbuk 15.92 78.69 6,074 60.498 Cheil Kunbuk - - 1.040 60,847 Haman - - 2.688 101,204 222,549 As rehabilitation of old workings and/or exploration of veins at depth proceed, additional estimation of ore reserves may become apparent and necessary. With regard to the problem of beneficiation and upgrading of low-grade ores in the district, it would be advisable to make decisions on location, treating capacity and mill flowsheet after sufficient amount of exploration is completed as suggested in the report.
복합 밀링 공정으로 제조된 산화물 분산 강화 강의 미세조직 및 고온 기계적 특성
이정욱,김영균,김정한,김휘준,이기안,Lee, Jung-Uk,Kim, Young-Kyun,Kim, Jeoung Han,Kim, Hwi-Jin,Lee, Kee-Ahn 한국분말재료학회 (*구 분말야금학회) 2021 한국분말재료학회지 (KPMI) Vol.28 No.5
Oxide dispersion-strengthened (ODS) steel has excellent high-temperature properties, corrosion resistance, and oxidation resistance, and is expected to be applicable in various fields. Recently, various studies on mechanical alloying (MA) have been conducted for the dispersion of oxide particles in ODS steel with a high number density. In this study, ODS steel is manufactured by introducing a complex milling process in which planetary ball milling, cryogenic ball milling, and drum ball milling are sequentially performed, and the microstructure and high-temperature mechanical properties of the ODS steel are investigated. The microstructure observation revealed that the structure is stretched in the extrusion direction, even after the heat treatment. In addition, transmission electron microscopy (TEM) analysis confirmed the presence of oxide particles in the range of 5 to 10 nm. As a result of the room-temperature and high-temperature compression tests, the yield strengths were measured as 1430, 1388, 418, and 163 MPa at 25, 500, 700, and 900℃, respectively. Based on these results, the correlation between the microstructure and mechanical properties of ODS steel manufactured using the composite milling process is also discussed.
Java/RTI를 위한 Level One Test Procedures 구현
이정욱(Jung-uk Lee),김용주(Yong-joo Kim),김영찬(Young-chan Kim) 한국시뮬레이션학회 2004 한국시뮬레이션학회 논문지 Vol.12 No.4
HLA (High Level Architecture) is the object, time, and interface standard that proposed for distribution simulation in the US Department of Defense. The HLA is defined by three components: Rules, the HLA Interface Specification, and the Object Model Template (OMT). The RTI (Run-Time Infrastructure) software implements the interface specification. It provides services to simulation applications. To test whether a RTI software is suitable for the standard and all service was implemented is performed through two phases of processes proposed by DMSO. In this paper, we implement Level One Test Procedures of DMSO and apply to NetCust s RTI software. The experimental results are discussed.