Incidence and natural course of inflammatory bowel disease in Korea, 2006-2012: a nationwide population-based study.

Kim, Hyun Jung,Hann, Hoo Jae,Hong, Sung No,Kim, Kyoung Hoon,Ahn, Il Min,Song, Ji Yang,Lee, Sang Hyuk,Ahn, Hyeong Sik Raven Press 2015 Inflammatory bowel diseases Vol.21 No.3

<P>Although a rising trend in the incidence of inflammatory bowel disease (IBD) in Asia has been recognized, national-level, population-based studies are lacking. In this study, we investigate the epidemiological features and natural course of IBD in Korea, including incidence, bowel resection rates, survival, and cause of death.</P>

Effectiveness of acupuncture-type interventions to prevent nausea and vomiting during and after cesarean delivery under spinal anesthesia : A systematic review

Kim, Eun-Sook,Cho, Jung-Hoon,Jang, Jun-Bock,Lee, Jin-Moo,Lee, Chang-Hoo,Lee, Kyung-Sub The Society of Korean Medicine Obstetrics and Gyne 2009 大韓韓方婦人科學會誌 Vol.22 No.2

목 적: 이 논문은 제왕절개 분만을 위한 척수마취로 인해 수술 중 또는 그 후에 발생할 수 있는 오심 및 구토에 대한 침관련 치료의 항구토 효과를 규명하기 위한 계통적 리뷰 논문이다. 방 법: 제왕절개 분만을 위한 척수마취로 인해 발생할 수 있는 오심 및 구토를 예방하기 위한 침관련 치료에 대한 randomized clinical trials(RCT's)를 검색하기 위해 2008년 3월까지 수록된 6개의 데이터베이스(MEDLINE, EMBASE, The Cochrane Library, CINAHL, AMED and PsycINFO)를 검색하였다. 논문의 선정 기준은 원저이며, 플라시보 대조군을 설정한 무작위 임상시험이고, 오심 또는 구토에 대한 결과가 실려 있는 것으로 하였다. 결 과: 총 5개의 논문을 선정하였으며 각 논문들의 연구방법은 일반적으로 좋은 편이었다. 5개의 논문들을 종합한 결과는 수술중 오심 발생률(OR=0.468, 95%CI:0.250 -0.876, P=0.018), 수술 후 오심 발생률(OR=0.616, 95%CI:0.042-0.942, P=0.026), 수술 후 구토 발생률(OR=0.640, 95%CI:0.432-0.948, P=0.026)이 침관련 치료군이 대조군에 비해서 통계적으로 의미있게 적었다. 결 론: 본 문헌 고찰을 통해 제왕절개 수술을 위해 시행한 척수 마취로 인해 수술중 또는 수술후 발생한 오심 및 구토에 대해 침관련 치료가 예방효과가 있음을 밝힐 수 있었다.

A population-based approach indicates an overall higher patient mortality with peritoneal dialysis compared to hemodialysis in Korea

Kim, Hyunwook,Kim, Kyoung Hoon,Park, Kisoo,Kang, Shin-Wook,Yoo, Tae-Hyun,Ahn, Song Vogue,Ahn, Hyeong Sik,Hann, Hoo Jae,Lee, Shina,Ryu, Jung-Hwa,Kim, Seung-Jung,Kang, Duk-Hee,Choi, Kyu Bok,Ryu, Dong-Ry Springer-Verlag 2014 Kidney international Vol.86 No.5

To date, only a few large-scale studies have measured the effect of dialysis modality on mortality in Asian populations. Here, we sought to compare survival between incident hemodialysis (HD) and peritoneal dialysis (PD) patients using the Korean Health Insurance Review & Assessment Service database. This enabled us to perform a population-based complete survey that included 32,280 incident dialysis patients and followed them for a median of 26.5 months. To reduce biases due to nonrandomization, we first matched 7049 patient pairs with similar propensity scores. Using the log-rank test, we found the mortality rate in PD patients was significantly higher than that in HD patients. Subsequent subgroup analyses indicated that in older patients (55 years and older), with the exception of the subgroup of patients with no comorbidities and the subgroup of patients with malignancy, PD was consistently associated with a higher mortality rate. In younger patients (under 55 years), regardless of the covariates, the survival rate of PD patients was comparable to that of HD patients. Thus, while the overall mortality rate was higher in incident PD patients, mortality rates of some incident PD and HD patients were comparable in Korea.

만성 간염, 간경변 및 간세포암종 환자 혈청에서 상피성 성장인자 농도의 변동

김병훈,최정혜,김홍주,이동후,조용현,권기운,유용걸,조영중,이제,양성규 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.1

Background/Aims. Epidermal growth factors (EGF) is known to activate mitogen activated protein kinase (MAP kinase) in hepatocytes by the route of both Raf-dependent and Raf-indefendent pathways. And this is likely to play important role in normal liver cell growth and regeneration. EGF is also reported as a potent mitogen and one of the angiogenic factors. To elucidate the dynamic changes of the serum concentration of epidermal growth factor in chronic liver disease and its correlation with role of EGF and mechanism of tumor development, this study is intended to employ an ELISA in 38 biopsy-proven cases. Methods '. Sera taken out of 5 patients with chronic persistent hepatitis. 4 patients with chronic active hepatitis, 19 patients with liver cirrhosis, 10 patients with hepato- cellular carcinoma that pathological diagnosis was proven later were tested for EGF employing Quantikine ELISA Kits (R & D Systems Inc. Minneapolis, MN). The statistical analysis was evaluated by student's t-test. Results . EGF concentration was 253.33±69.5pg/ml(Mean±SE) in hepatocellular carcinoma, 246.60±91.19pg/ml(Mean±SE) in chronic active hepatitis, 222.71±115.97pg/ml (Mean±SE) in chronic persistent hepatitis, 141.15±23.12pg/ml(Mean±SE) in liver cirrhosis in orders. Serum EGF concentration in hepatocellular carcinoma was significantly higher than that in liver cirrhosis(p value=0.021695). However, comparing to the remaining other groups, no significant difference was found. Conclusion .' These results support that the reconstruction of the capillary networks in liver cirrhosis resplts in down-regulation of the EGF in comparison to chronic hepatitis. But it is suggested that revaluation of EGF stimulates MAP kinase activity eventually playing in tumorigenesis of the liver with neoangiogenesis.

한국인 간세포암종의 연령군별 임상적 특징

김병훈,이동후,이숭환,조영중,양성규,조용현 대한내과학회 2000 대한내과학회지 Vol.59 No.2

Background : Hepatocellular carcinoma(HCC) has characteristic differences in both viral profiles and the most frequently occurring age in each country. It also has clinically distinct features between adult patients of the age under 65 and senile patients over 65 years. Herein we investigate differences in clinical features of the patients with HCC of the three different age groups : young patients (group 1) below 45 years of age; most frequently occurring age (45 - 65 year) (group 2); and elderly patients (group 3) above 65 years of age. Methods : The 371 HCC patients hospitalized and followed-up from 1986 to February 1997 have been analyzed. At the time of diagnosis there was no significant difference among the three groups in alcohol intake, cigarette smoking, sex, family history of liver disease, mean values of aminotransferases, Child-Pugh class, tumor location, TNM stage, tumor size, varix grade, metastasis, abdominal pain, ascites, encephalopathy, fever, or jaundice. Results : In the younger group HCC showed (1) a high incidence of HBsAg positivity (group 1, 95.3%; group 2, 78.6%; group 3, 25%; p$lt;0.001) ; (2) a low positive rate of anti-HCV (group 1, 0%; group 2, 7.7%; group 3, 44.4; p$lt;0.001); (3) a low incidence of NBNC(group 1, 4.9%; group 2, 14.1%; group 3, 30.4%; p$lt;0.01); (4) a high incidence of diffuse type (group 1, 40.5%; group 2, 29.5%; group 3, 11.9%; p$lt;0.05); (5) a higher levels of serum AFP (group 1, 4,180 ng/mL; group 2, 3,224 ng/mL; group 3, 2,025 ng/mL; between group 1 and group 3, p$lt;0.05). But three different levels of AFP ($lt;20 ng/mL, 20-400 ng/mL, $gt;400 ng/mL) showed no differences among the three age groups (p=0.23766). (6) The overall survival rates did not differ statistically among the three groups (mean survival: group 1, 12 months; group 2, 18 months; group 3, 15 months; p=0.4635, log rank test). Conclusion : These data support the younger patients with HCC are the most frequently associated with HBV contrarily to the elderly patients the more frequently associated with HCV or NBNC rather than HBV. This suggests, in turn, that the onset of HCC occurs one or two decades later in those with adult-acquired HCV than it does in lifelong HBV patients after neonatal vertical infection.(Korean J Med 59:142-150, 2000)

Effects of Recipient Oocyte and Embryo Culture System on Production of Hanwoo (Korean Native Cattle) Somatic Cell Nuclear Transferred Embryos

Kim, Dong-Hoon,Kim, Se-Woong,Lee, Min-Jung,Bae, Seong-Hoon,Im, Gi-Sun,Lim, Hyun-Joo,Yang, Byoung-Chul,Seong, Hwan-Hoo The Korean Society of Animal Reproduction 2008 Reproductive & developmental biology Vol.32 No.3

This study was conducted to investigate an effective recipient oocyte and culture system for producing of Hanwoo (Korean native cattle) somatic cell nuclear transfer (SCNT) embryos. Hanwoo ear skin fibroblasts were used as donor cells. In vitro matured Hanwoo or Holstein oocytes were enucleated, and single donor cells were transferred into the perivitelline space of the enucleated oocytes. The couplets were subsequently fused and activated. The reconstructed embryos were cultured in a conventional or sequential culture system. In the former, embryos were cultured in CR2aa medium for eight days; in the latter, embryos were cultured in modified CR2aa-A (mCR2-A) for three days and then further cultured in modified CR2aa-B (mCR2-B) for five days. In the experiment with the recipient oocyte, the rate of embryo development to the blastocyst stage was significantly (p<0.05) higher in Hanwoo recipient oocytes than in Holstein ones (48.8% vs 38.9%). BIastocysts derived from Hanwoo recipient oocytes contained significantly (p<0.05) higher numbers of total cells than those derived from Holstein recipient oocytes ($156.0{\pm}68.2$ vs $134.7{\pm}54.8$). There was no difference in the mean proportion of apoptotic cells in blastocysts between the sources of recipient oocytes. In the experiment with the embryo culture system, the blastocyst rate was somewhat higher in sequential system than in conventional system (50.0% vs 43.5%), though there was no significant difference. The numbers of total ($160.0{\pm}69.0$ vs $156.7{\pm}68.4$) and apoptotic cells ($14.0{\pm}10.4$ vs $11.8{\pm}6.4$) were not different between the culture systems. In conclusion, the present study demonstrated that Hanwoo recipient oocytes and the sequential culture system were more effective in supporting the production of Hanwoo SCNT embryos.

Effects of Recipient Oocyte and Embryo Culture System on Production of Hanwoo (Korean Native Cattle) Somatic Cell Nuclear Transferred Embryos

Dong-Hoon Kim,Se-woong Kim,Min-Jung Lee,Seong-Hoon Bae,Gi-Sun Im,Hyun-Joo Lim,Byoung-Chul Yang,Hwan-Hoo Seong 한국동물생명공학회(구 한국동물번식학회) 2008 Reproductive & developmental biology Vol.32 No.3

This study was conducted to investigate an effective recipient oocyte and culture system for producing of Hanwoo (Korean native cattle) somatic cell nuclear transfer (SCNT) embryos. Hanwoo ear skin fibroblasts were used as donor cells. In vitro matured Hanwoo or Holstein oocytes were enucleated, and single donor cells were transferred into the perivitelline space of the enucleated oocytes. The couplets were subsequently fused and activated. The reconstructed embryos were cultured in a conventional or sequential culture system. In the former, embryos were cultured in CR2aa medium for eight days; in the latter, embryos were cultured in modified CR2aa-A (mCR2-A) for three days and then further cultured in modified CR2aa-B (mCR2-B) for five days. In the experiment with the recipient oocyte, the rate of embryo development to the blastocyst stage was significantly (p<0.05) higher in Hanwoo recipient oocytes than in Holstein ones (48.8% vs 38.9%). BIastocysts derived from Hanwoo recipient oocytes contained significantly (p<0.05) higher numbers of total cells than those derived from Holstein recipient oocytes (156.0+-68.2 vs 134.7+-54.8)). There was no difference in the mean proportion of apoptotic cells in blastocysts between the sources of recipient oocytes. In the experiment with the embryo culture system, the blastocyst rate was somewhat higher in sequential system than in conventional system (50.0% vs 43.5%), though there was no significant difference. The numbers of total (160.0+-69.0 vs 156.7+-68.4) and apoptotic cells (14.0+-10.4 vs 11.8+-6.4)) were not different between the culture systems. In conclusion, the present study demonstrated that Hanwoo recipient oocytes and the sequential culture system were more effective in supporting the production of Hanwoo SCNT embryos.

생산흐름 분석을 통한 자동차 조립공장의 협업 공정/자재 계획

고후상(Hoo Sang Ko),이교일(Kyo Il Lee),김기범(Gibom Kim),한영근(Young-Geun Han),박태근(Tae Geun Park),허준(Jun Heo),노상도(Sang Do Noh),박영진(Young-jin Park),정경훈(Kyung Hoon Jung) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

Automotive companies should perform process planning and its evaluation concurrently with new car developments so that they can be highly competitive in the modern automotive market. Process planners should make decisions in the manner of concurrent and collaborative engineering in order to reduce the manufacturing preparation time and cost when developing new cars. Automated generation of analysis models from the integrated database, which contains process and material information, reduces time to prepare analyses and makes the models reliable. In this research, we developed a web-based system for concurrent and collaborative system for production flow analysis, using web, database, and simulation technology. An integrated database is designed to automatically generate analysis models from process and material plans without reworking the data. This system enables process planners to evaluate their decision fast and share their opinions with others easily. With this system, it is possible to save time and cost for assembly process and material planning, and reliability of process plans can be improved.

스마트그리드 산업체 직무 분석을 통한 교육과정 개발

한후석(Hoo Sek Han),김희선(Hee Sun Kim),김정훈(Jung Hoon Kim) 대한전기학회 2014 대한전기학회 학술대회 논문집 Vol.2014 No.5

최근 전력산업은 에너지소비의 효율화, 녹색 에너지의 활용 및 신성장동력의 산업화를 가속시키기 위해 스마트그리드로가 산업의 변화를 주도하고 있다. 스마트그리드를 성숙된 산업으로 발전시키기 위해서는 이 산업을 이끌어 나갈 혁신적인 인력양성뿐만 아니라 필요한 인력을 적재적소에 공급할 수 있는 인력공급망(SCM)이 필요하며, 공급할 대학의 인력과 공급되어진 산업체의 인력에 대한 교육이 매우 중요하다. 본 논문에서는 스마트그리드 분야 현장에서 요구되는 직무가 무엇인지 직무체계 연구를 하였으며 직무체계 연구를 근거로 하여 스마트그리드 산업에 필요한 인력을 공급하는 대학의 교과과정을 신설하거나 개편하는데 기초자료가 될 수 있는 교육과정을 개발하였다.

안드로이드 단말기용 선박 위치 및 항로표시시스템 설계

김범무(Kim Bum Moo),이동인(Lee Dong In),양후열(Yang Hoo Yeol),김명섭(Kim Myeongseop),경도현(Gyeong Dohyeon),이정훈(Jung Hoon Lee),정민아(Min A Jeong),이성로(Seong Ro Lee) 한국통신학회 2011 한국통신학회 학술대회논문집 Vol.2011 No.11