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정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성
안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4
연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.
건물 내 계단에서의 통행특성 관찰을 통한 압전 발전량 예측에 관한 연구
이미희(Yi Mi-Hui),나욱정(Na Wook-Jung),홍원화(Hong Won-Hwa),전규엽(Jeon Gyu-Yeob) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.9
Piezoelectric energy harvesting generated by ground reaction force of pedestrian is one of the human-powered energy systems and grows rapidly. Under the circumstances, mechanical issues and the problems about planning and design, which have never been studied, should be treated simultaneously to develop the efficiency of the new technology. Therefore, this paper conducts an experimental study on where to install and how much energy can be generated by the piezoelectric generator on stairs. Firstly, the distribution of pedestrian walking on 3 types-straight, return and spiral stairs-of stairs are analyzed. The number of pedestrians are estimated by calculating the number of steps by a zone which is divided into same size of 30cm × 30㎝. As a result, it shows a large distribution in the middle of the stairs in case of straight and spiral stairs. In case of the return stairs, it shows a large distribution not in the middle, but inside of the stairs. After observing pedestrian walking characteristics by the walking distribution, we estimate the electricity generation by the number of the devices installed on the stairs. According to the estimation, the less devices installed, the less total generation made. However, the generation by a device grows 1.6∼1.9 times when assumed that only one device is installed on the most high density zone in scenario 4 comparing to scenario 1.
Is Laparoscopy-assisted Radical Gastrectomy Safe in Patients with Child-Pugh Class A Cirrhosis?
Kang, Sin Jae,Jung, Mi Ran,Cheong, Oh,Park, Young Kyu,Kim, Ho Goon,Kim, Dong Yi,Kim, Hoi Won,Ryu, Seong Yeob The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.4
Purpose: We investigated early postoperative morbidity and mortality in patients with liver cirrhosis who had undergone radical gastrectomy for gastric cancer. Materials and Methods: We retrospectively reviewed the medical records of 41 patients who underwent radical gastrectomy at the Chonnam National University Hwasun Hospital (Hwasun-gun, Korea) between August 2004 and June 2009. There were few patients with Child-Pugh class B or C; therefore, we restricted patient selection to those with Child-Pugh class A. Results: Postoperative complications were observed in 22 (53.7%) patients. The most common complications were ascites (46.3%), postoperative hemorrhage (22.0%) and wound infection (12.2%). Intra-abdominal abscess developed in one (2.4%) patient who had undergone open gastrectomy. Massive ascites occurred in 4 (9.8%) patients. Of the patients who underwent open gastrectomy, nine (21.9%) patients required blood transfusions as a result of postoperative hemorrhage. However, most of these patients had advanced gastric cancer. In contrast, most patients who underwent laparoscopic gastrectomy had early stage gastric cancer, and when the confounding effect from the different stages between the two groups was corrected statistically, no statistically significant difference was found. There was also no significant difference between open and laparoscopic gastrectomy in the occurrence rate of other postoperative complications such as ascites, wound infection, and intra-abdominal abscess. No postoperative mortality occurred. Conclusions: Laparoscopic gastrectomy is a feasible surgical procedure for patients with moderate hepatic dysfunction.
복도 내 압전발전장치 도입을 위한 통행특성 관찰 및 시지각적 동선유도 효과에 관한 연구
김인호(Kim In-Ho),이미희(Yi Mi-Hui),나욱정(Na,Wook-Jung),최준호(Choi Jun-Ho),전규엽(Jeon Gyu-Yeob),홍원화(Hong Won-Hwa) 한국건축친환경설비학회 2011 한국건축친환경설비학회 학술발표대회 논문집 Vol.2011 No.10
Despite the many advantages, human-powered energy harvesting systems using the piezoelectric generator has not been highly utilized as a next energy generation source due to the high initial investment cost. Therefore, improving the efficiency of the systems in the planning step is needed to shorten the payback period. In this paper, we made a walking distribution chart by observing the pedestrian walking characteristic of the passers-by in corridor and studied the improvement effect of Visual Perception Effect. To conduct the experiment, we divided the corridor into 9 zones and analyzed the records of the locations of passers-by which the CCTV camera had recorded. As a result of survey, we found out the highest distribution has been shown on zone 6 in normal cases, and others showed a similar distribution graph except zone 1 & 9. In case of that we utilized the Visual Perception Effect on zone 3 & 7, each passage distribution has been increased by 133% and 7%. We found out that it has an effect to increase 68% electricity generation amount than normal case in the sum of annual electricity generation when we applied the Visual Perception Effect on zone 3 & 7.
Gastric Outlet Obstruction due to Eosinophilic Gastroenteritis
Ho Goon Kim,Mi Ran Jung,Hyo Kang,Oh Cheong,Jae Kyun Ju,Young Kyu Park,Seong Yeob Ryu,Dong Yi Kim,Young Jin,Shin Kon Kim 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.6
Despite of its rarity, eosinophilic gastroenteritis (EG) needs to be recognized by the clinician because this disease can masquerade as irritable bowel syndrome and it may be misdiagnosed in clinical practice. We report here on a female patient with gastric outlet obstruction that was due to EG, and we review the relevant literature for either an association or a causality of EG.
백내장 수술 후 발생한 급성 안내염의 임상경과와 시력예후 인자
정자영,고병이,김병엽.Ja Young Jung. M.D.. Byung Yi Ko. M.D.. Byeoung Yeob Kim. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.8
Purpose: To determine the factors related to the clinical outcome of acute endophthalmitis after cataract surgery. Methods: Authors performed a retrospective study of 65 eyes of 65 patients who had been treated for endophthalmitis from 2001 to 2006 at our hospital. We analyzed the relationship between final visual outcomes and prognostic factors. Results: Final visual acuities were 0.5 or better in 49.2% of all eyes. Of 57 eyes, 29 eyes (50.8%) were culture positive. Staphylococcus epidermidis and Streptococcus pneumoniae were the most common organisms isolated. Cases with baseline acuity of counting fingers or better, cases with culture-negative or gram-positive infection, and cases not requiring vitrectomy had better prognoses. Conclusions: Baseline visual acuity, type of cultured organism, and method of treatment are significantly related to visual prognosis. J Korean Ophthalmol Soc 49(8):1242-1247, 2008