여가활동 참여도가 여가생활 만족도에 미치는 영향분석

김영숙,이정연 慶星大學校 1998 論文集 Vol.19 No.2

The purpose of this study was to examine the housewives' leisure activity and leisure life satisfaction. This study analysed the effects of socio-demographic and economic variables on the housewives' leisure activity. For these purpose, questionnaire was given to the 316 housewives who were lived in Pusan. The data were analysed by Frequency, Percentage, Mean, ANOVA, T-test, Pearson's Correlation and Multiple Regression Analysis. The main findings of the research are as follows: 1. Leisure activities are classified in physical, children and social concerned, self-developing, restful, religious-social, home-oriented, time-spending by factor analysis. The level of average participation are high in time-spending type, but low in self-developing type. 2. There are significant differences in participation level of leisure activities according to related variables. Physical and children-concerned type shows significant differences by age of housewife's education level, income and houses type. Self-developing type differs by husband's occupation, housewife's education level and income. Restful and time-spending type are differed to age of housewife, age of the youngest child and housewife's education level. 3. Leisure life satisfaction shows significant differences by employment type. Fulltime housewives are more satisfied than working housewives. 4. Leisure life satisfaction is high when participation level is high in children-concerned, self-developing, religious-social type and employment type. But leisure life satisfaction is low when preference level is high in self-developing type. The results of this study show the housewives' leisure activity and leisure life satisfaction differ by related variables. For further study and practice, I suggest politic development of leisure programs and increase the level of housewives's life satisfaction.

정신분열병 환자에서 가족력, 산과적 합병증 및 신체미세기형의 관련성에 관한 연구

안용민,김용식,정희연,신지용,윤세창,배안,이중서,주은정,이창인 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 저자들은 태생기 동안에 받는 유전외적 요인, 즉 환경적 요인이 산발성 정신분열병 환자들의 발병에 크게 관여할 것이라고 가정하였다. 이를 검증하기 위하여 형제 중 1인 이상이 발병하여 가족력을 분명히 알 수 있는 정신분열병 환자군(이하 형제 환자군)과 가족력이 없는 산발성 정신분열병 환자군(이하 산발성 환자군) 및 정상대조군을 대상으로 산과적 합병증, 신체미세기형 및 정신분열병의 임상 양상을 비교하였다. 방 법 : 연구 대상은 형제 환자군 43명(남 22명, 여 21명), 산발성 환자군 43명(남 23명, 여 20명), 정상대조군 43명(남 20명, 여 23명)이었다. 산과적 합병증은 Lewis 척도를 이용하여 평가하였고 신체미세기형은 Waldrop 척도를 이용하여 측정하였다. 임상 양상으로서 발병 연령, 병전 기능 수준, 정신병리, 약물에 대한 반응, 회복시의 전반적 기능 수준, 지연성 운동장애의 유무를 평가하였다. 결 과 : 정상대조군과 정신분열병 환자군 전체를 비교하였을 때 산과적 합병증과 신체미세기형의 총점과 각 소항목의 점수에 차이가 없었다. 산발성 환자군과 형제 환자군을 비교하였을 때 산과적 합병증의 전체 점수에서는 유의한 차이가 없었으나, 출생 당시에 태아가 받은 스트레스 항목의 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형에서는 전체 점수 및 입의 미세기형 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형의 전체 점수가 4점 이상인 환자수도 산발성 환자군에서 높은 경향성을 보였다. 산과적 합병증과 신체미세기형 사이의 상호 연관성은 찾을 수 없었다. 정신분열병의 임상 양상 중에서는 Krawiecka 척도의 총점 및 양성 증상 점수와 회복시의 전반적 기능 수준만이 형제 환자군에 비해 산발성 환자군에서 유의하게 높았다. 성별에 따라서는 형제 환자군에서 남자 환자의 산과적 합병증이 유의하게 높았다. 결 론 : 본 연구를 통해 산과적 합병증 및 신체미세기형 연구가 정신분열병의 원인을 규명하기 위한 유용한 방법임이 시사되었지만, 가족력, 산과적 합병증 및 신체미세기형의 관련성에 대해서는 분명한 결론을 내리지 못하였다. The authors hypothesized that sporadic schizophrenic patients had more chances of receiving environmental insults during the fetal neural development compared with familial schizophrenics. We tested our hypothesis by comparing obstetric complications(OCs), minor physical anomalies(MPAs) and other clinical features, and examining the correlation between OCs and MPAs in schizophrenic patients who had one or more sibling with schizophrenia(sibling group) and sporadic schizophrenics(sporadic group) and normal controls. OCs were evaluated by the scale of Lewis, and MPAs were measured by the Waldrop scale. There were no significant difference in OCs and MPAs between schizophrenic and control groups. Sporadic group had significantly higher fetal distress, total Waldrop score and Waldrop score for mouth than sibling group. And there was a tendency that the number of subjects having the Waldrop score over 4 points was greater in the sporadic group. No significant correlation was observed between CCs and MPAs. The scores of initial psychopathology and post-treatment functioning were much higher in the sporadic group, but the other clinical feature showed no difference. Although male patients had more OCs than female patients in sibling group, no sex difference were observed as a whole. Our results suggest that, if the methodological weakness were complemented, OCs and MPAs would be useful tools in the search for the cause of schizophrenia.

身體 微細畸形 및 産科的 合倂症과 精神分裂症의 家族歷

홍경수,주연호,김용식,신철진,강웅구,이중서,정희연,주은정 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

저자들은 정신분열병의 일부에서는 태생기 동안 유전 외적인 환경적 요인이 크게 작용할 것이라는 가정 하에 형제 정신분열병 환자군(남 15. 여 7)과 산발성 정신분열병 환자군(남 16, 여 7) 및 정상 대조군(남 16, 여 7)을 대상으로 가족력에 따른 산과적 합병증과 신체 미세 기형을 비교하였다. 산과적 합병증은 Lewis 척도를 이용하여 연구 대상의 어머니와 면담하여 평가하였고 신체미세기형은 Waldrop 척도를 이용하여 측정하였다. 또한 산과적 합병증 및 신체 미세기형과 가족력에에 따라 발병 연령 등의 임상 양상들이 차이를 보이는지 비교함으로써 정신분열병을 좀 더 동질적인 아형으로 나눌 수 있는지를 검토하였다. 1) 형제 환자군, 산발성 환자군 및 정상 대조군의 세균에서 산과적 합병증의 개개의 항목 및 전체 점수의 유의한 차이는 없었다. 신체 미세기형의 경우 입의 미세기 형에서 유의한 차이가 있었으나 그 외에 각 부위별 점수 및 전체 점수에서는 세 군간에 유의한 차이가 없었다. 그러나 대부분의 신체 미세기형 세부 항목 및 전체점수에서 산발성 환자군이 형제 환자군에 비해 높은 신체 미세기형의 점수를 보이는 경향이 있었다. 2) 산과적 합병증의 전체 점수와 신체 미세기형의 전체 점수 사이에 상호 연관성을 찾아볼 수 없었다. 3) 발병연령·정신병리·약물에 대한 반응·병전 기능수준·지연성 운동장애 유무 등의 임상 양상들을 비교하였을때 산발성 환자군과 형제 환자군간에 유의한 차이가 없었다. 4) 산과적 합병증 및 신체 미세기형과 임상 양상들을 비교하였을 때, 형제 환자군에서 분만시간과 회복시 전반적 기능수준간에, 산발성 환자군에서 산과적 합병증의 전체 점수와 발병 연령간에 상관관계가 있었으나 전체적으로 일관된 결과가 도출되지는 못하였다. 위와 같은 결과를 종합하여 볼 때, 산과적 합병증이나 신체 미세기형이 정신분열병의 원인을 밝히는데 유익한 도구가 될 수는 있지만, 가족력 유무에 따라 정신분열병을 보다 동질적인 아형으로 구분하기 힘들다고 생각되었다. In order to test the hypothesis that familial schizophrenics have fewer chances of receiving organic insults during the fetal neural development than sporadic schizophrenics, the authors compared obstetric complications, minor physical anomalies, and other clinical features in sibling schizophrenics, sporadic schizophrenics and controls. Obstetric complications were evaluated by the scale of Lewis, and minor physical anomalies were measured by the Waldrop scale. Sporadic schizophrenics had a significantly higher Waldrop score for mouth than sibling schizophrenics. Although there was some tendency of higher total scores for minor physical anomalies in sporadic schizophrenics, there were no statistically significant differences in obstetric complications and the other minor physical anomalies among three groups. There was no significant correlation between obstetric complications and minor physical anomalies. The clinical features such as age of onset, psychopathology, response to drugs, premorbid functioning, and tardive dyskinesia were not significantly different between sibling and sporadic scizophrenics. In conclusion, while the obstetric complications and minor physical anomalies were suggested to be useful in the search for the cause of schizophrenia, it was difficult to categorize schizophrenics into more homogeneous groups according to family history of schizophrenia using the parameter of obstetric complications and/ or minor physical anomalies.

Benzene-Induced Hematotoxicity and Myelotoxicity by Short-Term Repeated Oral Administration in Mice

Jung-Yeon Yi,Byung-Il Yoon 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1

Exposure dose of benzene has been postulated to be critical to induce hemopoietic malignancies. By long-term inhalation of benzene, 300 ppm has been shown to be the dose that induces high frequency of leukemia with the least animal mortality in the mouse. With regard to the benzene studies, determination of the oral dose that will be corresponding to the critical inhalation dose could be important to design the experimental protocol based on oral administration. Based on the background data such as the respiratory volume, absorption factor, and so on, we, therefore, calculated a potential oral dose that is expected to be corresponding to 300 ppm of inhalation dose. The determined oral dose was 150 ㎎/㎏ B.W. We then evaluated, using C57BL/6 mice, the toxic effects of benzene on the peripheral blood and the bone marrow (BM) by oral administration of the selected dose once a day for 1 and 2 weeks. Leukocyte, red blood cell number and BM cellularity were respectively decreased to 47.8%, 72.3% and 66.7% of the respective control level by 1-week oral administration of benzene, and to 30.8%, 60.2% and 80.2% by 2-week oral administration. Changes in the leukocyte numbers were mainly due to the marked decrease of lymphocytes. According to the results, the changes of the parameters examined were generally corresponding to the change levels by the 2-week inhalation. In conclusion, the selected dose, 150 ㎎/㎏ B.W., was a reliable dose corresponding to the 300 ppm benzene inhalation, which was verified by in vivo mouse study.

Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene

Yi, Jung-Yeon,Hirabayashi, Yoko,Choi, Yang-Kyu,Kodama, Yukio,Kanno, Jun,Han, Jeong-Hee,Inoue, Tohru,Yoon, Byung-Il Springer-Verlag 2009 Archives of toxicology Vol.83 No.8

Histopathological findings observed in the organs of wild rats(Rattus norvegicus) and roving cats in Korea

Jung-Yeon Yi,Byung-IL Yoon 한국실험동물학회 2010 한국실험동물학회 학술발표대회 논문집 Vol.2010 No.2

Induction of Adventitious Roots and Analysis of Ginsenoside Content and the Genes Involved in Triterpene Biosynthesis in Panax ginseng

( Jung Yeon Han ),( Su Jin Jung ),( Sang Woo Kim ),( Yong Soo Kwon ),( Myong Jong Yi ),( Jae Seon Yi ),( Yong Eui Choi ) 한국식물학회 2006 Journal of Plant Biology Vol.49 No.1

Benzene-induced activation of caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene

Jung-Yeon Yi,Yoko Hirabayashi,Yang-Kyu Choi,Tohru Inoue,Byung-IL Yoon 한국실험동물학회 2010 한국실험동물학회 학술발표대회 논문집 Vol.2010 No.2

Primary Subcutaneous Leiomyosarcoma of the Hamster Hind Leg

YI, Jung-Yeon,KIM, Yeong-Hun,YOON, Byung-Il Japanese Society of Veterinary Science 2008 The Journal of veterinary medical science Vol.70 No.5

<P>We report the first case of a primary subcutaneous leiomyosarcoma that originated in the hind leg of a hamster and metastasized to the bone marrow, lung and diaphragm. A 10-month-old female Syrian golden hamster was presented with a large, firm, white subcutaneous mass in the right hind leg. The tumor invaded into the bone marrow and small nodules were also present in the lung and diaphragm; however, no tumor masses were found in the visceral organs. Histologically, the tumors were spindle cell sarcomas, composed of densely packed pleomorphic spindle cells with oval to elongate nuclei and moderate amounts of eosinophilic cytoplasm. Immunohistochemically, the neoplastic cells were positive for vimentin, desmin, and smooth muscle actin, but negative for α-sarcomeric actin and S-100. Thus, the diagnosis was primary leiomyosarcoma of the hind leg with metastasis to the bone marrow, lung and diaphragm. To the best of our knowledge, this is the first report of spontaneous primary subcutaneous leiomyosarcoma of the hind leg with distant metastasis in laboratory animals.</P>

Prevention and Control of Antimicrobial Resistance and Zoonoses : Spontaneous Metastatic Leiomyosarcoma Arising at Skeletal Muscle Sites in the Hamster

( Jung Yeon Yi ),( Yeong Hun Kim ),( Byung Il Yoon ) 대한인수공통전염병학회 2007 창립총회 및 학술대회 초록집 Vol.2007 No.1