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FRT Operation for Single-Phase Grid-Tied Inverter with Active Power Decoupling Capability
Jun-ichi Itoh,Satoshi Nakamura,Satoshi Nagai,Hiroki Watanabe 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper proposes a Fault Ride-Through (FRT) operation for a single-phase grid-tied inverter with an active power decoupling capability. The power decoupling circuit achieves the double-line-frequency power pulsation compensation with a small capacitance; consequently, a transient response with a sudden load change becomes worsen because a large energy buffer, i.e. bulky electrolytic capacitors, does not apply. In particular, high overshoot voltages occur in a DC-link voltage when the grid voltage sag of the single-phase grid occurs, resulting in the interrupt of the FRT operation due to the over voltage protection. In order to solve this problem, the buffer capacitance is designed in the consideration of the overshoot amount of the DC-link voltage. The theoretical value of the overshoot amount is verified with a 1-kW prototype. As an experimental result, The error between the experimental and the calculation value is within 10%. Furthermore, the proposed control achieved both the FRT operation and the active power decoupling capability.
Jun Sato,Kazuhide Inage,Masayuki Miyagi,Yoshihiro Sakuma,Kazuyo Yamauchi,Masao Koda,Takeo Furuya,Junichi Nakamura,Miyako Suzuki,Go Kubota,Yasuhiro Oikawa,Takeshi Sainoh,Kazuki Fujimoto,Yasuhiro Shiga 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.4
Study Design: An experimental animal study. Purpose: To evaluate effects of anti-vascular endothelial growth factor (VEGF) on the content and distribution of the calcitonin generelated peptide (CGRP) in the dorsal ganglia in a rat model. Overview of Literature: Increased expression of VEGF in degenerative disc disease increases the levels of inflammatory cytokines and nerve ingrowth into the damaged discs. In animal models, increased levels of VEGF can persist for up to 2 weeks after an injury. Methods: Through abdominal surgery, the dorsal root ganglia (DRG) innervating L5/L6 intervertebral disc were labeled (FluoroGold neurotracer) in 24, 8-week old Sprague Dawley rats. The rats were randomly allocated to three groups of eight rats each. The anti- VEGF group underwent L5/6 intervertebral disc puncture using a 26-gauge needle, intradiscal injection of 33.3 μg of the pegaptanib sodium, a VEGF165 aptamer. The control-puncture group underwent disc puncture and intradiscal injection of 10 μL saline solution, and the sham-surgery group underwent labeling but no disc puncture. Two rats in each group were sacrificed on postoperative days 1, 7, 14, and 28 after surgery. L1–L6 DRGs were harvested, sectioned, and immunostained to detect the content and distribution of CGRP. Results: Compared with the control, the percentage of CGRP-positive cells was lower in the anti-VEGF group (p <0.05; 40.6% and 58.1% on postoperative day 1, 44.3% and 55.4% on day 7, and 42.4% and 59.3% on day 14). The percentage was higher in the control group compared with that of the sham group (p <0.05; sham group, 34.1%, 40.7%, and 33.7% on postoperative days 1, 7, and 14, respectively). Conclusions: Decreasing CGRP-positive cells using anti-VEGF therapy provides fundamental evidence for a possible therapeutic role of anti-VEGF in patients with discogenic lower back pain.
Nakamura, M.,Choi, K.H.,Choi, S.K.,Do, C.S.,Jun, J.H.,Kwon, H.K.,Lee, S.M.,Moon, R.J.,Yi, K.J.,Jang, I.S. North-Holland ; Elsevier Science Ltd 2010 european journal of pharmacology Vol.635 No.1
Neurons within the periaqueductal gray (PAG) have been implicated in the central regulation of pain signals by affecting the descending inhibitory pathway. Here we report on the functional role of presynaptic kainate receptors within the PAG. Using a conventional whole-cell patch clamp technique, we recorded GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) from mechanically isolated rat PAG neurons in the presence of 300nM tetrodotoxin and 20@?M dl-2-amino-5-phosphonovaleric acid under voltage-clamp conditions. Kainic acid at a 10@?M concentration significantly increased the frequency of GABAergic mIPSCs without affecting their amplitude, suggesting that kainic acid acts presynaptically to enhance spontaneous GABA release. The kainic acid-induced increase in mIPSC frequency was completely blocked by CNQX, a selective AMPA/kainate receptor antagonist. While neither AMPA nor NMDA affected GABAergic mIPSC frequency, ATPA, a selective agonist of GluR5-containing kainate receptors, increased GABAergic mIPSC frequency in a concentration-dependent manner. The kainic acid-induced increase in mIPSC frequency was completely suppressed either in the presence of 100@?M Cd<SUP>2+</SUP>, a general voltage-dependent Ca<SUP>2+</SUP> channel (VDCC) blocker, or in the Na<SUP>+</SUP>-free external solution. These results suggest that presynaptic kainate receptors have a low permeability to Ca<SUP>2+</SUP>, and that their activation elicits a presynaptic depolarization large enough to activate presynaptic VDCCs. Presynaptic kainate receptors on GABAergic nerve terminals appear to modulate GABAergic transmission, and in doing so may play an important role in the regulation of PAG neuron excitability.
Nakamura, Chikashi,Hasegawa, Miki,Shimada, Kazumi,Shirai, Makoto,Miyake, Jun The Korean Society for Biotechnology and Bioengine 2000 Biotechnology and Bioprocess Engineering Vol.5 No.6
In this study, a direct detection system for triazine derivative herbicides was developed using the photosynthetic reaction center (RC) from the purple bacterium, Rhodobacter sphaeroides, and surface plasmon resonance (SPR) apparatus. The histidine-tagged RCs were immobilized on an SPR gold chip using nickel-nitrilotriacetic acid groups as a binder for one of the triazine herbicide, atrazine. The SPR responses were proportional to the sample concentrations of atrazine in the range 0.1-1 $\mu\textrm{g}$/mL. The sensitivity of the direct detection of atrazine using the RC-assembled sensor chip was higher than that using the antibody-immobilized chip. The other types of herbicides, DCMU or MCPP, were not detected with such high sensitivity. The results indicated the high binding selectivity of the RC complex.
Teppei Nakamura,Jun Mizutani,Kouichi Sasaki,Naoyuki Yamamoto,Kenji Takazawa 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6
Pharmaceutical angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce arterial stiffness; the possible effect of food-derived putative ACE inhibitory peptides on this degenerative process, however, has not been reported. In the present study, casein hydrolysate containing the lactotripeptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), which has been found to have an antihypertensive effect in a number of clinical studies, was investigated for its ability to improve hemodynamic parameters, including central systolic blood pressure (cSBP), in hypertensive subjects. Twelve hypertensive subjects who were not on prescribed medication were monitored for various hemodynamic parameters, including brachial blood pressure (peripheral blood pressure), cSBP, and augmentation index (AI), at the start and then after 3, 6, and 9 weeks of a daily treatment comprising four tablets containing VPP and IPP. Compared with basal levels, treatment with casein hydrolysate for 6 and/or 9 weeks showed a significant reduction in peripheral systolic and diastolic blood pressure, AI, and cSBP, but not in heart rate or pulse pressure. cSBP showed a reduction sooner and greater (−21.8mm Hg) than did brachial systolic blood pressure (−16.4mm Hg) during the 9-week treatment. Although small and not placebo-controlled, this study suggests that continuous intake of VPP and IPP might have the potential to improve arterial stiffness as well as cSBP and peripheral brachial blood pressure.
Postal Addresses As An Assay of Cultural Cognition
Hiroko Nakamura,Hiroshi Yama,Gary L. Brase,Nasriah Zakaria,Yoshiko Arai,Norhayati Zakaria,Shafiz A. Mohd Yusof,Jun Kawaguchi 대한사고개발학회 2014 The International Journal of Creativity & Problem Vol.24 No.2
The present study investigate/d cultural differences in semantic processing, using a city-to-state and state-to-city priming task, in Japan, Malaysia and the United States. Prior research suggests that Easterners tend to engage in context-dependent cognition whereas Westerners tend to engage in context-independent cognition (Nisbett et al., 2001). According to this view, Japanese and Malaysians should show a greater facilitation effect when state name (context) is presented before city name (object) and/or should be more strongly affected by the prime as a contextual cue. However, if domain-specific knowledge about postal addressing order affects semantic priming, both Malaysians and Americans (who share a city-to-state postal address style) should show greater facilitation from city-to-state priming. The results showed cultural differences in the long SOA (700ms) priming task: Americans and Japanese showed significant differences between congruent pairs (e.g., Texas-Dallas) and incongruent pairs (e.g., Texas-Chicago), both in state- to-city and city-to-state priming, whereas Malaysian didn’t show such differences in state-to-city priming. On the other hand, in the short SOA (200ms) priming task, there were no differences between Easterners and Westerners in amount of priming. These results imply that when the priming order didn’t fit the domain-specific knowledge about addressing order, but was consistent with the culturally engaged cognitive tendency, this domain-general cognitive tendency facilitated the target processing via conscious use of strategies.
Inhibitory Effects of Garcinia cambogia Extract on CYP2B6 Enzyme Activity
Yu, Jun,Choi, Min,Park, Jong,Rehman, Shaheed,Nakamura, Katsunori,Yoo, Hye Georg Thieme Verlag KG 2017 Planta medica Vol.83 No.11
<B>Abstract</B><P>This study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner. Furthermore, the inhibition was potentiated following preincubation with NADPH, indicating that G. cambogia extract is a time-dependent inhibitor of CYP2B6. Meanwhile, hydroxycitric acid, the major bioactive ingredient of G. cambogia extract, did not exhibit significant inhibition effects on cytochrome P450 enzyme activities. G. cambogia extract could modulate the pharmacokinetics of CYP2B6 substrate drugs and lead to interactions with those drugs. Therefore, caution may be required with respect to concomitant intake of dietary supplements containing G. cambogia extract with CYP2B6 substrates.</P>
Yasunori Nakamura,Jun Sano,Kohji Ohki,Toshimasa Higuchi,Kotaro Aihara,Seiichi Mizuno,Osami Kajimoto,Satoshi Nakagawa,Yoshitaka Kajimoto 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
Casein hydrolysate, prepared with Aspergillus oryzaeprotease, contains angiotensin I-converting enzyme in-hibitory peptides, such as Val-Pro-Pro and Ile-Pro-Pro. We conducted a randomized, double-blind, placebo-controlled studyto evaluate the effect of casein hydrolysate on the blood pressure of 144 subjects with high-normal blood pressure (n . 104)and mild hypertension (n . 40). Subjects were randomly assigned to two groups for a 12-week intake period. In the test group,both systolic (SBP) and diastolic (DBP) blood pressure decreased significantly compared with the placebo group: SBP/DBPsignificantly decreased from 138.2. 6.5/84.4. 5.3 mm Hg at week 0 to 132.3. 7.3 (P. .001)/81.2. 4.8 mm Hg (P..001) at week 12. In the stratified analysis, the test product showed an antihypertensive effect in both the subject group withhigh-normal blood pressure and that with mild hypertension. No side effect was observed in any subjects in this study. Theseresults demonstrate that the casein hydrolysate, prepared with A. oryzaeprotease, produced a significant reduction in bloodpressure in a population of subjects with high-normal blood pressure or mild hypertension without an adverse event.