RISS 검색 - 국내학술지논문

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
Distinct clinical features and outcomes in never‐smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement

Kim, Hye Ryun,Shim, Hyo Sup,Chung, Jin‐,Haeng,Lee, Young Joo,Hong, Yun Kyoung,Rha, Sun Young,Kim, Se Hoon,Ha, Sang‐,Jun,Kim, Se Kyu,Chung, Kyung Young,Soo, Ross,Kim, Joo Hang,Cho, Byoung C Wiley Subscription Services, Inc., A Wiley Company 2012 Cancer Vol.118 No.3
- 원문보기
AbstractBACKGROUND:The objectives of this study were to determine the proportions of major oncogenic alterations and to examine survival in genotype‐specific subsets of never‐smokers with nonsmall cell lung cancer (NSCLC).METHODS:The authors concurrently analyzed mutations in the epidermal growth factor receptor (EGFR) and v‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) genes and investigated anaplastic lymphoma kinase (ALK) gene rearrangements in samples from 229 never‐smokers with NSCLC. ALK rearrangements were identified by fluorescent in situ hybridization and were confirmed by immunohistochemistry. Mutations in EGFR (exons 18 to 21) and KRAS (codons 12 and 13) were determined by direct sequencing.RESULTS:Of 229 tumors, the frequency of EGFR mutations, ALK rearrangements, KRAS mutations, and no mutations (wild type [WT]) in any of the 3 genes (WT/WT/WT) was 48%, 8.3%, 3.5%, and 40.2%, respectively. All genetic alterations were mutually exclusive. The median progression‐free survival after treatment with EGFR tyrosine kinase inhibitors (TKIs) was 12.8 months, 6.3 months, 2.1 months, and 1.6 months in patients with EGFR mutations, the WT/WT/WT genotype, KRAS mutations, and ALK rearrangements, respectively. In a Cox regression model, the adjusted hazard ratio for the risk of disease progression after treatment with EGFR TKIs was 0.59 (95% confidence interval [CI], 0.40‐0.87; P = .008) for patients with EGFR mutations, 4.58 (95% CI, 2.07‐10.15; P < .001) for patients with ALK rearrangements, and 4.23 (95% CI, 1.65‐10.8; P = .003) for patients with KRAS mutations. Overall survival also differed significantly among genotypes.CONCLUSIONS:To the authors' knowledge, this was the largest comprehensive and concurrent analysis to date of 3 major oncogenic alterations in a cohort of East Asian never‐smokers with NSCLC. Because survival outcomes differed among genotypes, and drugs that target specific alterations currently are available, genetic profiling to identify genotype‐specific subsets can lead to successful treatment with appropriate kinase inhibitors. Cancer 2012;. © 2011 American Cancer Society.
2
Social Adjustment for Undocumented Migrant Workers in South Korea: Role of Religious Institutions

Madhu Sudhan Atteraya,Jung Ji Myoung,Dong Eun Lee,Jun Hang Ryun,Shreejana Gnawali 계명대학교 국제학연구소 2015 국제학논총 Vol.23 No.-
- 원문보기
- 복사/대출신청
This study explores the difficulties faced by undocumented migrant workers in the context of a lack of institutional welfare support. The study then explores the role that religious institutions play in the social adjustment of undocumented migrant workers to difficult life situations. In order to explore the social adjustment of undocumented migrant workers, we conducted observational field work and in-depth interviews of undocumented migrant workers and Buddhist and Christian social welfare service providers. We found that faith-based organizations with their own purposes and goals are active in social service delivery for undocumented migrant workers. Undocumented migrant workers have been supported by religious institutions through improvements to their work-related quality of life and to their living conditions. The study finds that support from faith-based organizations is structured within the principles of the organization’s religion, and social services are limited to what falls within these boundaries.

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

맨처음 페이지로 1 맨끝 페이지로

상세검색

RISS 보유자료

상세검색

해외전자자료

연관 검색어 추천