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Role for SUMOylation in Disturbed Flow-induced Atherosclerotic Plaque Formation
Jun-ichi Abe,Nhat-Tu Le,허경선 대한의용생체공학회 2015 Biomedical Engineering Letters (BMEL) Vol.5 No.3
Although atherosclerosis is a multi-factorial disease, thefocalization of atherosclerotic plaques on the vessel wallsuggests that local factors such as patterns of local bloodflow are critical in the progression of atherosclerosis. Bloodflow creates various types of forces onto the surface ofvascular endothelial cells (ECs). Among those various typesof forces, fluid shear stress has a major influence on thestructure and function of ECs. At the branch points and thelesser curvature of the aortic arch, blood flow is disturbed (dflow)and atherosclerotic plaques are frequently detected. Atthe straight parts of the arterial tree and the greater curvatureof aortic arch, blood flow is steady (s-flow, high shear stress)and atherosclerotic plaques are rare. These two patterns ofblood flow (d-flow and s-flow) affects EC structure andfunction differently. However, molecular mechanisms underlinethe difference remains unclear. To provide insights into thisquestion, studies have suggested a number of theories withmultiple proposed signaling pathways, and the role ofpost-translational modifications has emerged. Particularly,SUMOylation is highlighted based on its potentiality toregulate a wide range of cellular functions. EC dysfunctioninduced by SUMOylation is proposed to accelerate d-flowinducedatherosclerosis. In this review, we focus onSUMOylation and its role in regulating transcriptional networksand propose a mechanistic link between d-flow and ECdysfunction. Since a strong correlation exists between d-flowand atherosclerotic plaque formation, understanding themechanism of d-flow-induced SUMOylation events mayreveal new paths towards therapeutic interventions againstEC dysfunction and atherosclerosis.
Sluicing, Right Dislocation, and Scopal Parallelism
Jun Abe 현대문법학회 2018 현대문법연구 Vol.100 No.-
The question I raise in this paper is why the Japanese counterpart of the sprouting type of sluicing does not appear to show island sensitivity. I argue that this apparent difference is attributed to another well-established one between these two languages: pro- drop vs. non-pro-drop languages. Thus, sluices are not real instances of the sprouting-type but rather of the merger type, which has an overt correlate in the antecedent clause, i.e., indefinite pro in relevant cases. As substantial evidence for this proposal, I demonstrate that indefinite pro actually functions as a correlate to a sluice in Japanese by examining how it behaves with respect to scopal parallelism. Given this, it is predicted that in Japanese sluicing examples, the implicit correlates that are identified as indefinite pro can take wide scope, unlike truly implicit correlates.
AUTO TUNING OF AN AC SERVO MOTOR USING NOVEL REPETITIVE CONTROL METHOD
Jun Oyama,Tsuyoshi Higuchi,Takashi Abe,Kenichirou Hayashi,Eiji Yamada 전력전자학회 1995 ICPE(ISPE)논문집 Vol.1995 No.10
For tuning the P1D parameters of an AC servo system, even a skillful engineer takes a long time and these parameteis must be re-tuned according to each application In previous woiks, we proposed a lepetitive control method with learning process to drive the horizontal-axis direct-drive robot arm with constant speed and also applied this control method to the position control in which the arm reciprocates between several points In this paper, we propose an auto tuning method of the AC servo motor Using the repetitive control method especially for periodic speed control It is very simple and powerful Availability of the control methods is confirmed experimentally.
The Effect of Asynchronous Carrier on Matrix Converter Characteristics
Jun OYAMA,Tsuyoshi HIGUCHI,Takashi ABE,Eiji YAMADA,Hideki HAYASHI,Takashi KOGA 전력전자학회 1998 ICPE(ISPE)논문집 Vol.- No.-
In a matrix converter, input side and output side are coupled with each other through switching elements. Since disturbances on either side affect directly on the other side, it requires a high-speed on-line control system to compensate them.<br/> We proposed in previous papers a new control strategy and an on-line control circuit for a matrix converter. The control circuit could keep the output voltage at commanded value against fluctuation in the supply voltage. Furthermore wave forms of the output voltage and the input current were always kept sinusoidal. The switching pattern was generated by comparing modified voltage references with a carrier. The carrier was synchronized with the supply voltage using a PLL system, which made the control circuitcomplicatedand costly.<br/> This paper discusses on the possibility of an asynchronized carrier. Experiment results show the input current distortion in case of asynchronous carrier is bigger than that of synchronous earner However, the detenoration can be minimized by increased carrier frequency.
Jun Oyama,Tsuyoshi Higuchi,Takashi Abe,Keisuke Tanaka 대한전기학회 2006 Journal of Electrical Engineering & Technology Vol.1 No.1
We proposed a novel segment type switched reluctance motor (SRM) in which the segment core was embedded in aluminum (conductive metal) rotor block in order to increase the mechanical strength and easy manufacturing as well as to improve the performance characteristics and reduce the vibration and acoustic noise. This paper explains the operation principle and the drive system and shows the experimental results in comparison with the VR type SRM.
Oyama Jun,Higuchi Tsuyoshi,Abe Takashi,Tanaka Keisuke The Korean Institute of Electrical Engineers 2006 Journal of Electrical Engineering & Technology Vol.1 No.1
We proposed a novel segment type switched reluctance motor (SRM) in which the segment core was embedded in aluminum (conductive metal) rotor block in order to increase the mechanical strength and easy manufacturing as well as to improve the performance characteristics and reduce the vibration and acoustic noise. This paper explains the operation principle and the drive system and shows the experimental results in comparison with the VR type SRM.
Evaluation of Histological Changes in Back Muscle Injuries in Rats over Time
Koki Abe,Kazuhide Inage,Yoshihiro Sakuma,Sumihisa Orita,Kazuyo Yamauchi,Miyako Suzuki,Go Kubota,Yasuhiro Oikawa,Takeshi Sainoh,Jun Sato,Kazuki Fujimoto,Yasuhiro Shiga,Hirohito Kanamoto,Kazuhisa Takaha 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.1
Study Design: Animal model study. Purpose: The purpose of this study was to evaluate the histological variation in the injured muscle and production of calcitonin generelated peptide in rats over time. Overview of Literature: Vertebral surgery has been reported to cause atrophy of the back muscles, which may result in pain. However, few reports have described the time series histological variation in the injured muscle and changes in the dominant nerve. Methods: We used 30 male, 8-week-old Sprague-Dawley rats. The right and left sides of the paravertebral muscle were considered as the injured and uninjured sides, respectively. A 115 g weight was dropped from a height of 1 m on the right paravertebral muscle. Hematoxylin and eosin (H&E) staining of the muscle was performed 1–3 weeks after injury for histological evaluation. Fluoro-Gold (FG) was injected into the paravertebral muscle. The L2 dorsal root ganglia on both sides were resected 1, 2, and 3 weeks after injury, and immunohistochemical staining for calcitonin gene-related peptide was performed. Results: H&E staining of the paravertebral muscle showed infiltration of inflammatory cells and the presence of granulation tissue in the injured part on the ipsilateral side 1 week after injury. Muscle atrophy occurred 3 weeks after injury, but was repaired via spontaneous replacement of muscle cells/fibers. In contrast, compared with the uninjured side, the percentage of cells double-labeled with FG and calcitonin gene-related peptide in FG-positive cells in the dorsal root ganglia of the injured side was significantly increased at each time point throughout the study period. Conclusions: These results suggest that sensitization of the dominant nerve in the dorsal root ganglia, which may be caused by cicatrix formation, can protract injured muscle pain. This information may be helpful in elucidating the underlying mechanism of persistent pain after back muscle injury.
Application of Impact-Echo Method for Heterogeneous Materials
Sanghun LEE,Jun ABE,Shunsuke GOTO,Takao ENDO,TMitsuhiro TAKEDA,Masafumi KITATSUJI 한국방재학회 2014 한국방재학회 학술발표대회논문집 Vol.2014 No.-
Heterogeneous materials such as rock cannot be expected to have homogeneity so as to be used as structural materials. For example, in order to test large rocks more than one cubic meter, measures need to be taken against weaknesses such as internal cracks and fracture zones that can easily be overlooked in compressive strength tests. The impact-echo method could be available for evaluating strength and detecting internal defects in-situ concrete component with relatively good accuracy. In this study, measurements using the impact-echo method were carried for several types of rock specimens used at automobile crash safety tasting, and, by comparing the results with compression strength tests, the applicability of the impact-echo method for strength estimation of heterogeneous materials was evaluated.This work was supported by JSPS KAKENHI Grant Number 25420462.