가자의 즉각형 알레르기 반응 억제 효과

엄용대,신민교,이영미,김형민,신태용,정종길,송호준 대한본초학회 2000 大韓本草學會誌 Vol.15 No.1

We investigated the effects of methanol extract of Fructus Chebula (MEFC) on local and systemic anaphylaxis. Passive cutaneous anaphylaxis inhibited to 61.42 12.8 % by oral administration of MEFC(I.0 glkg). MEFC inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.05-1.0 glkg . Administrations of MEFC (1.0 glkg) 60 min before, 5 min after, and 10 min after the compound 48/80 treatment were shown the mortality rates as 0%. MEFC (0.01-1.0 glkg) inhibited the histamine release significantly from the rat peritoneal mast cells by compound 48/80. These results indicate that MEFC inhibits mast cell mediated anaphylactic reactions by inhibition of mast cell degranulation in vivo and in vitro.

韓國産 薔薇科 植物에 관한 本草學的 硏究 I

정종길,황상욱,송호준,신민교 한국전통의학연구소 2004 한국전통의학지 Vol.14 No.1

For the purpose of developing Korean Herbalogy with the plants of Rosaceae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigated and the results obtained as follows: 1. There were totaled to 36 genera and 262 in Korea and among them medicinal plants are 27 genera, 117species, some 44% in total, but the number of species may be added because of the similiar plants. 2. According to sum of 262 species in Rosaceae family, they were classified into Agrimonia genera 3, Potentilla genera 26, Prunus genera 48,pyrus genera 17, Rosa genera 24, Rubus genera 28, Sorbaria genera 17, Spiraea genera 20. Thus it was noticed that Prunus genera was the main kind in total. 3. According to the oriental names which can be used for medical purpose, the medicinal plants belonging to the Rosaceae family were classified as Herba 24, Radix 43, Foilum 31, Fructus 48, Semen 11, cortex 14, Lignum, Ramulus;12 each Flos 3, pericarpium 3, resina 2, the others 6. so Fructus is 24% of all and it is the most applied in the clinical treatments. 4. According to nature and flavour of medicinal plants, they were classified into balance 84, warmth, heat; 44 each, cold, cool; 35 each bitter taste 79, sweet taste 74, sour taste 61 thus it was noticed that balance and bitter taste is the main in nature and flavour of medicinal plants 5. According to meridian tropism of herbs they were classified into liver meridian 50 lung meridian 28, stomach meridian 22, spleen meridian 20, heart meridian 19 thus it was noticed that liver meridian is the main kind 6. According to the Properties and Principal curative action, they were classified into drugs for treating detoxicant 72, drugs for treating febrifugal 55, drugs for invigorating blood circulation 53, drugs for removing dampness 46, drugs for expelling wind and drugs to stop bleeding 38 each, drugs to cure tramatic swelling and drugs for relieving pain 36 each. Thus it was noticed that drugs for treating detoxicant and febrifugal was the main kind 7. It was researched that toxic drugs include minor toxin were 10 kinds From this result, it was revealed that Fructus was the main kind in the plants for medical purpose of Rosaceae. and toxic plants was slightly poisonous that it will be used for clinical treatments more easily. It is considered that many experiments and clinical approaches must be continued to use Rosaceae plants widely.

韓國産 박과 植物에 관한 本草學的 硏究

全吉煥,宋昊埈,辛民敎 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.1

韓國産 박과 Cucurbitaceae에 속한 植物에 대하여 本草學的으로 文獻을 통하여 調査한 結果 다음과 같이 要約되었다. 1. 植物 總 53種 中 오이속·Cucumis 植物이 10種, 박속·lagenaria 植物 總 6種, 호박속·Cucurbita과 하늘타리속·Trichosanthes 植物이 各各 5種, Melothria 植物이 4種, Hernsleya과 유자속·Momordica 植物이 各各 3種, 뚜껑덩굴속·Aetinostemma, 수박속·Citrullus 과 수세미오이속·Luffa 植物이 各各 2種, 그 外 동아속·Benincasa, Bolbostemma, Corona, Diplocydos, 돌외속·Gymnostemma, Gymnopetalum, Hodgsonia. 산외속·Schizopepon, Sechiam, Thladiantha 植物이 各各 1種의 順으로 調査되어 Cucumis 植物이 가장 많이 나타났음을 알 수 있었다. 2. 植物은 總 19屬 53種으로 調査되었으며 그 가운데 藥用植物은 괄樓, 冬瓜, 南瓜, 甛瓜, 絲瓜 等의 15屬 34種으로서 約 64%를 차지하고 있었다. 3. 植物 中 藥用植物을 藥用 部位別로 分類해보면 種子類 23種, 果實類 19種, 根類 16種, 葉類 11種, 果皮類 10種, 莖·藤類 9種, 체類 4種, 全草類와 果ㅁ類가 各各 3種 그 外 塊莖, 霜, ㅁ, 幼芽, 液汁 및 絡類가 各各 1種의 順으로 調査되어 種子類 藥物이 가장 많이 活用되었다. 4. 藥性에 있어서 寒凉性 藥物이 22種, 平性 藥物이 12種, 溫熱性 藥物이 3種 等으로 나타나 寒凉性 藥物이 가장 많이 있음을 알 수 있었다. 5. 效能에 있어서는 淸熱解毒 藥物이 21種, 利水消腫 藥物이 20種, 潤肺化痰 藥物이 12種, 止痛 藥物과 生津止渴 藥物이 各各 7種 等으로 調査되어 淸熱解毒과 利水消腫 藥物이 가장 많이 나타났다. 6. 有毒 藥物로는 苦瓜, 王瓜, 黃瓜, 苦壺蘆子, 木ㅁ子, 合子草, 羅鍋저, 甛瓜체等으로 나타나 있으나 木ㅁ子를 除外하고는 毒性이 極烈하지 않았다. 以上의 내용으로 보아 韓國産 박과 植物中 藥用植物이 64%를 차지하였고 이 가운데 種子와 果實類 藥用植物이 가장 많았으며 아울러 毒性 藥物이 적어 臨床에 容易하게 使用될수 있을 것으로 생각되며, 同科의 藥用植物에 대하여 實驗的인 硏究가 이루어져야 할 것으로 생각된다. For the purpose of developing Korean Herbalogy with the plants of Cucurbitaceae which grow wild and is plante d in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigative and the results obtained were as follows: 1) There were totaled 19 genera and 53 species in Korea and among them medecinal plants are 15 genera, 34 species, some 64% in total but the number of species may be added because of similar plants. 2)According to the oriental name which can be used for medical purpose, the medicinal plants beloning to the Cucurbitaceae wer e classified as Semen 23, Fructus 19, Radix 16, Folium 11, Exocarpium 10, Caulis 9, Herba 3, ect, Thus it was noticed that Semen was the main kind. 3)According to sum of 53 species in Cucurbitaceae they were dassified into Cucumis genera 10, Lageneria genera 6, Cucurbita and Trichosanthes genera 5)Melothira genera 4,Hemsleya and Monordica genera 3, Actinostemma, Citrullus and Luffa genera 2, Benincase, Bolbostemma, Cocc ina, Diploccylos, Gymnostemma, Gymnopetalum, Hodgsonia, Schizopepon, Sechiam and Talandina genera 1 etc. Thus it was noticed that Cucumis genera was the main kind. 4)According to nature and flavour of medicinal plants, they were dassified into cold and cool; 22, balance 12, wormth and heat; 3. Thus it was noticed that cold and cool is the main in nature and flavour of medicinal plants. 5)According to the Properties and Principal Curative action, they were classified into, clearing up heat and toxin 21, drugs for inducing diuresis to allevitae edema 20, drugs for nourishing the lung and resolving phlegm 12, drugs for analegesic and promoting the production of body fluid to quench thirst 7. 6)Comparing to whole medical plants 53 kinds, toxic durgs include minor toxin were 8 kinds. Thus toxic durgs were rare. From this result, It was revealed that the plants for medical purpose in Cucurbitaceae was 64% kinds of the whole, in which semen was mostly abundunt,toxic plants were so rare that it will be used for clinical treatments more easily. It is considered that many dinical experiments and approaches must be continued to use widely.

Glucose Oxidase가 척수지각신경절세포에 미치는 영향과 천마의 효과에 관한 연구

송호준,이용석,손영우,이강창,정종길,신민교,홍기연 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : To clarify the cytotoxic effect of glucose oxidase(GO) and protective effect of gastrodiae Rhizoma (GR) on spinal sensory ganglion(DRG) neurons, neurotoxicity mediated by GO was measured by MTT assay and neurofilament enzymeimmuno assay(EIA). Methods : DRG neurons were cultured in the media containing various concentrations of GO for 3 hours. In addition, neuroprotective effects of GR, on GO-induced neurotoxicity in DRG neurons were examined after DRG neurons were preincubated with various concentrations of GR for 2 hours before 15mU/ml GO for 3 hours. Results : GO decreased remarkably cell viability in dependently in these cultures, and also RG increased cell viability and amount of neurofilament in DRG neurons damaged by GO. Conclusion : It is suggested that GO has toxic effect in cultured mouse DRG neurons, and also RG was effective in the protection of GO-induced neurotoxicity in these cultures.

韓國人에서 HumFIBRA/FGA와 D21S11 遺傳座의 對立遺傳子 頻度와 遺傳的 變異의 分析

김윤신,황적준,이혜린,구태완,한길로,김성민,이혜승 大韓法醫學會 1998 대한법의학회지 Vol.22 No.1

Allele-and genotype frequencies of the two short tandem repeat (STR) loci, HumFGA and D21S11, were determined in Korean population(n=196). DNA typing was accomplished by applying fluorescence-labeled PCR products and a differently labeled sequenced allelic ladders, followed by automated analysis using ABI 377 automatic sequencer and GeneScan 2.02 software. Prior to typing, allelic ladder of each locus was constructed with a combination of all alleles occuring from the population sample. A total of 15 alleles and 48 genotypes with the heterozygosity of 0.854 for HumFGA, and 12 alleles and 33 genotypes with the heterozygosity of 0.787 for D21S11 are observed in a population of 196 genetically unrelated individuals. No deviations from Hardy-Weinberg equilibrium were observed(p=0.753 for HumFGA, p=0.262 for D21S11). The data presented here (power of discrimination and average power of exclusion) show that both STR Loci, HumFGA and D21S11, are very informative for individualization from criminal evidences, and are also useful for parentage testing.

한국인에서 다변성 D12S391 유전좌의 집단유전학적 연구

이용욱,김성민,구태완,이혜린,강일호,한길로,이혜승,황적준 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1

The hypervariable short tandem repeat(STR) locus D12S391 was investigated in a Korean population. A total of 14 alleles were detected by size under denaturing conditions in 517 unrelated individuals. To confirm all of the alleles detected in a Korean population, a total of 34 fragments were sequenced. Prior to allele designation, we constructed the allelic ladders containing 11 alleles sequenced in this study. Allele 18 is the most common with a frequency of 0.281 in Koreans, and one variant allele 19.3 which have been confirmed by sequencing, was detected. The observed heterozygosity, the power of discrimination (PD), and the mean exclusion chance (MEC) for the locus D12S392 is 0.781, 0.946 and 0.652 , respectively. No deviation from Hardy-Weinberg equilibrium was observed in a Korean population (p=0.557). In the 424 meioses in 105 Korean families confirmed using other 17 STR loci, no mutation was detected in locus D12S391. The STR locus D12S391system is useful both for the analysis identification and parternity.

Maximizing Network Lifetime of Directional Sensor Networks Considering Coverage Reliability

Gil, Joon-Min,Park, Jong Hyuk,Jeong, Young-Sik SAGE Publications 2013 International journal of distributed sensor networ Vol.2013 No.-

Data center selection based on neuro-fuzzy inference systems in cloud computing environments

Gil, Joon-Min,Park, Jong Hyuk,Jeong, Young-Sik Springer-Verlag 2013 The Journal of supercomputing Vol.66 No.3

A Log Analysis System with REST Web Services for Desktop Grids and its Application to Resource Group-based Task Scheduling

Joon Min Gil,Mi Hye Kim 한국정보처리학회 2011 Journal of information processing systems Vol.7 No.4

A Log Analysis System with REST Web Services for Desktop Grids and its Application to Resource Group-based Task Scheduling

Gil, Joon-Min,Kim, Mi-Hye Korea Information Processing Society 2011 Journal of information processing systems Vol.7 No.4

It is important that desktop grids should be able to aggressively deal with the dynamic properties that arise from the volatility and heterogeneity of resources. Therefore, it is required that task scheduling be able to positively consider the execution behavior that is characterized by an individual resource. In this paper, we implement a log analysis system with REST web services, which can analyze the execution behavior by utilizing the actual log data of desktop grid systems. To verify the log analysis system, we conducted simulations and showed that the resource group-based task scheduling, based on the analysis of the execution behavior, offers a faster turnaround time than the existing one even if few resources are used.