전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

肺吸蟲症에 있어서 尿를 이용한 免疫學的 診斷에 관한 硏究

李榮喆,李駿商,林漢鍾 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.3

Human paragonimiasis is one of the most common trematode diseases and of very important public health problems in Korea. Since neither skin test always represents current infection nor recovery of Puragovzinius westermani ova, the immunodiagnosis of human paragonimiasis is not always possible, a more feasible, sensitive and specific method is required. To investigate the feasibility and diagnostic accuracy of using the enzyme-linked immunosorbent assay (ELISA) with a urine sample in the immunodiagnosis of human paragonimiasis. 72 normal control subjects. 100 subjects with skin test positive for paragonimiasis. 19 patients with paragonimiasis. 13 subjects with serum optical density of more than 1.00 for Paragonimus antigen and clonorchiasis subjects were studied. ELISA was performed with Verona! buffered saline antigen of Paragonimus westermani. peroxidase conjugated anti-rabbit IgG and orthophenylene diamine as a substrate by micro-method. The results obtained are as follows: 1. The mean O.D. (optical density) values of ELISA of normal control subjects was 0.19±0.07 in the urine samples and 0.16 & 0.09 in the serum samples. 2. The mean O.D. values in the urine samples of 100 positives by skin test was 0.47±1 0.64 and in the serum samples was 0.65±0.72. The relation of the absorbance values between the urine (x-axis) and serum (y-axis) samples made the regression equation: y = 0.95x+0.206, and showed high correlation (r = 0.847, n = 100, p < 0.01). 3. Pseudopodia showed at the wheal by the skin test in the 12 (63%) out of 19 paragonimiasis. The mean O.D. values of 19 paragonimiasis was 1.41±0.58 in the urine samples and 1.64±0.38 in the serum samples. The O.D. values of confirmed paragocimiasis cases were 0.5 or over in the almost every cases using a urine sample. 4. Six cases of paragonimiasis which were treated effectively showed same reactions of the skin test and the O.D. values in the serum samples of other paragoniniiasis before treatment, but the O.D. values in the urine samples was a tendency of decrease. In conclusion, these findings suggested that ELISA using a urine sample was more feasible and sensitive in the immunodiagnosis of human paragonimiasis in the mass screening.

알레르기 환자에서 특이알레르겐 항체 양성율과 관련요인

이선화,남해선,이성수,안현철,황규윤,박준수,,박춘식 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

Recently, allergic diseases are very prevalent in Korea, resulting in physical and economic losses during the life. It is well-known that the principle therapy is identification, eradication, and desensitization of allergens. There are many allergic diagnostic tools for identification of specific-allergens. However, none of them is satisfied with its efficiency due to lack of validity. Recently MAST-CLA has been widely used in the allergic clinical fields because of its simplicity and simultaneous identification of allergens. This study was designed to determine the positivity of allergen-specific antibodies using MAST-CLA in patients with allergic diseases, and evaluate the efficacy for allergen detection, compared to results of skin prick test. During June 2000 - September 2001, 325 study subjects visited Soonchunhyang University Chunan Hospital for the evaluation of allergic problems. Among them, 289 subjects were diagnosed with allergic disease and included for the study. Thirty four subjects visited children's allergic unit were evaluated specific allergens using a skin prick test at the same time. Our result as follows; 1. The positive rates of allergen-specific antibodies and total IgE were 51.2% and 73.4%, retrospectively. 2. There was significant difference in positive rate in age group, showing highest in teen ages(73.6%), but insignificant difference in sex in allergen-specific antibodies. 3. The positive rate was 60.4% in allergic rhinitis, 51.3% in allergic dermatitis, 46.9% in bronchial asthma, and 39.1% in urticaria in order(P=0.073). 4. Significant difference in month or season was observed, with highest rate in April(78.1%) and May(72.1%). The highest season was in spring(62.7%), and then summer(52.8%), fall(50.3%), and winter(41.4%) in order (P=0.04). 5. The three highest allergen-specific antibodies were D. pteronyssinus(39.3%), D. farinae(38.3%), and house dust(24.3%) in Korean inhalant pannel, However, in food pannel types of allergen-specific antibody were different as D. farinae(18.5%), Alternaria(18.5%), house dust(17.3%). 6. There were significant agreements between MAST-CLA and Skin prick test (D. farianae Kappa=0.636;D. pteronyssinus Kappa=0.78, both P<0.001) In conclusion, MAST-CLA could detect allergen-specific antibodies in patients with allergic diseases as a simple and valid tool of screening of allergy. Especially, it could be a useful measure of multiple allergens simultaneously in children However, more detailed allergens and valid assay for unmeasured allergens should be identified for Korean-specific allergens.

TiO₂(Rutile)-H₂O 현탁용액의 유동성질에 미치는 농도 및 온도효과

이철우,한상준,김응렬 漢陽大學校 基礎科學硏究所 1990 基礎科學論文集 Vol.9 No.-

TiO₂- water 현탁계의 유동성질을 계의 농도와 온도의 변화에 따라 Couette 형회전 점도계를 이용하여 측정하였으며 Ree-Eyring flow equation으로부터 유도된 dilatant flow equation에 적용하여 고찰하였다. Rutile-water 현탁계는 30%wt 이상의 고농도에서는 thixotropy를 나타내고 25%wt 이하의 농도에서는 dilatancy를 나타내었으며 유동에 대한 활성화 에너지는 약 14Kcal/mol정도였다. 본연구에서는 유동성질간의 전이를 한 물질 내에서 구조의 형성과 파괴가 경쟁적으로 일어난다는 견지에서 고찰하였다. Rheological properties of Rutile-water suspension with various conditions of particle concentrations and temperatures. The rheologicl properties were measured using Couette type rotational viscometer. And we calculated flow parameters with applied to BKHR flow equation. Rutile-water suspension shows dilatancy at lower concentration relatively (at below 28%wt.) but at higher concentration(above 30%wt.) thixotropic flow was observed. And the activation energy for flow was about 14Kcal/mol. In this paper we studied this transition in the view point of competitive rate process between structure formation and deformation in the same material.

형상기억복합재료의 제조공정 및 신뢰성 평가

이진경,박영철,이규창,최일국,이준현 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.6

형상기억복합재료는 복합재료내에 압축잔류응력을 발생시킴으로써 재료의 인장강도를 증가시키는데 사용되어지고 있다. 본 연구에서는 형상기억복합재료를 제조하기 위하여 TiNi 강화재와 A16061 기지재를 사요하였으며 핫프레스 방법에 의해 TiNi/A16061 형상기억복합재료를 제조하였다. 그러나 핫 프레스 방법에 의해 제조된 형상기억복합재료는 하중을 받을시 강화재와 기지재 사이에 계면손상현상이 발생하였으며 이를 위하여 냉간압연을 실시하였다. 냉간압연을 받은 시험편은 냉간압연을 받지 않은 시험편에 비하여 인장강도가 현저히 증가하였다. 또한 본 연구에서는 고온에서 형상기억복합재료의 미시적 손상을 평가하기 위하여 음향방출기법을 이용하였다. Shape memory alloy has been used to improve the tensile strength of composite by the occurrence of compressive residual stress in matrix using its shape memory effect. In order to fabricate shape memory alloy composite, TiNi alloy and Al6061 were used as reinforcing material and matrix, respectively. In this study, TiNi/Al6061 shape memory alloy composite was made by using hot press method. However, the specimen fabricated by this method had the bonding problem at the boundary between TiNi fiber and Al matrix when the load was applied to it. A cold rolling was imposed to the specimen to improve the bonding effect. It was found that tensile strength of specimen subjected to cold rolling was more increased than that of specimen which did not underwent cold rolling. In addition, acoustic emission technique was used to quantify the microscopic damage behavior of cold rolled TiNi/Al6061 shape memory alloy composite at high temperature.

펠렛형 제올라이트를 이용한 이산화황의 흡착특성

이재희,김정국,양희철,김준형,이제근 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.1

KA, NaA, CaA 및 NaX 제올라이트가 충전된 실험실 규모의 흡착층을 이용하여 SO_2 유입농도, 충전층 높이 및 공간속도를 변화시키면서 SO_2 흡착실험을 수행하였다. 평형흡착량과 파과시간 모두 제올라이트 세공크기에 따라 KA, NaA, CaA, NaX 순으로 증가하였다. NaX상에서 SO_2를 흡착시킬 경우 SO_2 유입농도 504ppm 이하에서 파과시간은 증가하나 역시 물질전달범위도 증가하여 물질전달 속도는 감소하였다. Wheeler 식으로부터 제올라이트상의 파과시간에 대한 평형흡착량, 공간속도 및 1/C_0의 관계를 확인한 결과, 504ppm 이상보다 504ppm 이하의 저농도에서 파과시간이 상대적으로 증가하였다. The experimental of SO_2 adsorption, with varying SO_2 concentration, packed-bed depth, and space velocity, was carried out using a lab-scale fixed bed with zeolites, such as KA, NaA, CaA and NaX. Both of an equilibrium adsorption capacity and a breakthrough time increased with zeolite pore size, in order of KA, NaA, CaA and NaX. Breakthrough time of NaX increased under SO_2 concentration of 504 ppm, but mass transfer rate decreased due to expansion of mass transfer zone. Breakthrough time is relatively increased in the low gas concentration(<504 ppm) more than high concentration(>504 ppm), which is proved by the effects of equilibrium adsorption capacity, space velocity and l/C_0 for the zeolite from the relationship of Wheeler equation.

국내 민간투자(SOC)사업의 효율화 방안에 대한 연구

이호경,김상철,윤준선,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study is to examine the theoretical concept and practical example of Social Overhead Capital(SOC) project based on development of nation the world. Also, the critical access is to find the way we can develop domestic SOC project underway in private and nationwide. Furthermore, anther access is to propose clearly how to utilize BOT, BTO in financial, technical, CM method focusing on more systematic and effective result.

근력강화 운동프로그램이 시설 노인의 자세균형에 미치는 효과

이철인,박돈목,박래준 대구대학교 2005 대구대학교 학술논문집 Vol.1 No.1

This study was conducted to examine the influence and effect of muscle enforcement program on Activity of daily living(ADL) improvement and posture balance of the old, and to provide more effective muscle enforcement program and educational data. The muscle enforcement exercise program was performed on the old(institution, 16 men, 10 women) for 8 weeks from April 22, 2002 through June 17,2002. Programed Exercise 1 - Exercise 10 were practised 8 times per program for 3 days a week. The load of exercise was increased per two weeks. The methods of measurement were questionnaire, Indiana 47903(action-response analysis machine) and Sample exercise protocol for KAT 2000(balance training device). SAS/PC statistic analysis was used for data analysis. T-test was used for analysis of change before and after exercise in this study. The summary and conclusions are as follows: 1. On subjectively recognized health states, the healthy were 42.3%. On the satisfaction with health states, the satisfied were 50.0%. On the factors of effects on daily-life behavior performance, the group who had troubles was 50%and the group who was so and so was 34.6% compared with the old of the same age. On prospect about health states in the future, the group who would be better was 38.%. On effective methods for problem solving, exercise was 42.3%. 88.5% of respondents answered the need of health care. The participation intention in health program was 92.3%. 2. On the change of psychological emotion and behavior aspects, the group who had repeated complaints or anxieties and reduced activities or interests was effective(P<0.01). 3. On the effects of action-response, the results of 8weeks regular exercise program were not different significantly compared with before and after exercise. The behavior quickness of the old by muscle enforcement program was not increased. This means that the old needs much time for exercise sense training because of the regression of cognition sense. 4. In the effect of posture balance, the whole grades were effective from 1272.69 before excercise to 476.92 after exercise(P<0.01). Especially right balance 657.65 was lowered to 208.57 after exercise most effectively(P<0.01). Rear balance 776.34 before exercise was lowered to 136.65 after exercise. The results of measurement were significant(P<0.05). 이 연구는 시설노인의 근력증가와 자세균형 및 운동수행능력 향상을 위한 방법의 하나로 노인들의 일상생활동작 수행개선과 자세균형에 미치는 영향과 효과를 검증하고 시설노인들의 체계적이며 효율성이 높은 근력 강화운동 프로그램과 교육자료를 제공하기 위하여 시설노인들의 일반적 특성 및 건강관리실태, 운동프로그램 참가 전 관련변수의 특성과 심리적 정서 및 행동양상의 변화 효과를 규명, 운동프로그램을 실시하기 전과 후의 동작반응효과, 그리고 근력강화 운동프로그램으로 노인들의 자세균형 효과를 연구하였다. 연구절차는 대구시내의 Y요양원과 양로원 시설에 남자 16명, 여 10명, 전체 26명을 대상으로 2002년 4월 22일부터 2002년 6월 17일 까지 8주 동안 운동프로그램을 실시하였다. 프로그램화된 운동1~운동10까지 기본적으로 주 3회에 각 항목별 1Set당 8회로 실시하도록 하였으며, 또한 2주마다 부하량을 증가시켰지만 1Set당 8회로 실시하도록 하였다. 측정도구는 INDIANA 47903(동작반응분석기)와 Sample exercise protocol for KAT 2000(균형훈련장치도구)을 측정도구로 사용하였다. 자료분석은 SAS/PC 통계분석을 이용하였으며, 본 조사에서는 운동전과 운동후의 변화를 분석하기 의해 짝 비교 t-검정을 이용하였다. 1. 대상자의 참가 전 관련변수의 특성 중 주관적으로 인식하는 건강상태는 건강하다고 응답한 사람이 42.3%이었으며, 자신의 건강수준에 대한 만족도 에 만족한다가 34.6%이었다. 건강상태가 일상생활동작수행에 영향을 미치는 요인으로는 50.0%가 지장을 받는다고 하였으며, 비슷한 연령층의 노인들과 비교한 자신의 건강상태에 관하여는 그저 그렇다고 응답한사람은 34.6%이었다. 앞으로의 건강에 대한 전망에 대해 더 좋아질 것이라는 사람은 38.5%이었으며, 건강상의 문제해결을 위한 효과적인 방법에 대해서는 42.3%가 운동이라고 하였다. 그리고 건강관리의 필요성에 대한 응답에는 88.5%이었고, 건강프로그램 참가의사에는 92.3%이었다. 2. 노인들의 심리적 정서와 행동양상의 변화는 반복적인 불평을 하거나 걱정을 한다와 활동이나 관심이 줄어들었다가 효과가 있었다(P<0.01). 3. 동작반응 효과는 8주간의 규칙적인 운동프로그램의 동작반응효과에 대한 결과는 운동전과 운동 후를 비교해볼 때 전혀 차이가 없었다(P>0.897). 근력강화프로그램으로는 노인들의 민첩성 능력의 증가는 변화가 없었으며 이는 노인들의 인지 감각기능의 퇴행으로 많은 시간의 운동감각훈련이 필요한 것으로 생각된다. 4. 자세균형효과에는 전체점수가 운동전의 1272.69에서 운동 후의 476.92로 큰 효과가 있었으며(P<0.01), 특히 오른쪽 균형은 657.65에서 운동 후의 208.57로 낮아 통계적인 유의성이 있었으며(P<0.01), 뒤쪽의 균형 역시 운동전 776.34와 운동 후 136.65의 수행력을 측정한 결과도 유의성이 있었다(P<0.05).

사람 성상세포종 세포주에서 사이토카인에 의한 Fas 및 FasL mRNA의 발현 조절

김옥준,임정희,최철희,최인홍,이병인,최일생 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

다중 질의 결합을 통한 검색 효과의 개선

이기호,이준호,이규철 한국문헌정보학회 1997 한국문헌정보학회지 Vol.31 No.1

일반적으로 주어진 정보 요구에 대하여 서로 다른 사용자는 서로 다른 질의를 생성할 수 있으며, 또는 한명의 사용자가 통제어의 사용 여부에 따라 서로 다른 질의를 생성할 수 있다. 최근 정보 검색 분야의 연구들은 이러한 서로 다른 질의 표현의 서로 다른 문서 집합을 검색함을 보여준다. 본 논문에서는 하나의 사용자 질의에 대하여 다양한 적합성 피드백 방법을 적용함으로써 다중의 질의들을 자동으로 생성한 후, 생성된 다중 질의들을 다시 하나의 질의로 결합하는 방법을 제안한다. 또한 실험을 통하여 자동으로 생성된 다중의 질의들을 결합함으로써 보다 높은 검색 효과를 얻을 수 있음을 입증한다 Different users or the same user using controlled versus free-text vocabularies could generate different queries for the same information need. It has been known in the information retrieval literature that different query representations may retrieve different sets of documents. In this paper, we first generate multiple query vectors from a given information problem by using different relevance feedback methods. Then we combine the multiple query vectors into a single query vector. We also show through experiments that significant improvements can be achieved by the combination of the multiple query vectors