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Joomin Kim,Sekwon Oh,Daewon Kim 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
In this paper, the implementation of a work distribution function for tele-operation under multi-user and multi-robot environments is described. First of all, XML-based UDS(Unit-task Description Structure) is defined to make task scenarios and to distribute the work to multi-users. Considering the role of users and control methods, various kinds of switching modes are defined, and a switching controller is designed. To prove the work distribution function, a simulation environment including a Marilou robotic simulator based slave robot environment is implemented. In this environment, the effectiveness of the work distribution function is tested.
Therapeutic Effect of Human Mesenchymal Stem Cell-Conditioned Medium on Erectile Dysfunction
Kim Seul Gi,You Dalsan,Kim Kyung,Aum Joomin,Kim Yu Seon,Jang Myoung Jin,Moon Kyung Hyun,Kang Hyun-Wook 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.4
Purpose: Owing to the safety and cost effectiveness of conditioned medium (CM), its therapeutic effects have attracted significant attention from many researchers. To date, numerous studies have been conducted on CM; however, little has been done with regard to erectile dysfunction (ED). In this research, the potential of human mesenchymal stem cell-derived CM (MSC-CM) for the treatment of ED was investigated. Materials and Methods: A high concentration of MSC-CM was prepared through 3D spheroid culturing with bone marrowderived MSCs and cut-off filtering. The composition of CM was analyzed using biochemical assays, and the effect of the preparation process on the quality of CM was investigated. The therapeutic effects of MSC-CM were evaluated through animal studies using a cavernous nerve (CN) injury rat model. Results: 3D spheroid culturing afforded a 278-fold increase in the total protein content of CM, as compared to that from 2D cultures; the protein concentration increased by 19 times on increasing the centrifugation time for cut-off filtering. Biochemical assays indicated that the CM contains various types of angiogenic, neurotrophic, and anti-inflammatory factors. Histological assay results showed that MSC-CM has angio- and neuro-trophic effect in a CN injury rat model in vivo, and these therapeutic effects appear in a dose-dependent manner. Conclusions: The experimental results confirmed the therapeutic effect of MSC-CM in healing damaged cavernosal tissue and restoring erectile function. These results successfully demonstrated that MSC-CM has significant potential for the treatment of ED.
2단계 신경망과 계층적 프레임 탐색 방법을 이용한 MPEG 비디오 분할
김주민(Joomin Kim),최영우(Yeongwoo Choi),정규식(Kusik Chung) 한국정보과학회 2002 정보과학회논문지 : 소프트웨어 및 응용 Vol.29 No.1·2
In this paper, we are proposing a hierarchical segmentation method that first segments the video data into units of shots by detecting cut and dissolve, and then decides types of camera operations or object movements in each shot. In our previous work[1], each picture group is divided into one of the three detailed categories, Shot(in case of scene change), Move(in case of camera operation or object movement) and Static(in case of almost no change between images), by analysing DC(Direct Current) component of I(Intra) frame. In this process, we have designed two-stage hierarchical neural network with inputs of various multiple features combined. Then, the system detects the accurate shot position, types of camera operations or object movements by searching P(Predicted), B(Bi-directional) frames of the current picture group selectively and hierarchically. Also, he statistical distributions of macro block types in P or B frames are used for the accurate detection of cut position, and another neural network with inputs of macro block types and motion vectors method can reduce the processing time by using only DC coefficients of I frames without decoding and by searching P, B frames selectively and hierarchically. The proposed method classified the picture groups in the accuracy of 93.9-100.0% and the cuts in the accuracy of 96.1-100.0% with three different together is used to detect dissolve, types of camera operations and object movements. The proposed types of video data. Also, it classified the types of camera movements or object movements in the accuracy of 90.13% and 89.28% with two different types of video data. 본 논문에서는 MPEG 비디오 데이타의 컷(cut)과 디졸브(dissolve)를 검출하여 샷(shot) 단위로 분할하고 각 샷의 카메라 동작 또는 객체 움직임의 형태를 분류하는 방법을 제안하고자 한다. 정확한 샷의 위치와 카메라, 객체의 세분화된 동작을 구별하기 위한 전단계의 연구에서[1] 우선 MPEG 데이타의 I(Intra) 프레임의 DC(Direct Current) 계수를 분석하여 픽처 그룹을 Shot(장면이 바뀐 경우), Move(카메라 동작 또는 객체가 움직인 경우), Static(영상의 변화가 거의 없는 경우)으로 세분화하여 분류하였다. 이 과정에서 2단계 구조의 신경망을 구성하고 여러 종류의 특징을 서로 다른 해상도에서 추출하여 결합시키는 방법을 제안하였다. 다음 단계로 Shot 또는 Move로 분류된 픽처 그룹의 P(Predicted), B(Bidirectional) 프레임을 선별적, 계층적으로 탐색하여 컷의 정확한 발생 위치와 카메라 동작 또는 객체 움직임의 종류를 결정하는 방법을 제안한다. P, B 프레임의 매크로 블록의 종류별 분포를 통계적으로 이용하여 컷의 발생 위치를 검출하며, P, B 프레임의 매크로 블록 종류와 움직임 벡터를 동시에 사용하는 신경망을 구성하여 디졸브, 카메라 동작, 객체 움직임의 종류를 검출한다. 본 논문에서 제안하는 방법은 MPEG 데이타의 압축을 풀지 않은 상태에서 I 프레임의 DC 계수만을 사용하여 픽처 그룹을 분류하며, 분류된 픽처 그룹 내에서 일부의 P, B 프레임만을 계층적으로 선택하여 탐색함으로서 처리 시간을 감소시키고자 하였다. 세 종류의 서로 다른 비디오 데이타를 사용한 실험에서 93.9-100.0%로 픽처 그룹을, 96.1-100.0%로 컷을 검출하였다. 또한 두 종류의 비디오 데이타를 사용한 실험에서 90.13% 및 89.28%의 정확성으로 카메라 동작 또는 객체 움직임을 분류하였다.
Jang, Myoung Jin,You, Dalsan,Park, Jin Young,Kim, Kyung,Aum, Joomin,Lee, Chunwoo,Song, Geehyun,Shin, Ha Chul,Suh, Nayoung,Kim, Yong Man,Kim, Choung-Soo Korean Society for Stem Cell Research 2018 International journal of stem cells Vol.11 No.2
<P>Although previous and ongoing clinical studies have used stromal cells during renal ischemia-reperfusion injury (IRI), there is little consensus regarding the optimal protocol. We aimed to optimize the protocol for hypoxic preconditioned human bone marrow-derived mesenchymal stromal cell (HP-hBMSC) therapy in a rat model of renal IRI. We determined the optimal injection route (renal arterial, renal parenchymal, and tail venous injection), dose (low-dose: 1×10<SUP>6</SUP>, moderate-dose: 2×10<SUP>6</SUP>, and high-dose: 4×10<SUP>6</SUP>), and injection period (pre-, concurrent-, and post-IRI). During optimal injection route study, renal arterial injections significantly reduced the decreasing glomerular filtration rate (GFR), as compared to GFRs for the IRI control group, 2 and 4 days after IRI. Therapeutic effects and histological recoveries were the greatest in the group receiving renal arterial injections. During the dose finding study, high-dose injections significantly reduced the decreasing GFR, as compared to GFRs for the IRI control group, 3 days after IRI. Therapeutic effects and histological recoveries were the greatest in the high-dose injection group. While determining the optimal injection timing study, concurrent-IRI injection reduced elevated serum creatinine levels, as compared to those of the IRI control group, 1 day after IRI. Pre-IRI injection significantly reduced the decreasing GFR, as compared with GFRs for the IRI control group, 1 day after IRI. Therapeutic effects and histological recoveries were the greatest in the concurrent-IRI group. In conclusion, the concurrent-IRI administration of a high dose of HP-hBMSC via the renal artery leads to an optimal recovery of renal function after renal IRI.</P>
Joomin Lee,Hyun A Kim,Jae-Joon Lee 대한지역사회영양학회 2018 Nutrition Research and Practice Vol.12 No.4
BACKGROUND/OBJECTIVES: Obesity is a global health problem of significant importance which increases mortality. In place of anti-obesity drugs, natural products are being developed as alternative therapeutic materials. In this study, we investigated the effect of Brassica juncea L. leaf extract (BLE) on fat deposition and lipid profiles in high-fat, high-cholesterol diet (HFC)-induced obese rats. MATERIALS/METHODS: Male Sprague-Dawley rats were divided into four groups (n = 8 per group) according to diet: normal diet group (ND), high-fat/high-cholesterol diet group (HFC), HFC with 3% BLE diet group (HFC-A1), and HFC with 5% BLE diet group (HFC-A2). Each group was fed for 6 weeks. Rat body and adipose tissue weights, serum biochemical parameters, and tissue lipid contents were determined. The expression levels of mRNA and proteins involved in lipid and cholesterol metabolism were determined by reverse transcription polymerase chain reaction and western blot analysis, respectively. RESULTS: The HFC-A2 group showed significantly lower body weight gain and food efficiency ratio than the HFC group. BLE supplementation caused mesenteric, epididymal, and total adipose tissue weights to decrease. The serum levels of triglyceride, total cholesterol, and low-density lipoprotein cholesterol were significantly reduced, and high-density lipoprotein cholesterol was significantly increased in rats fed BLE. These results were related to lower glucose-6-phosphate dehydrogenase, acetyl-coA carboxylase, and fatty acid synthase mRNA expression, and to higher expression of the cholesterol 7α-hydroxylase and low density lipoprotein-receptor, as well as increased protein levels of peroxisome proliferator-activated receptor α. Histological analysis of the liver revealed decreased lipid droplets in HFC rats treated with BLE. CONCLUSIONS: Supplementation of HFC with 3% or 5% BLE inhibited body fat accumulation, improved lipid profiles, and modulated lipogenesis- and cholesterol metabolism-related gene and protein expression.