자궁경부에 발생한 배아성 횡문근육종 2예

박정열,조준식,김대연,이동헌,김종혁,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.3

횡문근육종은 소아와 청소년기에 가장 흔한 연부조직 육종이다. 발생 부위는 일반적으로 두부 및 경부, 그 다음으로 비뇨생식계이다 조직학적으로 배아성 횡문근육종, 국화상 육종, 폐포성 횡문근육종, 다형성 횡문근육종으로 나누어진다. 횡문근육종의 약 20%가 비뇨생식기에서 발생하고, 50% 이상이 배아성 횡문근육종이다. 여성 생식기의 배아성 횡문근육종은 드문 악성 종양으로,주로 유소아의 질에서 발생하며, 자궁경부에서 발생하는 횡문근육종은 청소년기에 흔하고, 질에서 기원하는 횡문근육종이 자궁경부에 기원하는 경우보다 5배 정도 많다. 폐경기여성에서는 자궁체부에서 가장 흔히 발생한다. 비뇨생식기의 횡문근육종의 치료는 과거에는 골반장기 적출술만으로 치료를 시도하였으나. 서서히 다중 항암화학요법, 방사선요법, 근치적 절제술을 포함한 병합요법으로 바뀌어가고 있으며, 이에 따라 생존율이 현저하게 향상되었다. 이에 저자들은 최근 본원 산부인과에서 자궁경부에 발생한 배아성 횡문근육종 2예를 경험하였기에 문헌 고찰과 아울러 보고하는 바이다. Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and young adult. Genitourinary tract is the econd most common site of rhabdomyosarcoma. Rhabdomyosarcoma can be classified into one of four major types; embryonal, alveolar, pleomorphic and undifferentiated. Embryonal rhabdomyosarcoma of the female genital tract is rare malignant tumor and usually occurs during childhood in the vagina. In rare cases, rhabdomyosarcoma can originate in the uterine cervix, with a peak incidence in the second decade. Recently we have experienced two cases of embryonal rhabdomyosarcoma of the uterine cervix. These cases are presented with a brief review of the literature.

균일 가열 수직 원형관에서의 R-12 임계열유속 예측 상관식 개발을 위한 파라미터의 경향성 분석

이지수,이성우,박주용,김준연,심재우 한국공업화학회 2004 응용화학 Vol.8 No.2

The important parameters that have significant effects on the prediction of CHF (Critical Heat Flux) for R-12 (Dichlorodifluoromethane) were investigated. This was a preliminary study for a R-12 CHF correlation in uniformly heated vertical round tubes. Experimental data of Celata [1], Green and Stevens [2], Groenveld [3], Ilic [4], Katto [5], Merilo and Ahmad [6] and Stevens and Miles [7] were used for this analysis. Four representative CHF data sets at pressure condition of 9, 15, 19, and 27 bar were selected, analyzed, and compared to evaluate the effects other than the system pressure on the CHF were tube diameter (D), mass flux of water (G), and local true mass fraction of vapor (X_(t)). The results of this study have reaffirmed the feasibility that an advanced R-12 CHF correlation for uniformly heated vertical round tubes can be found.

정신분열병과 Glutathione S-Transferase M1유전자 다형성

배치운,조자현,김연주,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : This study aimed to test the possible association between Glutathione S-Transferase Ml gene (GSTMl) variants and schizophrenia. Methods : One hundred and eleven inpatients with schizophrenia and 130 healthy controls were recruited. Genotyping was performed by polymerase chain reaction-based method. Results : The GSTMl null genotype was significantly more frequent in patients with schizophrenia than in controls (p=0.014, odd ratio=1.93, 95% confidence interva1=1.115-3.351), while GSTMl genotype vahants were not associated with either tardive dyskinesia (TD) or total Abnormal Involuntary Movement Scale (AIMS) scores. Conclusion : The present study suggests that the GSTMl polymorphism may confer susceptibility to the development of schizophrenia but not to TD, at least in Korean population.

정신분열병 환자의 말초 임파구에서 도파민 수용체 mRNA의 변화

곽용태,최철희,김옥준,주연호,김형섭,강성숙,구민성,선우일남 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 정신분열병은 주로 청소년기에 발병하는 정신과에서 가장 흔한 질환 중의 하나이다. 이 질환의 원인이나 병인은 아직 불확실하지만 뇌 도파민계의 기능장애가 중요한 기전으로 생각되고 있으나 부검없이 뇌 도파민계를 직접 관찰할수 없으므로 많은 혼란이 있어왔다. 이를 극복하기 위하여 최근에 발견된 말초 임파구의 도파민 수용체를 이용하여 정신분열병에 있어서 말초 임파구 도파민 수용체가 뇌 도파민계의 기능을 반영하는 말초표식인자일 가능성이 있는지를 규명한다. 방 법 : 3년 이상 항정신병 약물을 복용중인 정신분열병 환자(약물투약군) 44명, 최근 3개월 이상 항정신병 약물을 복용하지 않은 환자(약물비투약군) 43명, 정상대조군 31명을 대상으로 말초 임파구의 D3, D5 도파민 수용체를 정량적 역전사 중합효소 연쇄반응(quantitative reverse transcritpase polymerase chain reaction)을 이용하여서 정량 비교하였고, 또한 항정신병 약물을 복용하지 않은 환자들에 있어서 약물 투여 후 도파민 수용체의 변화 및 임상양상의 변화를 관찰하였다. 결 과 : 1) 말초혈액 임파구의 D3R/βA는 약물비투약군에서 정상대조군이나 약물투약군에 비하여 통계적으로 유의하게 있게 증가되어 있었다. D5R/βA의 경우 약물비투약군이 약물투약군에서만 비하여 유의하게 증가되었다. 그러나 약물투약군과 정상대조군 간에는 도파민 수용체 mRNA(D3R/βA, D5R/βA)양에 있어서 차이가 없었다. 2) 항정신병 약물을 새로 투여하는 환자에서 항정신병 약물을 투여 후 임파구 도파민 수용체의 변화를 추적 관찰한 결과 증가하는 경향을 보였다. 3) 약물비투약군을 정상 대조군과 비교하여 D3R/βA mRNA가 정상범위에 속하는 군과 높은 군으로 나누어서 임상척도와 비교 분석한 결과 임파구 도파민 수용체가 증가한 군에서 다음과 같은 임상특징을 관찰할 수 있었다. (1) 정신병리증상이(BPRS) 현저하였다. (2) 약물치료에 대해 양성 정신병리증상(pBPRS)의 호전도가 낮았다. (3) 약물치료시 추체외로 부작용이 심하였다. 결 론 : 이상의 연구결과로 말초 임파구에서 발현되는 도파민 수용체는 정신분열병의 소군 분류 및 예후 예측에 있어서 임상적 의의가 있는 것을 알 수 있었다. 따라서 말초임파구에서 발현되는 도파민 수용체는 비록 이에 상응하는 뇌의 해부학적 위치는 알 수 없지만 중추신경계의 도파민 수용체의 기능을 반영할 가능성이 높다고 생각되었다. Objectives : Schizophrenia, commonly developed in adolescence and young adulthood, is one of the most common mental diseases in psychiatry. The etiology or pathogenesis of this disease is uncertain yet, but the dysfunction of dopaminergic system in the brain has been proposed. However, there is no direct evidence of dysfunction of brain dopaminergic systems in schizophrenic patients because the direct assessment of brain dopaminergic systems is almost impossible at present. To overcome this problem, recently founded dopamine receptors and their mRNAs in peripheral lymphocytes was used. The purpose of this study was to define whether the dopamine receptors of peripheral lymphocytes can be the peripheral markers of schizophrenia or not. Methods : The total numbers of subjects are 87 schizophrenic patients. Among them 44 patients were schizophrenics who had been taking antipsychotic drugs for more than 3 years(medicated patients), 43 schizophrenics who recently are not taken antipsychotic drugs for more than 3 months(drug-free patients). For controls age and sex matched 31 healthy persons were enrolled. Sequential reverse transcription and quantitative polymerase chain reaction of the mRNA were used to investigate the expression of dopamine receptors in peripheral lymphocytes. The gene expression of dopamine receptors were compared in each groups and after starting antipsychotic medicines in drug-free patients, the clinical scales and the dopamine receptors of peripheral lymphocytes were sequentially studied before, 2 weeks after and 8 weeks after medication. Results : 1) In drug-free schizophrenics, D3 dopamine receptor mRNA expression of peripheral lymphocytes was significantly increased comparing with that of controls and drug-medicated schizophrenics and D5 dopamine receptor mRNA expression was increased comparing with only that of drug-medicated schizophrenics. There was no difference between controls and drug-medicated schizophrenics. 2) After antipsychotic medication, dopamine receptors of lymphocytes were increased tendency. 3) Drug-free patients were divided into two groups according to dopamine receptor expression in controls to evaluate the significance of increased dopamine receptor expression. The group of patients with increaseddopamine receptor expressio had following clinical characteristics. (1) More severe psychiatric symptoms (2) Poor pharmacological response of pBPRS on medicines (3) Severe extrapyramidal side effects after pharmacological treatment Conculsion : These results revealed that the molecular biologically determined dopamine receptors of peripheral lymphocytes were reactive, and increased expression of dopamine receptor in peripheral lymphocyte had clinical significance for subgrouping and prognostication. These findings suggested that dopamine receptors of peripheral lymphocyte may represent dopamine receptors of the brain, even the location cannot be determined.

Ziprasidone의 자연적 임상경험에 대한 후향적 조사 연구 : 3개 대학병원의 경험

이승재,강도형,홍경수,주연호,김남식,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3

Objectives : This naturalistic retrospective study investigated the effectiveness of ziprasidone measured by mean improve-ments of the Cltnical Global Impression (CGI-I). Secondary objectives included prescribing patterns, tolerability and safety. Methods : From May to July 2006, 98 psychiatric patients who have been taking ziprasidone for at least 2 weeks were selected. Their current clinical statuses were assessed by the interview and laboratory tests including electrocardiogram (ECG). Data on DSM-IV diagnoses, dosing, concomitant psychotropic medications, clinical changes, adverse effects, and laboratory findings were collected retrospectively. Results : Ziprasidone was mostly prescribed for a switch from another antipsychotics for the treatment of schizophrenia. Two main reasons for a switch were unsatisfactory efficacy and poor tolerance, especially weight gain, of the preceding anti-psychotic medication, Participants as a whole showed mean 2.7±1.0 of the CGI-Improvement. Significant weight reduction after switching to ziprasidone occurred, which was related to the clinical improvement. No significant increase of the QTc interval except one case was observed. Conclusion : The present study confirmed previous tolerability and safety data of ziprasidone as well as the results of its effectiveness.

Reduced Brain Gray Matter Concentration in Patients With Obstructive Sleep Apnea Syndrome

Joo, Eun Yeon,Tae, Woo Suk,Lee, Min Joo,Kang, Jung Woo,Park, Hwan Seok,Lee, Jun Young,Suh, Minah,Hong, Seung Bong Oxford University Press 2010 SLEEP Vol.33 No.2

Treatment of Elastosis Perforans Serpiginosa with the 585-nm Pulsed-dye Laser

( Yeon Gu Choi ),( Sang Yeon Kim ),( Ji Soo Park ),( Kyu Yeon Kim ),( Bo Bin Cha ),( Jin Seop Kim ),( Gyoo Huh ),( Heun Joo Lee ),( Young Jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

Poster Session 2 : Activation of Toll Like receptor-2 induce interleukin-15 in fibroblast Like synoviocytes in rheumatoid arthritis

( Joo Yeon Jhun ),( Mi La Cho ),( Kyoung Woon Kim ),( Hye Jwa Oh ),( So Yeon Min ),( Chong Hyeon Yoon ),( Jun Ki Min ),( Sang Heon Lee ),( Sung Hwan Park ),( Ho Youn Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

Systemic Human T Cell Developmental Processes in Humanized Mice Cotransplanted With Human Fetal Thymus/Liver Tissue and Hematopoietic Stem Cells

Joo, Sung-Yeon,Chung, Yun Shin,Choi, Bongkum,Kim, Miyoung,Kim, Jong-Hwa,Jun, Tae-Gook,Chang, Jun,Sprent, Jonathan,Surh, Charles D.,Joh, Jae-won,Kim, Sung Joo Lippincott Williams Wilkins, Inc. 2012 Transplantation Vol.94 No.11

BACKGROUND: In many humanized mouse models, there are few T cells in the engrafted human cell, whereas the number of B cells is high. We attempted to overcome this limitation and investigate whether the entire process of human T cell development arose similarly to the process in humans, as previously reported. METHODS: To produce an advanced humanized mice model, we transplanted human fetal liver/thymus tissue subrenally and injected human CD34 stem cells intravenously into NOD/SCID/IL2Rgamma null (NSG) mice. RESULTS: Humanized mice transplanted with fetal thymus/liver tissues and fetal liver-derived CD34 stem cells (FLT+FLCD34) showed higher levels of human cells and T cells than mice transplanted with fetal liver-derived CD34 stem cells only (FLCD34). In the transplanted thymus tissue of FLT+FLCD34 mice, thymus seeding progenitors (TSPs), early thymic progenitors (ETPs), pre-T cells, and all the other human T cell populations were identified. In the periphery, FLT+FLCD34 mice have high levels of CD45RA T cells; conversely, FLCD34 mice have higher levels of CD45RO T cells. The CD45RO T cells of FLCD34 mice proliferated rapidly after stimulation and exhibited innate T cells properties, expressing PLZF (promyelocytic leukemia zinc finger protein). CONCLUSION: Human T cells educated by mouse MHC II in mice without a human thymus differ from normal human T cells. On the basis of these findings, numerous T cell-tropic human diseases could be explored in our humanized mice and molecular aspects of human T cell development could be also studied extensively.

Poster Session 2 : Oral Presentation ; Immunology : Activation of Toll Like receptor-2 induce interleukin-15 in fibroblast Like synoviocytes in rheumatoid arthritis

( Joo Yeon Jhun ),( Mi La Cho ),( Kyoung Woon Kim ),( Hye Jwa Oh ),( So Yeon Min ),( Chong Hyeon Yoon ),( Jun Ki Min ),( Sang Heon Lee ),( Sung Hwan Park ),( Ho Youn Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2005 62회 KSBMB Annual Meeting in 2005 Vol.- No.-