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Lee, Jongkyu,Hwangbo, Cheol,Lee, Jung Joon,Seo, Juhee,Lee, Jeong-Hyung National Hellenic Research Foundation 2010 ONCOLOGY REPORTS Vol.23 No.1
<P>Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapeutics due to its ability to induce apoptosis selectively in cancer cells. However, sensitivity of cancer cells for induction of apoptosis by TRAIL varies considerably. Therefore, it is important to develop agents that overcome this resistance. We show, for the first time, that eupatolide, the sesquiterpene lactone isolated from the medicinal plant Inula britannica, sensitizes human breast cancer cells to TRAIL-induced apoptosis. Treatment with TRAIL in combination with subtoxic concentrations of eupatolide enhanced the TRAIL-induced cytotoxicity in MCF-7, MDA-MB-231 and MDA-MB-453 breast cancer cells, whereas each reagent alone slightly induced cell death. The combination induced sub-G1 phase DNA content and annexin V-staining in MCF-7 cells, which are major features of apoptosis. Apoptotic characteristics induced by the combined treatment were significantly inhibited by a pan-caspase inhibitor. The sensitization to TRAIL-induced apoptosis was accompanied by the activation of caspase-8 and was concomitant with Bid and poly(ADP-ribose) polymerase (PARP) cleavage. Treatment of eupatolide alone significantly down-regulated the expression of cellular FLICE inhibitory protein (c-FLIP) in MCF-7 cells. Furthermore, enforced expression of c-FLIP significantly attenuated the apoptosis induced by this combination in MCF-7 cells, suggesting a key role for c-FLIP down-regulation in these events. We also observed that euaptolide inhibited AKT phosphorylation in a dose- and time-dependent manner. Moreover, inhibition of Akt by LY294002, a specific PI3K inhibitor, down-regulated c-FLIP expression in MCF-7 cells. Taken together, these results indicate that eupatolide could augment TRAIL-induced apoptosis in human breast cancer cells by down-regulating c-FLIP expression through the inhibition of AKT phosphorylation and be a valuable compound to overcome TRAIL resistance in breast cancer cells.</P>
JongKyu Lee,DaeHo Kim,Manh Ha Nguyen,Young Jun Bae,Philaxay Manilak 강원대학교 산림과학연구소 2021 Journal of Forest Science Vol.37 No.2
Mushroom survey and collection were conducted in the Dong Hua Sao National Biodiversity Conservation Area (DHSNBCA), which is located about 30 km east of Pakse and about 10 km south of the town of Paksong, Champasak Province of Lao-PDR, from from at the early July to October in 2019. During this periods, mushroom specimens were collected from 6 different locations, and then they were identified and classified into 103 species, 74 genera, 37 families, 15 orders and 6 classes by morphological and molecular analyses. The mushrooms belongs to Ascomycota were classified into 10 species, 6 genera, 4 families, 3 orders and 2 classes, while those belongs to Basidiomycota were classified into 92 species, 67 genera, 32 families, 11 orders, and 3 classes, respectively. In addition, 1 species of Myxomycota was also identified. Among these mushrooms, the most species-rich families are Marasmiaceae (17.3%), Polyporaceae (13.1%), Mycenaceae (8.9%), Agricaceae (8.3%), Xylariaceae (6.5%), Auriculariaceae (4.8%), Ganodermtaceae (3.6%), Dacrymycetaceae (3.0%), Meruliaceae (3.0%), Russulaceae (3.0%) and comprised 71.4% of the total specimens identified.
Anti-doping education and dietary supplementation practice in Korean elite university athletes
Jongkyu Kim,Namju Lee,Eung-Joon Kim,Sun-kyung Ki,Jaeryang Yoon,Mi-sook Lee 한국영양학회 2011 Nutrition Research and Practice Vol.5 No.4
This study was conducted to investigate relationships and gender differences in dietary supplement (DS) and oriental supplement (OS) prevalence as well as anti-doping awareness during training and the game period. Korea National Sport University athletes (343 male and 136 female) participated in this study and completed DS and OS practice and anti-doping awareness questionnaires. Forty-six percent of athletes used DS during the training period, and there was significantly higher DS use in females (53%) compared to males (43%) (P < 0.05). Twenty-eight percent of athletes used OS, and there was significantly higher OS use in females (35%) than males (26%) (P < 0.05) during the training period. The primary reason of DS use was to supply energy both in males (36%) and females (28%). The main reason for male athletes' OS use was to supply energy (41%). Meanwhile, the reasons for female athletes' OS use were to supply energy (23%), to maintain health (19%), and to improve recovery ability (20%), which showed a significant gender difference (P < 0.05). Athletes rated their perceived degree of satisfaction, perceived importance, and beliefs in efficacy of DS and OS use all over 50% during the training period, and no gender differences were detected. In a comparison between athletes educated about anti-doping (at least more than one time) and non-received athletes, DS and OS use during the training period was 2.30 (1.47-3.60) and 1.71 (1.03-2.82), respectively. DS and OS use immediately before the game period was 2.38 (1.50-3.80) and 3.99 (1.20-13.28), respectively. Elite athletes' anti-doping education was highly related to increased DS use during the training period and immediately before the game. Although elite athletes use various DS and OS during the training period and before the game period, doping education for elite athletes is related with DS and OS use during the training period and before the game.
Simulation Study of the Disruption Load in KSTAR Device with a Modified Passive Stabilizer
Jongkyu Lee,J. Y. Kim 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.3
The structure of the passive stabilizer system in KSTAR (Korea Superconducting Tokamak AdvancedResearch) device was recently modified mainly in relation to the upgrade of the verticalposition control system. Corresponding to this design change in one of the plasma facing components,a simulation study was performed to see how the disruption load and the characteristicsvaried. During the vertical drift phase, the vertical growth rate is shown to be increased by about8 times while the vertical force on the passive stabilizer is reduced by about 5 times for the newpassive stabilizer compared with the old one. Meanwhile, during the thermal and current quenchphase, relatively small differences were observed in the disruption load and characteristics betweenthe two models.
이종규(Jongkyu Lee),김인동(Indong Kim),고찬희(Chanhee Ko),맹세호(Seiho Maeng) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This paper is represented study on the robust design of an intake system using a transmission loss and a frequency weighting function. First, transmission loss is measured to obtain the performance value of noise reduction for the intake system. The robust design parameters of an intake system are extracted by adapting a cost function with the taguchi method. Subsequently, the frequency weighting function is developed using subjective evaluation where 6 special engineers participated in the experiment. Finally, a comparative work between the proposed frequency weighted optimal design and unweighted optimal design of the transmission loss at part condition is undertaken. Here, overall level of transmission loss at current and each optimal condition are presented to validate the effectiveness of the proposed methodology.
이종규(Jongkyu Lee),김인동(Indong Kim) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_2
In this paper, in order to develop a linear regression model for the sound quality index of vehicle interior noise, an objective measurement data of vehicles driving in acceleration was measured. On the basis of analysis, psychoacoustic parameters were extracted and subjective evaluation was performed by noise and vibration expert evaluators. The subjective evaluation was used paired comparisons and semantic differential methods to evaluate sound Quality of vehicle interior noise. By using paired comparison which evaluate two pairs of vehicle interior noise, it was estimated preference of vehicle. With the methods of semantic differential and factor analysis, it was evaluated words of two pairs of adjective which expressed appropriately the sense of evaluator about noise source. Therefore sound quality characteristics of vehicle were differentiated. From results of both the correlation analysis and the multiple factor regression analysis, sound quality evaluation model for the sense of human hearing was derived and was indexed.
이종규(Jongkyu Lee),박영원(Youngwon Park),채장범(Jangbom Chai),장한기(Hankee Jang) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
In this thesis, we developed the sound quality index in vehicles by analyzing an objective measurement and a subjective evaluation data with statistical method. In order to develop the sound quality index for interior noise, objective measurement of vehicles driving in acceleration was measured. Simultaneously, subjective evaluation in 10-scale was performed by noise and vibration engineers. Also, the correlation analysis of psycho-acoustic parameters was performed based on objective measurement and subjective evaluation. The most critical factors at wide open test condition were adopted. Next, the new equation of sound quality index was derived through regression analysis of the factors. Finally, a testing was conducted in order to validate the effectiveness of the proposed index.
김종규(Jongkyu Kim),배태성(Taesung Bae),이동우(Dongwoo Lee),이권희(Kwonhee Lee) 한국자동차공학회 2009 한국자동차공학회 학술대회 및 전시회 Vol.2009 No.11
The basic purpose of a tire is to enable better vehicle performances such as driving performance, rolling resistance, durability, ride comfort, noise, wear resistance, etc, by providing a flexible cushion. In response to improvement of vehicle performances, the design method of a tire is developing much. This study proposes a structural design method for a tire contour by considering both the tread contour and the sidewall contour, simultaneously. However, the existing studies of tire contour optimization were interested in the tread contour and the sidewall, respectively. The durability, maneuverability and ride comfort are the commonly investigated performances in tire contour design. The durability, maneuverability and ride comfort can be measured by the value of strain energy density, tension and vertical stiffness, respectively. The optimization technique using metamodel is introduced to maximize durability satisfying the imposed constraints of tension and ride comfort. To achieve this, the responses defined in optimization formulation are expressed in mathematically explicit form with respect to the design variables by using kriging surrogate model, resulting a simple optimization problem. Then, the simulated annealing algorithm is utilized to find global optimum.