http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Ji Hoon Kim ),( Jung Soo Kim ),( Ha Ryeong Ryu ),( Cheol Hun Yoon ),( Eun Hee Lee ),( Jong Rok Lee ),( Joo Young Roh ),( Youn Jae Chung ),( Jin Ok Baek ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Atopic dermatitis is a chronic recurrent inflammatory skin disease that often that affects up to 20% of children. The pathogenesis of atopic dermatitis is not fully understood, but newly identified immune cells such as ILC2s have been suggested to play an important role. Food allergy is a known provoking cause of AD, but the exact relationship between oral tolerance to food antigen and development of AD is still unknown. Objectives: To show 1) oral tolerance can hindered the development of AD-like skin lesions in mouse model by epicutaneous sensitization with OVA. 2) ILC2s play acrucial role in oral tolerance-induced epicutaneous sensitization mouse model. Methods: BALB/C female mice were sensitized with OVA by epicutaneous application. Experimental group was feed with OVA by oral route before treatment. We analyzed changes of antibodies, cells and cytokines in MLN andskin of each group. Results: Epicutaneous sensitization increased level of anti-OVA IgE and IgG1, while oral tolerance decreasedlevel of anti-OVA IgE and IgG1. In oral tolerance group, increased DCs, iTregs, TGF-モ in MNL and decreased IL-5, IL-13, Ccr3 in skin were shown. Also, ILC2s were decreased in oral tolerance group. Conclusion: 1. Oral tolerance induced by OVA hindered the development of AD-like skin lesions in epicutaneous sensitized mice with OVA. 2. MLN-induced Tregs plays main role in induction of oral tolerance. 3. When AD-like skin lesions occur after oral tolerance, ILC2s are increased. They are con
A case of mushroom dermatitis by matsutake mushroom ingestion
( Ji Hoon Kim ),( Jeong Soo Kim ),( Ha Ryeong Ryu ),( Chyl Hyun Yoon ),( Jin Ok Baek ),( Joo Young Roh ),( Jong Rok Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Mushrooms are antigenically rich, and type I, III and IV immunopathologic reactions to different species of mushrooms have been reported. Matsutake mushroom (Tricholoma matsutake) is a typical edible mushroom available in Asian meals. There have been several cases of allergic responses after ingestion of matsutake mushroom mainly composed of anaphylactic reactions. A 34 years-old female patient presented with pruritic confluenterythematous targetoid maculopatches on her legs spreading to abdomen. She was 34-weeks pregnant primipara and the eruption started 1 week earlier. She could not remind any specific history of either infectious symptom or specific drug ingestion. On histopathologic examination, non-specific features were observed, including focal spongiotic epidermis, papillary dermal edema, and superficial perivascular infiltration of lymphocytes and eosinophils. Leukocytosis with eosinophilia was found on initial laboratory examination. Upon further questioning, she revealed a history of natural matsutake mushroom consumption 1 week before the onset of the eruption. A diagnosis of mushroom dermatitis was made, and the lesion improved after treatment of systemic steroid combined with cyclosporine. Here we reported a rare case of mushroom dermatitis which developed 1 week after ingestion of raw matsutake mushrooms. Matsutake mushroom should be considered as a possible causative allergen and detailed history would be necessary.
Spinal Arteriovenous Malformation Masquerating Zoster Sine Herpete
( Ji Young Lee ),( Se Jin Ok ),( Chang Keun Oh ),( Sun Kyung Park ),( Do Wan Kim ),( Jong Yeun Yang ) 대한통증학회 2013 The Korean Journal of Pain Vol.26 No.1
Zoster sine herpete (ZSH) is difficult to diagnosis during an acute period due to the absence of the characteristic zosteriform dermatomal rash; therefore, progression to postherpetic neuralgia is more common than typical zoster. In addition, misdiagnosis of other neuropathic pain as ZSH is common in clinical situations. Here, we report a case of spinal arteriovenous malformation that mimics ZSH. This is a rare condition; therefore, high clinical suspicion for a correct diagnosis and proper examination are not easy. However, early diagnosis and definitive treatment are essential to prevent neurologic deficit and mortality. (Korean J Pain 2013; 26: 72-75)
Ji Yun Lee,Jin Ho Paik,Koung Jin Suh,김지원,Se Hyun Kim,Jin Won Kim,Yu Jung Kim,Keun-Wook Lee,Jee Hyun Kim,Soo-Mee Bang,Jong-Seok Lee,Jeong-Ok Lee 대한혈액학회 2021 Blood Research Vol.56 No.4
Background High-dose chemotherapy followed by autologous stem cell transplantation (HDC-ASCT) as a consolidation treatment is a promising approach for eligible patients with newly diagnosed primary central nervous system lymphoma (PCNSL). Methods In this retrospective analysis, 22 patients with newly diagnosed PCNSL received chemotherapy with rituximab, methotrexate, procarbazine, and vincristine. Those who showed complete or partial response subsequently received consolidation HDC-ASCT with a thiotepa- based conditioning regimen but did not undergo radiotherapy. Results The PCNSL patients had a median age of 57 years (range, 49‒67 yr); of the total patients, 9.1% had a performance status of 2 or higher, and 72.1% had multiple lesions. Approximately 82% of patients received six cycles of induction chemotherapy, which was well tolerated with excellent disease control. The rate of confirmed or unconfirmed complete response increased from 45.5% at the period of interim analysis to 81.8% prior to the initiation of HDC-ASCT. With a median follow-up of 19.6 months (range, 7.5‒56.5 mo), the 2-year progression-free survival and overall survival estimates were 84% and 88%, respectively. No treatment-related deaths occurred. Grade 3 toxicity was recorded in 90.9% of the patients after undergoing the HDC-ASCT, and the most common grade 3 adverse event was febrile neutropenia without sepsis. Conclusion The discussed treatment approach is feasible in patients with newly diagnosed PCNSL, yielding encouraging results.
Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney Injury In Vitro and In Vivo
Jong-Hyun Nho,Ho-Kyung Jung,Mu-Jin Lee,Ji-Hun Jang,Mi-Ok Sim,Da-Eun Jeong,Hyun-Woo Cho,Jong-Choon Kim 한국독성학회 2018 Toxicological Research Vol.34 No.2
Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that 10 μM cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells. To confirm the effect of cynaroside on cisplatin-induced kidney injury in vivo, we used cisplatin exposure animal model (20 mg/kg, balb/c mice, i.p., once a day for 3 days). Renal dysfunction, tubular damage and neutrophilia induced by cisplatin injection were decreased by cynaroside (10 mg/kg, i.p., once a day for 3 days). Results indicated that cynaroside decreased cisplatin-induced kidney injury in vitro and in vivo, and it could be used for improving cisplatin-induced side effects. However, further experiments are required regarding toxicity by high dose cynaroside and caspase-3/MST-1-linked signal transduction in the animal model.