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트리암시놀론아세토나이드 함유 구강점막 필름제의 제제설계 및 평가
이계주,박종범,신광현,이덕근,황성주 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
To design and evaluate the double-layered mucoadhesive film preparation for the treatment of aphthous stomatitis, the film consisting of an adhesive layer containing triamcinolone acetonide and impermeable protective layer was prepared by a solvent-casting evaporation technique and subsequent drying. The polymers, Polycarbophil®, Carbopol®, CMC and gelatin, swell appoximately 2 times its volume in 30 minutes when added to water. In vitro adhesive time was longer than 8hrs and adhesive force was 177-482g/㎤. The diffusion rate of triamcinolone acetonide from film was faster than that of commercial tablet but slower than that of the film. the effect of plasticizer on the protective layer showed that the more amount of plasticizer, the greater elongation, the lesser tensile strength. The stability of drug in the film revealed that no significant reduction in the content of triamcinolone acetonide during a period of six months at room temperature and 40℃ 75% RH. Drug deposit amount permeated through hsmster cheek pouch mucosa from film was greater than that of control film and tablet. In human oral mucosa, adhesive time was between 2.38∼2.83hrs. The adhesive feeling to the human muoscal membrane of sample was better than compared with commercial film and tablet.
Numerical Modeling for Systematization of Line Heating Process
Shin, Jong-Gye,Kim, Won-Don,Lee, Jang-Hyun The Society of Naval Architects of Korea 1996 Journal of hydrospace technology Vol.2 No.1
Sculptured surface structures such as ship hulls are traditionally formed up to the required double curved shape by line heating method. The nature of the line heating process is a transient thermal process, followed by a thermo-elastic-plastic stress field. The permanant shape is dependent on many factors involved in the process, Among them are torch speed and path, supplied heat type and amount , and plate size. Thus, the work is essentially leaded by experts with lots of experiences. However, in order to effectively improve productivity through automation, each factor should be clearly examined how much it affects the final shape. This can not be done only by experiments, but can be achieved by a mechanics-based approach. In this paper, we propose a conceptual configuration for plate forming system, and then present simulations of the line heating process with numerical data in practices and suggest a computerized process of the line heating for practical applications. The modeling of heating torch, water cooling, and the plate to be formed is proposed for the finite element analysis after the mechanics of line heating is studied. Parametric studies are given and discussed for the effects of plate thickness, torch speed and initial curvature in forming a saddle typed surface.
Finite Difference Analysis of Safe Load and Critical Time in a Four-Parameter Viscoelastic Column
Shin, Jong-Gye,Lee, Jae-Yeul The Society of Naval Architects of Korea 1996 Journal of hydrospace technology Vol.2 No.2
A creep-buckling analysis is studied for a simply-supported viscoelastic column. The fluid-type four-parameter model is employed because of its general applicability to creep materials. Using the imperfection-based incremental approach, a nonlinear load deflection equation is derived. Safe load and critical (or life) time which characterize the stability of the viscoelastic column are obtained mathematically and interpreted physically. A finite difference algorithm is applied to solve the second-order differential equation of the viscoelastic stress-strain relation. Numerical calculation has been made and discussed far a SUS316 stainless steel column.
Development of a Control System for Automated Line Heating Process by an Object-Oriented Approach
Shin, Jong-Gye,Ryu, Cheol-Ho,Choe, Sung-Won The Society of Naval Architects of Korea 2002 Journal of ship and ocean technology Vol.6 No.4
A control system for an automated line heating process is developed by use of object-oriented methodology. The main function of the control system is to provide real-time heating information to technicians or automated machines. The information includes heating location, torch speed, heating order, and others. The system development is achieved by following the five steps in the object-oriented procedure. First, requirements are specified and corresponding objects are determined. Then, the analysis, design, and implementation of the proposed system are sequentially carried out. The system consists of six subsystems, or modules. These are (1) the inference module with an artificial neural network algorithm, (2) the analysis module with the Finite Element Method and kinematics analysis, (3) the data access module to store and retrieve the forming information, (4) the communication module, (5) the display module, and (6) the measurement module. The system is useful, irrespective of the heating sources, i.e. flame/gas, laser, or high frequency induction heating. A newly developed automated line heating machine is connected to the proposed system. Experiments and discussions follow.