성인에서 Haemophilus influenzae 감염증의 임상양상과 미생물학적 특성

이종섭,황병연,정희진,김우주,박승철,이도현,이창규,신종희,황규잠,이영희 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.2

목적 : H. influenzae는 성인에서 흔히 호흡기 감염을 일으키는 균주로, 최근 ampicillin 내성 β-lactamase 생성 균주들이 지속적인 증가를 보이고 있어, 이에 국내 성인에서 H. influenzae에 의한 감염의 임상양상과 분리된 균주들의 미생물학적 특성을 조사하고자 하였다. 방법 : 1998년 3월부터 1999년 9월까지 고려대 구로병원에 내원한 환자중에서 H. influenzae가 분리된 68명을 대상으로 임상양상을 조사하고 항균제 감수성 검사를 시행하였다. 분리된 33주에 대해서 혈청형, 생물형, 세포외막 단백분석을 시행하였고, β-lactamase 생성여부에 따른 감염 환자군간 임상상 및 예후의 차이를 비교하였다. 결과 : 환자의 평균연령은 68세였고, 지역사회 획득감염이 전체의 85%를 차지하였다. 폐렴과 기관지염과 같은 하기도 감염이 전체환자의 75%를 차지하였고 분리 검체 역시 객담이 84%로 가장 많았다. 환자의 71%가 기저질환을 가지고 있었으며, 그 중에 만성 폐쇄성 폐질환, 심혈관 질환, 악성종양, 당뇨병이 대부분이었다. 혈청형으로는 nontypeable 형이 68%로 가장 많았고 b형은 한 예도 없었다. β-lactamase 생성율은 63.2%였고, β-lactamase 양성균주의 항균제 내성율이 음성균주에 비하여 높았으나 β-lactamase 생성 여부에 관계없이 cefotaxime, azithromycin, ciprofloxacin에 대하여 100%의 감수성을 나타내었고 cefaclor, cefuroxime에 대해서는 10% 이하의 낮은 내성율을 보여 이들 항균제들이 치료에 효과적일 것으로 사료된다. 세포외막 단백분석에서는 C형과 D형이 전체의 64%로 가장 많았으며, 혈청형과의 유의한 연관성은 보이지 않았다. 결론 : 성인에서 H. influenzae는 주로 만성 기저질환자에서 급성 호흡기감염 또는 만성 폐쇄성 폐질환의 급성 악화를 유발한다. 기존의 보고에 비해 β-lactamase 양성율이 증가하였고, 이에 따른 항균제 내성율도 증가하여 항균제의 선택에 유의하여야 할 것으로 생각된다. 세포외막 단백분석상 특정한 유형의 균주에 의해 감염이 집중적으로 발생하고 있어 향후 역학 조사의 도구로 이용할 수 있겠다. Purpose : H. influenzae is one of the common causative microorganisms of respiratory tract infections in adults. Recently. β-lactamase producing, ampicillin-resistant H. infiuenzae has become worldwide problem as well as in Korea. We studied to investigate the clinical features and microbiologic characteristics of H. infiuenzae infections in adults. Materials & Methods : From March 1998 to September 1999, 68 patients were enrolled in this study. Clinical features of H. infiuenzae infections were investigated, 68 isolates were subjected to the β-lactamase test, and 33 isolates were used for serotyping. biotyping, antibiotic susceptibility and outer membrane protein (OMP) analysis. Results : Mean age of study patients was 68 years-old and the acquisition rate in community was 85%. Pneumonia and bronchitis were the most common type of infection such as 80%, sputum was the most common clinical specimen for H. mQuenzae isolation. 70% of patients had chronic underlying diseases. Non-typeable strains were 68% and β-lactamase producing rate was 63%. There was no difference in the clinical features and prognosis of H. influenzae infection between the β-lactamase positivie and -negative groups. The susceptibility of cefotaxime, azithromycin, and ciprofloxacin was 100% and that of cefaclor, cefuroxime was under 10% in spite of β-lactamase positivity. In OMP analysis, C and D types were dominant (64%). Conclusion : H. influenzae caused acute respiratory infections in adults with chronic underlying disorders. This study shows higher β-lactamase producing rate and antibiotic-resistance rate than that were reported previously. OMP analysis shows that two major types of strains cause clinical infections intensively.

심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

평면형 Bi-Sb 다중접합 열전변환기의 특성

이현철,유호종,김진섭,함성호,신장규,이종현,이정희,권성원,박세일 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

A planar Bi-Sb multijunction thermal converter for the precise measurements of ac voltage and current has been fabricated and its characteristics was discussed. In order to convert ac power into heat, a bifilar thin film Pt-heater, which could cancel its Thomson and Peltier effects, was prepared on the Si_(3)N_(4)/SiO_(2)/Si_(3)N_(4) diaphragm for the thermal isolation between heater and silicon substrate. To convert the temperature or the heat generated by the heater into dc voltage and current, hot and cold junctions of the Bi-Sb thermopile, which has a large difference in Seebeck coefficients, were formed on the dielectric diaphragm and the silicon substrate, respectively. The respective thermal sensitivity of the thermal converter with a bifilar heater was about 10.1 mV/mW and 14.8 mV/mW in the air and vacuum, which is about eight times higher than that of commercial 3-dimensional thermal converter. In the case of ac 2 V-input voltage, the ac-dc voltage transfer difference was about ±2.0 ppm, and in the case of ac 10 mA-input current, the ac-dc current transfer difference was about ± 0.6 ppm, in the frequency range from 10 Hz to 10 kHz.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

沿岸施設物의 配置 및 環境影響評價에 關한 硏究

李宗燮,張善德 釜山水産大學校 1988 釜山水産大學 硏究報告 Vol.28 No.1

Environmental assessment procedures pertaining to the construction of coastal facilities are reviewed. Hydraulic environmental factors are divided into the primary and the secondary factors and are discussed. Conservative equations on these physical phenomena were systematized and then it's application range and numerical prediction techniques were classfied in details. The flow chart on basic concepts for the optimum layout planning of coastal facilities and some application cases were suggested.

海外投資에서 政治的危險 對應戰略

李鍾燮 군산대학교 1985 論文集 Vol.10 No.-

Foreign investment has played an increasingly important role in the world economy since the Second World War because international trade is hindered by various means.Especially foreign investment is essential for our nation which keeps poor resources. Because companies engaged in foreign investment carry out their business activities within the host country circumstance, the operations of these companies are affected by forces and events, as it were political risks, that are controlled directly or indirectly by the host government.The representative examples of political risks are war, nationalization, expropriation, and remittance restriction. Although there is no general method on how to manage political risks, companies should make out strategy in its various phases to get away from loss.In the previous phase to foreign investment, companies should analize deeply the possibility of political risks in the host country.In the next phase, they should exert every efforts to avoid from political risks.And in the phase of met with the political risks, they should endeavor every efforts to minimize their loss. In addition to above, government-sponsored investment insurance and guarantee program can mitigate political risks for companies doing business in foreign country. To activate of foreign business, our nation operates the system of foreign investment insurance through the Export-Import bank, but it includes some institutional inertias and consequently the supplements are able to present as follows. First, as our nation's system of foreign investment insurance is modelled on developed nations', there are some absurd contents for application in our more small scale companies than theirs, therefore, it need to alleviate the regulation for support our companies. Second, it is absured that a method of calculation in the insured amount and the premium is applied indiscriminately to all sorts of project.Therefore, classification according to projects such as manufacturing, service, institutional loans, and natural resources is appropriate. Third, because companies' overseas business operation is indispansable to our nation, there is need to substitute positive assistance of government for current passive one. As mentioned above, companies' reactive strategy for political risks and government assistance for companies' loss from them are both important for successful foreign investment.

동양달팽이의 雄性 生殖器官에 대한 形態學的 硏究

이훈섭,정계헌,박종안 한국패류학회 1992 The Korean Journal of Malacology Vol.8 No.1

포트폴리오 收支論的 國際收支 調整 理論小考

李鐘燮,林龍澤 군산대학교 산업개발연구소 1987 産業開發硏究 Vol.6 No.-

정밀전단금형에서 판누름압력과 삼각돌기가 전단특성에 미치는 영향

이종구,오환섭 한국공작기계학회 1996 한국생산제조학회지 Vol.5 No.3

This study was performed the blankholding force and Vee-ring effects on blanking characteristics such as maximum blanking force, burnish, dish-shape, hardness, etc. in fine-blanking die by the experimental method. Two types of aluminum (Al.1050-o, Al. 5052-H) Such as annealed and unannealed materials were used for the experiment. In order to get a hydrostatic pressure effect, the clearance was set to 0.5% of the thickness of strip, and the counter punch and stripper plate with Vee-ring was set-up. While this experiment was carrying out, the average blanking velocity was constant (37.5mm/sec). As a result of this study, we got a good surface roughness and a glassy shear plane(burnish) of the sheet over 90% thickness, and such as the excellent accuracy of dimensions, the good squareness and the reduction of dish-shape could be obtained, and also the additional results obtained were such that the hardness of shear plane was increased and the maximum blanking force was reduced in the condition of Vee-ring height of 1.0~1.5mm, and blankholding force of 1200kg.

유한요소법을 이용한 정밀전단 변형부의 응력해석

이종구,오환섭 한국공작기계학회 1999 한국생산제조학회지 Vol.8 No.6

The goal of this study is to analyse the stress and the strain occurring within the work piece at the fine-blanking process and hence to assume the size, direction and a distribution chart of the shearing stress as the penetration of the punch is being increased trough the application of the FEM. For this analysis we introduced the piece-wise linear method in the non linear structural analysis program for large deformation sheet metal forming and we defined it as the problem of the non linear contact. Therefore, we modeled the above problems as quadratic-nodded axi-symmetrical elements for the characteristics of the work piece. From the result of this analysis, it was found that the shearing stress is a great deal occurred on the surface of the work piece during the beginning process of the punch penetration and it's effect is expected to influence importantly for th formation of burnish because the deeper is the penetration of the punch in the narrow clearance zone, the greater is the degree of the strain stress.