후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

자궁경부 종양에서 Nested PCR을 이용한 인유두종 바이러스 16형 및 18형의 검출과 임상적 의의

최규연,이종국,최승도,배동한,김휘준,김민관 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

The aim of this study is to estimate the prevalence of HPV types(16, 18) in cervix of gynecologic patients and to elucidate the relationship of HPV types(16, 18) and clinical characteristics. Human papilloma virus(HPV) has attracted attention as one of the viruses linked to human cancers. Numerous clinical, epidemiological, and molecular studies indicate that certain genital HPV types are associated with cervical carcinoma. Of 100 types of HPV identified today, at least 40 have been found in the anogenital mucosa. A classification of these types into three groups with differing pathogenicity has been proposed: HPV type 6, 11, 42, 43, and 44 are detected more frequently in benign lesions such as condylomata; HPV type 31, 33, 35, 51, 52, and 58 are found more often in low grade squamous intraepithelial lesions than invasive lesions; and HPV 16, 18, 45, and 56 are predominant in high grade squamous intraepithelial lesions and invasive carcinoma. To detect HPV types prevalent in carcinoma of the uterine cervix, a type-specific, sensitive polymerase chain reaction(PCR)-based assay for HPV types 16, 18 was applied to 18 cervical carcinomas(15 squamous cell carcinomas and 3 adenocarcinomas), 21 cases of cervical intraepithelial neoplasia(CIN), and 42 samples of cervicitis and histologically normal. DNA extraction from cervical swab was done using DNAzol™(MBI, USA) and Nested PCR was done using HPV detection kit(Bioneer, Korea). The amplified product was analyzed directly on the basis of the site of ethidium bromide-stained band visible after agarose gel electrophoresis. The results were as follows 1. The positivity rates of HPV type 16 and HPV type 18 were 12.5%(90/718), 2,5%(18/718). so, HPV 16 positive cases(12.5%) was five folds as HPV 18 positive cases(2.5%) 2. Forty eight percents(39/81) of HPV 16 or HPV 18 positive cases were CIN, microinvasive cancer. 3. Age, Gestation number, Clinical stage, Histologic cell type in relation to HPV types were not statistically significant.

성인의 경부 전면 중앙부위에서 발생한 기형종 1예

최월용,정효진,채종인,하태인,정상렬,이광재,채병도,최영식 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Teratomas are embryonal neoplasms that show characteristics of three germ cell layers(ectoderm, mesoderm, and endoderm). They are distributed in the following regions: sacrococcygeal(57%), gonadal(29%), mediastinal(7%), cervical(3%), retroperitoneal(4%), and intracranial(3%) regions. Non-gonadal treatomas present in infancy whereas gonadal are seen in adolescence. Especially, teratomas that occurred in midline neck of adult are very rare and are confused with thyroglossal duct cysts, cystic hygromas, and thyroid tumors. We report, along with the review of appropriate literature, a case of histopathologically confirmed benign teratoma in the midline neck of a 33 years old woman.

산전 초음파로 진단된 골형성부전증 TypeⅡ 1예

김종수,최승도,선우재근,배동한 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Osteogenesis Imperfecta(Ol) is a heritable disorder of which the defects make bones brittle, and is usually associated with blue sclerae, hearing loss, abnormalities of dentition, or a combination of these features. One of these, the perinatal form on OI TypeⅡ is rare disorder characterized by poorly ossified calvaria, beaded rib, and short, bowed limbs. We recently experienced a case of OI Type Ⅱ diagnosed in utero by ultrasonogram and confirmed by postnatal radiograph and autopsy. So, we report the case with a brief review of the literature.

뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

국내 콘크리트 기준의 발전 방향에 대한 고찰

심종성,최장환,문도영,박성재 漢陽大學校 工學技術硏究所 2002 工學技術論文集 Vol.11 No.-

유럽 각국의 규준을 통합한 유로 Code의 등장과 북미지역을 중심으로 한 기술통합의 흐름과 같은 Global Network화의 추세에 적극적으로 대처하고자 Asia Concrete Model Code(ACMC)의 제정이 제안되었다. 현재까지 ACMC 위원회는 LevelⅠ과 Level Ⅱ의 draft를 완성하였으며, Level Ⅲ에서는 국가/지역조건을 고려한 실제적인 지침을 준비하고 있는 단계이다. 따라서 본 연구에서는 각 시방들을 비교·분석하고 현재 제안된 ACMC Level Ⅲ Document 및 Perforomance Based Design과 관련된 문헌들을 고찰함으로써 국내현황에 적합한 ACMC Level Ⅲ Document의 작성방안을 제안하고자한다. Asian Concrete Model Code (ACMC) was proposed to cope with appearance of Euro-Code and a trend of Global Network such as a flow of the technique unification of North America. ACMC Committee has completed two drafts of LevelⅠ and LevelⅡ. Also, prectial specification considering national/regional condition is being prepared in draft of Level Ⅲ Document. On the study, each specification was analyzed and compared and a number of references were studied in order to propose ACMC Level Ⅲ Document considering domestic conditions.

편두통 환자의 임상 양상 및 생체전기 자율반응과의 상관성 고찰

이현종,정인태,김수영,이두익,김건식,이재동,이윤호,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : We had a clinical report in headache but didn't in migraine. We have planned this study in order to get the basic data of migraine in oriental medicine. Methods : The patient of 36 in migraine checked sec, age, onset, family history, severity of pain, influences of life, induced cause, clinical pain characteristics, associated symptom, treatment style, and paescription, frequency, using period of analgesics by a questionnaire and differentiated syndromes in migraine and evaluated autonomic bioelectric response recorder(ABR-2000). Results : There are 23.4% in prevalence rate of migraine. The ratio of sex is M: F=1:17. The age of an attack is the highest in thirties. The patient are the most in forties. The mean duration of illness is 12.0±9.9 years. 83.4% had a family history. 61.1% had a moderate grade in severity of pain. 77.8% selected fatigue in induced cause of migraine. 69.4% had tingling sense, nausea and vomiting in the associated symptoms. 91.7% used analgesics for treatment and 51.5% of them used analgesics voluntarily. 61.9% of them take analgesics less than once in a week. 33.6% had the phlegm syncope headache in differentiation of syndrome. In ABR-2000 results, item of graph showed low tendency mostly. Conclusions : We expected that this re port of clinical progress, differentiation of syndromes and ABR-2000 results in migraine would be used basic data by oriental medicine to treat migraine.

임신중 우측난소의 자궁내막장종의 성장과 파열의 1례

이종학,홍순도,남상욱,최종호,허광현,박일영 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2

계명의대 산부인과에서 35세된 경산부에서 임신과 동반된 우측 난소의 자궁내막낭종의 성장과 파열을 경험하였기에 이에 문헌고찰과 함께 보고하는 바이다 Pregnancy had long been considered to have beneficial effect on endometriosis. During the pregnancy, extrauterine endomertrial tissues did not growth or enlarged because of physiologic amenorrhea and producing hormonal effect. However, we experienced a patient who underwent emergency exploratory laparotmy at gestation week 34/4 for rupture of an ovarian endometriotic cyst. The patient had a Cesarean section delivery of a 1,960gm female baby, who died at 1st day of life.

난소에서 발생한 내배엽동 종양 1예

김종수,최승도,선우재근,배동한 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

The endodermal sinus tumor(EST) of ovary is originated from the undifferentiated primitive germ cell of the embryonal stage. This tumor is the third most frequent malignant germ cell tumors of the ovary and highly malignant. About one-third of patients are premenarcheal at the time of diagnosis. Acute abdominal or pelvic pain is the most initial symptom. The treatment of the EST consists of surgical exploration, unilateral salpingo-oophorectomy and a frozen section for diagnosis. All patients with ESTs are treated with either adjuvant or therapeutic chemotherapy. We experienced one case of the endodermal sinus tumor of the ovary in 21 years old women, who had complaint with abdominal distension and pain. So we report the case with brief review of literatures.

일부 농촌지역 청소년층의 성장발육과 영양상태에 관한 연구

김종진,윤태영,최중명,박순영,구도서,박양원 慶熙大學校 1987 論文集 Vol.16 No.-

In order to assess the physical growth and development, and nutritional status of primary, middle and high school students in the town of Samchoek, Kangwon province as rural area, physiques of 3,793 persons(Male; 1,884. Female; 1,909)were measured from May 1 to May 31 in 1986 and various physical and nutritional indices related to them were calculated.