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Membrane Neuraminidase 3 inhibits megakaryocytic differentiation of leukemic K562 cells
Seok-Jo Kim,Young-Choon Lee,Seok-Jong Suh,Un-Ho Jin,Cheorl-Ho Kim 한국당과학회 2008 한국당과학회 학술대회 Vol.2008 No.1
The induction of hST3Gal V and reduction of membrane type sialidase are directly linked for expression of differentiation maker protein, CD41b surface antigen. When membrane type sialidase gene is expressed in phorbol 12-myristate 13-acetate-treated cells, Neu3 inhibited the PMA-induced ERK1/2 and p38 MAPK phosphorylation in the K562 cells. Down-regulation of expression of CD41b surface antigen was dependent on expression of Neu3 gene. However, a Neu 3 inhibitor Neu5Ac2en induced morphological changes, showing megakaryocytic differentiation of K562 cells, with expression of CD41b surface antigen, while a specific glucosylceramide synthase inhibitor PDMP inhibited megakaryocytic differentiation of K562 cells. The molecular mechanisms involved in Neu 3 -involved inhibition of CD41b surface antigen expression in K562 cells have been suggested: the Neu 3 degrades membrane sialic acids and the resulting signal pathway of the PKC/ERKs/ p38 MAPK is down-regulated, decreasing the CD41b expression and inhibiting the megakaryocytic differentiation of K562 cells.
한국 여대생의 체지방측정을 통한 측정기기들 간의 비교연구
장은재(Un-Jae Chang),조진남(Jin-Nam Jo),황종현(Jong-Hyun Hwang) 한국식품영양과학회 1997 한국식품영양과학회지 Vol.26 No.3
본 연구에서 결과는 1) 4가지 체지방 함량 측정기기를 사용하여 두 측정자 간의 결과를 비교해 보면 유의적인 차이가 없음을 알 수 있었다. 2) 체지방 함량 측정 기기들 간의 비교는 4가지 기기 모두 유의적인 차이가 있었으나, 근적외선법과 Spectrum Ⅱ, 피하지방 두께 측정법과 TBF-105 사이에서 근접한 결과를 보였다. 그러므로 비만판정시 한가지의 기기만을 사용하였을 때 동일인을 대상으로 하더라도 측정자의 오차와 측정기기 각각의 측정 오류를 충분히 고려하지 못하므로 정확한 판정이라 할 수 없다. 또한 현재 사용되는 대부분의 기기들이 제조사에서 제공한 외국인의 체지방분포의 기초자료를 중심으로 추정된 공식을 그대로 사용하므로 한국인에 적용할 경우 그 결과가 의문시 되어진다. 따라서 각 기기들의 가정과 단점을 보완하기 위해 보다 많은 변수를 포함하며, 한국인을 대상으로 추정된 우리의 실정에 맞는 새로운 공식의 개발이 요구되어진다. The purpose of this study is to provide the reference data for estimating body composition and developing equations for prediction of percent body fat. This study was designed of two aspects: Comparison of percent body fat measurements between two operators. Comparison of percent body fat measurements among four instruments. Percent body fat of college girls(n=71) aged 18~24 was measured by skinfold thickness, near-infrared interactance(Futrex-5000), and bioelectrical impedance analysis(TBF-105, Spectrum Ⅱ). All measurements were duplicated & measured by two operators. The results are summarized as follows: Percent body fat observed from two operators had no significant difference. There was significant difference from four instruments. However, we found close relation between Skinfold thickness & TBF-105, Spectrum Ⅱ & Near-infrared interactance. Four instruments have several assumptions and limitations. Therefore, many researches for developing new equations are required for Korean people.
포스터 전시 : 담도,췌장 ; 췌장에서 발견된 간질증(Fascioliasis) 1예
하종 ( Jong Ha ),조활석 ( Hwal Suk Jo ),이은정 ( Eun Jung Lee ),윤지향 ( Ji Hyang Yoon ),조중현 ( Jung Hyun Jo ),정운태 ( Un Tae Jung ),이옥재 ( Ok Jae Lee ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
46세 여자환자가 20일 전부터 시작된 좌상복부 동통을 주소로 내원하였다. 환자는 1999년 4월 간질증에 의한 간농양으로 타병원(연세 대학교 의료원)에서 입원하여 biltricid (praziquantel) 25mg/kg 1일 3회 복용하여 치료하였던 환자로, 내원 20일 전부터 누웠을 때 악화되는 좌상복부동통이 있어 연세 대학교 의료원에 방문하여 검사한 혈청거사에서 amylase/lipase가 83 IU/dL / 473 U/L 나왔고, 복부초음파검사
Grain-Refined AZ92 Alloy with Superior Strength and Ductility
Lee, Jong Un,Kim, Sang-Hoon,Jo, Wan-Kuen,Hong, Won-Hwa,Kim, Woong,Bae, Jun Ho,Park, Sung Hyuk Springer-Verlag 2018 METALS AND MATERIALS International Vol.24 No.4
<P>Grain-refined AZ92 (GR-AZ92) alloy with superior tensile properties is developed by adding 1 wt% Zn and a very small amount of SiC (0.17 wt%) to commercial AZ91 alloy for enhancing the solid-solution strengthening effect and refining the crystal grains, respectively. The homogenized GR-AZ92 alloy with an average grain size of 91 mu m exhibits a tensile yield strength (TYS) of 125 MPa, ultimate tensile strength (UTS) of 281 MPa, and elongation of 12.1%, which are significantly higher than those of AZ91 alloy with a grain size of 420 mu m (TYS of 94 MPa, UTS of 192 MPa, and elongation of 7.0%). The peak-aging time of GR-AZ92 alloy (8 h) is significantly shorter than that of AZ91 alloy (32 h) owing to a larger amount of grain boundaries in the former, which serve as nucleation sites of Mg17Al12 precipitates. A short-aging treatment for less than 1 h of the GR-AZ92 alloy causes an effective improvement in its strength without a significant reduction in its ductility. The 30-min-aged GR-AZ92 alloy has an excellent combination of strength and ductility, with a TYS of 142 MPa, UTS of 304 MPa, and elongation of 8.0%.</P>
Bronchogenic cyst masquerading as malignant pericardial effusion with tamponade
( Kang-un Choi ),( Byung-jun Kim ),( Hong-ju Kim ),( Jang Won Son ),( Jong-seon Park ),( Dong-gu Shin ),( Young-jo Kim ) 영남대학교 의과대학 2017 Yeungnam University Journal of Medicine Vol.34 No.1
We report on a rare case involving a 23-year-old female patient with mediastinal cystic mass complicated with acute pericarditis and cardiac tamponade. Pericardial fluid demonstrated lymphocyte-predominant exu-date and the level of carcinoembryonic antigen (CEA) was unexpectedly elevated. Successive aspiration of mediastinal cystic mass revealed a very high level of CEA (>100,000 U/mL) and carbohydrate antigen 19-9 (>15,000 ng/mL). This patient was clinically diagnosed as an infected bronchogenic cyst complicated with pericarditis and cardiac tamponade. The treatment resulted in alleviation of her symptoms.