식단배식시 간호사의 개선내용이 잔식량 감소에 미치는 효과 : 일 대학병원을 중심으로

조남수,민순,정영주,장숙희,김연희,주예란 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

The purpose of this study was to provide basic materials for the supply of the high quality of meals which meets the need of patients of university hospital in G city, affording the increase their quality and to make proper preparations through the analysis of the cause of leftover food for the improvement of hospital service and for the efficiency of hospital management. For this study, questionnaires from the total 302 patients hospitalized (1st 149, 2nd 100 and 3rd 53 investigated persons) during May 28 to October 28, 2001 were used and the measurement of leftover food was performed in each hospital ward for 1 week. A tool of research was consisted of the total 22 structured questionnaires to improve satisfaction of patient meal and to reduce leftover food, For the distribution of meals, the contents of improved education are 1) The improved ways for the satisfaction of rice and soup were searched 2) Several kinds of Kimchi were diversified 3) Kindness education was repeatedly performed to all distributors for 20 minutes every Thursday afternoon ;1) The preparation of clean meals was educated and supervised 5) Since there was much leftover food, when patients enter hospitalization and leave the hospital, and they change meals, and they miss changed meals, both official document and oral cooperation were requested to each hospital ward person in charge. The research results are as follows: 1. In food quality and service, the negative opinion was shown in the item of food temperature, food amount, cleanness of dinner table, kindness of food distributor. And the positive opinions of Eat much. Eat by half. in the item of food intake amount supplied by the hospital were shown. It was investigated that the leftover food was due to the great amount of food. 2. In the determination of leftover food among several hospital wards, 63 hospital ward (medical treatment hospital) gave the largest leftover food in the first and the second investigation. In the third investigation, 73 hospital ward with long-term patients among hospital wards with the largest leftover food gave the order of soup-kimchi-rice, kimchi-soup-rice as leftover foods. Summarizing these results, it is considered that the reduction of leftover food by the improvement education in hospital meals distribution might help the nutrition intake as well as service improvement in hospital manger and social benefit.

서울시민의 수돗물 불소화에 대한 인식

장재연,조수남,윤제용 대한상하수도학회 2003 상하수도학회지 Vol.17 No.2

Public perception concerning water fluoridation and influencing factors were assessed. A mailing survey was conducted in 1999 with a representative sample of the general Seoul citizen (response rate=40.1%), who consisted of 1108 adults aged between 20 and 78. The data were analyzed using the chi-square test and structural equation modeling. 48.3% favored and 11.4% opposed water fluoridation while 40.5% were not certain. The contact on information about water fluoridation was the most significantly influencing factor on the perception concerning water fluoridation while experience of marriage, income and the perception of tap water were also significant. 52.8% expect governmental health authorities to take the decisions about water fluoridation.

돼지에서 개량된 회장 캐눌러 삽관법 1례

김명철,이재일,이수진,조종민,김남중 충남대학교 수의과대학 동물의과학연구소 2001 動物醫科學硏究誌 Vol.9 No.-

Intestinal cannulation was developed for the study of enteric microflora, nutritional requirements and status. However, already established techniques revealed cause often leakage of the intestinal contents and necrosis of skin. For the prevention of contamination from the ingesta, modified ileal cannulation was performed in a pig. The pig was anesthetized by tiletamine-zolazepam(4.4㎎/㎏, IM) administration 10 minutes after administration of xylazine(0.5㎎/㎏, IM). We inserted resin cannula in the ileum incised and put the inner ring after employing purse-string suture in the ileum. We made the puncture incision in the body wall through which the cannula is drawn. The cannula was placed surgically at the ventral placement of cranial part and at the dorsal placement of caudal part. Cannula was fixed by placement of two outer washer, and sealed with cannula stopper. Laparotomy incision was closed by mattress suture. The pig was given postoperative penicillin(20,000 IU/㎏ IM) to prevent secondary infection for 3 days. There were not observed the entering of rubber cannula into the abdominal cavity, the contamination of ingesta and necrosis of skin, and good result was revealed.

Impact of high temperatures on emergency admissions in 6 cities of korea

Soo-nam Jo(조수남),Jae-Yeon Jang(장재연) 한국환경독성학회 2010 한국독성학회 심포지움 및 학술발표회 Vol.2010 No.11

Secondary adrenal insufficiency caused by sorafenib administration in a patient with hepatocellular carcinoma

Jo, Soo Yeon,Ryu, Soo Hyung,Kim, Mi Young,Moon, Jeong Seop,Yoon, Won Jae,Kim, Jin Nam Yeungnam University College of Medicine 2016 Yeungnam University Journal of Medicine Vol.33 No.2

Sorafenib (Nexavar) has been regarded as a treatment for unresectable hepatocellular carcinoma (HCC), with side effects that include hand-foot skin reaction, diarrhea, rash, fatigue, hypertension, nausea, anorexia, weight loss, and alopecia. Thyroid disorder, such as endocrine side effect, has also been reported. However no case involving adrenal insufficiency has been reported. Here, we report a case of adrenal insufficiency which occurred after taking sorafenib in a patient with HCC. A 56-year-old man visited our hospital due to right upper quadrant abdominal pain and he was diagnosed as multiple disseminated and unresectable HCCs with portal vein invasion; therefore transarterial chemoembolization was performed and sorafenib administration was started. Two months later, he was admitted to the hospital complaining of severe fatigue. The laboratory results showed cortisol of <$0.2{\mu}g/dL$ and adrenocorticotropic hormone of <1.00 pg/mL. The patient had no history of taking steroids or herbal medications. Secondary adrenal insufficiency was diagnosed and prednisolone 10 mg per day was started immediately; as a result, fatigue remarkably improved. This may be the first report indicating a possible association between sorafenib and adrenal insufficiency and it implies that the possibility of adrenal insufficiency should be considered in patients taking sorafenib who complain of severe fatigue.

Secondary adrenal insufficiency caused by sorafenib administration in a patient with hepatocellular carcinoma

( Soo Yeon Jo ),( Soo Hyung Ryu ),( Mi Young Kim ),( Jeong Seop Moon ),( Won Jae Yoon ),( Jin Nam Kim ) 영남대학교 의과대학 2016 Yeungnam University Journal of Medicine Vol.33 No.2

Sorafenib (Nexavar) has been regarded as a treatment for unresectable hepatocellular carcinoma (HCC), with side effects that include hand-foot skin reaction, diarrhea, rash, fatigue, hypertension, nausea, anorexia, weight loss, and alopecia. Thyroid disorder, such as endocrine side effect, has also been reported. However no case involving adrenal insufficiency has been reported. Here, we report a case of adrenal insufficiency which occurred after taking sorafenib in a patient with HCC. A 56-year-old man visited our hospital due to right upper quadrant abdominal pain and he was diagnosed as multiple disseminated and unresectable HCCs with portal vein invasion; therefore transarterial chemoembolization was performed and sorafenib administration was started. Two months later, he was admitted to the hospital complaining of severe fatigue. The laboratory results showed cortisol of <0.2μ g/dL and adrenocorticotropic hormone of <1.00 pg/mL. The patient had no history of taking steroids or herbal medications. Secondary adrenal insufficiency was diagnosed and prednisolone 10 mg per day was started immediately; as a result, fatigue remarkably improved. This may be the first report indicating a possible association between sorafenib and adrenal insufficiency and it implies that the possibility of adrenal insufficiency should be considered in patients taking sorafenib who complain of severe fatigue.

만성 B형 간염에서 라미부딘 치료중 발생한 Viral Breakthrough 예의 임상 결과

안수현,장윤정,오성남,최도원,백수정,정원석,최창원,김경오,임형준,조남영,박종재,김재선,박영태,이명석,연종은,변관수,이창홍 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.4

목적: 만성 B형 간염의 치료 중 발생하는 약제 내성 변이종은 임상적으로는 치료 중 음전되었던 혈청 HBV DNA가 다시 양전되는 viral breakthrough 로 진단할 수 있다. 현재 약제 내성 변이종이 발생했을 경우라도 라미부딘 치료를 계속 유지하는 것을 권장하고 있으나, viral breakthrough 발생 예들의 장기적 임상경과가 아직도 불명확하여 이것을 일반화하기는 어려운 상황이다. 이에 라미부딘 사용 중 viral breakthrough 가 발생한 예들을 대상으로 그 임상경과를 알아보고자 하였다. 대상과 방법: 9개월 이상 라미부딘을 투약한 만성 B형 간염 환자로 viral breakthrough가 발생한 74명을 대상으로 하였다(남/여 54/20, 평균연령 42세). Viral breakthrough 후 혈청 ALT치, 총 빌리루빈치, HBV DNA 역가, HBeAg, anti-HBe를 정기적으로 검사하면서 임상경과를 관찰하였다. Viral breakthrough 후 라미부딘의 투약기간은 평균 13개 월(1-41개월)이었다. 결과: Viral breakthrough 발생후 혈청 ALT치가 정상으로 유지되었던 환자는 8예(11%)에 불과했고 나머지 66예(89%)에서는 ALT치가 증가하였으며, 이중 30예(41%)에서 급성 악화(ALT 정상 상한치의 5배 이상 상승)를 보였다. 급성악화는 viral breakthrough 후 3개월 내에 19예 (63%)에서 발생하여 3개월 내에 발생한 예가 많았으나 12개월 이상 지나서 나타나는 예도 약 20%에서 있었다. 비대상성 악화는 6예에서 관찰되었다. Viral breakthrough 후 급성악화가 일어난 예와 없었던 예의 비교에서 급성악화를 예측할 수 있는 인자는 발견할 수 없었다. Viral breakthrough 후 발견할 수 없었다. Viral breakthrough 후 HBeAg이 음전된 예는 8예(11%)였으나 그 임상경과는 양호하지 않았다. 결론: 만성 B형 간염 환자 에서 라미부딘 투여 중 발생한 viral breakthrough 예 중 상당수에서 급성악화가 발생하였으며, HBeAg 이 소실되더라도 그 임상경과는 양호하지만은 않았다. Viral breakthrough 발생 후 주의 깊은 임상경과 의 관찰이 요구되며, 앞으로 viral breakthrough 후 급성악화 예에 대한 대규모 연구와 적절한 치료방향의 제시가 이루어져야 할 것으로 생각된다. Background/Aims: Long-term lamivudine therapy can induce the emergence of lamivudine resistant hepatitis B virus (HBV) mutants. Clinically emergence of the mutant is expressed by the reappearance of disappeared HBV DNA in serum. Continued lamivudine treatment has been usually recommended in cases of viral breakthrough. However, the clinical outcome in patients with viral breakthrough is not clear. The aim of this study was to investigate the clinical course of chronic hepatitis B patients after viral breakthrough during lamivudine therapy. Methods: A total of 74 patients with chronic hepatitis B who showed viral breakthrough after at least 6 months of lamivudine treatment were included in this study. They had positive HBeAg and HBV DNA before treatment. The median follow-up duration after breakthrough was 13 months. Results: After viral breakthrough, only 8 patients (11%) maintained normal ALT levels and 66 patients (89%) showed elevation of ALT. 30 patients (41%) showed acute exacerbation of hepatitis (ALT increase over five-times upper normal limit). These acute exacerbations occurred within three months after breakthrough in 19 patients (63%). In the cases of acute exacerbation, 6 patients showed decompensated progression such as elevation of serum total bilirubin. One of them died of hepatic failure. A predictive factor for acute exacerbation was not found. HBeAg seroconversion occurred in 8 patients after viral breakthrough but their clinical course was highly variable. Conclusions: Chronic hepatitis B patients who had viral breakthrough during lamivudine therapy should be followed carefully and regularly in mind of potential clinical deterioration. New strategies are needed to manage the cases of acute exacerbation after viral breakthrough.(Korean J Hepatol 2002;8:389-396)

<i>In vitro</i> skin permeation and cellular protective effects of flavonoids isolated from <i>Suaeda asparagoides</i> extracts

Park, Soo Nam,Kim, Sun Young,Lim, Gyu Nam,Jo, Na Rae,Lee, Min Hye Elsevier 2012 Journal of industrial and engineering chemistry Vol.18 No.2

<P><B>Abstract</B></P><P>The objective of this study was to compare astragalin (kaempferol-3-O-glucoside) isolated from <I>Suaeda asparagoides</I> extract with kaempferol, an aglycone of astragalin showing the anti-oxidative activity, the cellular protective effect, and skin permeability. Kaempferol was superior to (+)-α-tocopherol and <SMALL>L</SMALL>-ascorbic acid known as strong antioxidants in the antioxidative activity by DPPH method and chemiluminescence assay. Astragalin and kaempferol exhibited more prominent cellular protective effect than the lipid peroxidation chain blocker, (+)-α-tocopherol. In this <I>in vitro</I> permeation experiment of astragalin and kaempferol through the ICR mouse skin, kaempferol permeated deeper into the skin than astragalin. These results indicate that kaempferol and astragalin can function as antioxidants in biological systems, particularly skin exposed to solar radiation, and protect cellular membranes against reactive oxygen species.</P>

악성 종양 표지자가 상승된 만성 흉수를 동반한 종격동 기형종

엄수정 ( Soo Jung Um ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ),노미숙 ( Mee Sook Roh ),김기남 ( Ki Nam Kim ),이기남 ( Ki Nam Lee ),최필조 ( Pil Jo Choi ),방정희 ( Jung Heui Bang ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.66 No.2

Most mediastinal teratomas are histologically well-differentiated tumors and benign. The majority of patients with a mediastinal teratoma are asymptomatic and their tumors are usually discovered incidentally on chest radiography. On rare occasions this tumor will rupture spontaneously into the adjacent organs. A 72-year-old female patient was admitted for dyspnea and she had a multiloculated pleural effusion in the left lung field. Although repeated pleural biopsy and pleural fluid cytology did not prove the presence of malignancy, we assumed that this was a malignant effusion because it revealed consistently high levels of carcinoembryonic antigen and carbohydrate antigen 19-9, and the chest CT scan did not show typical fat or bone density in the mass. Secondary infection and an uncontrolled septic condition due to pleural empyema finally compelled the patient to undergo a surgical operation. Mature teratoma was the final diagnosis and she has done well without recurrence for 2 months.

Induction of apoptosis in MCF-7 and MDA-MB-231 breast cancer cells by Oligonol is mediated by Bcl-2 family regulation and MEK/ERK signaling

Jo, Eun-Hye,Lee, Soo-Jin,Ahn, Nam-Shik,Park, Joon-Suk,Hwang, Jae-Woong,Kim, Sung-Hoon,Aruoma, Okezie I.,Lee, Yong-Soon,Kang, Kyung-Sun Lippincott Williams & Wilkins 2007 EUROPEAN JOURNAL OF CANCER PREVENTION Vol.16 No.4

Oligonol is a novel catechin-rich biotechnology product. The role of oligonol in modulating intracellular signaling mechanisms was investigated with the view of demonstrating its potential chemopreventive effect and the ability to inhibit cell proliferation using the estrogen-responsive MCF-7 and the estrogen-unresponsive MDA-MB-231 human breast cancer cell lines. Cell survival assay indicated that Oligonol was cytotoxic to both cells. Oligonol triggered apoptosis as revealed by the morphological features typical of nucleus staining and the accumulation of sub-G1 peak. Treatment with 25 μg/ml Oligonol resulted in an activation of caspase-7 and up-regulation of Bad on MCF-7 cells, while the Oligonol (20 μg/ml) induced up-regulation of Bcl-2 protein in a time–response manner on MDA-MB-231 cells. ERK1/2 in both cells were inactivated after Oligonol treatment in a time-dependent manner, and also inactivated upstream MEK1/2. Oligonol triggers apoptosis in MCF-7 and MDA-MB-231 cells through the modulation of pro-apoptotic Bcl-2 family proteins and MEK/ERK signaling pathway.