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Han, Jisu,Jin, Wook,Ho, Ngoc Anh,Hong, Jeongpyo,Kim, Yoon Ju,Shin, Yungyeong,Lee, Hanki,Suh, Joo-Won Elsevier 2018 Biochemical and biophysical research communication Vol.499 No.4
<P><B>Abstract</B></P> <P>The coumarins decursin and decursinol angelate, which are found in <I>Angelica gigas</I> Nakai, have a variety of biological functions. Here, we show that treatment with these compounds improves wound healing by HaCaT human keratinocytes. Wound healing was increased by treatment with up to a threshold concentration of decursin, decursinol angelate, a mixture of both, and a nano-emulsion of these compounds, but inhibited by treatment with higher concentrations. Immunoblotting and fluorescence imaging of cells expressing an epidermal growth factor receptor (EGFR) biosensor demonstrated that these compounds did not stimulate wound healing by inducing EGFR phosphorylation. Rather, transcriptional analysis revealed that decursin and decursinol angelate improved wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Decursin and decursinol angelate can improve wound healing below proper concentration. </LI> <LI> The treatment of these compounds upregulates the genes of extracellular matrix remodeling proteins for wound healing. </LI> <LI> Also, these compounds upregulate the genes of inflammatory cytokines, and growth factors. </LI> <LI> The genes upregulated by decursin are different by decursinol angelate even though their structure is very similar. </LI> </UL> </P>
Han, Jisu,Kim, Youngmin,Jackson, David H.K.,Jeong, Kwang-Eun,Chae, Ho-Jeong,Lee, Kwan-Young,Kim, Hyung Ju Elsevier 2018 Electrochemistry communications Vol.96 No.-
<P><B>Abstract</B></P> <P>In this study, an atomically controlled thin TiO<SUB>2</SUB> layer was coated on Au/C by atomic layer deposition (ALD). The resulting TiO<SUB>2</SUB> coated Au/C (ALD(TiO<SUB>2</SUB>)-Au/C) was used as a catalyst for electrocatalytic glycerol oxidation in alkaline media. Interactions between Au and TiO<SUB>2</SUB> in the ALD(TiO<SUB>2</SUB>)-Au/C catalyst improved the catalytic activity and stability for glycerol oxidation. Additionally, the reaction pathway for glycerol oxidation changes due to the Au-TiO<SUB>2</SUB> interfaces formed by ALD. This performance enhancement of electrocatalytic glycerol oxidation on ALD(TiO<SUB>2</SUB>)-Au/C is attributed to the role of TiO<SUB>2</SUB> in facilitating oxidation of the Au surface.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The role of Au-TiO<SUB>2</SUB> interfacial sites was studied for glycerol electrooxidation. </LI> <LI> Thin TiO<SUB>2</SUB> layers were deposited on Au/C by atomic layer deposition to form Au-TiO<SUB>2</SUB> interfaces. </LI> <LI> TiO<SUB>2</SUB> deposition on Au/C led to improved catalytic performances for glycerol electrooxidation in alkaline medium. </LI> </UL> </P>
Jisu Han,Ju Ri Ham,Mi Ja Lee,Hyun-Jin Lee,Young-Jin Son,Mi-Kyung Lee 한국식품영양과학회 2023 Preventive Nutrition and Food Science Vol.28 No.3
The cultivar “Nulichal,” a type of naked waxy barley (Hordeum vulgare L.), was developed by the National Institute of Crop Science, Rural Development Administration, Korea, in 2010. In this study, we investigated the anti-inflammatory and antioxidant properties of the “Nulichal” ethanol extract (NRE) using various assays. The NRE exhibited a total phenolic content of 7.55±0.30 mg gallic acid equivalent/g and a flavonoid content of 1.74±0.08 mg rutin equivalent/g. Cell viability assays showed no toxicity of NRE on RAW264.7 macrophage cells up to concentrations of 500µg/mL. The NRE (300 and 500µg/mL) significantly reduced nitric oxide (NO) production induced by lipopolysaccharides (LPS). It also down-regulated the mRNA expression and protein levels of inducible NO synthase and cyclooxygenase-2 in a dose-dependent manner. Moreover, the NRE treatment significantly decreased the levels of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, and their mRNA expression compared to LPS treatment alone. The NRE demonstrated strong free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl and 2,2’-azino-bis(3-ethylbenzothiazoline- 6-sulfonic acid) radicals in a dose-dependent manner. The ferric reducing antioxidant power assay also showed increased antioxidant activity with increasing NRE concentrations. These findings suggest that the NRE can be used as a functional food with anti-inflammatory and antioxidant properties.