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Sun Ru,Gu Qun,Zhang Xufeng,Zeng Ruiqi,Chen Dan,Yao Jingjing,Min Jingjing 한국독성학회 2024 Toxicological Research Vol.40 No.2
Chronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an independent risk factor for stroke. It has been reported that cilostazol has a protective effect on the focal cerebral ischemic infarct. However, its impact on vascular injury in CRF combined stroke and its molecular protection mechanism have not been investigated. In this study, we carried out the effect of cilostazol on CRF combined stroke rats, and the results confirmed that it improved the neurobehavior, renal function as well as pathologic changes in both the kidney and brain. In addition, the inflammation and oxidative stress factors in the kidney and brain were suppressed. Moreover, the rates of brain edema and infarction were decreased. The injured brain-blood barrier (BBB) was recovered with less Evans blue extravasation and more expressions of zonula occludens-1(ZO-1) and occludin. More cerebral blood flow (CBF) in the ipsilateral hemisphere and more expression of CD31 and vascular endothelial growth factor (VEGF) in brain and kidney were found in the cilostazol group. Furthermore, cell apoptosis and cell autophagy became less, on the contrary, proteins of vascular endothelial growth factor receptor 2 (VEGFR2) after the cilostazol treatment were increased. More importantly, this protective effect is related to the pathway of Janus Kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), mammalian target of rapamycin (mTOR), and the hypoxia inducible factor-1α (HIF-1α). In conclusion, our results confirmed that cilostazol exerted a protective effect on the brain and kidney function, specifically in vascular injury, oxidative stress, cell apoptosis, cell autophagy, and inflammation response in CRF combined with stroke rats which were related to the upregulation of JAK/STAT3/mTOR signal pathway.
Jingjing Sun,Wei Wang,Congyu Yao,Fangqun Dai,Xiangjie Zhu,Junzhong Liu,Jianhua Hao 한국미생물학회 2018 The journal of microbiology Vol.56 No.9
A novel gene (bgl) encoding a cold-adapted β-glucosidase was cloned from the marine bacterium Alteromonas sp. L82. Based on sequence analysis and its putative catalytic conserved region, Bgl belonged to the glycoside hydrolase family 1. Bgl was overexpressed in E. coli and purified by Ni2+ affinity chromatography. The purified recombinant β- glucosidase showed maximum activity at temperatures between 25°C to 45°C and over the pH range 6 to 8. The enzyme lost activity quickly after incubation at 40°C. Therefore, recombinant β-glucosidase appears to be a cold-adapted enzyme. The addition of reducing agent doubled its activity and 2 M NaCl did not influence its activity. Recombinant β-glucosidase was also tolerant of 700 mM glucose and some organic solvents. Bgl had a Km of 0.55 mM, a Vmax of 83.6 U/mg, a kcat of 74.3 s-1 and kcat/Km of 135.1 at 40°C, pH 7 with 4-nitrophenyl-β-D-glucopyranoside as a substrate. These properties indicate Bgl may be an interesting candidate for biotechnological and industrial applications.
An Efficient Reactive Power Regulation based DPC Method for AC/DC Converters
Huang Jingjing,Sun Yuangang,Tong Xiangqian,Li Ning 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
To eliminate the cyclical fluctuation problems of the reactive power existing in the traditional direct power control (DPC), a novel method is proposed for the threephase voltage source AC/DC converter. It employs two switching tables to select the proper switching states according to the instantaneous reactive power deviations. The design principle of the switching tables is provided to ensure the efficient reactive power regulation. Moreover, it should guarantee the steady characteristic of the converter system. The simulation model established under the MATLAB/Simulink environment and the experiment were presented to compare the characteristics obtained by the proposed strategy with that obtained by the traditional DPC strategy. The results show that the ac current obtained by the proposed strategy has the much lower total harmonic distortion rate (THD), and the fluctuation range of the reactive power has the more than two times reduction.
Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators
( Yujia Han ),( Jingjing Liu ),( Sungjin Ahn ),( Seungchan An ),( Hyejin Ko ),( Jeayoung C. Shin ),( Sun Hee Jin ),( Min Won Ki ),( So Hun Lee ),( Kang Hyuk Lee ),( Song Seok Shin ),( Won Jun Choi ),( 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.5
Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin- secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.
Distortional and local buckling of steel-concrete composite box-beam
Lizhong Jiang,Jingjing Qi,Andrew Scanlon,Linlin Sun 국제구조공학회 2013 Steel and Composite Structures, An International J Vol.14 No.3
Distortional and local buckling are important factors that influences the bearing capacity of steel-concrete composite box-beam. Through theoretical analysis of distortional buckling forms, a stability analysis calculation model of composite box beam considering rotation of steel beam top flange is resented. The critical bending moment calculation formula of distortional buckling is established. In addition, mechanical behaviors of a steel beam web in the negative moment zone subjected separately to bending stress, shear stress and combined stress are investigated. Elastic buckling factors of steel web under different stress conditions are calculated. On the basis of local buckling analysis results, a limiting value for height-to thickness ratio of a steel web in the elastic stage is proposed. Numerical examples are presented to verify the proposed models.
Peng Zhou,Jingjing Guo,Jian Sun,Defang Zou 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.7
The arrangement of disc cutter on a cutter head is important to improve the performance of TBM (tunnel boring machine) cutter, cutter life and cutter disc bearing life, then reduce vibration of TBM and reduce the noise. The rock breaking with double disc cutters is the basis of study on the distribution of disc cutter on cutter head, and it plays an important role on optimum arrangement of disc cutter on cutter head. In the process of rock breaking with double disc cutters, the axial vertical distance between two cutters is an important construction parameter, which directly affects rock breaking efficiency. Therefore, research on optimal cutter spacing and analysis of adaptability between cutter spacing and rock characteristics play an important role in optimizing the arrangement of cutter on the cutter head and improving the rock breaking efficiency of TBM. This paper analyzed the breaking rock force of double disc cutters. Taking granite samples as an example, the process of rock breaking with double disc cutters was simulated. Then rock fragmentation analysis based on different cutter spacing was carried out. Finally, the rock of different cutter spacing adaptability was studied. A series of conclusions about double disc cutters breaking rock were drawn.
Tao Liu,Jingjing Dong,Chaonan Ye,Xianyan Wu,Wei Fan,Linlin Lu,Jingyu Kang,Xingzhong Gao,Baozhong Sun,Honglei Yi 한국섬유공학회 2022 Fibers and polymers Vol.23 No.12
In this work, the bending modal properties of three-dimensional (3D) braided composites were investigated withthe experimental and numerical methods. Three braided angles were selected to study the braided angle effect on the modalbehavior of 3D braided composites. According to the experimental parameters, a homogeneous model containing the interior,surface and corner representative unit cells of the braided composites were proposed to compute the elastic constants of eachcomposite. Besides, the fiber breakage defects were introduced to the homogeneous model to improve the accuracy ofpredicting the modal behavior of the braided composite. The results indicate that the increase of the braided angle and thefiber breakage defects could apparently reduce the natural frequency of the braided composite. The modal propertiessimulated by the homogeneous models containing some fiber breakage defects could fit well with the correspondingexperimental results. The proposed method to create the homogenous model can be used to predict the modal behavior of the3D braided composites.