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CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin
Jingbo Ma,Xiaolong Xu,Chunjin Fu,Peng Xia,Ming Tian,Liuhai Zheng,Kun Chen,Xiaolian Liu,Yilei Li,Le Yu,Qinchang Zhu,Yangyang Yu,Rongrong Fan,Haibo Jiang,Zhifen Li,Chuanbin Yang,Chengchao Xu,Ying Long,J 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed in cancers of digestive system. Nanobody represents a novel antibody format for cancer targeted imaging and drug delivery. Nanobody targeting CHD17 as an imaging probe and a delivery vehicle of toxin remains to be explored for its theragnostic potential in gastric cancer. Methods: Naïve nanobody phage library was screened against CDH17 Domain 1-3 and identified nanobodies were extensively characterized with various assays. Nanobodies labeled with imaging probe were tested in vitro and in vivo for gastric cancer detection. A CDH17 Nanobody fused with toxin PE38 was evaluated for gastric cancer inhibition in vitro and in vivo. Results: Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery. It could efficiently co-localize with CDH17-positive gastric cancer cells in zebrafish embryos and rapidly visualize the tumor mass in mice within 3 h when conjugated with imaging dyes. E8 nanobody fused with toxin PE38 showed excellent anti-tumor effect and remarkably improved the mice survival in cell-derived (CDX) and patient-derived xenograft (PDX) models. The immunotoxin also enhanced the anti-tumor effect of clinical drug 5-Fluorouracil. Conclusions: The study presents a novel imaging and drug delivery strategy by targeting CDH17. CDH17 nanobodybased immunotoxin is potentially a promising therapeutic modality for clinical translation against gastric cancer.
The Design of Anti-aliasing Analog Filter for Data Acquisition in the Surface Measurement
Xu Jingbo,Xu Xiaohong,Yang Pengyu,Lin Haijun,Guo Xin 보안공학연구지원센터 2014 International Journal of Signal Processing, Image Vol.7 No.5
In the surface measurement system, the data acquisition is key part and the anti-aliasing analog filter is necessary. This paper deals with the design of the anti-aliasing analog filter. Based on the principle of anti-aliasing filtering, the parameters of filter are computed, the filter circuit is designed, and the frequency characteristic is drawn. Combined with digital filter, the filtering can maintain the low frequency components very well and suppress effectively the high frequency signals in the original surface profile, which reduces the distortion caused by noise and makes the filtering effect better. This method has been applied in the surface measurement system and the actually measured data verified the performance of the filter.
A monolithic silicon multi-sensor for measuring three-axis acceleration, pressure and temperature
Xu Jingbo,Zhao Yulong,Jiang Zhuangde,Sun Jian 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.4
A monolithic multi-sensor for small unmanned aerial vehicles is presented in the paper; it consists of a three-axis piezoresistive accelerometer, a piezoresistive absolute pressure sensor and a silicon thermistor temperature sensor. The accelerometer is designed with four silicon beams supporting the seismic mass and appropriate piezoresistors arrangement to detect three-axis acceleration and greatly reduce cross-axis sensitivities. For minimizing the effect of stress on the temperature sensor, the thermistor is designed along [100] and [010] crystal orientation. The multi-sensor is fabricated on SOI wafers by using MEMS bulk-micromachining technology. Some effective micromachining steps are applied in the fabrication. The two-step wet anisotropic etching process on the backside of the wafers can form the whole backside shape of the multi-sensor. The metal electrode sputtered on the Pyrex glass can avoid sticking between the Pyrex glass and the seismic mass in the process of anodic bonding. The die size of the multi-sensor is 4×6×0.9mm3. The measured results show that the multi-sensor is appropriate for its application field.
Transceiver Optimization for the Multi-Antenna Downlink in MIMO Cognitive System
( Wentao Zhu ),( Jingbo Yang ),( Tingting Jia ),( Xu Liu ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.12
Transceiver optimization in multiple input multiple output (MIMO) cognitive systems is studied in this paper. The joint transceiver beamformer design is introduced to minimize the transmit power at secondary base station (SBS) while simultaneously controlling the interference to primary users (PUs) and satisfying the secondary users (SUs) signal-to-interference-plus-noise ratio (SINR) based on the convex optimization method. Due to the limited cooperation between SBS and PUs, the channel state information (CSI) usually cannot be obtained perfectly at the SBS in cognitive system. In this study, both perfect and imperfect CSI scenarios are considered in the beamformer design, and the proposed method is robust to CSI error. Numerical results validate the effectiveness of the proposed algorithm.
Yating Liu,Jingbo Duan,Yihang Gao,Buqing Xu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.3
The thermal buckle and flutter behaviors of the asymmetrically curved-fiber composite panel in supersonic air flow are studied in frequency and time domains. Based on the Mindlin thick plate theory, the Von Karman large-deformation assumption and the quasisteady supersonic piston theory were adopted to describe deformations and supersonic loads of the composite panel, respectively. According to Hamilton variational principle, the nonlinear aerothermoelastic equations of the asymmetrically curvilinear-fiber panel were established with frequency domain characteristics obtained by the complex mode method and time domain responses obtained by the Newmark method, respectively. After verifying the correctness of the current method, the influences of temperature gradient, curvilinear-fiber orientation and incoming airflow pressure on the static large-deflection, mode coalescence, flutter-buckling boundary, time-history responses and phase-plane plots of the composite panel were discussed in detail.
Li, Chunbao,Zhou, Guanghong,Xu, Xinglian,Zhang, Jingbo,Xu, Shuqin,Ji, Yanfeng Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.12
This study was designed to explore the effects of marbling on meat quality characteristics and intramuscular connective tissue of beef longissimus muscle. Chemical determinations, histological and mechanical measurements were performed on the raw and cooked meat at d 4 postmortem. The results showed that crude fat, collagen, fiber diameter and maximum transition temperature of intramuscular connective tissue increased (p<0.05) with the increase of marbling score. The cooking losses, collagen solubility, WBSF and perimysial thickness decreased (p<0.05) with the increasing marbling. WBSF correlated (p<0.05) with moisture, crude fat, collagen, cooking losses, sarcomere length and perimysial thickness. The development of marbling results in the decline in cooking losses, the avoidance of sarcomere shortening, and the disorganization of the perimysia, which accounts for the improvement of beef tenderness.
Study on the Method of Closed Loop Control for Gas Engine
Xiaocheng Ge,Zhongming Xu,Jingbo Li,Bowen Zou 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.4
With the increasing number of vehicles, society and environmental problems become much more seriously. Aiming at the serious problems, CNG engine, which has better emission performance, has been paid much more attention. However, the CNG engine also has its own disadvantages, such as engine power deterioration, great influence of different mixture ratios of the gas and air on the optimum ignition time of the engine, and so on. Therefore, adaptive control for the air-fuel ratio and ignition timing should be properly adjusted with the consideration of the engine power, economy and emissions. There are two methods of controlling the ignition timing: mechanical and electronic control. In this paper, we develop an adoptive control method based on electronic control. According to the verification, the method can improve the efficiency of the CNG engine. It can be shown the validity of the adoptive method.
magnetostratigraphy, 26Al-10Be, Yx02 borehole, tectonic evolution, Daxing Uplift, Beijing Sub-plain
Fubing He,Xiwei Xu,Fang Tian,Zhenhua Liu,Yueze Zhang,Lingyan Bai,Yubin Cui,Kai Wang,Wenzhi Niu,Jingbo Ni,Xiaoyong Liu,Mengmeng Cao 한국지질과학협의회 2024 Geosciences Journal Vol.28 No.2
The buried Daxing Uplift connects the Beijing Sag and Dachang Sag, which is the critical tectonic unit for understanding the structural evolution of the Beijing Sub-plain and its linkages to regional tectonics. This study combines paleomagnetic, 26Al-10Be isochron dates and sedimentary analyses from a new borehole (Yx02) in the northeastern Beijing Sub-plain to shed fresh light on regional tectonic processes and the sedimentary history since the Pliocene. The main findings are as follows: (1) the Daxing Uplift had formed three depositional episodes: alluvial-fan, lacustrine-delta, and alluvial-fan sedimentation since the Cenozoic; (2) The borehole records the Brunhes, Gauss normal chron, and the Matuyama, Gilbert reversed chron in the Daxing Uplift, the corresponding depths are 0–148.9 m, 148.9–315.0 m, 315.0–520.5 m and 520.5–650 m; (3) An important tectonic event started in ~4.3 Ma, disintegrated NE-trending basin and range terrain, reactivated the NW-trending Nankou-Sunhe fault, and formed Shunyi fault in Beijing Sub-plain. Sedimentation occurs exclusively in the Beijing Sag and the northeastern Daxing Uplift during ~4.3–1.77 Ma; (4) During ~1.77–1.07 Ma, a transition from an extension to a strike-slip occurred, and is described not only in a progressively higher increase of the overall deposition rate, but also in a decrease of the relative deposition disparity between sags and uplifts. Since then, the Beijing Sub-plain has been shaped, associated with an overall subsidence depression in the Bohai Bay Basin. This work enhances our understanding of the formation and evolution of the Beijing Sub-plain, the division of tectonic episodes, and the initiation time of the latest tectonic movement in the break-up region, North China Craton, since the Neogene.