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동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예
신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3
Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.
Jin Chong-Shik,Kim Mi-Sun,Lee Eun-Hee,Lee Joon-Ho,Lee Jong-Hyun,Moon Su-Jin,Lee Bo-Ra,Jung Kyung-Phil,Li Hong-Yuan Kyung Hee Oriental Medicine Research Center 2002 Oriental pharmacy and experimental medicine Vol.2 No.1
There are over 4,000 different chemicals in cigarette smoke, including nicotine and tar. These compounds influence on lung tissue directly or indirectly. In this study, we have examined whether an aqueous extract of Se-Yeon-Eum (SYE), composed of Oriental medicine that has been known to be effective to symptom by smoking, inhibits nicotine- or cigarette smoke extract (CSE)-induced cytotoxicity in human embryonic lung fibroblast, MRC-9. Assessment of cell viability using 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay indicated that SYE inhibited not only nicotine-induced cytotoxicity but also CSE-induced cytotoxicity. These results suggest the possibility that the use of SYE may be useful for improvement of many symptoms by smoking.
이진환,최준식,범진필,이종기 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.1
The displacement of protein bound sulfonamides (sulfisoxazole, sulfamethoxazole, sulfisomidine) by furosemide was investigated in bovine serum albumin by equilibrium dialysis method. Furosemide (2 × 10^(-4)M) in bovine serum albumin (7.24 × 10^(-5), 1.45 × 10^(-4), 2.89 × 10^(-4)M). Sulfisoxazole and furosemide were bound reversibly to bovine serum albumin and competitive for the same binding sites when administered together. Consequently, dosage regimen of sulfisoxazole should be adjusted carefully when sulfisoxazole is administered along with furosemide.
정진민,정희영,신완식,강문원,한경자,김종진,전성주 대한감염학회 1987 감염 Vol.19 No.1
Nocardiosis is an acute, subacute, or chronic infection, most often beginning in the lung and usually affects the immunocompromised host. Nocardia is a soil saprophyte widely distributed throughout the world. Nocardial infections are not that rare in the United States, probably between 500 and 1000 cases are recognized each year, but very rare in Korea. We have experienced a case of disseminated nocardiosis which showed a characteristic clinical course of nocardial infection. The diagnosis was made by the pus culture with the skin biopsy around the pustule of the Lt. upper arm showing characteristic acid fastness with branching hyphae. Isolation revealed that the organism was Nocardia asteroides. We report a case of disseminated Nocardia asteroides infection with the review of the relavant literatures.
Chin Chong Shik,Jung Ho Jin,Hong Seung-gweon Korean Chemical Society 1992 Bulletin of the Korean Chemical Society Vol.13 No.4
Rhodium(I) and iridium(II) complexes, M(Cl$O_4$)(CO)$(PPh_3)_2$ and [M(CO)$(PPh_3)_3$]Cl$O_4$ (M = Rh, Ir), and RhX(CO)$(PPh_3)_2$ (X = Cl, Br, OH) catalyze the carbonylation of benzyl alcohols to produce phenylacetic acids under 6 atm of CO at $110^{\circ}C$ in deuterated chloroform. Benzyl alcohols initially undergo dehydration to give dibenzyl ethers which are then carbonylated to benzyl phenylacetates, and the hydrolysis of benzyl phenylacetate produces phenylacetic acids and benzyl alcohols. The carbonylation is accompanied with dehydrogenation followed by hydrogenolysis of benzyl alcohols giving benzaldehydes and methylbenzenes which are also produced by CO2 elimination of phenylacetic acids. Phenylacetic acid is also produced in the reactions of benzyl bromide with CO catalytically in the presence of Rh(Cl$O_4$)(CO)$(PPh_3)_2$ and $H_2O$, and stoichiometrically with Rh(OH)(CO)$(PPh_3)_2$ in the absence of $H_2O$.
Woo, Jin-Chun,Chin, Chong-Shik Korean Chemical Society 1983 Bulletin of the Korean Chemical Society Vol.4 No.4
It has been found that the acrylonitrile solution of trans-$RhCl(CO)(Ph_3P)_2$ produces propionitrile catalytically at $90^{\circ}C$ under $P_{H_2}$=3 atm. This catalytic hydrogenation proceeds only for a certain period of time producing ca. 50 moles of propionitrile per mole of the rhodium complex. The hydrogenation with trans-$RhCl(CO)(Ph_3P)_2$ in the presence of formaldehyde is much faster than in the absence of formaldehyde, and continues without a decrease in the rate for a prolonged period of time. It is suggested that the hydrogenation with trans-$RhCl(CO)(Ph_3P)_2$ proceeds through the unsaturated route initiated by the dissociation of CO from trans- $RhCl(CO)(Ph_3P)_2$ to give coordinatively unsaturated $RhCl(Ph_3P)_2$.
박종원,강문원,신완식,김춘추,오용석,유진홍,김동집,김양리,한치화 대한내과학회 1995 대한내과학회지 Vol.49 No.4
Typhlitis is a life-threatening disease of bowel, mainly ileum or cecum, complicated in the immunocompromised hosts. Recently we experienced four cases of typhlitis in leukemic patients following cytotoxic chemotherapy. All the patients were diagnosed as acute myelogenous leukemia and received cytotoxic chemotherapy followed by granulocytopenia. They mainly showed fever, abdominal pain, and diarrhea. In one case, he suffered from intestinal obstruction. Abdominal CT showed diffuse thickening of ileocecal region or ascending colon. Stool culture revealed Staphylococcus aureus in two cases and Entercoccus species in one case. Staphylococcus aureus was isolated from blood culture in one case. They were managed medically and three out of four cases survived.
혈액종양 병동에서 발생한 Escherichia coli 균혈증의 분자역학적 분석
박종원,유진홍,허동호,김동욱,한치화,김양리,김경미,신완식,김춘추,강문원,김동집 대한감염학회 1995 감염 Vol.27 No.2
목적:'94년 7월부터 9월사이에 가톨릭의대부속성모병원 혈액종양병동에서 발생한 E.coli 균혈증 8예를 대상으로 분리된 균주에 대한 분자역학적 분석을 통해 병원내 전파가능성 여부를 비롯한 발생원인의 규명을 하고자 연구를 시작하였다. 방법:혈액배양에서 분리된 E.coli 8균주를 대상으로 입원당시의 의무기록에 대한 컴토분석과 병행하여 플라스미드 형별 및 FIGE를 시행하여 균주간의 일치도 여부를 분석하였다. 결과: 1)8에 모두 급성백혈병 환자였으며 이중 4명이 같은 병실에 입원하고 있었다. 8명 모두 발병당시 백혈구수가 1,000/㎕ 미만이었다. 2)8예 모두 fluoroquinolone에 100% 의 내성율을 보였다. 3)FIGE상 8예 모두 다른 유형을 보였다. 4)플라스미드 형별상 8예 모두 다른 유형을 보였다. 결론:이상의 결과로 보아 혈액종양병동에서 발생된 E.coli 균혈증은 어느 특정한 단일 클론에 의해 전파되었을 가능성은 적다고 사료된다. Background: In order to analyze an Escherichia coli bacteremic outbreak in eight leukemic patients in hemato-oncology unit from July to September, 1994. Methods: We have examined the antibiogram, plasmid typing, and field inversion gel electrophoresis of eight isolates of E.coli. Results: All patients were diagnosed as acute leukemia. Among them, four patients were in the same room at the time of the outbreak. All showed granulocytopenia and had received ciprofloxacin as a gut decontamination regimen. All strains showed resistance to fluoroquinolones. The plasmid typing patterns were quite different from each other. The analysis of field inversion gel electrophoresis also revealed eight different patterns. Conclusion: Disproving our initial assumption that the outbreak might have originated from a single clone, the genotyping patterns showed little evidence of person-to-person transmission. We have shown that molecular typing is useful in distinguishing individual strains of E.coli isolates for epidemiological purposes.
구인두 칸디다증 치료에 대한 Fluconazole의 효과
신완식,강문원,이상헌,윤임중,진종률,임영,김동집,김춘추,박종원,문찬수 대한감염학회 1991 감염 Vol.23 No.2
The efficacy analysis of oral or intravenous fluconazole in the treatment of oropharyngeal candidiasis of 20 patients. In the pretreatment clinical assessment, 11 cases were grade Ⅱ, and 9 cases were grade Ⅲ. In the pretreatment oropharyngeal culture, 3 cases were 1 positive, 15 cases were 2 positive, and 2 cases were 3 positive. Oral or intravenous fluconazole 100㎎ once daily were administered. In the posttreatment efficacy assessment, the clinical improvement time was 1-3 days, the clinical cure time was 3-11 days, the mean clinical effectiveness time was 5.6 days, and the mean clinical effectiveness time was 8.1 days. Fluconazole had a few and short-term side effects that included nausea, headache, and transient liver function abnormalities.