Stevens-Johnson Syndrome Induced by Vandetanib

Jimi Yoon,오지원,김지연 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-

Vandetanib is a once-daily oral anticancer drug that selectively inhibits key signaling pathways in cancer by targeting vascular endothelial growth factor receptors, epidermal growth factor receptors tyrosine kinase, and rearranged during transfection-dependent tumor cell proliferation and survival. The most frequently reported adverse events attributed to vandetanib include diarrhea, elevated aminotransferase,asymptomatic corrected QT interval prolongation,and hypertension. Though a number of randomized, doubleblind studies, including cutaneous adverse events attributed to vandetanib, have been reported along with these general symptoms, no case of Stevens-Johnson syndrome (SJS) has been reported. This paper demonstrates a case of SJS induced by vandetanib. (Ann Dermatol 23(S3) S343∼S345, 2011)

CASE REPORT : A Granulomatous Drug Eruption Induced by Entecavir

( Jimi Yoon ),( Donghwa Park ),( Chiyeon Kim ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.4

Entecavir (Baraclude®, Bristol-Myers Squibb) is a potent and selective antiviral agent that has demonstrated efficacy in patients with chronic hepatitis B. The most frequent adverse events attributed to entecavir include increased alanine aminotransferase, upper respiratory tract infection, headache, abdominal pain, cough, pyrexia, fatigue, and diarrhea. Although quite a few randomized double-blind studies including ones investigating adverse events along with these general symptoms have been reported, few cases of cutaneous adverse events have been described in detail. We demonstrate a case of granulomatous drug eruption as a cutaneous adverse event induced by entecavir. (Ann Dermatol 25(4) 493∼495, 2013)

Clinical research of dermatomyositis

( Dong Hwa Park ),( Jimi Yoon ),( Chi Yeon Kim ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3

여대생들의 커피 전문점 서비스 품질 인식이 고객 만족, 브랜드 이미지, 고객 충성도에 미치는 영향

김병수(Byoungsoo Kim),윤지미(Jimi Yoon),문신영(Shin-Young Moon) 한국콘텐츠학회 2013 한국콘텐츠학회논문지 Vol.13 No.12

국내 커피 시장에서 커피 전문점들간 경쟁이 치열해지고 있으며, 각 커피 전문점들은 높은 수준의 서비스품질을 통해 고객 충성도를 제고하고자 노력하고 있다. 이런 맥락에서 본 연구에서는 커피 전문점의 주 고객층인 여대생들의 커피 전문점 서비스 품질의 인지 정도를 살펴보고, 각 서비스 품질이 의사 결정에 미치는 영향을 살펴보고자 한다. 특히, 본 연구에서는 기존 문헌들에서 고려된 커피 전문점 서비스 품질들을 서비스 품질의 유형성, 서비스 환경, 서비스 제품, 서비스 전달로 구분하여, 각 서비스 품질 요인이 고객만족과 브랜드 이미지에 미치는 영향을 분석하였다. 또한 고객 충성도를 재 구매 의도와 추천 의도로 구별하여, 고객 만족과 브랜드 이미지가 재 구매 의도와 추천 의도에 미치는 영향을 살펴보았다. 제안한 연구모형은 커피 전문점을 자주 방문하는 여대생 206명을 통해 검증되었다. 본 연구 결과 서비스 제품과 서비스전달은 고객 만족과 브랜드 이미지에 모두 유의한 영향을 미쳤지만, 서비스 품질의 유형성과 서비스 환경은 유의한 영향을 미치지 못하였다. 고객 만족과 브랜드 이미지는 재 구매 의도와 추천 의도 형성에 중요한 역할을 담당하였다. In the highly competitive coffee market, each coffee shop is striving to improve customer loyalty by providing a high level of service quality. To deepen our understanding of service quality in the coffee shop market, this study identifies the key elements of service quality of coffee shops and investigates their impacts on decision-making processes of female university students. This study also investigates the effects of customer satisfaction and brand image on customer loyalty in a coffee shop market. Moreover, it considers the two critical customer loyalty: repurchasing intention and recommendation intention. Data collected from 206 female university students were empirically tested against a research model using partial least squares. Analysis results showed that service product and service delivery significantly affect customer satisfaction and brand image whereas service intangible and service environment do not significantly influence on them. Customer satisfaction and brand image play an important role on the formation of repurchasing and recommendation intention.

Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study

Kim Kyoung Jin,Choi Jimi,Kim Ji Yoon,Bae Jae Hyun,Kim Kyeong Jin,Kim Hee Young,Yoo Hye Jin,Seo Ji A,Kim Nan Hee,Choi Kyung Mook,Baik Sei Hyun,김신곤,김남훈 한국지질동맥경화학회 2021 지질·동맥경화학회지 Vol.10 No.3

Objective: We aimed to investigate the association between statin use and the risk of major osteoporotic fractures in patients with metabolic syndrome (MetS). Methods: A nested case-control study was performed in patients with MetS (≥50 years) who had no history of osteoporotic fracture using the Korean National Health Insurance Service- Health Screening Cohort. This study included 17,041 patients diagnosed with new-onset osteoporotic fractures and controls matched in a 1:1 ratio by age, sex, body mass index, cohort entry date, and follow-up duration. Conditional logistic regression analysis was used to evaluate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: During a 4-year follow-up period, the risk of major osteoporotic fractures was significantly reduced by 9% (OR, 0.91; 95% CI, 0.85–0.97) in statin users compared with that in non-users. Among subtypes of major osteoporotic fracture, a risk reduction with statin therapy was significant for vertebral fracture (OR, 0.86; 95% CI, 0.79–0.94) but not for non-vertebral fracture (OR, 0.97; 95% CI, 0.88–1.06). Longer duration (OR, 0.97; 95% CI, 0.96–0.99, per 1-year increase) and higher cumulative dose (OR, 0.97; 95% CI, 0.95–0.99, per 365 defined daily doses) of statins were negatively associated with the risk of major osteoporotic fracture. Conclusion: This study supports the hypothesis that statin therapy has a beneficial effect on major osteoporotic fractures, especially vertebral fractures, in patients with MetS.

Gender differences in the presentation of chest pain in obstructive coronary artery disease: results from the Korean Women’s Chest Pain Registry

Dong-Hyuk Cho,Jimi Choi,Mi-Na Kim,Hack-Lyoung Kim,Yong Hyun Kim,Jin Oh Na,Jin-Ok Jeong,Hyun Ju Yoon,Mi-Seung Shin,Myung-A Kim,홍경순,Gil Ja Shin,Seong-Mi Park,Wan Joo Shim 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3

Background/Aims: Chest pain in patients with obstructive coronary artery disease (OCAD) is affected by several social factors. The gender-based differences in chest pain among Koreans have yet to be investigated. Methods: The study consecutively enrolled 1,549 patients (male/female, 514/1,035; 61 ± 11 years old) with suspected angina. The predictive factors for OCAD based on gender were evaluated. Results: Men experienced more squeezing type pain on the left side of chest, while women demonstrated more dull quality pain in the retrosternal and epigastric area. After adjustment for risk factors, pain in the retrosternal area (odds ratio [OR], 1.491; 95% confidence interval [CI], 1.178 to 1.887) and aggravation by exercise (OR, 2.235; 95% CI, 1.745 to 2.861) were positively associated with OCAD. In men, shorter duration (OR, 1.581; 95% CI, 1.086 to 2.303) and dyspnea (OR, 1.610; 95% CI, 1.040 to 2.490) increased the probability for OCAD, while left-sided chest pain suggested a low probability for OCAD (OR, 0.590; 95% CI, 0.388 to 0.897). In women, aggravation by emotional stress (OR, 0.348; 95% CI, 0.162 to 0.746) and dizziness (OR, 0.457; 95% CI, 0.246 to 0.849) decreased the probability for OCAD. Conclusions: This is the first study to focus on gender differences in chest pain among Koreans with angina. Symptoms with high probability for OCAD were different between sexes. Our findings suggest that patient’s medical history in pretest assessment for OCAD should be individualized considering gender.

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

Choi, Eunhee,Choe, Hyerim,Min, Jaewon,Choi, Ji Yoon,Kim, Jimi,Lee, Hyunsook Nature Publishing Group 2009 The EMBO journal Vol.28 No.14

<P>Regulation of BubR1 is central to the control of APC/C activity. We have found that BubR1 forms a complex with PCAF and is acetylated at lysine 250. Using mass spectrometry and acetylated BubR1-specific antibodies, we have confirmed that BubR1 acetylation occurs at prometaphase. Importantly, BubR1 acetylation was required for checkpoint function, through the inhibition of ubiquitin-dependent BubR1 degradation. BubR1 degradation began before the onset of anaphase. It was noted that the pre-anaphase degradation was regulated by BubR1 acetylation. Degradation of an acetylation-mimetic form, BubR1–K250Q, was inhibited and chromosome segregation in cells expressing BubR1–K250Q was markedly delayed. By contrast, the acetylation-deficient mutant, BubR1–K250R, was unstable, and mitosis was accelerated in BubR1–K250R-expressing cells. Furthermore, we found that APC/C–Cdc20 was responsible for BubR1 degradation during mitosis. On the basis of our collective results, we propose that the acetylation status of BubR1 is a molecular switch that converts BubR1 from an inhibitor to a substrate of the APC/C complex, thus providing an efficient way to modulate APC/C activity and mitotic timing.</P>