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- 저자 : Jieun Jung (검색결과 382 건)
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Yoon, Jung Hyun,Han, Kyunghwa,Koh, Jieun,Kim, Ga Ram,Kim, Hye Jung,Park, Young Mi,Youk, Ji Hyun,Chung, Jin,Chae, In Hye,Choi, Eun Jung,Moon, Hee Jung Elsevier 2019 Ultrasound in medicine & biology Vol.45 No.10
<P><B>Abstract</B></P> <P>The purpose of this study was to determine whether disease recurrence and intrinsic characteristics of ductal carcinoma <I>in situ</I> (DCIS) are associated with the imaging method of detection in asymptomatic women. This multicenter, retrospective study included 844 women treated for asymptomatic DCIS who had pre-operative mammography and breast ultrasonography (US) studies available. Of the 844 women, 25 (3.0%) developed recurrences. Patients in the US group had significantly lower 5- and 10-y recurrence-free survival (RFS) rates compared with patients in the mammography group (<I>p</I> = 0.011). US-detected DCIS showed significantly lower 5-and 10-y RFS rates compared with mammography-detected DCIS in patients <50 y or with mammographically dense breasts (<I>p</I> = 0.002 and 0.002, respectively). US as the detection modality (hazard ratio [HR]: 4.451; 95% confidence interval [CI]: 1.530, 12.950; <I>p</I> = 0.006) and HER2 positivity (HR: 4.036; 95% CI: 1.438; 11.330; <I>p</I> = 0.008) were significantly associated with recurrence. We concluded that US as the detection modality and HER2 positivity were significantly associated with recurrence in patients treated for asymptomatic DCIS.</P>
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Jung-Wook Kho,Minhyung Jung,Soowan Kim,Jieun Lim,Hong Geun Kim,Doo-Hyung Lee 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.04
Plant virus can enhance its transmission by altering the settling preference of its vector. Nevertheless, most of the studies have focused on the spread of one virus in a field whereas often times there are more than single virus infecting same crop. Furthermore, mixed-infection of multiple viruses tends to cause more severe virus symptoms and changes vector’s biology and behavior different than singular infection. Thus, we are currently investigating the spatial transmission pattern of persistently transmitted potato leafroll virus and non-persistently transmitted potato virus y. However, due to impracticability of obtaining empirical data, we are programming an individual-based modelling software while taking biology of potato, biology and behavior of aphid and different characteristics of two viruses into consideration.
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Hepatoprotective Effect of Aged Black Garlic Extract in Rodents
Jung Hyu Shin,Chang Woo Lee,Soo Jin Oh,Jieun Yun,Moo Rim Kang,Sang-Bae Han,Heungsik Park,Jae Chul Jung,Yoon Hoo Chung,Jong Soon Kang 한국독성학회 2014 Toxicological Research Vol.30 No.1
In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
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Detection of Helicobacter pylori with Dual-Modal Glyconanoparticles
Jieun Jung,Injae Shin 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.01
Helicobacter pylori is a Gram-negative, microaerophilic bacterium found in the stomach and causes chronic gastritis and gastric ulcers. It is also associated with the development of duodenal ulcers and stomach cancer. Therefore, sensitive detection of H. pylori is crucial for diagnosis and treatment of H. pylori associated diseases. It has been known that H. pylori expresses a sialic acid-binding adhesin (SabA) and a Leb-binding adhesin (BabA) that adhere, through glycan-adhesin interactions, to the human gastric mucosa for infection. To detect H. pyroli expressing BabA, we prepared fluorescent magnetic glyconanoparticles by conjugating aminoethylated Lea, Leband H1 oligosaccharides to carboxy- containing fluorescent magnetic nanoparticles. The successful preparation of glyconanoparticles was examined by zeta potential and transmission electron microscopy (TEM). When H. pyroli J99 strain which expresses BabA was incubated with three kinds of glyconanoparticles, fluorescence microscopy analysis showed that Leb and H1 conjugated but not Lea conjugated nanoparticles bound to this strain. However, these glyconanoparticles did not recognize H. pyroli strains lacking BabA. Finally, they were employed to enrich BabA expressing H. pyroli by using a magnet. It is expected that fluorescent magnetic glyconanoparticleswill be powerful tools to sensitively detect pathogens including H. pylori.
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Jung, Jieun,Jang, Hye Ji,Eom, Su Jin,Choi, Nam Soon,Lee, Na-Kyoung,Paik, Hyun-Dong The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.1
Background: Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion of ginsenosides in fermented red ginseng extract (FRGE). Methods: Red ginseng extract (RGE) was fermented using Lactobacillus plantarum KCCM 11613P. This study investigated the ginsenosides and their antioxidant capacity in FRGE using diverse methods. Results: Properties of RGE were changed upon fermentation. Fermentation reduced the pH value, but increased the titratable acidity and viable cell counts of lactic acid bacteria. L. plantarum KCCM 11613P converted ginsenosides $Rb_2$ and $Rb_3$ to ginsenoside Rd in RGE. Fermentation also enhanced the antioxidant effects of RGE. FRGE reduced 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and reducing power; however, it improved the inhibition of ${\beta}$-carotene and linoleic acid oxidation and the lipid peroxidation. This suggested that the fermentation of RGE is effective for producing ginsenoside Rd as precursor of ginsenoside compound K and inhibition of lipid oxidation. Conclusion: This study showed that RGE fermented by L. plantarum KCCM 11613P may contribute to the development of functional food materials.
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Disproportionate Patterns of Retaliatory Antidumping Filings by Developing and Developed Countries
Jung Hur,Jieun Jung 한국경제연구학회 2013 Korea and the World Economy Vol.14 No.3
Using global antidumping cases for 72 manufacturing sectors, in 28 countries from 1991 to 2006, we investigated whether there are different patterns of retaliatory antidumping duties (AD) between the developed and developing countries. We find that the four traditional AD heavy users, which are the developed countries, such as Australia, Canada, EU and US, tend to be more sensitive to initiated AD than measured AD of exporting countries, while the five new AD heavy users, which are the developing countries, such as Argentina, Brazil, India, Mexico, South Africa, tend to be more sensitive to measured AD than initiated AD. However, the disproportionate reactions of countries disappear for the period of 1998-2006, which implies an institutional learning from past experience of retaliatory AD. For the whole period, we also find that it disappears only at the country level.
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Jung, Jieun,Paik, Hyun-Dong,Yoon, Hyun Joo,Jang, Hye Ji,Jeewanthi, Renda Kankanamge Chaturika,Jee, Hee-Sook,Li, Xiang,Lee, Na-Kyoung,Lee, Si-Kyung Korean Society for Food Science of Animal Resource 2016 한국축산식품학회지 Vol.36 No.3
The objective of this study was to investigate characteristics and functionality of yogurt applied red ginseng extract. Yogurts added with red ginseng extract (0.5, 1, 1.5, and 2%) were produced using Lactobacillus acidophilus and Streptococcus thermophilus and stored at refrigerated temperature. During fermentation, pH was decreased whereas titratable aicidity and viable cell counts of L. acidophilus and S. thermophilus were increased. The composition of yogurt samples was measured on day 1, an increase of red ginseng extract content in yogurt resulted in an increase in lactose, protein, total solids, and ash content, whereas fat and moisture content decreased. The pH value and cell counts of L. acidophilus and S. thermophilus were declined, however titratable acidity was increased during storage period. The antioxidant capacity was measured as diverse methods. During refrigerated storage time, the value of antioxidant effect was decreased, however, yogurt fortified with red ginseng extract had higher capacity than plain yogurt. The antioxidant effect was improved in proportion to concentration of red ginseng extract. These data suggests that red ginseng extract could affect to reduce fermentation time of yogurt and enhance antioxidant capacity.
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Glyconoparticles for probing Mammalian Cell Surface Lectins
Jieun Jung,Seong-Hyun Park,Injae Shin 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.01
Recognition of glycans, which are present in the form of glycoconjugates in cells, by proteins is crucial for a variety of physiological and pathological processes. Accordingly, understanding the role of glycan-mediated binding events and blocking glycan-protein interactions associated with diseases are of great importance for both basic biological research and biomedical applications. To investigate binding of glycans by lectins on the mammalian cell surface,we prepared Lewis antigen conjugated fluorescent magnetic nanoparticles and applied them to detect human DC-SIGN and mouse SIGN-R1 on mammalian cell-surfaces. To our knowledge, glycan-modified fluorescent magnetic nanoparticles have not been used to study glycan-mediated recognition events. When DCEK, DCEK-DC-SIGN, and DCEK-SIGN-R1 cells were incubated with glyconanoparticles, Lea and Leb but not H1 conjugated nanoparticles bind to DC-SIGN and SIGN-R1 expressing cells. Subsequently, glyconanoparticles were internalized by the DC-SIGN and SIGN-R1-expressing cells. However, these events were greatly suppressed by pre-treatment of cells with mannan which is a tight ligand for these lectins, indicating that glyconanoparticles mostly enter cells via lectin-mediated endocytosis. Finally, we found that glyconanoparticles lead to induction of immune responses by examining the production of reactive oxygen species. This study will provide opportunities for developing finely tuned multifunctional nanoparticle-based drug and diagnostic nanoplatforms.
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Jung, Jieun,Kim, Jong-Wan,Moon, Ho-Jin,Hong, Jin Young,Hyun, Jung Keun Hindawi Publishing Corporation 2016 Stem cells international Vol.2016 No.-
<P>Neural stem cells (NSCs) have a high potency for differentiation to neurons and glial cells for replacement of damaged cells and paracrine effects for the regeneration and remyelination of host axons. Dental pulp is known to have a potential to differentiate into neural-like cells; therefore, dental pulp may be used as an autologous cell source for neural repair. In this study, we selectively expanded stem cells from human dental pulp in an initial culture using NSC media under xeno- and serum-free conditions. At the initial step of primary culture, human dental pulp was divided into two groups according to the culture media: 10% fetal bovine serum medium group (FBS group) and NSC culture medium group (NSC group). In the NSC group relative to the FBS group, the expression of NSC markers and the concentrations of leukemia inhibitory factor, nerve growth factor, and stem cell factor were higher, although their expression levels were lower than those of human fetal NSCs. The transplanted cells of the NSC group survived well within the normal brain and injured spinal cord of rats and expressed nestin and Sox2. Under the xeno- and serum-free conditions, autologous human dental pulp-derived stem cells might prove useful for clinical cell-based therapies to repair damaged neural tissues.</P>
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