Semiconducting 2,6,9,10-Tetrakis(phenylethynyl)anthracene Derivatives: Effect of Substitution Positions on Molecular Energies

Hur†, Jung A,Bae, Suk Young,Kim, Kyung Hwan,Lee, Tae Wan,Cho, Min Ju,Choi, Dong Hoon American Chemical Society 2011 ORGANIC LETTERS Vol.13 No.8

<P>2,6-Bis((4-hexylphenyl)ethynyl)-9,10-bis(phenylethynyl)anthracene, <B>4</B>, and 9,10-bis((4-hexylphenyl)ethynyl)-2,6-bis (phenyl ethynyl)anthracene, <B>5</B>, have been synthesized to study their electronic and photophysical properties. It should be noted that the difference between these compounds is the substitution position of 1-ethynyl-4-hexylbenzene groups into an anthracene ring. In particular, substitution in the 9,10-positions of the anthracene ring enhanced J-aggregated intermolecular interactions. Since <B>5</B> has a lower bandgap energy and more compact film morphology, it exhibited higher hole mobility (∼0.27 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>) in thin-film transistor devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2011/orlef7.2011.13.issue-8/ol200299s/production/images/medium/ol-2011-00299s_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol200299s'>ACS Electronic Supporting Info</A></P>

Three New Monotypic Genera of the Caloplacoid Lichens (Teloschistaceae, Lichen-Forming Ascomycetes)

( Sergii Y Kondratyuk ),( Laszlo Lokos ),( Jung A Kim ),( Anna S Kondratiuk ),( Min Hye Jeong ),( Seol Hwa Jang ),( Soon Ok Oh ),( Jae Seoun Hur ) 한국균학회 2015 Mycobiology Vol.43 No.3

Three monophyletic branches are strongly supported in a phylogenetic analysis of the Teloschistaceae based on combined data sets of internal transcribed spacer and large subunit nrDNA and 12S small subunit mtDNA sequences. These are described as new monotypic genera: Jasonhuria S. Y. Kondr., L. Lokos et S. -O. Oh, Loekoesia S. Y. Kondr., S. -O. Oh et J. -S. Hur and Olegblumia S. Y. Kondr., L. Lokos et J. -S. Hur. Three new combinations for the type species of these genera are proposed.

알부민이 첨가된 시험관내 약역학 감염모델을 이용한 폐렴알균 치료에서 Ceftriaxone 일일 1회 요법

허지안,전혜선,박선희,최수미,김시현,이동건,최정현,유진홍,신완식 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

배경 : Penicillin 내성 폐렴알균이 증가하는 지역에서 대안 중의 하나로 사용되는 ceftriaxone (CTR)의 적절한 용법, 용량을 파악하는 것이 중요하다. 본 연구는 임상에서 분리된 폐렴알균을 대상으로 시험관내 약역학 감염모델을 이용하여 알부민이 첨가된 경우와 첨가되지 않은 경우 CTR의 일일 1회 요법의 효과를 비교해 보고자 하였다. 재료 및 방법 : Penicillin 감수성(SM24), 중간내성(SM47), 내성(SM60)주를 대상으로 2-구획 시험관내 약역학 감염모델을 적용하였다. CTR 주입은 2 g씩 24시간마다로 사람의 약동학을 모의하였다. 알부민은 모델에서 4g/ dL가 유지되도록 하였다. 살균효과는 0, 2, 4, 6, 24, 30, 48시간째 집락수 변화로 측정하였다. 결과 : 모든 균주에서 알부민이 첨가되지 않은 경우 6시간 이내에 살균력이 관찰되었다. 최저억제농도 및 알부민 첨가유무에 관계없이 3주 모두 24시간째 살균력이 관찰되었고, 48시간째는 모두 측정한계 이하의 집락수로 감소하였다. 전 실험과정에서 CTR에 대한 내성주는 출현하지 않았다. 결론 : CTR의 일일 1회 요법은 알부민이 첨가되었을 때, 감수성, 중간내성, 내성주 모두에서 살균력 발현이 지연되었으나 최종효과는 알부민이 없을 때와 다르지 않았다. 앞으로 알부민 결합효과와 관련된 기초적인 추가 연구가 필요할 것으로 생각된다. Background : During the era of increasing penicillin resistant Streptococcus pneumoniae, it is important to have knowledge about adequate dosage and dosing interval of ceftriaxone (CTR). We examined efficacies of once-daily CTR and compared results in an in vitro pharmacodynamic infection model (IVPDIM) supplemented with albumin and those without albumin. Methods : Using three clinically isolated S. pneumoniae that were susceptible (SM24), intermediate (SM47) and resistant (SM60) against CTR, we utilized a two-compartment IVPDIM. CTR 2 g was administered intravenously every 24 h. Human albumin was added with concentration of 4 g/dL. Samples were removed at multiple time points over a 48-h period to determine the colony counts. Results : In SM24 and SM60, bactericidal effects were observed within 6 hours in groups without albumin. The number of colonies during 1st 6 hours were more decreased in albumin-free groups than in albumin-supplemented groups (P<0.05). In SM47, similar results were found during 1st 6 hours (P=0.03). But, regrowth was observed in albumin supplemented group at 30 h. Irrespective of results of minimal inhibitory concentrations and albumin supplementation, bactericidal effects were shown at 24 h in all 3 strains. All groups were decreased below the detection limit at 48 h. Development of resistance was not detected throughout the entire study period in either strain. Conclusions : Although extents of killing in albumin supplemented broth of once-daily CTR dosing were delayed in all 3 strains compared with those of albumin free broth, final efficacies were not different between the two groups.

각종 소화성질환에서의 Campylobacter Pylori의 검출에 관하여

허정욱,강영우,박준호,박승국,하경임,김재룡,안성훈,박선우 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

Peptic disorders are among the most common maladies in korea as the world. In most cases their etiologies not be established and their pathophysioolgy remain obscure. Although the persence of fastric bacteria has been logn established, recently campylobacter pylori seems to be etiologic agent of peptic disorders. Campylobacter pylori is visualized in most cases of peptic disorders and not visualized after treatment of bctericidal agents, bismuth compound or metronidazole. We had a following results for identification of campylocacter pylori in stomach and duodenal mcuosa via endoscipc biopsy. 1. We studied 54 patients who had dyspeptic symptoms, 29 males. 2. Most patients are in 5th decades, next in 3rd and 6th in order. 3. Ptients were composed of 27 peptic ulcer, 22 gastitis and 5 gastric carcinoma. 4. Campylobacter pylori was identified in 69% of total patients, peptic ulcer 63%, gastritis 77%, stomach carcinoma leastly.

담수어 잉어(Cyprinus carpio)의 각 조직의 3'-nucleotidase 활성도의 분포

허정욱 최신의학사 1991 最新醫學 Vol.34 No.3

미만성 경화 아형 갑상선 유두암 1예

최정민,이송주,김부경,최영식,박요한,김정훈,허방 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

The diffuse sclerosing variant (DSV) is a rare malignant tumour that accounts for 0.7-5.3% of all papillary thyroid cancers. DSV tends to occur at a younger age and has a higher incidence of cervical lymph node metastases, compared with papillary thyroid carcinoma. A 62-year-old female patient diagnosed thyroid nodule with diffuse and mild increased 18F-deoxy-glucose (FDG) on FDG positron emission tomography (PET)-computed tomogram (CT) scan. The ultrasound images showed typical findings of DSV such as diffusely enlarged thyroid lobes and diffusely scattered microcalcification. We performed this patient ultrasonography guided fine needle aspiration and cytologic analysis revealed papillary carcinoma. Total thyroidectomy with central compartment node dissection and lateral lymph node dissection was performed and finally diagnosed DVS. The authors report this case with literature review.

Brucella abortus 국내 분리주의 36kDa 외막단백을 암호하는 omp2b 유전자의 염기 분석

허지연,김지영,송근호,김명철,박창식,김태용,김정화,전무형 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

B. abortus 국내 분리주의 분자유전학적 성상을 규명하고 분자역학적 연구에 필요한 기초자료를 얻기 위해 36kDa OMP를 암호하는 omp2b 유전자를 PCR법으로 확인하고,그리고 omp2b 유전자의 핵염기 서열과 아미노산 서열을 결정하고 이 결과를 Brucella 표준균주 및 여러 동물에서 분리된 Brucella 분리주와 상호 비교 분석하였던 바 다음과 같은 결과를 얻었다. 1. B. abortus 분리 주 (7주)에 대해 omp2b primers를 이용하여 PCR을 수행한 바 공시한 참조균주와 분 리균주 모두에서 1,251bp의 특이한 DNA 절편이 각각 증폭되었다. 2. omp2b 유전자의 1,089bp에 대한 염기서열과 이에 대한 362개의 아미노산 서열을 결정하였다. 분리 균주의 omp2b 유전자의 염기서열을 참조균주와 비교 분석한 결과 B. abortus 2308 (biovar 1) 및 B abortus B3196 (biovar 5)과는 99.6%∼100% 및 99.5%∼99.9%의 매우 높은 상동성을 나타내었고,B. abortus 45/20 (biovar 1)과는 97.1%~97.4%의 상동성을 나타내었다. 또한 362개의 아미노산 서열에 대해 분석하였던 바,분리균주들은 B.abortustus 2308 (biovar 1) 및 B. abortus B3196 (biovar 5)과는 99.2%∼100%의 매우 높은 상동성을 보였으며,B. abortus 45/20 (biovar 1)과는 96.4%∼ 97.2%의 상동성을 보였다. 3. 본 시험에 공사된 브루셈라균주의 omp2b 유전자 서열과 여러 동물에서 분리된 브루셀라 분리주의 자료를 바탕으로 phylogenetic tree를 작성 한 바,국내 분리주는 B. abortus 2308 (biovar 1),B. abortus B3196 (biovar 5),B. abortus 45/20 (biovar 1),B. suis 1330 (biovar 1),B. melitensis 16M (biovar 1),B. canis NCTC 01854,B. neotomae 5K33과 97.3% 이상의 높은 근연성을 보이며 동일한 cluster에 소속되었으며,omp2b 유전자는 매우 잘 보존됨을 알 수 있었다. omp2b gene of Brucella abortus isolates encoding 36kDa outer membrane protein (OMP) was amplified by polymerase chain reaction (PCR) and the sequences of nucleotide and amino acid were determined and analyzed to obtain the basic data for molecular epidemiological features of brucellosis in Korea. In PCR using omp2b primers for the gene of 36kDa aMP, the specific signals at 1,251bp were demonstrated, The nucleotide sequences of omp2b gene of 1,089bp were sequenced by dye terminator cycle sequencing method, and 362 amino acid sequences were predicted. As compared the nucleotide sequences with those of B. abortus reference strains, the isolates showed the very high homology to the reference strains ranging 97.1%∼100%. The similar results were also obtained in the analysis of the amino acid sequences. In the phylogenetic tree, the isolates clustered with the reference strains and the majority of strains originated from pig, dog, wood rat and cattle.

조류 닭(Gallus domesticus)의 각 조직의 3'-nucleotidase 활성도의 분포

허정욱 中央醫學社 1991 中央醫學 Vol.56 No.3

3'-Nucleotidase (3'-ribonucleotide phosphohydrolase, EC 3.1.3.6) in chickins, Gallus domesticus, tissues has been studied. The activity of this enzyme has been found in every tissues so examined. Muscle contained the highest activities (expressed as that amount of 1 ?mol of 3'-adenylic acid formed to inorganic phosphate per min under the conditions described below). The lowest activity was found in gills, heart, and intestine.

선형 연결된 처리기들의 스케쥴링

허정연 慶南大學校 附設 工業技術硏究所 1997 硏究論文集 Vol.15 No.1

본 논문은 선형으로 2개이상 연결되어 있는 병렬처리기에서 실행되는 프로그램의 병렬처리를 분석하였으며 선형연결된 프로세서들은 그래프로 표현되며 통신에 따라 발생하는 제약조건을 가진다. 본 연구는 선형 연결된 프로세서들에게 통신지연을 고려한 단편화된 프로그램들의 할당 알고리즘을 찾고 최적 할당 알고리즘을 위한 휴리스틱 방법을 모색하였다. This paper analyzes parallel processing of program at the system which are linearly connected processors with two or more processors, this system is presented graph theoretic model which describes the communication constraints of linearly connected processors. This study find assignment of program fragments to linearly connected processors that require communication delay and investigate heuristic method for optimal assignment algorithm.

가변실행 시간을 갖는 태스크의 할당에 관한 연구

허정연 경남대학교 신소재연구소 1996 論文集 Vol.7 No.-

본 논문에서는 균일 분포함수에 의한 랜덤길이를 갖는 태스크를 생성하고, 이들 선행관계를 포아송(Poisson) 분포에 따른 난수를 발생시켜 설정하였다. 이렇게 생성된 태스크들을 두 개의 프로세서로 구성된 시스템에( 경우 1) 임계경로(critical path)를 한 프로세서에 할당한 다음 나머니 태스크들을 다른 프로세서에 할당한 경우, (경우 2) 태스크의 도착 순서와 선행관계에 따라 두 프로세서에 할당한 경우를 조사하였다. 시뮬레이션 결과 태스크 수가 적을 경우 (경우 2)가 (경우 1) 보다 더 빠르게 실행되나 태스크 수가 증가하면 (경우 2)의 교체회수(number of swapping)가 증가하였다. 만약 교체비용이 매우 작아서 전체 실행시간에 비해 무시할 수 있다면 (경우 1)의 스케쥴링이 태스크 수에 관계없이 우수함을 알 수 있었다. This paper is studied about two task allocations at the two processor system. Tasks used in this simulation have length made by uniform random number generation. precedent relation made by Poisson random number generation. First scheduling is that tasks on the critical path allocate one processor and another tasks are other processor, second scheduling is that tasks allocate according to order of arriving and precedent relation. In this simulation, When number of task are small, execution time of second schedule is fast then first schedule and when number of task are increas, number of swapping of second schedule is large. By this results, if swap cost is little as compared with execution time so that second scheduling is better then first scheduling nothing to do with number of tasks.