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시상부위에 발생한 단일성 뇌농양 : 증례 보고 및 문헌고찰 Report of Two Cases and Review of the Literature
곽호신,김동규,이상형,정희원,이현구,김현집,한대희 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.12
The authors present two cases of solitary thalamic abscess which were intially diagnosed as malignant thalamic glioma. After treatment with steroids and osmotic agents, the patients' clinical conditions improved after two to three days. However, sudden deterioration of consciousness level developed and the CT scan showed acute hydrocephalus with increment of thalamic low-density lesions. We performed extraventricular drainage and obtained CSF containing numerous inflammatory cells. This suggested the possibility that the lesion was a pyogenic abscess. which progressed to ventriculitis, rather than a malignant glioma. Stereotactic aspiration of the lesion confirmed thalamic abscess. These findings and review of previous reports of thalamic abscess suggested that early diagnosis and stereotactic drainage of the thalamic abscess is of primary importance.
Eun-Ja Lee,Hong-Jib Choi,Dong-Hyun Shin,Chan-Ho Kwon,J. Grover Shannon,Jeong-Dong Lee 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Soybean is desirable as a forage crop because of it has high protein and oil concentration. Wild soybean, a progenitor of cultivated soybean, has a softer stem and higher protein content in seed than cultivated soybean. There is little information on yield and forage quality for wild soybean and its derivatives. The objective of this study was to determine the forage yield and quality of wild soybeans and selected soybeans derived from a cross G. max ×G. soja. Forage yield and quality were assessed for three grain soybean cultivars, three wild soybeans and three selected lines from G. max×G. soja. Forage quality attributes such as crude protein (CP), crude fat (CF), neutral detergent fiber (NDF), acid detergent fiber (ADF), digestible dry matter (DDM), dry matter intake (DMI) and relative feed value (RFV) were determined at the R2, R4 and R6 developmental stages. Forage yield and CF were highest at stage R6 in G. max, G. soja and selected G. max×G. soja lines. CP content was similar between R2 and R4 but increased sharply after R4 and peaked at R6 in G. max and selected lines from G. soja×G. max. On the other hand, CP content was similar between R4 and R6 stage in wild soybeans. Generally, NDF and ADF were highest at stage R4 but decreased at stage R6. DDM, DMI, and RFV increased between R4 and R6. These results suggest that R6 was the optimal harvest stage to provide forage of highest quality and yield. A study was conducted in 2011 to evaluate forage yield and quality at stage R6 in 25 lines from PI483463 (G. soja)×Hutcheson (G. max) and four cultivated grain soybeans. Hutcheson had the highest forage yield with 24.7t/ha infresh weight (FW) among grain soybeans. Line W11 had the highest forage yield(25.7t/ha,FW) among G. soja×G. max selections and four other lines had similar forage yield compared to Hutcheson. Generally the 25 lines from this G. max×G. soja cross had thinner main stems and branches than cultivated soybeans. When the 25 lines were evaluated for their feed quality as per forage grade by AFGC, nine lines rated prime grade and all 25 lines were classified as forage Grade 1. Results of this study indicate crosses between wild and cultivated soybean show promise for improving soybean as a forage crop.
(Sang Ah Chang),(Bong Yun Cha),(Soon Jib Yoo),(Yo Bae Ahn),(Ki Ho Song),(Je Ho Han),(Jong Min Lee),(Hyun Sik Son),(Kun Ho Yoon),(Moo Il Kang),(Kwang Woo Lee),(Ho Young Son),(Sung Ku Kang) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.2
N/A Background : It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. Methods : About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats. Results : In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats. Conclusion : These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.
강성구,서선희,이광우,손호영,손현식,강무일,한제호,유순집,차봉연,고승현,안유배,윤건호,송기호 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.3
Background: Neonatal porcine pancreas is an attractive alternative source for islet transplantation because of its growth potential and availability. Porcine neonatal pancreatic cell clusters(NPCCs) consist mainly of protodifferentiated cells expressing both the duct cell marker pancytokeratin and islet hormones. In this study, we investigated to expand and mature the pancreas duct cells contained in porcine NPCCs with extracellular matrix. Methods: For NPCCs, pancreas obtained from neonatal pigs were minced, digested with collagenase and cultured overnight, Then NPCCs were further disparsed to small cell groups and cultured on HTB-9 extracellular matrix: the tissue attached and formed monolayer patches. At the 3rd and 8th days, tissue was fixed, immunostained for pancytokeratin (panCK), vimentin (VT) and islet hormones. Results: During 5 days culture, the total cell numbers increased 3.2 fold on the matrix, and 1.6 fold on the sticky dish, respectively. Insulin positive cells (Ins+) were 6.0% of total cells at day 3 and increased 1.6 fold in nurnbers at day 8. There was significant increase in DNA content of NPCCs in monolayers on both sticky dishes and HTB-9 matrix. In contrast, insulin content of both groups decreased during culture periods. Until 8 days of culture affer dispersion of porcine NPCC, most duct cells costained with panCK and VT. Conclusion: We observed NPCCs were composed of many of duct cells which were known to be endocrine precursor cells and monolayer culture of NPCC with extracellular matrix resulted in the proliferation and differentiation of pancreatic duct cells
Oh, Ki-Won,Kang, Moon-Il,Lee, Young-Won,Ahn, Yoo-Bae,Song, Ki-Ho,Yoo, Soon-Jib,Yoon, Kun-Ho,Cha, Bong-Yun,Lee, Kwang-Woo,Son, Ho-Young,Kang, Sung-Koo 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Background : Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Recently, a mutation (677C→T) was identified in the methylenetetrahydrofolate reductase (MTHFR) gene leading to the substitution of valine (V) for alanine (A). This mutation causes a reduced folate-dependent enzyme activity which leads to increased serum homocysteine. In this study, we examined the association between the V allele of the methylenetetrahydrofolate reductase gene and macroangiopathy in Korean patients with type 2 diabetes mellitus. Methods : In 54 type 2 diabetic patients with macroangiopathy and 198 normal subjects, the MTHFR genotypes were analyzed by polymerase chain reaction (PCR) followed by HinfI digestion. To confirm the detection of the MTHFR polymorphism by the PCR-restriction fragment length polymorphism (RFLP) analysis, DNA Sequencing was performed on the PCR products. Results : The allele frequency of the V mutation was slightly higher in the patients than in the normal subjects but that was not statistically significant. The crude Ors and 95% Cis for the allele frequency of the V mutation were 1.16 (0.76-1.79). Genotype frequencies were 35.9% for AA, 48.4% for AV, and 15.7% for VV in the normal subjects and 31.5% for AA, 50.0% for AV, and 18.5% for VV in the patients. The crude Ors and 95% Cis for the VV genotype were 1,22 (0.56-2.67). In multiple regression model, the VV genotype was not associated with diabetic macroangiopathy. Conclusion : Although the frequencies of VV genotype in Korean normals (□16%) are higher than those of other ethical populations (□12%), this mutation is not associated with macroangiopathy in type 2 diabetic patients. But, our sample size was to small and larger Cohort studies will be needed to confirm the effect of MTHFR polymorphism on the development of macroangiopathy in diabetic patients. (The Journal of Korean Diabetes Association 23(5):625-634, 1999)
Homocysteine, Folate and Methylenetetrahydrofolate Reductase Polymorphism in Korean Normal Subjects
Oh, Ki-Won,Kang, Moo-Il,Lee, Woon-Young,Ahn, Yoo-Bae,Song, Ki-Ho,Yoo, Soon-Jib,Yoon, Kun-Ho,Cha, Bong-Yun,Lee, Kwang-Woo,Son, Ho-Young,Kang, Sung-Koo 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Objective : Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Recently, a mutatin (677C→T) was identified in the methylenetetrahydrofolate reductase gene leading to the substitution of valine(V) for alanine(A). This mutation causes a reduced folate-dependent enzyme activity which leads to increased serum homocysteine. In this study, we examined the association between the V allele of the methylenetetrahydrofolate reductase gene and serum total homocysteine and folate concentrations in Korean healthy subjects. Methods : In 198 healthy subjects, the methylenetetrahydrofolate reductase gene genotypes were analyzed by polymerase chain reaction followed by HinfI digestion. Serum total homocysteine and folate concentrations were measured in age- and sex-matched 14 healthy subjects in each of the three methylenetetrahydrofolate reductase genotypes. Results : Homozygosity for 677C→T mutation in the methylenetetrahydrofolate reductase gene was found in 31 (15.7%) of 198 healthy subjects. In healthy subjects, those bearing the VV genotype tend to have higher serum total homocysteine concentrations than AA genotype but this was not statistically significant. Correlation between serum total homocysteine concentrations and other clinical variables showed that serum folate and creatinine were significant. Conclusion : We conclude that although the frequency of VV genotype in Korean healthy subjects is higher than that of other reports, this mutation is not associated with increased serum total homocysteine concentrations in Korean healthy subjects. (The Korean Journal of Internal Medicine 57(6):1030-1036, 1999)
정상한국인에서 혈중 호모시스테인과 엽산 농도 및 Methylenetetrahydrofolate Reductase 유전자 다형성
오기원(Ki Won oh),이원영(Won Young Lee),안유배(Yoo Bae Ahn),송기호(Ki Ho Song),유순집(Soon Jib Yoo),윤건호(Kun Ho Yoon),강무일(Moo Il Kang),차봉연(Bong Youn Cha),이광우(Kwang Woo Lee),손호영(Ho Young Son),강성구(Sung Ku Kang) 대한내과학회 1999 대한내과학회지 Vol.57 No.6
N/A Background : Hyperhomocysteinemia is an independent risk factor for cardiovascualr disease. Recently, a mutation (677C→T) was identified in the methylenetetrahydrofolate reductase gene leading to the substitution of valine(V) for alanine(A). This mutation causes a reduced folate-dependent enzyme activity which leads to increased homocysteine. In this study, we examined the association between the V allele of the methylenetetrahydrofolate reductase gene and serum total homocysteine and folate concentrations in Korean healthy subjects. Methods : In 198 healthy subjects, the methylenetetrahydrofolate reductase genotypes were analyzed by polymerase chain reaction followed by HinfI digestion. Serum total homocysteine and folate concentrations were measured in age- and sex-matched 14 healthy subjects in each of three methylenetetrahydrofolate reductase genotypes. Results : Homozygosity for 677C→T mutation in the methylenetetrahydrofolate reductase gene was found in 31 (15.7%) of 198 healthy subjects. In healthy subjects, those bearing the VV genotype tend to have higher serum total homocysteine concentrations 1.5 μmol/L(18.6%) than AA genotype but this was not statistically significant. Correlation between serum total homocysteine concentrations and other clinical variables showed that serum folate and creatinine were significant. Conclusion : We conclude that although the frequency of VV genotype in Korean healthy subjects is higher than that of other reports, this mutation is not associated with increased serum total homocysteine concentrations in Korean healthy subjects. (Korean J Med 57:1030-1036, 1999)