Olanzapine May Inhibit Colonic Motility Associated with the 5-HT Receptor and Myosin Light Chain Kinase

Jiarui Zhang,Ying Qiao,Jingjing Le,Daliang Sun,Yangtai Guan,Zezhi Li 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.2

ObjectiveaaTo study whether the effects of olanzapine on gastrointestinal motility is related to the serotonin antagonism and myosin light chain kinase. MethodsaaMale Sprague-Dawley rats were randomly divided into four groups. Olanzapine gavage was performed for each treatment group during the course of 30 continuous days, while the same volume of saline was given to the rats in the control group. Defecation of the rats was observed on days 7 and 30 after olanzapine gavage. The effects of olanzapine on contraction of colonic smooth muscles were observed in ex vivo experiments. A Western blot was used to evaluate expression levels of the serotonin transporter (SERT) and MLCK in colon segments of the rats. ResultsaaCompared to the control group, 5–160 μM of olanzapine could inhibit dose-dependently the contraction of colonic smooth muscle ex vivo experiments. The maximum smooth muscle contraction effects of 5-HT and acetylcholine significantly decreased after treatment with 40–160 μM of olanzapine. Constipation was found in the olanzapine-treated rats on day 7 and have sustained day 30 after gavage. Expression of MLCK in olanzapine-treated rats was significantly decreased, whereas the expression of SERT significantly increased on the day 7, then significantly decreased on the day 30 after olanzapine gavage. ConclusionaaSERT and MLCK may involve in the inhibition of colonic contraction induced by olanzapine.

Experimental and Mechanism Investigation on Boiling Heat Transfer Characteristics of Alumina/Water Nanofluid on a Cylindrical Tube

Hao Zhang,Zeng-en Li,Shan Qing,Zhuangzhuang Jia,Jiarui Xu,Lin Ma,Sixian Wang,Aimin Zhang,Zhumei Luo 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.10

Nucleate pool boiling heat transfer experiments have been conducted to nanofluids on a horizontal cylinder tube under atmospheric pressure. The nanofluids are prepared by dispersing Al2O3 nanoparticles into distilled water at concentrations of 0.001, 0.01, 0.1, 1 and 2 wt.% with or without sodium, 4-dodecylbenzenesulfonate (SDBS). The experimental results showed that: nanofluids at lower concentrations (0.001 wt.% to 1 wt.%) can obviously enhance the pool boiling heat transfer performance, but signs of deterioration can be observed at higher concentration (2 wt.%). The presence of SDBS can obviously enhance the pool boiling heat transfer performance, and with the presence of SDBS, a maximum enhancement ratio of BHTC of 69.88%, and a maximum decrease ratio of super heat of 41.12% can be found in Group NS5 and NS4, respectively. The tube diameter and wall thickness of heating surface are the influential factors for boiling heat transfer coefficient. Besides, we find that Rohsenow formula failed to predict the characteristics of nanofluids. The mechanism study shows that: the decrease of surface tension, which leads to the decrease of bubble departure diameter, and the presence of agglomerates in nanofluids are the reasons for the enhanced pool boiling heat transfer performance. At higher concentration, particle deposition will lead to the decrease of distribution density of the vaporization core, and as a result of that, the boiling heat transfer performance will deteriorate.

The actuation equation of macro-fiber composite coupled plate and its active control over the vibration of plate and shell

Tu, Jianwei,Zhang, Jiarui,Zhu, Qianying,Liu, Fan,Luo, Wei Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.2

Plate and shell structure is widely applied in engineering, i.e. building roofs, aircraft wings, ship platforms, and satellite solar arrays. Its vibration problem has become increasingly prominent due to the tendency of lightening, upsizing and flexibility. As a new smart material with great actuating force and toughness, macro-fiber composite (MFC) is composed of piezoelectric fiber and epoxy resin basal body, which can be directly pasted onto the surface of plate and shell and is suitable for vibration control. This paper deduces the actuation equation of MFC coupled plate in different boundary conditions, an equivalent finite element modeling method is proposed which uses MFC actuating force as the applied excitation, and on this basis the active control simulation and experiment of MFC over plate and shell structure vibration are accomplished. The results indicate that MFC is able to implement effective control over plate and shell structure vibration in multi-band range. The comparison between experiment and simulation proves that the actuation equation deduced herein, effective and practicable, can be applied into the simulation calculation of MFC vibration control over plate and shell structure.

Synthesis of hierarchical α-Fe₂O₃ nanotubes for high-performance lithium-ion batteries

Gu, Cuiping,Song, Xinjie,Zhang, Simin,Ryu, Si Ok,Huang, Jiarui Elsevier 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.714 No.-

<P><B>Abstract</B></P> <P>Hierarchical α-Fe<SUB>2</SUB>O<SUB>3</SUB> nanotubes are facially synthesized via a sacrificial template strategy without chemical etching, and are then employed as the anode material for lithium-ion batteries (LIBs). FeC<SUB>2</SUB>O<SUB>4</SUB>·2H<SUB>2</SUB>O nanorods are used as the sacrificial template to prepare nanotubes consisting of numerous nanosheets. The resultant hierarchical hollow structures possess an inter-diameter range of 400–600 nm and exhibit a large specific surface area. The as-prepared hierarchical nanotubes demonstrate remarkable improvement in cycling stability (500 cycles) and a reversible Li<SUP>+</SUP> storage capacity as high as 764.2 mAh g<SUP>−1</SUP> at a current density of 0.5 A g<SUP>−1</SUP>. This excellent electrochemical performance suggests that the hierarchical α-Fe<SUB>2</SUB>O<SUB>3</SUB> nanotubes prepared herein are promising candidate anode materials for LIBs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hierarchical α-Fe<SUB>2</SUB>O<SUB>3</SUB> nanotubes were obtained via a sacrificial template strategy. </LI> <LI> The hierarchical α-Fe<SUB>2</SUB>O<SUB>3</SUB> nanotubes exhibited high lithium ion storage performance. </LI> <LI> High performance was attributed to the tubular structure and large surface area. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Hierarchical α-Fe<SUB>2</SUB>O<SUB>3</SUB> nanotubes obtained via a sacrificial template strategy followed by calcination process, showed excellent lithium ion storage performances.</P> <P>[DISPLAY OMISSION]</P>

Anomalous Ferromagnetism and Electron Microscopy Characterization of High-Quality Neodymium Oxychlorides Nanocrystals

Xinliang Zheng,Juan Feng,Jiarui Zhang,Hongna Xing,Jiming Zheng,Mingzi Wang,Yan Zong,Jintao Bai,Xinghua Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.3

High-quality neodymium oxychlorides nanocrystals with cubic shape were synthesized by a nonhydrolytic thermolysis route. The morphology and crystal structure of the neodymium oxychlorides nanocubes were characterized by transmission electron microscopy at the nanoscale. Transmission electron microscope (TEM) image shows that the neodymium oxychlorides nanocrystals are nearly monodispersed with cube-like shape. X-ray diffraction (XRD) and selected area electron diffraction (SAED) patterns of numerous neodymium oxychlorides nanocubes suggest a pure crystal phase with tetragonal PbFCl matlockite structure. HRTEM image of individual neodymium oxychlorides nanocubes indicate that each nanocubes have a singlecrystalline nature with high quality. Unlike the anti-ferromagnetism of the bulk, the neodymium oxychlorides nanocubes show clearly anomalous ferromagnetic characteristic at room temperature. This finding provides a new platform for the exploration of diluted magnetic semiconductors, rare earth-based nanomaterials and so on.

Modified Model Free Adaptive Control for a Class of Nonlinear Systems with Multi-threshold Quantized Observations

Xiangquan Li,Zhengguang Xu,Yanrong Lu,Jiarui Cui,Lixin Zhang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.10

This paper addresses a pattern-moving-based modified model free adaptive control (PMFAC) scheme and illustrates the convergence of its tracking error for a class of nonlinear systems with unknown model and multi-threshold quantized observations. The basic idea is to consider the system’s quantization error as an external disturbance and an improved performance index function of control law is proposed from the perspective of twoplayer zero-sum game (TP-ZSG) based on the existed MFAC algorithms. The PMFAC scheme is established which mainly includes an improved tracking control law and a pseudo-partial derivative (PPD) estimation algorithm. Under certain conditions, the bounded convergence of system tracking error and the stability of PMFAC system with quantization errors can be guaranteed. The theoretical results are demonstrated by two numerical examples.

Experimental Study on Lime-Treated Waste Soil Based on Water Transfer Mechanism

Fanlu Min,Jiawei Ma,Nan Zhang,Hangbiao Song,Jiarui Du,Dengfeng Wang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.5

A large amount of waste soil (mud) is being produced from the construction of civil and infrastructures. As a result, resource utilization of the waste soil has become even more important in geotechnical engineering community. This study quantitatively investigates the underlying modification mechanism of lime-treated waste soil based on water transfer mechanism. Content of different types of water was first measured, and content of each hydration product and the Atterberg limits of soils before and after the lime treatment were then analyzed. It is found the mechanism of lime treatment is to transfer free water with low potential energy to bound water and hydration water with high potential energy. In addition, the formation of hydrates gel mainly improves soil plasticity by affecting the limit of soil plasticity. The hydration water can be used to evaluate the effectiveness of treatment and the growth potential.

Prevention of acetaminophen-induced hepatocyte injury: JNK inhibition and GSTA1 involvement

Chang Yicong,He Jingshan,Ma Bingke,Ishfaq Muhammad,Wang Jiaqi,Zhang Ruichen,Yuan Liang,Liu Jiarui,Li Changwen,Liu Fangping 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.2

Background Glutathione S-transferase A1 (GSTA1) is a detoxification enzyme and a sensitive marker for hepatotoxicity. We investigated the effects of JNK inhibition on different degrees of Acetaminophen (APAP)-induced hepatocyte injury and GSTA1 expression. Objective This study aimed to investigate the role of JNK signaling pathway in APAP-induced different degrees of hepatocyte injury and its correlation with GSTA1 by inhibiting the phosphorylation of JNK by SP600125. Results 6 and 8 mM APAP induced different degrees of hepatocyte injury and apoptosis, both activated JNK signaling pathway. In contrast, JNK inhibitor significantly reduced activation of JNK and c-JUN on exposure to APAP. Meanwhile, the levels of hepatocyte injury, oxidative stress, and apoptosis obviously decreased. Importantly, GSTA1 expression was significantly increased by JNK inhibition. Conclusions JNK inhibition attenuates APAP-induced hepatocyte injury and oxidative stress and increases GSTA1 expression. Furthermore, GSTA1 may be involved in this signaling pathway for detoxification. Background Glutathione S-transferase A1 (GSTA1) is a detoxification enzyme and a sensitive marker for hepatotoxicity. We investigated the effects of JNK inhibition on different degrees of Acetaminophen (APAP)-induced hepatocyte injury and GSTA1 expression. Objective This study aimed to investigate the role of JNK signaling pathway in APAP-induced different degrees of hepatocyte injury and its correlation with GSTA1 by inhibiting the phosphorylation of JNK by SP600125. Results 6 and 8 mM APAP induced different degrees of hepatocyte injury and apoptosis, both activated JNK signaling pathway. In contrast, JNK inhibitor significantly reduced activation of JNK and c-JUN on exposure to APAP. Meanwhile, the levels of hepatocyte injury, oxidative stress, and apoptosis obviously decreased. Importantly, GSTA1 expression was significantly increased by JNK inhibition. Conclusions JNK inhibition attenuates APAP-induced hepatocyte injury and oxidative stress and increases GSTA1 expression. Furthermore, GSTA1 may be involved in this signaling pathway for detoxification.

Epidemiological investigation and phylogenetic analysis of Classical Swine Fever virus in Yunnan province from 2015 to 2021

Jun Yao,Linlin Su,Qiaoping Wang,Lin Gao,Jiarui Xie,Yuwen He,Xianghua Shu,Chunlian Song,Jun Chai,Yifang Zhang,Shibiao Yang 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.4

Background: Classical swine fever virus (CSFV), the causative agent of classical swine fever (CFS), is a highly contagious disease that poses a serious threat to Chinese pig populations. Objectives: Many provinces of China, such as Shandong, Henan, Hebei, Heilongjiang, and Liaoning provinces, have reported epidemics of CSFV, while the references to the epidemic of CSFV in Yunnan province are rare. This study examined the epidemic characteristics of the CSFV in Yunnan province. Methods: In this study, 326 tissue samples were collected from different regions in Yunnan province from 2015 to 2021. A reverse transcription-polymerase chain reaction (RT-PCR), sequences analysis, and phylogenetic analysis were performed for the pathogenic detection and analysis of these 326 clinical specimens. Results: Approximately 3.37% (11/326) of specimens tested positive for the CSFV by RT-PCR, which is lower than that of other regions of China. Sequence analysis of the partial E2 sequences of eleven CSFV strains showed that they shared 89.0–100.0% nucleotide (nt) and 95.0–100.0% amino acid (aa) homology, respectively. Phylogenetic analysis showed that these novel isolates belonged to the subgenotypes 2.1c and 2.1d, with subgenotype 2.1c being predominant. Conclusions: The CSFV was sporadic in China’s Yunnan province from 2015 to 2021. Both 2.1c and 2.1d subgenotypes were found in this region, but 2.1c was dominant.