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Jiahua Zhang,Wei-jun Wang,Dao-bing Zhang,Biao Zhang,Fei Meng 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.11
Based on the existing research, the 3D active and passive failure mechanisms of a pressurized tunnel face are constructed. The nonlinear failure criterion is introduced into the limit analysis by virtue of the tangent technique. By neglecting the randomness of soil parameters, the collapse pressure of active failure and the blowout pressure of passive failure, namely the lower and upper limit of retaining pressure, are obtained along with the failure ranges. On account of the randomness of soil properties, a three-dimensional stochastic model of a pressurized tunnel face is established, and the optimal range of retaining pressure of the pressurized tunnel face is presented on the basis of the multiple correlated failure modes. Taking Changsha Metro Line 2 as an example, the good agreement of the measured data in situ with the reasonable range of retaining pressure verifies the presented method. The combination of limit analysis and reliability method can provide more scientific and reasonable support parameters for the construction of pressurized tunnels in the future.
Zepeng Zhang,Guanzheng Zhuang,Maguy Jaber,Jiahua Gao,Shanmao Peng 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.56 No.-
This work aims to reveal the differences of structures and properties between organo-montmorillonite(OMt) and organo-palygorskite (OPal) in oil-based drillingfluids. Organoclays are prepared in aqueoussolution and characterized by XRD, SEM and TEM. Surfactants can intercalate into the interlayer space ofMt while they coat only on the palygorskite surface. OMt can form “house of cards” structure while OPalforms “haystack” structure. Temperature rising promotes network structure and rheological properties oforganoclays in oil. The decline of rheological properties at high temperature is mainly caused by thedissolution of surfactants into oil, instead of thermal decomposition.
Nie, Zhaogang,Zhang, Jiahua,Zhang, Xia,Lim, Ki-Soo Cambridge University Press (Materials Research Soc 2009 Journal of materials research Vol.24 No.5
<P>High-quality SrAl12O19:Pr<SUP>3+</SUP> nanodisks and nanoplates were fabricated via a new processing technique based on a modified polymer steric entrapment method. Serious agglomeration and large particle size distribution of final products, which usually occurred in the conventional method, were eliminated completely. The effects of new synthetic processes on the morphology, crystallization, and yield of products and the relevant mechanisms were discussed. As far as we know, SrAl12O19:Pr<SUP>3+</SUP> nanodisks with mean diameter ∼60 nm and thickness between 5 and 10 nm were successfully synthesized for the first time by this low-cost technique. The new synthetic method may provide a general route to synthesize other refractory mixed-oxide nanocrystals. Photon cascade emission involving transitions <SUP>1</SUP>S0-<SUP>1</SUP>I6 followed by <SUP>3</SUP>P0-<SUP>3</SUP>H4 in SrAl12O19:1% Pr<SUP>3+</SUP> nanodisks was investigated. Size-effect-induced blue shift of the 4<I>f</I>5<I>d</I> states of Pr<SUP>3+</SUP> was observed in SrAl12O19:1% Pr<SUP>3+</SUP> nanodisks, in which the quantum efficiency was preserved, as in the bulk counterparts.</P>
Polymorphisms in Exon 2 of MHC Class II DRB3 Gene of 10 Domestic Goats in Southwest China
Zhao, Yongju,Xu, Huizhong,Shi, Lixiang,Zhang, Jiahua Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.6
Polymorphism of the second exon of the caprine leukocyte antigen-DRB3 gene (CLA-$DRB3^*02$) was investigated in this study. The 285 bp PCR product of 258 individuals from 10 domestic goat breeds in Southwest China was digested with restriction endonucleases PstI and HaeIII and then genotyped. Three alleles and 4 restriction digestion profiles were distinguished by digestion of the PCR fragment by PstI, and 8 alleles and 13 genotypes by HaeIII. For HaeIII restriction enzyme sites, the Chi-square ($X^2$) test showed that all goat breeds in this study did not fit with the Hardy-Weinberg equilibrium (p<0.01 or p<0.05). The highly polymorphic nature of CLA-$DRB3^*02$ was demonstrated and the ranges of gene heterozygosity (He) and polymorphism information content (PIC) were 0.36-0.63 and 0.32-0.55, respectively. Clustering analysis showed that the 10 goat breeds clustered into two groups and Dazu Black goat had a close genetic relationship with Chengdu Grey, Jintang Black and Nanjiang Yellow goats.
The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells
Yuan Yuan,Caihua Xue,Qiang Wu,Mengjie Wang,Jiahua Liu,Longfei Zhang,Qianwen Xing,Jingyan Liang,Hua Wu,Zhi Chen 한국유전학회 2021 Genes & Genomics Vol.43 No.2
Background Procyanidin B2 (PCB2) can increase the levels of anti-infammatory and immune mediators. Objectives However, its molecular mechanism in human breast cancer remains unclear. This study aimed to investigate the antitumor efect of PCB2 on MCF-7 cells and to examine the underlying mechanism. Methods The fow cytometry and EdU incorporation assays were measured the PCB2-induced BMECs. The expression levels of infammatory factors and immune response genes were upregulated in MCF-7 cells, high-throughput sequencing was used to detect diferentially expressed genes in blank and PCB2-treated MCF-7 cells. Results The results showed that PCB2 induced the apoptosis of MCF-7 cells. CD36 profles were afected in MCF-7 cells. Additionally, prediction software identifed a miR-145-5p binding site in the CD36 sequence. Luciferase reporter assays and Western blot analysis were used to verify the regulatory relationships between the diferentially expressed miRNA miR145-5p and CD36. MiR-145-5p and its key target (CD36) constitute a potential miRNA-mRNA regulatory pair. Functional studies in MCF-7 cells revealed that CD36 promotes but miR-145-5p inhibits apoptosis. Conclusion Overall, these data suggest that miR-145-5p inhibits the enhancing efect of PCB2 on CD36 expression by binding CD36 and subsequently regulating apoptosis, the immune response and anti-infammatory pathways. These results provide theoretical and experimental support for the treatment of breast cancer.