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Jiabin Liu,Haiying Zhang,Yun Zhang,Nan Li,Yuku Wen,Fanglei Cao,Hao Ai,Xiaoou Xue 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.12
Premature ovarian failure (POF) is a long-term adverse effect of chemotherapy treatment. However, current available treatment regimens are not optimal. Emerging evidence suggests that bone marrow-derived mesenchymal stem cells (BMSCs) could restore the structure and function of injured tissues, but the homing and restorative effects of BMSCs on chemotherapy injured ovaries are still not clear. In this study, we found that granulosa cell (GC) apoptosis induced by cisplatin was reduced when BMSCs were migrated to granulosa cells (GCs) in vitro. Chemo-therapy-induced POF was induced by intraperitoneal injection of cisplatin in rats. BMSCs labeled with enhanced green fluorescent protein (EGFP) were injected into the rats via the tail vein to investigate the homing and distribution of BMSCs in vivo. The number of BMSCs in the ovarian hilum and medulla was greater than in the cortex, but no BMSCs were found in the follicles and corpus lutea. In addition, the BMSCs treatment group’s antral follicle count and estradiol levels increased after 30 days, compared with the POF group. Hence, our study demonstrates that intravenously delivered BMSCs can home to the ovaries, and restore its structure and function in POF model rats.
Enhancing the Ag Precipitation by Surface Mechanical Attrition Treatment on Cu-Ag Alloys
Jiabin Liu,Lehao Zhang,Jingjing Liu,Liuyi Huang,Hao Gu,Youtong Fang,Liang Meng,Jian Zhang 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.5
The influence of surface mechanical attrition treatment (SMAT) on Ag precipitation in Cu-Ag alloys was investigated. Cu-6 wt% Ag was melt, cold rolled and solution treated to be Cu-Ag solid solution, which was either aged at 250 and 350 °C for 24 h directly or SMAT-ed before aging. Ag precipitates were hard be found in the directly aged Cu-Ag sample while they were observed clearly in the SMAT-ed counterpart at 250 °C. The Ag precipitates formed in the surface layer by SMAT are much coarser than those in the un-SMAT-ed sample. It is obvious that the precipitating behavior of Ag was promoted significantly by SMAT approach. A large number of defects were generated by SMAT and they were acting as fast atomic diffusion channels that facilitated the atomic diffusion of Ag.
Liu, Jiabin,Zhang, Haiying,Zhang, Yun,Li, Nan,Wen, Yuku,Cao, Fanglei,Ai, Hao,Xue, Xiaoou Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.12
Premature ovarian failure (POF) is a long-term adverse effect of chemotherapy treatment. However, current available treatment regimens are not optimal. Emerging evidence suggests that bone marrow-derived mesenchymal stem cells (BMSCs) could restore the structure and function of injured tissues, but the homing and restorative effects of BMSCs on chemotherapy injured ovaries are still not clear. In this study, we found that granulosa cell (GC) apoptosis induced by cisplatin was reduced when BMSCs were migrated to granulosa cells (GCs) in vitro. Chemotherapy-induced POF was induced by intraperitoneal injection of cisplatin in rats. BMSCs labeled with enhanced green fluorescent protein (EGFP) were injected into the rats via the tail vein to investigate the homing and distribution of BMSCs in vivo. The number of BMSCs in the ovarian hilum and medulla was greater than in the cortex, but no BMSCs were found in the follicles and corpus lutea. In addition, the BMSCs treatment group's antral follicle count and estradiol levels increased after 30 days, compared with the POF group. Hence, our study demonstrates that intravenously delivered BMSCs can home to the ovaries, and restore its structure and function in POF model rats.
Gao, Guangjun,Zhang, Yani,Zhang, Jie,Xie, Fei,Zhang, Yan,Wang, Jiabin Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.27 No.4
This paper investigated the wind-snow flow around the bogie region of a high-speed train under crosswinds using a coupled numerical method of the unsteady Realizable $k-{\varepsilon}$ turbulence model and discrete phase model (DPM). The flow features around the bogie region were discussed and the influence of bogie fairing height on the snow accumulation on the bogie was also analyzed. Here the high-speed train was running at a speed of 200 km/h in a natural environment with the crosswind speed of 15 m/s. The mesh resolution and methodology for CFD analysis were validated against wind tunnel experiments. The results show that large negative pressure occurs locally on the bottom of wheels, electric motors, gear covers, while the positive pressure occurs locally on those windward surfaces. The airflow travels through the complex bogie and flows towards the rear bogie plate, causing a backflow in the upper space of the bogie region. The snow particles mainly accumulate on the wheels, electric motors, windward sides of gear covers, side fairings and back plate of the bogie. Longer side fairings increase the snow accumulation on the bogie, especially on the back plate, side fairings and brake clamps. However, the fairing height shows little impact on snow accumulation on the upper region of the bogie. Compared to short side fairings, a full length side fairing model contributes to more than two times of snow accumulation on the brake clamps, and more than 20% on the whole bogie.
Guangjun Gao,Yani Zhang,Jie Zhang,Fei Xie,Yan Zhang,Jiabin Wang 한국풍공학회 2018 Wind and Structures, An International Journal (WAS Vol.27 No.4
This paper investigated the wind-snow flow around the bogie region of a high-speed train under crosswinds using a coupled numerical method of the unsteady Realizable k-ε turbulence model and discrete phase model (DPM). The flow features around the bogie region were discussed and the influence of bogie fairing height on the snow accumulation on the bogie was also analyzed. Here the high-speed train was running at a speed of 200 km/h in a natural environment with the crosswind speed of 15 m/s. The mesh resolution and methodology for CFD analysis were validated against wind tunnel experiments. The results show that large negative pressure occurs locally on the bottom of wheels, electric motors, gear covers, while the positive pressure occurs locally on those windward surfaces. The airflow travels through the complex bogie and flows towards the rear bogie plate, causing a backflow in the upper space of the bogie region. The snow particles mainly accumulate on the wheels, electric motors, windward sides of gear covers, side fairings and back plate of the bogie. Longer side fairings increase the snow accumulation on the bogie, especially on the back plate, side fairings and brake clamps. However, the fairing height shows little impact on snow accumulation on the upper region of the bogie. Compared to short side fairings, a full length side fairing model contributes to more than two times of snow accumulation on the brake clamps, and more than 20% on the whole bogie.
Jinghui Yao,Jiabin Zhou,Tianlei Zhang,Su Liu,Ke Du 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.11
Catalytic oxidation of toluene was implemented over SmMnO3, Sm0.8A0.2MnO3 (ABO3, A=Ce, Sr, Ca) and Sm1xCaxMnO3 (x=0.0, 0.1, 0.2, 0.3) perovskite oxides synthesized via sol-gel method. The effects of A-site substitution of SmMnO3 and the amount of calcium substitution of SmMnO3 perovskite-type catalyst on the catalytic activity of toluene were investigated in a fixed bed reactor. The structure and chemical properties of the perovskites were studied by XRD, SEM, XPS, and H2-TPR. The results showed that the substitution of Ce and Ca had a positive impact about the catalytic properties of toluene oxidation, while a negative impact was caused by the substitution of Sr. The catalytic activity of toluene oxidation followed the order of Sm0.8Ca0.2MnO3>Sm0.8Ce0.2MnO3>SmMnO3>Sm0.8Sr0.2MnO3 in terms of the temperature of T90%, at toluene concentration=1,000 ppm and weight hourly space velocity (WHSV)=3,000mL/ g·h. Sm0.8Ca0.2MnO3 had the highest catalytic capacity (T90%=238 oC), which could be attributed to its high adsorbed oxygen concentration, Mn4+/Mn3+, and the best low-temperature reducibility (H2 consumption=0.36). Meanwhile, the Sm0.8Ca0.2MnO3 catalysts showed great long-term stability after 30 h of the reaction, and the toluene degradation rate remained over 95% at 350 oC.
Dongmei Zhao,Guobing Zhang,Mingquan Wang,Chaoxue Zhang,Jiabin Li 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.2
Background/Aims: In recent years, greater assessment accuracy after transjugular intrahepatic portosystemic shunt (TIPS) to ascertain prognosis has become important in decompensated cirrhosis due to portal hypertension. The aim of this study was to assess the ratio of the portal pressure gradient (PPG) pre-TIPS (pre-PPG) to albumin (PPA), which influence ascites formation in cirrhotic patients in the 6-months after TIPS placement, and is a metric introduced in our study. Methods: This was a retrospective cohort study of 58 patients with decompensated cirrhosis admitted to an academic hospital for the purpose of TIPS placement. We collected the following data: demographics, laboratory measures, and PPG during the TIPS procedure. Then we analyzed the association between the above data and ascites formation post- TIPS in cirrhosis patients. Results: Twenty-two patients with ascites and 28 without ascites were evaluated. Univariate and binary logistic regression analysis were adjusted for the following variables: to determine prognosis; Child-Pugh scores, lymphocyte count, platelet count, hemoglobin level, albumin level and pre-PPG or PPA. The outcome showed that PPA was better than pre-PPG and albumin for predicting ascites according to area under receiver operating characteristic curves and a statistical model that also showed PPA’s influence 6-months post-TIPS. Conclusions: The combined measurement of pre-PPG and albumin, defined as PPA, may provide a better way to predict post-TIPS ascites in decompensated cirrhosis, which underlines the need for a large clinical trial in the future.
Ultralarge elastic deformation of nanoscale diamond
Banerjee, Amit,Bernoulli, Daniel,Zhang, Hongti,Yuen, Muk-Fung,Liu, Jiabin,Dong, Jichen,Ding, Feng,Lu, Jian,Dao, Ming,Zhang, Wenjun,Lu, Yang,Suresh, Subra American Association for the Advancement of Scienc 2018 Science Vol.360 No.6386
<P>Diamonds have substantial hardness and durability, but attempting to deform diamonds usually results in brittle fracture. We demonstrate ultralarge, fully reversible elastic deformation of nanoscale (similar to 300 nanometers) single-crystalline and polycrystalline diamond needles. For single-crystalline diamond, the maximum tensile strains (up to 9%) approached the theoretical elastic limit, and the corresponding maximum tensile stress reached similar to 89 to 98 gigapascals. After combining systematic computational simulations and characterization of pre- and postdeformation structural features, we ascribe the concurrent high strength and large elastic strain to the paucity of defects in the small-volume diamond nanoneedles and to the relatively smooth surfaces compared with those of microscale and larger specimens. The discovery offers the potential for new applications through optimized design of diamond nanostructure, geometry, elastic strains, and physical properties.</P>