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Qingqing Su,Guangming Chang,Fulian Yang,Fengyan Qin 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.1
The impact of weak filling joints with multiple angles on the energy dissipation mechanism is significant for surrounding rock engineering to prevent and mitigate disasters. In the present study, the sandstone samples containing weak filling joints were prefabricated, and dynamic splitting tests were conducted under three nominal loading rates with a modified Split Hopkinson Pressure Bar system. The effects of nominal loading rates and joint angles on time–based curves and energy–based curves were investigated systematically. The test results indicated that the nominal loading rate and joint angle had remarkable influences on energy dissipation characteristics. The sample containing a larger joint angle preferred brittle failure, whereas the sample with a smaller joint angle failed with a plastic feature. Moreover, the reflection energy decreased as the joint angle increased, which was opposite to the evolution tendencies of transmission energy and absorption energy. The transmission energy and absorption energy had different sensitivities to changes in joint angle and nominal loading rate. The exponential function could excellently describe the dependence of transmission energy, reflection energy, and absorption energy on joint angles. With the incremental joint angle, the energy reflection ratio had a contrary tendency to the energy transmission ratio.
Qiannan Guo,Runyao Wen,Bin Shao,Yudong Li,Xin Jin,Heran Deng,Jiannan Wu,Fengxi Su,Fengyan Yu 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2
Purpose: The long non-coding RNA H19, a conservatively imprinted gene, acts as a molecular sponge for the let-7 family, which has been identified as a set of tumor suppressors. However, the combined prognostic value of H19 and let-7a signature in breast cancer patients remains unclear. Methods: In this research we assessed the prognostic value of the combined H19 and let-7a signature in breast cancer patients by retrospectively reviewing that data of 79 patients who underwent neoadjuvant chemotherapy; we also investigated the expression and function of H19 in breast cancer cell lines in vitro. Survival data were calculated using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate survival analyses were conducted using the Cox proportional hazards regression method. As determined using X-tile, the optimal cutoff value for the risk score to assess progression-free survival (PFS) based on the combined signature was –0.1. Results: Patients with an overall positive treatment response had higher let-7a and lower H19 levels. In addition, let-7a expression was negatively correlated with H19 expression. Patients with a risk score of >–0.1 had shorter overall survival and PFS. In vitro data showed that chemoresistant cell lines exhibit higher H19 and lower let-7a levels and knockdown H19 restores paclitaxel sensitivity. Conclusion: Our results suggest that the combined let-7a and H19 signature is a novel prognostic factor for breast cancer patients treated with neoadjuvant chemotherapy.