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Youngjin Lee,Ji Hun Kim,Bora Lee,Jung Youn Kang,Jia Jia Lim,Hyung-Seop Youn,Jung-Gyu Lee,Jun Yop An,Kyoung Ryoung Park,Tae Gyun Kim,Do Han Kim,Soo Hyun Eom 한국구조생물학회 2015 Biodesign Vol.3 No.4
Mitochondrial calcium (Ca2+) homeostasis is essential for cell survival and death. The mitochondrial calcium uniporter(MCU) homo-tetramer is a selective Ca2+ channel responsible for mitochondrial Ca2+ uptake. Its paralog, MCUb, can form a Ca2+-impermeable hetero-tetramer with MCU exerting a dominant-negative function. We report the structural modeling for MCUb N-terminal domain (NTD), which showed 83% sequence homology with MCU NTD. The MCUb NTD model structure forms a stable globular domain via a hydrophobic interior and contains conserved putative phosphorylation and ubiquitination sites. The MCUb NTD structure is similar to that of MCU NTD with a root mean square deviation (RMSD) of 0.3 Å for 96 Cα atoms. The MCUb NTD forms a stable heterodimer with MCU NTD mainly by electrostatic interaction, although both NTDs are stable as monomers. Besides, our cross-linking results reveal that both NTDs form high-order oligomers. Our findings suggest that stable heterodimer formation of MCU-MCUb NTDs affects MCU NTD clustering, resulting in inefficient clustering of MCU for efficient Ca2+ permeation at the high [Ca2+] microdomain.
이여주 ( Yeo Joo Lee ),초가기 ( Jia Qi Chu ),이서용 ( Seo Yong Lee ),김수미 ( Su Mi Kim ),이광녕 ( Kwang Nyeong Lee ),고영준 ( Young Joon Ko ),이향심 ( Hyang Sim Lee ),조인수 ( In Soo Cho ),남석현 ( Seok Hyun Nam ),박종현 ( Jong H 한국가축위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.2
Foot-and-mouth disease (FMD) is one of the most infectious diseases affecting cloven-hoofed animals including cattle, sheep, goats, and pigs. Seven serotypes of foot-and-mouth disease virus with multiple subtypes within each serotype have been identified until now. In particular, it has been demonstrated that the outbreak of the serotype Asia1 reported from China, Mongolia and North Korea since 2005 is mostly classified into genetic group V. Though it has been recommended that Asia1 Shamir strain can be used as a high priority vaccine by World References Laboratory for FMD, the complete nucleotide sequences of the strain has not yet been determined. In this study, to be prepared for Asia1 type viruses that may be brought into Korea, the complete genome sequence of this vaccine strain Asia1 Shamir including its 5` and 3` non-coding region was identified.
이여주 ( Yeo Joo Lee ),초가기 ( Jia Qi Chu ),이서용 ( Seo Yong Lee ),김수미 ( Su Mi Kim ),이광녕 ( Kwang Nyeong Lee ),고영준 ( Young Joon Ko ),이향심 ( Hyang Sim Lee ),조인수 ( In Soo Cho ),남석현 ( Seok Hyun Nam ),박종현 ( Jong H 한국가축위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.2
Asia1/Shamir that has been recommended by World Reference Laboratory for foot-and-mouth disease (FMD) is used as a vaccine strain, and is being prepared in many countries including Korea. Although it is assumed that vaccine strain Asia1/Shamir has a wide antigenicity, sufficient molecular biological analysis has not been accomplished yet. Complete genome sequence analysis showed that the region with the most severe variations was 1D region of structural protein-coding sequence; particularly amino acid 141~157 residues in 1D region RGD sites for binding to susceptible cells. In addition, five amino acids in 1D region were identified as characteristic sites that are different from other known Asia1 viruses. Asia1/Shamir strain was shown to be genetically similar to group VI that had occurred in the Middle East, but showed low level of genetic similarity to the group V viruses that had occurred in the Southeast Asia and China. It is considered that, if these viruses, group I and II including group V are introduced into Korea, care would be paid in case of inoculating the vaccine strain Shamir available in Korea.
Jun, Hee-jin,Hoang, Minh-Hien,Lee, Jin Woo,Yaoyao, Jia,Lee, Ji-Hae,Lee, Dong-Ho,Lee, Hak-Ju,Seo, Woo-Duck,Hwang, Bang Yeon,Lee, Sung-Joon Kluwer Academic Publishers 2012 Biotechnology letters Vol.34 No.12
<P>A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.</P>
A New Complementary Quadriphase Jacket Sequence with Good Cross Correlation
Jia Hou,Kwang-Jae Lee,Moon-Ho Lee 한국전자파학회JEES 2005 Journal of Electromagnetic Engineering and Science Vol.5 No.4
In this paper, a set of new complementary quadriphase sequences based on Jacket matrix is proposed. It is with a good zero cross correlation zone and efficiently eliminates the inter-user interferences for CDMA systems. Unlike the conventional complementary sequence designs, the proposed sequences can be easily extended to large odd and even sizes by using a fast linear transform for multi-user communication systems. The computer simulation shows that the proposed sequences have better performance than conventional multi-user spreading CDMA systems using ZCZ sequence.