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( Ji Won Kim ),( Jae Seon Kim ),( Ho Kim ),( Yong Jeoung ),( Jin Sung Koh ),( Jung Wan Choe ),( Hyo Jung Kim ),( Beom Jae Lee ),( Jong Jae Park ),( Hong Sik Lee ),( Chang Duck Kim ),( Young Tae Bak ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although some pancreatic cystic neoplasms(PCNs) is a surgical indication, slow-growing and favorable prognosis have been suggested in contrast to ductal adenocarcinomas. The aim of this study was to evaluate natural course of PCNs and the detection of malignant transformation according to risk factor during follow up. Methods: We retrospectively reviewed a record of patients diagnosed with incidental PCNs from March 2000 to June 2013 in Guro and Anam hospital, Korea University College of Medicine, Seoul. Results: Of enrolled 301 patients, 19 patients were excluded (15 patients with less than 1 year of follow up, 4 patients with operation due to malignancy at initial cyst diagnosis). Data from total 282 patients was analyzed (Mean age: 59.4 years, median follow up: 28.5 months) and 97 patients had the risk factors such as more than 3cm in diameter or presence of mural nodule/solid portion. 41 patients (41/282, 14.5%) had changes in followed imaging CT (median duration of event in follow up imaging was 24 months), 32 cases showed increase of size and 9 cases changed in characteristics of cyst. Cyst-related malignancy was occurred in 5 patients (1.8%, 5/282). All these patients had risk factor and increase of size. Post-operative morbidity was observed in 31 of 93 cases (33.3%). 2 patients were died (1; intra-abdominal infection, 1; mechanical obstruction due to post operative adhesion). Motality during study period was in 9 patients but disease specifi c mortality was only one patient. Conclusions: Although the risk of malignant transformation of incidental PCNs was higher than the general population, detection of malignancy or disease specifi c mortality during surveillance was low, even if high risk group. Under surveillance the regular imaging follow up is seemed to be important especially in 2 years after initial cyst diagnosis.
( Ji Won Kim ),( Jeung Hui Pyo ),( Kyeong Jin Kim ),( Ho Kim ),( Yong Jeoung ),( Jong Dae Ji ),( Young Ho Lee ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.1
Behcet`s disease is an inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. A few cases of hematologic disease in patients with Behcet`s disease have been reported in the literature. However, acute precursor T cell lymphoblastic leukemia has never been described in association with Behcet`s disease. We recently encountered a case of acute precursor T cell lymphoblastic leukemia in a 62-year-old man with a prior diagnosis of Behcet`s disease. The patient presented with febrile neutropenia and his bone marrow biopsy revealed acute precursor T cell lymphoblastic leukemia. He was scheduled to undergo therapeutic chemotherapy, but unfortunately he died from pneumonia prior to treatment.
Effects of Single Treatment of Anti-Dementia Drugs on Sleep-Wake Patterns in Rats
Jung, Ji-Young,Roh, Moo-Taek,Ko, Kyung-Kyun,Jang, Hwan-Soo,Lee, Seong-Ryong,Ha, Jeoung-Hee,Jang, Il-Sung,Lee, Ho-Won,Lee, Maan-Gee The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.4
We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal and parietal cortex for the electroencephalography (EEG). EEG was recorded with a bio-potential amplifier for 8 h from 09:30 to 17:30. Vibration was recorded to monitor animal activity with a vibration measuring device. Sleep-wake states such as wake (W), slow-wave sleep (S) and paradoxical or rapid eye movement sleep (P), were scored every 10 sec by an experimenter. We measured mean episode duration and number of episode to determine which factor sleep disturbance was attributed to. Donepezil and memantine showed a significant increase in total W duration and decreases in total S and P duration and delta activity. Memantine showed increases in sleep latency and motor activity. Changes of S and P duration in memantine were attributed from changes of mean episode duration. Galantamine had little effect on sleep architecture. From these results, it is showed that galantamine may be an anti-dementia drug that does not cause sleep disturbances and memantine may be a drug that causes severe sleep disturbance.
유지영 ( Ji Young You ),이혜윤 ( Hye Yoon Lee ),이은숙 ( Eun Sook Lee ),배정원 ( Jeoung Won Bae ),우상욱 ( Sang Uk Woo ),박경화 ( Kyong Hwa Park ) 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.2
배경: 삼중음성유방암은 비삼중음성유방암군에 비해 조기라 해도 더 나쁜 예후를 보이는 걸로 알려져 있다. 따라서 삼중음성유방암의 초기 치료를 위해서 정확한 예후인자를 찾는 것이 중요하다. 본 연구에서는, T1-2 림프절 음성인 삼중음성유방암의 나쁜 예후와 관련된 예후인자를 찾아 보고자 하였다. 방법: 1995년부터 2006년까지 고려대학교 의료원 안암병원에서 유방암으로 근치절제술을 시행받은 환자 중 림프절 전이나 원격전이가 없는 환자를 대상으로 하였다. 이 중에서 호르몬 수용체 및 HER2 수용체 여부에 대한 기록이 있는 환자들만을 포함시켰다. 의무기록의 후향적 분석을 통해 삼중음성유방암 및 비삼중음성유방암 환자들의 임상병리적 특징이 분석되었다. 결과: 79명 (22.9%) 의 환자들이 삼중음성유방암군으로 분류되었다. 삼중음성유방암군에서 p53 양성 환자군에서 p53 음성 환자군보다 더 낮은 무병생존율을 보였다 (p=0.028). 다변량 회귀분석에서는 35세 이하의 낮은 연령이 삼중음성유방암과 관련된 독립적인 예후인자로 나타났으며, Ki-67은 단변량 회귀분석에서 삼중음성유방암과 통계적으로 유의하게 관련성을 보였다. 결론: 본 연구에서, T1-2 림프절 음성인 삼중음성유방암에서 연령은 독립적인 예후인자이고 어릴수록 나쁜 예후와 연관됨을 알 수 있었고, Ki-67 은 통계적으로 증명되지는 않았지만, 삼중음성유방암의 예후인자가 될 수 있을 것으로 생각된다. Purpose Triple-negative breast cancer typically results in poorer prognoses compared to non-triple negative breast cancer, even in early stages. The initial management of triple negative breast cancer patients and detection of clear prognostic factors are therefore of great importance. We aimed to identify specific prognostic factors associated with unfavorable outcomes of triple negative breast cancer in T1-2 node-negative breast cancer. Materials and Methods We analyzed breast cancer patients without lymph node metastasis or distant metastasis who underwent curative surgery at the Anam Hospital of the Korea University Medical Center between 1995 and 2006. Among them, patients were eligible for analysis, only if the reports about hormone receptor and human epidermal growth factor receptor-2 status were available. Clinico-pathological features were reviewed by retrospective examination and comparison of medical records of triple negative breast cancer and non-triple negative breast cancer patients. Results Seventy-nine patients (22.9%) were categorized to the triple negative breast cancer group. The disease-free survival rate of TNBC p53-positive patients was significantly lower than that of p53-negative patients (p =0.028). In multivariate analysis, young age was an independent prognostic factor for disease-free survival of the triple negative breast cancer group. High Ki-67 expression was a significant prognostic factor in univariate analysis in triple negative breast cancer, but it was not significant in multivariate analysis. Conclusion We suggest that age is an independent prognostic factor of triple negative breast cancer in T1-2 and node-negative patients and that Ki-67 could also be a prognostic factor in these patients.
골프클럽 소비자 혼란이 부정적 감정을 통해 소비자행동에 미치는 영향
이정학 ( Jeoung Hak Lee ),이지혜 ( Ji Hae Lee ),김욱기 ( Wook Ki Kim ),김정원 ( Jung Won Kim ) 한국스포츠정책과학원(구 한국스포츠개발원) 2014 체육과학연구 Vol.25 No.1
골프인구증가와 더불어 국내 골프용품 시장은 미국, 일본에 이어 세계에서 세 번째로 큰 규모로 성장하였다. 이러한 골프용품 시장의 성장과 함께 골프클럽의 선택 폭이 넓어지고 쉽게 구입할 수 있게 되었으나, 공급과잉으로 인하여 소비자들은 자신에게 맞는 제품을 선택, 사용하는데 혼란과 어려움을 겪고 있는 실정이다. 따라서 본 연구의 목적은 세 가지 차원의 소비자 혼란을 적용하여 골프시장에 과잉 공급되고 있는 골프클럽선택에 대한 소비자 혼란이 부정적 감정을 유발하는 원인이 될 수 있는지 살펴보고, 이 부정적 감정이 초래할 수 있는 행동적 결과로서 부정적 구전, 신뢰도, 구매지연에 미치는 영향을 실증적으로 검증하는 것이다. 본 연구의 대상은 2013년 8월 1일부터 9월 1일까지 서울, 경기도 그리고 강원도에 위치한 6개의 골프연습장과 4곳의 골프장에 설문지를 배포하여 비확률표본추출법 중 편의표본추출법을 이용하여 총 450부의 설문지를 배포하여 회수하였으며 총 432부를 PASW 18.0과 AMOS 18.0을 이용하여 분석을 실시하여 다음과 같은 결과를 도출하였다. 첫째, 골프클럽 구매과정에서 소비자 혼란의 모든 하위요인이 부정적 감정에 유의한 영향을 미치는 것으로 나타났다. 둘째, 부정적 감정은 부정적 구전에 유의한 영향을 미치는 것으로 나타났다. 셋째, 부정적 감정은 신뢰도에 유의한 영향을 미치는 것으로 나타났다. 넷째, 부정적 감정은 구매지연에 유의한 영향을 미치지 않았다. The ever-increasing golf club market made difficult and brought confusion to most of amateur golfers to differentiate and choose suitable clubs for them. Therefore, the purpose of study was to examine how consumer confusion proneness affects consumer`s negative emotion, negative word of mouth, trust and decision postponement, during the process of purchasing golf clubs. 450 questionnaires were distributed to recreational golfers in 6 different golf-driving rages and 4 golf courses located in Seoul, Gyeonggi and Gangwon area with a return rate of 98.4% (n=443). Total of 432 questionnaires were used for data analyses with PASW 18.0 and AMOS 18.0. The results of the study are as follow. First, all of the subordinate factors of consumer confusion proneness had a significant effect on the consumer`s negative emotion. Second, consumer`s negative emotion had a significant effect on negative word of mouth. Third, consumer`s negative emotion had a significant effect on trust. Fourth, consumer`s negative emotion had no significant effect on purchase postponement.
Kim, Ji-Hee,Lee, Kwang-Soon,Lee, Dong-Keon,Kim, Joohwan,Kwak, Su-Nam,Ha, Kwon-Soo,Choe, Jongseon,Won, Moo-Ho,Cho, Byung-Ryul,Jeoung, Dooil,Lee, Hansoo,Kwon, Young-Guen,Kim, Young-Myeong Mary Ann Liebert 2014 Antioxidants & redox signaling Vol.21 No.18
<P>Aims: Hypoxia induces expression of various genes and microRNAs (miRs) that regulate angiogenesis and vascular function. In this study, we investigated a new functional role of new hypoxia-responsive miR-101 in angiogenesis and its underlying mechanism for regulating heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) expression. Results: We found that hypoxia induced miR-101, which binds to the 3 ' untranslated region of cullin 3 (Cul3) and stabilizes nuclear factor erythroid-derived 2-related factor 2 (Nrf2) via inhibition of the proteasomal degradation pathway. miR-101 overexpression promoted Nrf2 nuclear accumulation, which was accompanied with increases in HO-1 induction, VEGF expression, and endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) production. The elevated NO-induced S-nitrosylation of Kelch-like ECH-associated protein 1 and subsequent induction of Nrf2-dependent HO-1 lead to further elevation of VEGF production via a positive feedback loop between the Nrf2/HO-1 and VEGF/eNOS axes. Moreover, miR-101 promoted angiogenic signals and angiogenesis both in vitro and in vivo, and these events were attenuated by inhibiting the biological activity of HO-1, VEGF, or eNOS. Moreover, these effects were also observed in aortic rings from HO-1(+/-) and eNOS(-/-) mice. Local overexpression of miR-101 improved therapeutic angiogenesis and perfusion recovery in the ischemic mouse hindlimb, whereas antagomiR-101 diminished regional blood flow. Innovation: Hypoxia-responsive miR-101 stimulates angiogenesis by activating the HO-1/VEGF/eNOS axis via Cul3 targeting. Thus, miR-101 is a novel angiomir. Conclusion: Our results provide new mechanistic insights into a functional role of miR-101 as a potential therapeutic target in angiogenesis and vascular remodeling. Antioxid. Redox Signal. 21, 2469-2482.</P>