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박영호,송윤섭,임용순,김영호,이남규,구자현,서병욱,김민의,전윤수 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2
Although ureteroscopy(URS) has been used widely to remove ureteral calculi, there is an argument against the belief that anesthesia or admission is needed for URS. We evaluated the experience of URS without anesthesia in female patients. From September 1997 to July 1998, URS was performed in 31 female patients without anesthesia. EHL(Electrohydraulic Lithotripsy) was used in 21 patients with impacted or large stone over 5mm. All patients were given oral antibiotics for 3 days and follow-up KUB was taken to confirm successful removal of the stone one week after the procedure. Successful treatment was defined as complete removal of the stone or residual fragments less than 2mm. Overall success rate was 96.7%(30 cases among 31 cases). All but one patient tolerated with analgesia through the entire procedures. There were only minimal complications such as mild flank pain and hematuria. So, we recommend that non-anesthetic ureteroscopic removal of stone as the first choice for treatment of lower ureteral stones in female based on the minimal morbidity, high success rate and low cost.
Cushing 증후군 2예 : 부신피질 선종으로 인한 due to Adrenocortical Adenoma
전영빈,이의용,김면호,박호진,유건,왕희정,이혁상,고일향 인제대학교 1984 仁濟醫學 Vol.5 No.3
Cushing's syndrome is the clinical and metabolic disorder resulting from a chronic excess of glucocorticoids. Approximately 20-25% of patients with Cushing's syndrome have primary overproduction of cortisol and other adrenal steroids due to an adrenal neoplasm. We recently experienced two cases of Cushing's syndrome due to adrenocortical adenoma. The diagnosis was confirmed by clinical features, biochemical, hormonal and radiological studies and finally pathologic examination. A brief review of literature was presented and our cases were reported.
Senescence is accelerated through donor cell specificity in cloned pigs.
Jeon, Hyun Yong,Jeong, Yeon Woo,Kim, Yeon Wook,Jeong, Yeon Ik,Hossein, Shamim M,Yang, Hyun,Hyun, Sang Hwan,Jeung, Eui-Bae,Hwang, Woo Suk D.A. Spandidos 2012 International journal of molecular medicine Vol.30 No.2
<P>Animals cloned by somatic cell nuclear transfer (SCNT) sometimes have abnormalities that result in large offspring syndrome or early death during gestation due to respiratory and metabolic defects. We cloned pigs using two sources of donor cells and observed phenotypic anomalies in three pigs cloned from one type of cell, s-pig fetal fibroblasts. These animals had many wrinkles on their faces and bodies and looked older than age-matched normal pigs. We performed the present study to examine whether the wrinkled phenotype in the cloned pigs was due to senescence, a genetic problem with donor specificity, or epigenetic problems with reprogramming. To address this issue, we investigated biomarkers of senescence, including telomere length and the expression of senescence-associated β-galactosidase (SA-β-gal), glyceraldehyde phosphate dehydrogenase (GAPDH) and β-actin. We also assessed the methylation status of euchromatic PRE-1 repetitive sequences and centromeric satellite DNA, and measured the mRNA levels of six imprinted genes, Copg2, Mest, Igf2R, GNAS, SNRPN and Ube3a. The telomeres of the wrinkled cloned pigs were much shorter than those of the normal cloned pigs and age-matched normal pigs. In the wrinkled cloned pigs, SA-β-gal activity was detected and GAPDH and β-actin were repressed. The mRNA levels of Mest, GNAS and Ube3a were reduced in the wrinkled cloned pigs, although there was no difference between the normal cloned pigs and normal controls. This gene expression analysis indicates that the wrinkled abnormality of our pigs originates from genetic abnormalities in the donor cells used for SCNT.</P>