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Tae Chul Moon,Chang Seob Seo,Kyungmi Haa,Jin Cheul Kim,Nam Kyung Hwang,Tae Gyun Hong,Jee Hyeun Kim,Do Hun Kim1,손종근,장현욱 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Meso-dihydroguaiaretic acid (MDGA) is a medicinal herbal product isolated from the aerial parts of Saururus chinensis that inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) (IC50 9.8 μM). However, this compound did not inhibit COX-2 protein expression in BMMC at concentrations up to 30 μM, indicating that MDGA directly inhibits COX-2 activity. In addition, this compound consistently inhibited the production of leukotriene C4 (IC50 1.3 μM). These results demonstrate that MDGA inhibits both COX-2 and 5-lipoxygenase. Furthermore, this compound strongly inhibited the degranulation reaction in BMMC (IC50 11.4 μM). Therefore, this compound might provide a basis for novel anti-inflammatory drug development.
Moon, Tae-Chul,Seo, Chang-Seob,Haa, Kyung-Mi,Kim, Jin-Cheul,Hwang, Nam-Kyung,Hong, Tae-Gyun,Kim, Jee-Hyeun,Kim, Do-Hun,Son, Jong-Keun,Chang, Hyeun-Wook 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Meso-dihydroguaiaretic acid (MDGA) is a medicinal herbal product isolated from the aerial parts of Saururus chinensis that inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin $D_2\;(PGD_2)$ generation in bone marrow-derived mast cells (BMMC) ($IC_{50}\;9.8\;{\mu}M$). However, this compound did not inhibit COX-2 protein expression in BMMC at concentrations up to $30\;{\mu}M$, indicating that MDGA directly inhibits COX-2 activity. In addition, this compound consistently inhibited the production of leukotriene $C_4\;(IC_{50}\;1.3\;{\mu}M)$. These results demonstrate that MDGA inhibits both COX-2 and 5-lipoxygenase. Furthermore, this compound strongly inhibited the degranulation reaction in BMMC ($IC_{50}\;11.4\;{\mu}M)$. Therefore, this compound might provide a basis for novel anti-inflammatory drug development.
문현준(Moon Hyeun Jun),박진우(Park Jin-Woo),윤영란(Yoon Young-Ran),지석원(Jee Suck-Won),김정길(Kim Jung-Gil) 한국건축친환경설비학회 2008 한국건축친환경설비학회 학술발표대회 논문집 Vol.- No.-
This paper presents the result of condensation and mold growth risk in two trouble spots in an apartment building. The selected apartment unit (size of 112㎡) is located in city center with severe winter. The comer walls in an extended balcony and a dress room exposed to outside are recognized as problem spots for condensation and mold infestation in the apartment building over years. This study analyses mold risks based on a mixed simulation approach with additional mechanisms of the mold phenomenon and an aggregation method to arrive at quantified mold growth risk. This mold risk indicator (MRI) approach is applied to the selected trouble spots for quantitative condensation and mold growth risks. This study reveals that humidity control is required to avoid condensation and mold risk in the trouble spots in an apartment building.
Park, Jae Hyeun,Lee, Jee Hye,Beak, Suk Hwan,Moon, Tae Chul,Lee, Jong Myung,Kim, Nung Soo,Nam, Kyung Soo,Chang, Hyeun Wook 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-
Extracellular phospholipase A₂ activity has been detected in urine of patients with acute pylonephritis (APN). This enzyme required micromolar Ca^(2-) ion for its maxium activity and showed a broad range of pH (4.5-10) optimum. Urine enzyme hydrolyzed phosphatidylethanolamine (PE) and phosphatidylserine (PS) more effectively than phosphatidylcholine (PC). PLA₂ activity in the urine of patients with APN was about 5-fold higher than that of healthy individuals. When urine was subjected to heparin-Sepharose column chromatography, phospholipase A₂ activity was detected in both heparin-non-binding and binding fractions. Both phospholipase A₂ activities were sensitive less than a micromolar calcium concentration and did not react with anti-human 14-kDa group Ⅱ phospholipase A₂ monoclonal antibody, HP-1. These findings suggest that two kinds of novel extracellular phospholipase A₂, which may not belong to the 14-kDa group Ⅱ phospholipase A₂ family, exist in urine of patients with APN.